LOCUS       NM_031673               2561 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus calpain 10 (Capn10), mRNA.
ACCESSION   NM_031673
VERSION     NM_031673.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2561)
  AUTHORS   Smith,M.A., Covington,M.D. and Schnellmann,R.G.
  TITLE     Loss of calpain 10 causes mitochondrial dysfunction during chronic
            hyperglycemia
  JOURNAL   Arch Biochem Biophys 523 (2), 161-168 (2012)
   PUBMED   22568896
  REMARK    GeneRIF: diabetes-induced renal mitochondrial dysfunction and renal
            injury may directly result from the loss of renal calpain 10
REFERENCE   2  (bases 1 to 2561)
  AUTHORS   Covington,M.D. and Schnellmann,R.G.
  TITLE     Chronic high glucose downregulates mitochondrial calpain 10 and
            contributes to renal cell death and diabetes-induced renal injury
  JOURNAL   Kidney Int 81 (4), 391-400 (2012)
   PUBMED   22012129
REFERENCE   3  (bases 1 to 2561)
  AUTHORS   Fong,P.Y., Fesinmeyer,M.D., White,E., Farin,F.M.,
            Srinouanprachanh,S., Afsharinejad,Z., Mandelson,M.T.,
            Brentnall,T.A., Barnett,M.J., Goodman,G.E. and Austin,M.A.
  TITLE     Association of diabetes susceptibility gene calpain-10 with
            pancreatic cancer among smokers
  JOURNAL   J Gastrointest Cancer 41 (3), 203-208 (2010)
   PUBMED   20178008
REFERENCE   4  (bases 1 to 2561)
  AUTHORS   Zhou,X., Wang,Y., Zhang,Y., Gao,P. and Zhu,D.
  TITLE     Association of CAPN10 gene with insulin sensitivity, glucose
            tolerance and renal function in essential hypertensive patients
  JOURNAL   Clin Chim Acta 411 (15-16), 1126-1131 (2010)
   PUBMED   20406624
REFERENCE   5  (bases 1 to 2561)
  AUTHORS   Ling,C., Groop,L., Guerra,S.D. and Lupi,R.
  TITLE     Calpain-10 expression is elevated in pancreatic islets from
            patients with type 2 diabetes
  JOURNAL   PLoS One 4 (8), e6558 (2009)
   PUBMED   19688040
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2561)
  AUTHORS   Paul,D.S., Harmon,A.W., Winston,C.P. and Patel,Y.M.
  TITLE     Calpain facilitates GLUT4 vesicle translocation during
            insulin-stimulated glucose uptake in adipocytes
  JOURNAL   Biochem J 376 (Pt 3), 625-632 (2003)
   PUBMED   12974673
REFERENCE   7  (bases 1 to 2561)
  AUTHORS   Sato,Y., Kuwajima,M., Kamiya,H. and Harashima,H.
  TITLE     Calpain 10 as a predictive gene for type 2 diabetes: evidence from
            a novel screening system using white blood cells of Otsuka
            Long-Evans Tokushima Fatty (OLETF) rats
  JOURNAL   Biol Pharm Bull 26 (12), 1765-1768 (2003)
   PUBMED   14646187
  REMARK    GeneRIF: 'Calpain 10 (CAPN10) is reported linked with type 2
            diabetes in certain human populations...' 'Levels of mRNA for type
            2 diabetes-related genes such as ...CPN10 were quantified in
            WBC...in OLETF rats... known to initiate type 2 diabetes at 18
            weeks...'
REFERENCE   8  (bases 1 to 2561)
  AUTHORS   Cox,N.J.
  TITLE     Challenges in identifying genetic variation affecting
            susceptibility to type 2 diabetes: examples from studies of the
            calpain-10 gene
  JOURNAL   Hum Mol Genet 10 (20), 2301-2305 (2001)
   PUBMED   11673414
  REMARK    Review article
REFERENCE   9  (bases 1 to 2561)
  AUTHORS   Ma,H., Fukiage,C., Kim,Y.H., Duncan,M.K., Reed,N.A., Shih,M.,
            Azuma,M. and Shearer,T.R.
