LOCUS       NM_031808               3494 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus calpain 6 (Capn6), mRNA.
ACCESSION   NM_031808 XM_346869
VERSION     NM_031808.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3494)
  AUTHORS   Tonami,K., Kurihara,Y., Aburatani,H., Uchijima,Y., Asano,T. and
            Kurihara,H.
  TITLE     Calpain 6 is involved in microtubule stabilization and cytoskeletal
            organization
  JOURNAL   Mol Cell Biol 27 (7), 2548-2561 (2007)
   PUBMED   17210638
REFERENCE   2  (bases 1 to 3494)
  AUTHORS   Markmann,A., Schafer,S., Linz,W., Lohn,M., Busch,A.E. and
            Wohlfart,P.
  TITLE     Down-regulation of calpain 9 is linked to hypertensive heart and
            kidney disease
  JOURNAL   Cell Physiol Biochem 15 (1-4), 109-116 (2005)
   PUBMED   15665521
REFERENCE   3  (bases 1 to 3494)
  AUTHORS   Shimizu,T., Kawakita,S., Li,Q.H., Fukuhara,S. and Fujisawa,J.
  TITLE     Human T-cell leukemia virus type 1 Tax protein stimulates the
            interferon-responsive enhancer element via NF-kappaB activity
  JOURNAL   FEBS Lett 539 (1-3), 73-77 (2003)
   PUBMED   12650929
REFERENCE   4  (bases 1 to 3494)
  AUTHORS   Matena,K., Boehm,T. and Dear,N.
  TITLE     Genomic organization of mouse Capn5 and Capn6 genes confirms that
            they are a distinct calpain subfamily
  JOURNAL   Genomics 48 (1), 117-120 (1998)
   PUBMED   9503024
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031808.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF067793.1, SRR26643294.63016.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               JAXUCZ010000021.1  112202036-112202178 c
            144-324             JAXUCZ010000021.1  112195286-112195466 c
            325-456             JAXUCZ010000021.1  112186032-112186163 c
            457-665             JAXUCZ010000021.1  112184460-112184668 c
            666-858             JAXUCZ010000021.1  112183785-112183977 c
            859-1052            JAXUCZ010000021.1  112183015-112183208 c
            1053-1130           JAXUCZ010000021.1  112182718-112182795 c
            1131-1317           JAXUCZ010000021.1  112182437-112182623 c
            1318-1440           JAXUCZ010000021.1  112180971-112181093 c
            1441-1643           JAXUCZ010000021.1  112180603-112180805 c
            1644-1765           JAXUCZ010000021.1  112179947-112180068 c
            1766-1902           JAXUCZ010000021.1  112179613-112179749 c
            1903-3494           JAXUCZ010000021.1  112177467-112179058 c
FEATURES             Location/Qualifiers
     source          1..3494
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq33"
     gene            1..3494
                     /gene="Capn6"
                     /note="calpain 6"
                     /db_xref="GeneID:83685"
                     /db_xref="RGD:70960"
     exon            1..143
                     /gene="Capn6"
                     /inference="alignment:Splign:2.1.0"
     exon            144..324
                     /gene="Capn6"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..2085
                     /gene="Capn6"
                     /codon_start=1
                     /product="calpain-6"
                     /protein_id="NP_113996.2"
