LOCUS       NM_019152               3020 bp    mRNA    linear   ROD 11-APR-2024
DEFINITION  Rattus norvegicus calpain 1 (Capn1), mRNA.
ACCESSION   NM_019152
VERSION     NM_019152.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3020)
  AUTHORS   Xue,X., Xi,W., Li,W., Xiao,J., Wang,Z. and Zhang,Y.
  TITLE     Hydrogen-rich saline alleviates cardiomyocyte apoptosis by reducing
            expression of calpain1 via miR-124-3p
  JOURNAL   ESC Heart Fail 10 (5), 3077-3090 (2023)
   PUBMED   37602925
  REMARK    GeneRIF: Hydrogen-rich saline alleviates cardiomyocyte apoptosis by
            reducing expression of calpain1 via miR-124-3p.
REFERENCE   2  (bases 1 to 3020)
  AUTHORS   Zhang,Y., Zhang,J., Sun,Z., Wang,H., Ning,R., Xu,L., Zhao,Y.,
            Yang,K., Xi,X. and Tian,J.
  TITLE     MAPK8 and CAPN1 as potential biomarkers of intervertebral disc
            degeneration overlapping immune infiltration, autophagy, and ceRNA
  JOURNAL   Front Immunol 14, 1188774 (2023)
   PUBMED   37325630
  REMARK    GeneRIF: MAPK8 and CAPN1 as potential biomarkers of intervertebral
            disc degeneration overlapping immune infiltration, autophagy, and
            ceRNA.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3020)
  AUTHORS   Zaman,V., Drasites,K.P., Myatich,A., Shams,R., Shields,D.C.,
            Matzelle,D., Haque,A. and Banik,N.L.
  TITLE     Inhibition of Calpain Attenuates Degeneration of Substantia Nigra
            Neurons in the Rotenone Rat Model of Parkinson's Disease
  JOURNAL   Int J Mol Sci 23 (22), 13849 (2022)
   PUBMED   36430329
  REMARK    GeneRIF: Inhibition of Calpain Attenuates Degeneration of
            Substantia Nigra Neurons in the Rotenone Rat Model of Parkinson's
            Disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3020)
  AUTHORS   Lin,J., Wang,F., Jiang,G., Zhang,T., Zhang,J., He,Q. and Fan,Y.
  TITLE     LXR activation ameliorates high glucose stress-induced aberrant
            mitochondrial dynamics via downregulation of Calpain1 expression in
            H9c2 cardiomyoblasts
  JOURNAL   Biochem Biophys Res Commun 614, 145-152 (2022)
   PUBMED   35597151
  REMARK    GeneRIF: LXR activation ameliorates high glucose stress-induced
            aberrant mitochondrial dynamics via downregulation of Calpain1
            expression in H9c2 cardiomyoblasts.
REFERENCE   5  (bases 1 to 3020)
  AUTHORS   Guo,J., Yang,J., Fu,J. and Tripathi,A.
  TITLE     Exercise improves the body function and protects the neuronal
            injury in Parkinson's disease rats by activating calpain 1 and
            kallikrein 6
  JOURNAL   Folia Neuropathol 60 (3), 301-307 (2022)
   PUBMED   36382482
  REMARK    GeneRIF: Exercise improves the body function and protects the
            neuronal injury in Parkinson's disease rats by activating calpain 1
            and kallikrein 6.
REFERENCE   6  (bases 1 to 3020)
  AUTHORS   Sorimachi,H., Amano,S., Ishiura,S. and Suzuki,K.
  TITLE     Primary sequences of rat mu-calpain large and small subunits are,
            respectively, moderately and highly similar to those of human
  JOURNAL   Biochim Biophys Acta 1309 (1-2), 37-41 (1996)
   PUBMED   8950173
REFERENCE   7  (bases 1 to 3020)
  AUTHORS   Michetti,M., Salamino,F., Tedesco,I., Averna,M., Minafra,R.,
            Melloni,E. and Pontremoli,S.
  TITLE     Autolysis of human erythrocyte calpain produces two active enzyme
            forms with different cell localization
  JOURNAL   FEBS Lett 392 (1), 11-15 (1996)
   PUBMED   8769305
REFERENCE   8  (bases 1 to 3020)
  AUTHORS   Karlsson,J.O., Blennow,K., Janson,I., Blomgren,K., Karlsson,I.,
            Regland,B., Wallin,A. and Gottfries,C.G.
  TITLE     Increased proteolytic activity in lymphocytes from patients with
            early onset Alzheimer's disease
  JOURNAL   Neurobiol Aging 16 (6), 901-906 (1995)
   PUBMED   8622780
REFERENCE   9  (bases 1 to 3020)
  AUTHORS   Sorimachi,H., Ohmi,S., Emori,Y., Kawasaki,H., Saido,T.C., Ohno,S.,
            Minami,Y. and Suzuki,K.