  TITLE     Characterization and expression of calpain 10. A novel ubiquitous
            calpain with nuclear localization
  JOURNAL   J Biol Chem 276 (30), 28525-28531 (2001)
   PUBMED   11375982
REFERENCE   10 (bases 1 to 2561)
  AUTHORS   Baier,L.J., Permana,P.A., Yang,X., Pratley,R.E., Hanson,R.L.,
            Shen,G.Q., Mott,D., Knowler,W.C., Cox,N.J., Horikawa,Y., Oda,N.,
            Bell,G.I. and Bogardus,C.
  TITLE     A calpain-10 gene polymorphism is associated with reduced muscle
            mRNA levels and insulin resistance
  JOURNAL   J Clin Invest 106 (7), R69-R73 (2000)
   PUBMED   11018080
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC085725.1 and AF227909.3.
            
            On Oct 11, 2005 this sequence version replaced NM_031673.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               BC085725.1         1-100
            101-2472            AF227909.3         1-2372
            2473-2561           BC085725.1         3866-3954
FEATURES             Location/Qualifiers
     source          1..2561
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q36"
     gene            1..2561
                     /gene="Capn10"
                     /note="calpain 10"
                     /db_xref="GeneID:63834"
                     /db_xref="RGD:69354"
     exon            1..264
                     /gene="Capn10"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..2124
                     /gene="Capn10"
                     /note="CANP 10; calcium-activated neutral proteinase 10"
                     /codon_start=1
                     /product="calpain-10"
                     /protein_id="NP_113861.1"
                     /db_xref="GeneID:63834"
                     /db_xref="RGD:69354"
                     /translation="MRAVRAETRARELFRDAAFPASDSSLFYNLSTPLAQFREDITWR
                     RPQDICATPQLFPDNPWEGQVKQGLLGDCWFLCACAALQKSRHLLDQVFPPGQPGWSD
                     QEYQGFFTCRIWQFGHWEEVTIDDRLPCLAGRLCFSRCQREDVFWLPLLEKAYAKVHG
                     SYEHLWAGQVADALVDLTGSLAERWSLKDIRKASGQQDRPSGGEHRACQQLLRLKDQC
                     LLSCSVLSPRAGARELGEFHAFIISDLQELRSQTGQGILLLRIHNPWGRRCWQGLWRE
                     GGEGWNQVEPAKESELLAQLQEGEFWVEEEEFLREFDEVTIGYPVTEAGHLQSLYTEK
                     VLCHTRALPGAWVTGQSAGGCRNNSCFPCNPKFWLRLLEPSEVCVAVLQRPRRRLVGQ
                     TRALAGASPAPVNLPGKDYQAVGLHIWKVEKRKISLPRVLSAPPVAGTACHAYDREIH
                     LRCELSPGYYLAVPSTFLKDVPGQFLLRVFSTGKISLSAVRLATKGASPGAALPAGEW
                     ETVQLQGSWRAGQTAGGSRNFASYPCNPCLPFSVPEGAGPRYIRITLQQHCRLSDSQL
                     HPIGFHVFQVPADGEKQDACSLLLQEPLLSCVPHCYAQEVSRLCLLSAGNYRIVPSTY
                     LPDTEGTFTVTIATRIDRQSIHSQEMLGQLLQEVSFMAVMKA"
     exon            265..396
                     /gene="Capn10"
                     /inference="alignment:Splign:2.1.0"
     exon            397..593
                     /gene="Capn10"
                     /inference="alignment:Splign:2.1.0"
     exon            594..811
                     /gene="Capn10"
                     /inference="alignment:Splign:2.1.0"
     exon            812..953
                     /gene="Capn10"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1120
                     /gene="Capn10"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1383
                     /gene="Capn10"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1586
                     /gene="Capn10"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1848
                     /gene="Capn10"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..2048