                     /db_xref="GeneID:83685"
                     /db_xref="RGD:70960"
                     /translation="MGPPLKLFKNQKYQELKQDCMKDGRLFCDPTFLPENDSLFFNRL
                     LPGKVVWKRPQDISDDPHLIVGNISNHQLIQGRLGNKAMISAFSCLAVQESHWTKAIP
                     NHKEQEWDPRKPEKYAGIFRFRFWHFGEWTEVVIDDLLPTINGDLVFSFSTSMNEFWN
                     ALLEKAYAKLLGCYEALDGLTITDIIMDFTGTLAEIIDMQKGRYTDLVEEKYKLFGEL
                     YKTFTKGGLISCSIESPSQEEQEVETDWGLLKGYTYTMTDIRKLRLGERLVEVFSTEK
                     LYMVRLRNPLGRQEWSGPWSEISEEWQQLTVTDRKNLGLVMSDDGEFWMSLEDFCHNF
                     HKLNVCRNVNNPVFGRKELESVVGCWTVDDDPLMNRSGGCYNNRDTFLQNPQYIFTVP
                     EDGHKVIMSLQQKDLRTYRRMGRPDNYIIGFELFKVEMNRRFRLHHLYIQERAGTSTY
                     IDTRTVFLSKYLKKGNYVLVPTMFQHGRTSEFLLRIFSEVPVQLRELTLDMPKMSCWN
                     LARGYPKVVTQITVHSAEGLEKKYANETVNPYLIIKCGKEEVRSPVQKNTVHAIFDTQ
                     AIFYRRTTDIPIIIQVWNSRKFCDQFLGQVTLDADPSDCRDLKSLYLRKKGGPTAKVK
                     QGHISFKVISSDDLTEL"
     exon            325..456
                     /gene="Capn6"
                     /inference="alignment:Splign:2.1.0"
     exon            457..665
                     /gene="Capn6"
                     /inference="alignment:Splign:2.1.0"
     exon            666..858
                     /gene="Capn6"
                     /inference="alignment:Splign:2.1.0"
     exon            859..1052
                     /gene="Capn6"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1130
                     /gene="Capn6"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1317
                     /gene="Capn6"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1440
                     /gene="Capn6"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1643
                     /gene="Capn6"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..1765
                     /gene="Capn6"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1902
                     /gene="Capn6"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..3494
                     /gene="Capn6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atctttgttc agctgcactg gctgaacaga cttagtgggg ttacctggct aagagcagca
       61 gcagcagcag cagcagcagc agcagcagca gcagcagcag cagcagcagc agcagcaaca
      121 gcagggctcc tgagataact cagacctagt tggataataa tgggtcctcc tctgaagctc
      181 ttcaaaaacc agaagtacca agaactgaag caagactgca tgaaggatgg ccgacttttc
      241 tgtgacccta ccttcctacc ggagaatgat tctctgtttt tcaaccggct gcttccagga
      301 aaggttgtgt ggaaacgtcc tcaggacatt tctgatgacc cccatctgat tgtgggcaac
      361 attagcaacc accagctgat ccagggaaga ctggggaaca aggcaatgat ttctgcattt
      421 tcctgtttgg ctgttcagga gtcacactgg acaaaggcga ttcccaacca taaggaacag
      481 gaatgggatc ctcgaaagcc agaaaaatat gctggaatct ttcgcttccg tttctggcat
      541 tttggagaat ggactgaggt ggtgattgac gacttgcttc ccaccatcaa tggagatctg
      601 gtcttctcat tctccacctc catgaatgag ttttggaatg ctctactgga aaaagcatat
      661 gcaaagcttc tgggctgtta tgaggctttg gatggtctga ccatcactga tatcatcatg
      721 gacttcacgg gcacattggc tgaaatcatt gacatgcaga aaggacgcta caccgatctt
      781 gttgaggaga agtacaagct gtttggagaa ctgtacaaaa cgttcaccaa aggaggtcta
      841 atttcctgct ccattgagtc tcccagccag gaggaacaag aagttgaaac agattggggt
