LOCUS       NM_001030037            3554 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus calpain 7 (Capn7), mRNA.
ACCESSION   NM_001030037 XM_224617
VERSION     NM_001030037.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3554)
  AUTHORS   Liu H, Jiang Y, Jin X, Zhu L, Shen X, Zhang Q, Wang B, Wang J, Hu
            Y, Yan G and Sun H.
  TITLE     CAPN 7 promotes the migration and invasion of human endometrial
            stromal cell by regulating matrix metalloproteinase 2 activity
  JOURNAL   Reprod Biol Endocrinol 11, 64 (2013)
   PUBMED   23855590
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3554)
  AUTHORS   Osako Y, Maemoto Y, Tanaka R, Suzuki H, Shibata H and Maki M.
  TITLE     Autolytic activity of human calpain 7 is enhanced by
            ESCRT-III-related protein IST1 through MIT-MIM interaction
  JOURNAL   FEBS J 277 (21), 4412-4426 (2010)
   PUBMED   20849418
REFERENCE   3  (bases 1 to 3554)
  AUTHORS   Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta
            R, Wang NS and Knepper MA.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 3554)
  AUTHORS   Gafni J, Hermel E, Young JE, Wellington CL, Hayden MR and Ellerby
            LM.
  TITLE     Inhibition of calpain cleavage of huntingtin reduces toxicity:
            accumulation of calpain/caspase fragments in the nucleus
  JOURNAL   J Biol Chem 279 (19), 20211-20220 (2004)
   PUBMED   14981075
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC099770.1.
            
            On Aug 5, 2005 this sequence version replaced XM_224617.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099770.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3554
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..3554
                     /gene="Capn7"
                     /note="calpain 7"
                     /db_xref="GeneID:306260"
                     /db_xref="RGD:1304855"
     exon            1..255
                     /gene="Capn7"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..2595
                     /gene="Capn7"
                     /codon_start=1
                     /product="calpain-7"
                     /protein_id="NP_001025208.1"
                     /db_xref="GeneID:306260"
                     /db_xref="RGD:1304855"
                     /translation="MDASALERDAVQFARLAVQRDHEGRYSEAVFYYKEAAQALIYAE
                     MAGSSLERIQEKISEYLERVQALHSAVQSKSTDPLKSKHQLDLERAHFLVTQAFDEDE
                     KGNVEDAIELYTEAVDLCLKTSYETADKTLQNKLKQLARQALDRAEALSEPLTKPFCK
                     LKSTNMKTKTPPVRTHFPLGPNPFLEKPQPFISPQSCDAQGQKYTAEEIEVLRTTSKI
                     NGAEYVPFMSVDLRERFAYPMPFCDRLGKLPLSPKQKATFSKWVRPEDLTNNPTMIYT
                     VSSFSIKQTIVSDCSFVASLAISAAYERRFNKKLITSIIYPQNKDGEPEYNPCGKYMV
                     KLHLNGVPRKVIIDDQLPVDHKGELLCSYSNNKSELWVSLIEKAYMKVMGGYDFPGSN
                     SNIDLHALTGWIPERIAMHSDSQTFSKDSSFRMLYQRFHKGDVLITASTGMMTEAEGE
                     KWGLVPTHAYAVLDIREFKGLRFIQLKNPWSHLRWKGRYSENDVKNWTPELQKYLNFD
                     PRTAQKIDNGIFWISWDDLCQYYDVVYLSWNPALFKESTCIHSTWDAKQGPVKDAYSL
                     ANNPQYKLEVQCPQGGAAVWVLLSRHITDKDDFANNREFITMVVYKTDGKKVYYPADP
                     APYIDGIRINSPHYLTKIKLTTPGTHTFTLVVSQYEKQNTIHYTVRVYSACSFTFSKI
                     PSPYTLSKRINGKWSGQSAGGCGNFQETHKNNPIYQFHIDKTGPLLIELRGPRQYSVG