  TITLE     A novel member of the calcium-dependent cysteine protease family
  JOURNAL   Biol Chem Hoppe Seyler 371 Suppl, 171-176 (1990)
   PUBMED   2400579
REFERENCE   10 (bases 1 to 3020)
  AUTHORS   Uemori,T., Shimojo,T., Asada,K., Asano,T., Kimizuka,F., Kato,I.,
            Maki,M., Hatanaka,M., Murachi,T., Hanzawa,H. et al.
  TITLE     Characterization of a functional domain of human calpastatin
  JOURNAL   Biochem Biophys Res Commun 166 (3), 1485-1493 (1990)
   PUBMED   2407243
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC061880.1.
            
            [WARNING] On Apr 12, 2024 this sequence was replaced by
            NM_019152.3.
            
            On Feb 9, 2004 this sequence version replaced NM_019152.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061880.1, U53858.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3020
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..3020
                     /gene="Capn1"
                     /note="calpain 1"
                     /db_xref="GeneID:29153"
                     /db_xref="RGD:2267"
     exon            1..50
                     /gene="Capn1"
                     /inference="alignment:Splign:2.1.0"
     exon            51..318
                     /gene="Capn1"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..2193
                     /gene="Capn1"
                     /EC_number="3.4.22.52"
                     /note="CANP 1; muCANP; calpain mu-type;
                     micromolar-calpain; calpain-1 large subunit;
                     calcium-activated neutral proteinase 1; calpain 1, (mu/I)
                     large subunit"
                     /codon_start=1
                     /product="calpain-1 catalytic subunit"
                     /protein_id="NP_062025.1"
                     /db_xref="GeneID:29153"
                     /db_xref="RGD:2267"
                     /translation="MAEELITPVYCTGVSAQVQKQRDKELGLGRHENAIKYLGQDYEN
                     LRARCLQNGVLFQDDAFPPVSHSLGFKELGPNSSKTYGIKWKRPTELLSNPQFIVDGA
                     TRTDICQGALGDCWLLAAIASLTLNETILHRVVPYGQSFQEGYAGIFHFQLWQFGEWV
                     DVVVDDLLPTKDGKLVFVHSAQGNEFWSALLEKAYAKVNGSYEALSGGCTSEAFEDFT
                     GGVTEWYDLQKAPSDLYQIILKALERGSLLGCSINISDIRDLEAITFKNLVRGHAYSV
                     TDAKQVTYQGQRVNLIRMRNPWGEVEWKGPWSDNSYEWNKVDPYEREQLRVKMEDGEF
                     WMSFRDFIREFTKLEICNLTPDALKSRTLRNWNTTFYEGTWRRGSTAGGCRNYPATFW
                     VNPQFKIRLEEVDDADDYDSRESGCSFLLALMQKHRRRERRFGRDMETIGFAVYQVPR
                     ELAGQPVHLKRDFFLANASRAQSEHFINLREVSNRIRLPPGEYIVVPSTFEPNKEGDF
                     LLRFFSEKKAGTQELDDQIQANLPDEKVLSEEEIDDNFKTLFSKLAGDDMEISVKELQ
                     TILNRIISKHKDLRTNGFSLESCRSMVNLMDRDGNGKLGLVEFNILWNRIRNYLTIFR
                     KFDLDKSGSMSAYEMRMAIEAAGFKLNKKLHELIITRYSEPDLAVDFDNFVCCLVRLE
                     TMFRFFKILDTDLDGVVTFDLFKWLQLTMFA"
     exon            319..388
                     /gene="Capn1"
                     /inference="alignment:Splign:2.1.0"
     exon            389..507
                     /gene="Capn1"
                     /inference="alignment:Splign:2.1.0"
     exon            508..641
                     /gene="Capn1"
                     /inference="alignment:Splign:2.1.0"
     exon            642..810
                     /gene="Capn1"
                     /inference="alignment:Splign:2.1.0"
     exon            811..894
                     /gene="Capn1"
                     /inference="alignment:Splign:2.1.0"
     exon            895..980
                     /gene="Capn1"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1055
                     /gene="Capn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1216
                     /gene="Capn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1392
                     /gene="Capn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1404
                     /gene="Capn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1613
                     /gene="Capn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1653
                     /gene="Capn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1719
                     /gene="Capn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..1777
                     /gene="Capn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1842
