LOCUS       NM_134461               4236 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Rattus norvegicus calpain 5 (Capn5), mRNA.
ACCESSION   NM_134461 XM_006229730
VERSION     NM_134461.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4236)
  AUTHORS   Schaefer,K.A., Toral,M.A., Velez,G., Cox,A.J., Baker,S.A.,
            Borcherding,N.C., Colgan,D.F., Bondada,V., Mashburn,C.B., Yu,C.G.,
            Geddes,J.W., Tsang,S.H., Bassuk,A.G. and Mahajan,V.B.
  TITLE     Calpain-5 Expression in the Retina Localizes to Photoreceptor
            Synapses
  JOURNAL   Invest Ophthalmol Vis Sci 57 (6), 2509-2521 (2016)
   PUBMED   27152965
REFERENCE   2  (bases 1 to 4236)
  AUTHORS   Singh,R., Brewer,M.K., Mashburn,C.B., Lou,D., Bondada,V., Graham,B.
            and Geddes,J.W.
  TITLE     Calpain 5 is highly expressed in the central nervous system (CNS),
            carries dual nuclear localization signals, and is associated with
            nuclear promyelocytic leukemia protein bodies
  JOURNAL   J Biol Chem 289 (28), 19383-19394 (2014)
   PUBMED   24838245
  REMARK    GeneRIF: CAPN5 is found in punctate domains associated with
            promyelocytic leukemia (PML) protein within the nucleus.
REFERENCE   3  (bases 1 to 4236)
  AUTHORS   Mahajan,V.B., Skeie,J.M., Bassuk,A.G., Fingert,J.H., Braun,T.A.,
            Daggett,H.T., Folk,J.C., Sheffield,V.C. and Stone,E.M.
  TITLE     Calpain-5 mutations cause autoimmune uveitis, retinal
            neovascularization, and photoreceptor degeneration
  JOURNAL   PLoS Genet 8 (10), e1003001 (2012)
   PUBMED   23055945
REFERENCE   4  (bases 1 to 4236)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   5  (bases 1 to 4236)
  AUTHORS   Bowden,M., Drummond,A.E., Salamonsen,L.A., Findlay,J.K. and Nie,G.
  TITLE     Evolutionary conservation of mammalian HTRA3 and its developmental
            regulation in the rat ovary
  JOURNAL   J Exp Zool B Mol Dev Evol 312 (7), 701-713 (2009)
   PUBMED   19415717
REFERENCE   6  (bases 1 to 4236)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 4236)
  AUTHORS   Waghray,A., Wang,D.S., McKinsey,D., Hayes,R.L. and Wang,K.K.
  TITLE     Molecular cloning and characterization of rat and human calpain-5
  JOURNAL   Biochem Biophys Res Commun 324 (1), 46-51 (2004)
   PUBMED   15464980
  REMARK    GeneRIF: Results describe the cloning and characterization of rat
            calpain-5, which is highly homologous to human and mouse sequences.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Sep 4, 2015 this sequence version replaced
            XM_006229730.2, NM_134461.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ223532.1, SRR26360190.1148041.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMN12840115 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-169               JAXUCZ010000001.1  161883974-161884142 c
            170-364             JAXUCZ010000001.1  161868909-161869103 c
            365-496             JAXUCZ010000001.1  161857951-161858082 c
            497-705             JAXUCZ010000001.1  161842315-161842523 c
            706-898             JAXUCZ010000001.1  161838855-161839047 c
            899-1092            JAXUCZ010000001.1  161837741-161837934 c
            1093-1170           JAXUCZ010000001.1  161837230-161837307 c
            1171-1366           JAXUCZ010000001.1  161835228-161835423 c
            1367-1489           JAXUCZ010000001.1  161834420-161834542 c
            1490-1686           JAXUCZ010000001.1  161832210-161832406 c
            1687-1802           JAXUCZ010000001.1  161831395-161831510 c
            1803-1939           JAXUCZ010000001.1  161830811-161830947 c
            1940-4236           JAXUCZ010000001.1  161827474-161829770 c
FEATURES             Location/Qualifiers
     source          1..4236
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..4236
                     /gene="Capn5"
                     /gene_synonym="Htra3"
                     /note="calpain 5"
                     /db_xref="GeneID:171495"
                     /db_xref="RGD:620084"
     exon            1..169
                     /gene="Capn5"
                     /gene_synonym="Htra3"
                     /inference="alignment:Splign:2.1.0"