                     FEVVAVSIAGDPGPHGFQRKSSGDYRCGFCYLELENIPAGIFNVIPSTFLPKQEGPFF
                     LDFNSTVPIKTTQLQ"
     exon            256..364
                     /gene="Capn7"
                     /inference="alignment:Splign:2.1.0"
     exon            365..522
                     /gene="Capn7"
                     /inference="alignment:Splign:2.1.0"
     exon            523..590
                     /gene="Capn7"
                     /inference="alignment:Splign:2.1.0"
     exon            591..791
                     /gene="Capn7"
                     /inference="alignment:Splign:2.1.0"
     exon            792..878
                     /gene="Capn7"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1005
                     /gene="Capn7"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1091
                     /gene="Capn7"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1185
                     /gene="Capn7"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1332
                     /gene="Capn7"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1439
                     /gene="Capn7"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1560
                     /gene="Capn7"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1705
                     /gene="Capn7"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1805
                     /gene="Capn7"
                     /inference="alignment:Splign:2.1.0"
     exon            1806..1941
                     /gene="Capn7"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..2017
                     /gene="Capn7"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2163
                     /gene="Capn7"
                     /inference="alignment:Splign:2.1.0"
     exon            2164..2226
                     /gene="Capn7"
                     /inference="alignment:Splign:2.1.0"
     exon            2227..2357
                     /gene="Capn7"
                     /inference="alignment:Splign:2.1.0"
     exon            2358..2450
                     /gene="Capn7"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..3538
                     /gene="Capn7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtagtggag gctccatctt ctcctcctcc gccctcaaaa gtaaactttg ccactctgct
       61 cgcggggtcc tcagttctcc tcgcagtgcc tccgggcggc gggggccggc gtcagggcct
      121 gtctgcctcc ccgggcgtgg ggccttgggc gccatggacg cgtcggcgct ggagcgggac
      181 gccgtgcagt tcgcgcggct ggcagtgcag cgcgaccacg aaggccgcta ctctgaggcg
      241 gtgttttact acaaggaagc tgcccaagcc ttaatttatg cagagatggc aggctccagc
      301 ctagaacgga tccaagaaaa gatcagtgaa tatctggaaa gagtccaagc tctacattct
      361 gcagttcagt caaaaagtac tgatcctttg aaatcaaaac atcagttgga tctagagcgc
      421 gcccactttc ttgttacaca agctttcgat gaggatgaga aggggaatgt ggaagatgcc
      481 atagagttgt atacagaagc cgtggacctc tgtctgaaaa cctcttatga aactgccgat
      541 aagactctgc aaaataaatt gaaacagttg gctcgacagg cactcgatag agcagaagca
      601 ttgagtgaac ctttgacaaa gccattttgc aaactcaagt caacaaatat gaaaacaaag
      661 actcctccag taagaacaca ttttcctcta ggaccgaatc ctttccttga aaagcctcag
      721 ccgtttataa gtccacagtc atgtgatgca caaggacaga agtacacggc agaagaaata
      781 gaagtgctca ggacaacatc aaaaatcaat ggtgcagagt atgttccttt catgagtgtt
      841 gatctgaggg agcgctttgc ttacccaatg cctttttgtg atagattggg caagcttcca