                     /gene="Capn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..1911
                     /gene="Capn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..1990
                     /gene="Capn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1991..2107
                     /gene="Capn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2108..2166
                     /gene="Capn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2167..2934
                     /gene="Capn1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaagccagc cccagggacc gcagcaatct cccaaactcc ccttccccag gatggcagag
       61 gagttaatca cacctgtgta ctgcaccggg gtgtcagccc aagtgcagaa gcaacgggac
      121 aaggagttgg gcttgggccg ccatgaaaat gccatcaagt acctgggcca ggattatgaa
      181 aatcttcgtg caagatgcct gcagaacggg gtcctcttcc aagacgatgc cttccctcca
      241 gtttctcata gcttgggctt caaggaactg ggtcccaatt cctctaaaac ctatggcatc
      301 aagtggaagc gtcctacgga actgctgtca aacccccagt tcatcgtgga tggagccacc
      361 cgaacggaca tctgccaggg agcactgggg gactgttggc tcctggctgc cattgcctcg
      421 ctcactctca acgagactat cctccaccga gtggttccct acggccagag cttccaggag
      481 ggctatgctg gcatctttca tttccagctg tggcagtttg gggagtgggt agatgtggtt
      541 gtggatgatt tgctacccac caaggatgga aagctggtgt tcgtgcactc tgcccagggc
      601 aacgagttct ggagcgctct cctggagaaa gcctatgcaa aagtgaatgg cagctatgag
      661 gccctttcgg gaggctgcac ctcagaggcc ttcgaggact ttaccggtgg ggtcactgag
      721 tggtacgatc tgcagaaggc acccagcgac ctctaccaga tcattctgaa ggccctggaa
      781 cgaggctcct tgctgggctg ctccattaat atctccgata tccgtgattt ggaggctatt
      841 acttttaaga acctggtgag gggccatgca tactctgtga cggatgccaa gcaggtcact
      901 taccagggcc agcgggtgaa cctaatccgg atgcggaacc cctggggtga agtggagtgg
      961 aaaggaccct ggagtgacaa ctcctatgag tggaacaaag tggaccccta tgaacgtgag
     1021 cagctgaggg tcaagatgga ggacggggag ttctggatgt ccttccggga cttcatacgt
     1081 gagttcacca aactggaaat ctgcaacctt acacctgacg cccttaagag cagaaccctc
     1141 cggaactgga ataccacatt ttacgagggc acctggcgcc ggggaagcac tgctggaggc
     1201 tgcaggaact acccagctac cttctgggta aacccccagt tcaagatccg gctggaggag
     1261 gtggatgacg cagacgacta tgacagtcga gagtccggct gcagcttctt gttggccctc
     1321 atgcagaagc atcgccgcag ggagcgtcgc tttggccggg acatggagac cattggtttt
     1381 gcagtgtacc aggtccctcg ggagttggcg ggtcagcctg tgcacttgaa gcgtgacttc
     1441 ttcctggcca atgcttctcg ggcacaatca gagcacttta tcaaccttcg agaggtcagt
     1501 aaccgcatcc gcctgccgcc gggggagtat atagtggtgc cctccacctt cgagcccaac
     1561 aaagagggtg actttctgct gcgcttcttt tcagagaaga aggctgggac ccaggaacta
     1621 gatgaccaga tccaggccaa cctccccgat gagaaagtgc tctctgaaga ggagatcgat
     1681 gacaacttca aaaccctgtt cagcaagttg gcaggggatg acatggagat cagtgtcaag
     1741 gagttacaga ccatcttgaa cagaatcatt agcaaacaca aagacctgcg cactaacggc
     1801 ttcagcctgg agtcgtgccg cagcatggtg aacctcatgg atcgagacgg taatgggaaa
     1861 ctgggcctgg tggagttcaa catcctgtgg aaccgcatcc gaaattacct gaccatcttc
     1921 cgaaagtttg acctggacaa gtctggcagc atgagtgctt atgagatgag gatggccatc
     1981 gaggctgcag gcttcaagct taacaagaag ctgcatgagc tcatcatcac ccgctactca
     2041 gagcccgacc tggccgtgga ctttgacaac tttgtgtgct gccttgtgcg cctggagacc
     2101 atgttccggt ttttcaaaat tctggacaca gacctggatg gtgttgtgac ctttgatcta
     2161 tttaagtggt tacagctgac tatgtttgca tgaagcggga tggctccgct gcctgtgttc
     2221 ttccttcttc ctctgccaag ccacacctcc ccgccatgcc gtaccagacc atgtcagctg
     2281 ccagtgcctt ccctcaaaaa aggagggcac cttgtcctcc tgtccccttg tcctcctgtc
     2341 ctttcacctc cccactacct ctgttcaatt gctctaggca gagtcacagg gcccttcctg
     2401 cccctgtagc taaggcaacc ctgacccctg ctcatggcta agagcaggaa ggcagctccc
     2461 tgcttactcc ttcctgcctc cggggcagga gtaggcatcc ctgcccctcc cactccctgc
     2521 tactgtccag atgtgtgtct cacctaatct gtggaggctc tagcccctgt catcccctag
     2581 acctgcagac ttcgtaacca ctagctagtt ccttgtctgc acctgggtgt tgaaggcctc
     2641 acctcactat gggagcccca cagccagttc accttcctgt gccttcatgt gcagcagcca
     2701 agatccctct gcaaaccaaa gtacacctct cctgcccgtg tgcccaccag gaacttcctg
     2761 gccgggaggg cactcaggcc ctccgtatcc ccacccccct tcctctattt tttaatattt
     2821 ttcaaggaaa tgcttgaggg actagtgtac tggttatgga ggaccaggac ctagggggtg
     2881 ggttggggag gtcccatgtt tcagtgcagt gggaaaataa aatgaaaggc cagaaaaaaa
     2941 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     3001 aaaaaaaaaa aaaaaaaaaa
//