     exon            170..364
                     /gene="Capn5"
                     /gene_synonym="Htra3"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..2122
                     /gene="Capn5"
                     /gene_synonym="Htra3"
                     /note="high-temperature requirement factor A3"
                     /codon_start=1
                     /product="calpain-5"
                     /protein_id="NP_604456.2"
                     /db_xref="GeneID:171495"
                     /db_xref="RGD:620084"
                     /translation="MFSCTKAYEDQNYSALKRACLRRKVLFEDPHFPATDDSLYYKGT
                     PGPTVRWKRPKDICDDPRLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQKVIP
                     DWKEQEWNPEKPDSYAGIFHFNFWRFGEWVDVVVDDRLPTVNNQLIYCHSNSKNEFWC
                     ALVEKAYAKLAGCYQALDGGNTADALVDFTGGVSEPIDLTEGDLATDEAKRSQLFERV
                     LKVHSRGGLISASIKAMTAADMETRLACGLVKGHAYAVTDVRKVRLGHGLLAFFKSEK
                     LDMIRLRNPWGEREWTGPWSDTSEEWQKVSKSEREKMGVTVQDDGEFWMTFEDMCRYF
                     TDIIKCRLINTSYLSIHKTWEEARLRGAWTRHEDPQQNRSGGCINHKDTFFQNPQYIF
                     EVKKPEDEVLICIQQRPKRSTRREGKGENLAIGFDIYKVEENRQYRMHSLQHKAASSI
                     YINSRSVFLRTELPEGRYVIIPTTFEPGHTGEFLLRVFTDVPSNCRELRLDEPPRTCW
                     SSLCGYPQQVTQVHVLGAAGLKDSSTGANSYVIIKCEGEKVRSAVQRGTSTPEYNVKG
                     IFYRKKLSQPITVQVWNHRVLKDEFLGQVHLKTAPDDLQDLHSLHLQDRSGRQPSDLP
                     GIVAVRVLCSASLTAV"
     exon            365..496
                     /gene="Capn5"
                     /gene_synonym="Htra3"
                     /inference="alignment:Splign:2.1.0"
     exon            497..705
                     /gene="Capn5"
                     /gene_synonym="Htra3"
                     /inference="alignment:Splign:2.1.0"
     exon            706..898
                     /gene="Capn5"
                     /gene_synonym="Htra3"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1092
                     /gene="Capn5"
                     /gene_synonym="Htra3"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1170
                     /gene="Capn5"
                     /gene_synonym="Htra3"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1366
                     /gene="Capn5"
                     /gene_synonym="Htra3"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1489
                     /gene="Capn5"
                     /gene_synonym="Htra3"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1686
                     /gene="Capn5"
                     /gene_synonym="Htra3"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1802
                     /gene="Capn5"
                     /gene_synonym="Htra3"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1939
                     /gene="Capn5"
                     /gene_synonym="Htra3"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..4236
                     /gene="Capn5"
                     /gene_synonym="Htra3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagaccgaa gccccggggt ccaagttccc gcccctgcct gcgggctgcc ggggcagcgt
       61 ttccccgcag agtcccaggc tgtggcgcgg gcagatccaa cctccgctcc agtgcccgca
      121 ccgtgccctg catctcagga gtccggctcc agctgcggcg acgcggcagg ggcctcccct
      181 aattggggac gtggtcacca tgttctcctg cacaaaggcc tatgaagacc agaattactc
      241 agctctgaag cgggcctgtc tgcgcaggaa ggtgctgttc gaggaccccc acttccctgc
      301 caccgacgac tcactctact ataagggtac cccagggccc acagtcaggt ggaagcggcc
      361 taaggatatc tgcgatgatc cccggctctt cgtcgatggc atcagctcgc atgacctgca
      421 ccagggccag gtgggcaact gctggtttgt ggccgcctgc tcatcactcg cctcccggga
      481 gtcactctgg caaaaggtca tcccagactg gaaggagcag gaatggaacc ccgagaagcc
      541 cgacagctat gctggcatct tccatttcaa cttctggcgc tttggggagt gggtggacgt
      601 ggtcgtcgat gaccggctgc ccacagtcaa caaccaactc atttactgcc actccaactc
      661 gaaaaatgag ttctggtgtg ccctggtgga gaaggcctat gccaagctgg caggctgtta
      721 ccaggccctg gacggaggca acacagccga tgcactggtg gatttcacag gcggtgtttc
      781 ggaacccatc gacctgaccg agggggactt ggccacagat gaggctaaga gaagccagct
      841 ctttgaacgt gtgttgaagg tgcacagcag aggtgggctc atcagtgcct ccatcaaggc