      901 ttatcaccta aacaaaaagc tacattttct aaatgggtgc gaccggagga tctcaccaac
      961 aaccctacaa tgatatacac tgtgtccagt tttagcataa agcagactat agtatcagac
     1021 tgttcctttg tggcatcgtt ggccatcagt gcagcatatg agagacgatt caataagaag
     1081 ttaatcacca gcataattta cccacagaat aaggatggag aaccagagta taatccctgt
     1141 gggaagtata tggtaaaact tcatctcaat ggtgtcccaa gaaaggtgat aattgatgat
     1201 cagttacctg ttgatcacaa aggagaatta ctatgttctt attccaacaa taaaagtgaa
     1261 ttatgggtgt cacttataga gaaagcatac atgaaagtta tgggaggata tgatttccca
     1321 ggatccaact caaatattga tctgcatgca ctgactgggt ggataccgga acggattgcc
     1381 atgcattcag atagccagac cttcagtaag gacagttcat tcaggatgct ttatcaaaga
     1441 tttcacaaag gggatgtcct catcaccgca tcaaccggaa tgatgactga agctgaaggg
     1501 gagaagtggg gcctggttcc cacgcatgcg tatgctgtgt tggatattag agagttcaag
     1561 gggctgagat ttattcagtt aaaaaaccct tggagccatt tacgctggaa aggcaggtac
     1621 agtgaaaatg atgtgaaaaa ctggacccca gaattgcaaa agtatttaaa ctttgatccc
     1681 cgaacagctc agaaaataga taatggaata ttttggatct cctgggatga cctttgccag
     1741 tattatgatg tagtttattt gagttggaac ccagctcttt ttaaagagtc aacctgcatt
     1801 cacagtactt gggatgctaa acaaggacct gtgaaagatg cgtacagctt ggccaacaac
     1861 ccccagtaca aactggaggt gcagtgtcca caagggggtg ctgcagtttg ggttttgctt
     1921 agtagacaca taacagacaa ggatgacttt gcaaataacc gtgagtttat cacaatggtt
     1981 gtgtacaaga ctgacggcaa gaaagtctat tacccagctg acccagctcc atacattgat
     2041 gggattcgaa ttaacagccc tcactacttg actaagataa agctgaccac gcctgggact
     2101 cacaccttca ccctagtggt ttctcagtat gagaaacaga atacgattca ttacactgtc
     2161 cgggtatatt cagcttgcag ctttactttc tcgaagatcc cttcaccata caccttatca
     2221 aagcggatta atggaaagtg gagtggtcaa agtgctggag gatgtggaaa ttttcaggag
     2281 actcacaaaa ataaccccat ctaccaattc catatcgata agactggtcc gttactaatt
     2341 gagctgaggg gaccaaggca atacagtgtt ggatttgagg ttgtagcagt ttccatagcg
     2401 ggagatcctg gtccccatgg ctttcagagg aaatctagtg gtgactatag gtgtggattt
     2461 tgctacttag aactggaaaa catacctgct gggatcttta atgtcatccc cagtactttt
     2521 ttgcctaaac aagaaggacc ctttttcttg gacttcaata gtactgtccc catcaagaca
     2581 acccaactcc agtgatagga ctctcagcta ttactggatt ccatacccac cagtcttcag
     2641 cttcagacaa ggagacacat catgacggtg aaccatcaga gtggaattaa atcaaaagcg
     2701 cgttacagtg gggtctggtg cttgttgtgg tgtttggatt tcagccagat ttcagtcaga
     2761 atcaccttaa tcacccgaaa cactgtttac aaggttttgt gcatacagac ttggcatgtg
     2821 cttcgtggct aactttgtat aagctacagg ttaggttcag ccatcactgt gaaatgcttt
     2881 tgctaacagg acaggggact aaagcaggat gaggacaact gagtgcaaga gcaggctatg
     2941 ttagcatctt gaaattcttg tttcctgttt ttacagagca cgtacgttta gcccgttttt
     3001 atgttgaacc caccatacat cttaagcaat gaattatgtc actgtaacta atttgaattt
     3061 ttcattgtgt ctttaaatat ttgctgttgt atagatgtta agctttaaaa agcagtttag
     3121 cttagcatga agatgctcag gcttgaaggt ggtgagtgtt cgctgcatcg tccatggtag
     3181 agaactgagg tatatctact gttgctgttt ttaattctta gcaggttggt gaatgtagta
     3241 acgggactgg aaatgttcag gtttagcgtg tagggttttt aattgctctg tagtcagtgc
     3301 tctcatcaca ggaatttgga gagtccttga gaattagtat atggtgattg agttacacag
     3361 cattcataaa aagtgagtgg tcaggaatta gtgtttacat aaaaatcatc agtacagagc
     3421 gatgctcaag attttcaagg tgtggaaaat agtatgggat ctgtcggtgt ctctacttta
     3481 taattatcaa aactatttct actgcctttg aatgaaataa aatatttata cttatggaaa
     3541 aaaaaaaaaa aaaa
//