                     /gene="Capn10"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2094
                     /gene="Capn10"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..2532
                     /gene="Capn10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagctctgca ccagtaggtc tcgcggttag ctaagcagcc caggtttgca gcgaaggcag
       61 cgcactcgct tccgggcggc gaccgagtcc aggggccgca aaggggagcc cagggcgccg
      121 aagatgcggg cggtccgggc cgagacgcgg gcgcgggagc tcttccggga cgccgcattc
      181 cccgcctcgg actcctcgct cttttacaac ttgtccacgc ctctggccca gtttcgggag
      241 gacatcactt ggagacggcc ccaggacatt tgtgccacac ctcaactgtt tccagataac
      301 ccatgggaag gacaggtgaa gcaagggctg ctgggggatt gctggttcct gtgtgcctgt
      361 gccgcccttc agaagagtcg acacctcctg gaccaggtct tccctccagg acagccaggc
      421 tggtctgacc aggaatacca aggcttcttc acctgtcgga tttggcagtt tggacactgg
      481 gaggaagtga ccatagatga ccgtctgcct tgtcttgccg ggagactctg cttttctcga
      541 tgccagagag aggatgtgtt ctggcttccc ttactggaaa aggcctacgc taaggttcat
      601 ggatcctatg agcacctgtg ggcagggcag gtggcagatg ccctggtgga tctcactggc
      661 agcctggcag agaggtggag cctgaaggac ataaggaaag ccagcggcca gcaggacaga
      721 cccagtggtg gagagcacag agcctgtcag cagctactcc gtctcaagga ccagtgtctg
      781 ctcagctgct ctgtgctgag cccgagagca ggtgctaggg agctcgggga gttccatgcc
      841 ttcattatct cagatctgca ggagctcagg agtcagactg gtcagggtat cctcctgctg
      901 aggattcaca acccttgggg ccggcgttgt tggcagggcc tctggagaga aggcggtgaa
      961 gggtggaacc aggtagagcc agctaaggag tctgagctgc tggcacaact ccaggaagga
     1021 gagttctggg tagaggaaga ggagttcctc agggagtttg atgaggtcac catcggctac
     1081 ccagtcacag aggccggcca cctgcaaagt ctctacacag agaaggtgct gtgccatacg
     1141 cgggcactgc ctggtgcctg ggtgacaggg caatcagctg gaggctgccg gaacaacagt
     1201 tgctttccct gcaaccccaa gttctggtta cggctcttgg aacccagtga ggtgtgtgtg
     1261 gctgtccttc agagaccccg gaggcgctta gtgggccaga cccgggcact ggcgggcgcc
     1321 agccctgcac cagtgaacct cccaggcaaa gactaccagg ctgtgggcct gcacatctgg
     1381 aaggtagaga aacggaagat cagcctgccc agagtcctgt ctgcaccccc ggtggctggc
     1441 actgcatgcc atgcgtatga tcgtgagatc cacttgcgtt gtgagctctc accaggctac
     1501 tacctggctg tccctagcac ctttttgaag gatgtgccag ggcagttcct gctccgagtc
     1561 ttctccaccg ggaaaatctc cctcagtgcc gtcaggctgg ccaccaaggg tgcatcacct
     1621 ggagcagccc tgcctgcagg cgagtgggag actgtgcagt tgcagggcag ctggagagct
     1681 ggccagacag ccgggggcag tagaaacttt gcctcttacc cctgcaatcc ctgcctcccc
     1741 ttctctgttc ctgagggtgc tggtccccgc tacatccgta tcaccctaca gcaacactgc
     1801 cggctcagtg acagccagct ccaccccatt ggtttccatg tctttcaggt tccagcagac
     1861 ggtgaaaaac aggatgcgtg ttccctgctg ctccaggagc cactgctaag ctgtgtacca
     1921 cattgctatg cccaggaagt aagccgcctc tgcctccttt ctgcggggaa ctacaggatt
     1981 gtgccctcca cctacctgcc agatacagag ggtaccttca cagtgaccat agcaaccaga
     2041 atagacagac agtccattca cagccaggag atgctgggcc agctactcca ggaggtctcc
     2101 ttcatggcag tgatgaaagc ctgacacaag aacctgtgtg ctggctgtgg ccagagtggc
     2161 tgtttctcct gcacccagca tccaggcaca tcttcaacca gtcatgagcc aagcttctcc
     2221 tcagccctga ggcctagtgt ggatcttagg gctaaaatag ggtgctttgt cctggattga
     2281 agacatcttg gggtccaatg ggtactgcag ggcggggtta ggactcccaa gtggtatctt
     2341 cattcctcag tgaaggccaa gaaggtccct ggggcccagg tttgctgggg aaagctttgc
     2401 agaatccaca ttcccttctt gattttggaa gccttattac accaggcagg cagattgtga
     2461 caaaagctaa aaactattta ttacttgaaa tatttttgga atgtgacttt ataaataaac
     2521 atgaataatt taaaaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