      901 tatgacagca gctgacatgg agacccgtct ggcctgtggt ctggtgaagg gccatgcata
      961 tgctgtcacc gatgtgcgca aggtgcgcct gggccatggc ctgctggcct tcttcaagtc
     1021 agagaagctg gacatgatcc gtctgaggaa cccctggggc gagcgggagt ggaccgggcc
     1081 ctggagtgac acgtcagagg aatggcagaa agtgagcaag agtgagaggg agaaaatggg
     1141 cgtgaccgta caggacgatg gtgaattctg gatgaccttt gaggacatgt gccgatactt
     1201 caccgacatc attaagtgcc gcctgattaa tacgtcctac ctgagcatcc acaagacatg
     1261 ggaggaggcc cggctgcgtg gtgcctggac gagacatgag gacccccagc agaaccgcag
     1321 tggaggctgc atcaaccaca aggacacttt cttccagaac ccacagtaca tatttgaagt
     1381 caagaagcca gaagatgaag tgctgatctg catccagcag cggcccaaac gctcgactcg
     1441 ccgagagggc aaaggggaga atctggccat cggcttcgac atctataagg tggaagagaa
     1501 ccgccagtac cggatgcaca gcctgcagca taaggccgcc agctccatct acatcaattc
     1561 tcggagtgtt ttcctgcgga cagagctgcc tgagggccgc tacgtcatca tccctaccac
     1621 ctttgagcca ggccacactg gcgagttcct gctccgcgtc ttcacagacg ttccctccaa
     1681 ctgccgggag ctacgcctgg atgagccccc tcgtacctgc tggagctccc tgtgtggcta
     1741 ccctcagcag gtgacccagg tccatgtcct gggagctgct ggcctcaagg actcttccac
     1801 aggagcaaac tcatatgtga tcatcaagtg tgagggtgaa aaggttcgct cagctgtgca
     1861 gagagggacc tcgacgccag agtacaatgt gaaaggcatc ttctatcgca agaaactgtc
     1921 tcagcccatc actgtgcagg tctggaatca ccgagtcctg aaggatgaat tcctgggcca
     1981 ggtgcacctg aagactgccc cggatgacct gcaggacctg cacagcctcc atctccagga
     2041 ccgcagtggc cggcagccca gcgacttgcc aggcatcgtc gctgtgcgtg tcctctgcag
     2101 tgcctctctc acggctgtct gatgccagcc agcctgccca gccccactag ttctcagcac
     2161 tactcgcatg tccccacctg gcctgggacc agcctgggaa ccagacactg ggccctttgc
     2221 ccgctcttcc actgacccac tgtgtgaccg aggagagccc tgcccctctc tgagcctcag
     2281 tgtttggagg gccccgaaga attcccctct cgtgggggag ttttcttgcc taagatttaa
     2341 agcggctcct tctacccagt gggcactgcc gtcaaggggc tatctgttga aaatgtttcc
     2401 cctggccctg ctatctgcag aggagtgcca agacgtcaat tgtttacaca caaactgcca
     2461 tgtcccaagt cccttccctc tcctcgtttg ctgtggggga ggttgcttcc ctccccagat
     2521 ctttgctgcg tagcttagag tgaccttaaa cttctgatcc ccctgcctcc acctcctcag
     2581 gtggaaccca gggctttgtg catgctaggc gagcgcttac caactgagct gcacacccaa
     2641 tcccactaca catcatttta aaaccatctt gaaagaaccc ttagcaggca tacgcaggac
     2701 gccccacctc catccattta attgctctat cgacttgccc tgttagccgc cccgggcttg
     2761 ctgattctca ggtcttcttg gagatagata ccttcctgag accaggctct gacttcactc
     2821 tcagcccctg aagagctatg gtcatgctgg tgatttccca acactctact tgtgatgttg
     2881 gaccaagtgg cccgggccag gctgatgtaa ggctatggga gacccaaggg ggacacatgg
     2941 tgcctctgct gaaggaccct ggggttttct tggaagaaaa gactgtagga tggatgtact
     3001 aggccttcag ggctagttca tctgttgggt gtcacagaca gggaccagag ggctttccac
     3061 cagcataccc caaagatcta aggaagccac cacactctta ctgtccgtac agaccaaaat
     3121 gttactctca gtcctcagca tttgatagtc ttagcattta aaacaatctc ggtgtaaagg
     3181 gaagtcggcc cccacatttg ttcttttcaa actcgttttg ttgggcttct gcttttatct
     3241 tgacattgaa catgagaggg cacggtcaca gtgggacctt ctcagaggag tctcagagaa
     3301 tgatggaggc gagatgttcc ttcctggctg ccgtctgcgt tctgtctctg gtccctccta
     3361 catggtccta ttcctggctg gaggtgctgg attctgactg ccatcttgct ccatggtggc
     3421 tcttctggcc tgggaccatt gtccacagta agggctagga gctgaactga aaggatgaga
     3481 ggattcctcc tgcacagtca gggcttccct tcaatgacct gggcctggga ttgtgcatcc
     3541 caccaggagc aagtcacttc aacctcccgt gcctcgattc ctccctcttg tagcatggcg
     3601 ctggcctctc ctgttgtgag gactcttaaa agaataagag caaggccaca ccacttccac
     3661 tgtgtgtctc tctattgtat actctgcacg gtcacatgat ccctccactt ctcaacggct
     3721 gtcgcaaatg aagactgcag tcaggaagcg gggatgagca cctgcctcac gatcttggct
     3781 ctcagggcct ggcgtgtggg tctcagctca gccatatccc tctgaggcac agggcaaacg
     3841 aggaccaagt agcagactgc agatgcttca cctggcatct agacactgcc ccccgccccc
     3901 cacctccagc agaactgggc cagcagctct gttcttgctt cctctctctt aagctaggcc
     3961 aggctggctc ctggctgtga aggaacctct ggtccctagg aaaccctgaa gactagacag
     4021 gtggggacag ggtagagcag ggacagcagt ggctttgttc accatttgca cccaggaggc
     4081 cttgtagtgt tacagttgca gtcatcagcc ctatgatgta cactacatgg accagcagga
     4141 cctggccttc actcctccag gctactatgc cctggggtca agggagagga actctgttat
     4201 cttctcagaa taaatattac tgccactcta gaggga
//