      901 ctactgaagg gttataccta caccatgact gatattcgca agctccgtct tggagaaaga
      961 cttgtggaag tcttcagtac ggagaagctg tatatggttc gcctaaggaa tccattggga
     1021 agacaagaat ggagcggccc ctggagtgaa atttcggaag agtggcagca actgactgta
     1081 accgatcgca agaacctggg gcttgttatg tctgatgatg gagaattttg gatgagtctg
     1141 gaagattttt gccacaactt tcacaaactg aatgtctgcc gcaatgtgaa taaccctgtt
     1201 ttcggtcgca aggagctgga atcagtggtg ggatgttgga ctgtggatga tgaccctctg
     1261 atgaaccgat cgggaggttg ctataacaac cgcgatacct tcctgcagaa tcctcagtac
     1321 atcttcactg tgcctgagga tggccataag gtcatcatgt cactgcagca gaaggatcta
     1381 cgcacttacc gccgaatggg aagacctgac aattacatca ttggttttga gctcttcaag
     1441 gtggagatga accgaagatt ccgccttcat cacctgtata ttcaggagcg agctggaact
     1501 tccacctata tcgacacccg taccgtgttt ctgagcaagt atctgaagaa gggcaactat
     1561 gttcttgttc caactatgtt ccagcatggc cgtaccagcg aatttctact gaggatcttc
     1621 tcggaagtgc ctgtccagct cagggaactg acattggaca tgcccaagat gtcttgctgg
     1681 aacctggcac gtggctaccc aaaggtggtt acccagatca ctgtccacag tgccgagggc
     1741 ctggagaaga agtatgccaa tgaaactgta aatccatatc tgatcatcaa atgtggaaag
     1801 gaagaagtcc gttctcctgt ccagaagaac accgtgcatg ccatttttga cacccaggcc
     1861 attttctacc gaaggaccac tgacattcct attatcatcc aggtctggaa tagcagaaaa
     1921 ttctgtgatc agttcctggg gcaggttact ctggatgctg accccagtga ctgccgtgat
     1981 ctgaaatctc tgtatctgcg taagaagggt ggtcccacgg ccaaagtcaa gcaaggccac
     2041 atcagtttca aagttatctc tagcgatgat ctcactgagc tctaagtatg catcatcaga
     2101 gaatcgtgcc agctttccat catctgtcag gcaccaggtc ttaaccaaga ttcacaatta
     2161 ctgaaattcc acacatttat taacgttttc tcttttccga tatttcccat acctcctgat
     2221 ccaagtagca tcagtagcta cagaacctat atacctccag cagctggaca ggggaggtga
     2281 caatcccatc tggagatcat acacacacac gtttactgag aaaagatcct tagggcttcc
     2341 aggggtgtga atcaaatggg acaataagaa tctgaccagc ctacatgtgt ctttgctgtt
     2401 tccacctgct cagcatatcg tccctgtagg gcatgttggt gaaggagaga ggtgatcaag
     2461 gccaagctgg tctagcctga catctcagct cctaactgac actacagatt tatcagcaac
     2521 atttcaccag tagccagagc tgacttttac cagtcccaac cctatgtcat catcaccacc
     2581 accaccacct ctggaaagtg tggtcctgcc ctaactcaag taactccccc acagtgtttt
     2641 accttcatgt tgaggaagct tcctaggtgc tttatcaaga gctggagttc aatgcacccg
     2701 agacagtgag aagggcttga actttagtca tttggaagcc agctgtgtgc cataagaggg
     2761 agaagttgaa gaagctgcag tgggagacaa agcctctgtc ccccatccat ccacacacac
     2821 ctacactcac acacgcgcag gtaagcgcgc acgaactacc attcagtcag tgggcaagaa
     2881 taaggactag tgaagaatca tgcacaccaa aagatggatg aatctattca gttataggac
     2941 agccagtttg gggtccctga ctacaatgtg aaacctcttg ctgctgctag atttacaaac
     3001 aagcccattg ccttgtgctt cctaatatca ttggtactga aaactctata tgggaccttg
     3061 agagtctggg aaccacccag accccccagg cttttccctc tgttcagaag ctccactccc
     3121 caggggtttg cttttcagta tgtctacaaa atttcctgtg aaccagtcat tatatgttct
     3181 tcccttcatc ctcatctgtc agtattctgc ccctattcaa ggcccagcat aaattccacc
     3241 tcctccatga agttctttca catcttttcc ccaagcccca cctccaacaa tatttcagtg
     3301 cttctgcaat gataaaaaaa acatagttgt agtatttagt ctagttcagc atgcactcat
     3361 ttaaaaataa cattttgtag ctctctcctt tttaacttac tcattttcta tcacattttg
     3421 cagtctttgt aacttttaca gtgcctttgc cacactgcct tacaaacaga atcacaataa
     3481 agttcatatt caat
//
