LOCUS       NM_022383               2564 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus cyclase associated actin cytoskeleton regulatory
            protein 1 (Cap1), mRNA.
ACCESSION   NM_022383
VERSION     NM_022383.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2564)
  AUTHORS   Zhang,X., Pizzoni,A., Hong,K., Naim,N., Qi,C., Korkhov,V. and
            Altschuler,D.L.
  TITLE     CAP1 binds and activates adenylyl cyclase in mammalian cells
  JOURNAL   Proc Natl Acad Sci U S A 118 (24) (2021)
   PUBMED   34099549
  REMARK    GeneRIF: CAP1 binds and activates adenylyl cyclase in mammalian
            cells.
REFERENCE   2  (bases 1 to 2564)
  AUTHORS   Rahmati,M. and Kazemi,A.
  TITLE     Various exercise intensities differentially regulate GAP-43 and
            CAP-1 expression in the rat hippocampus
  JOURNAL   Gene 692, 185-194 (2019)
   PUBMED   30682386
  REMARK    GeneRIF: Hippocampal Cap1 levels is sensitive to different exercise
            intensities.Highest corticosterone level and lactate production
            leads to reduction and induction of hippocampal Cap1.
REFERENCE   3  (bases 1 to 2564)
  AUTHORS   Zhang,H., Liu,Y., Li,Y., Zhou,Y., Chen,D., Shen,J., Yan,Y., Yan,S.,
            Wu,X., Li,A., Guo,A. and Cheng,C.
  TITLE     The expression of CAP1 after traumatic brain injury and its role in
            astrocyte proliferation
  JOURNAL   J Mol Neurosci 54 (4), 653-663 (2014)
   PUBMED   25060335
  REMARK    GeneRIF: Upregulation of CAP1 protein expression was associated
            with astrocyte proliferation after the trauma of the central
            nervous system.
REFERENCE   4  (bases 1 to 2564)
  AUTHORS   Zhu,X., Yao,L., Guo,A., Li,A., Sun,H., Wang,N., Liu,H., Duan,Z. and
            Cao,J.
  TITLE     CAP1 was associated with actin and involved in Schwann cell
            differentiation and motility after sciatic nerve injury
  JOURNAL   J Mol Histol 45 (3), 337-348 (2014)
   PUBMED   24272071
  REMARK    GeneRIF: CAP1 was associated with actin and involved in Schwann
            cell differentiation and motility after sciatic nerve injury.
REFERENCE   5  (bases 1 to 2564)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   6  (bases 1 to 2564)
  AUTHORS   Yamazaki,K., Takamura,M., Masugi,Y., Mori,T., Du,W., Hibi,T.,
            Hiraoka,N., Ohta,T., Ohki,M., Hirohashi,S. and Sakamoto,M.
  TITLE     Adenylate cyclase-associated protein 1 overexpressed in pancreatic
            cancers is involved in cancer cell motility
  JOURNAL   Lab Invest 89 (4), 425-432 (2009)
   PUBMED   19188911
REFERENCE   7  (bases 1 to 2564)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   8  (bases 1 to 2564)
  AUTHORS   Bertling,E., Hotulainen,P., Mattila,P.K., Matilainen,T.,
            Salminen,M. and Lappalainen,P.
  TITLE     Cyclase-associated protein 1 (CAP1) promotes cofilin-induced actin
            dynamics in mammalian nonmuscle cells
  JOURNAL   Mol Biol Cell 15 (5), 2324-2334 (2004)
   PUBMED   15004221
REFERENCE   9  (bases 1 to 2564)
  AUTHORS   Vojtek,A.B. and Cooper,J.A.
  TITLE     Identification and characterization of a cDNA encoding mouse CAP: a
            homolog of the yeast adenylyl cyclase associated protein
  JOURNAL   J Cell Sci 105 (Pt 3), 777-785 (1993)
   PUBMED   7691848
REFERENCE   10 (bases 1 to 2564)
  AUTHORS   Zelicof,A., Gatica,J. and Gerst,J.E.
  TITLE     Molecular cloning and characterization of a rat homolog of CAP, the
            adenylyl cyclase-associated protein from Saccharomyces cerevisiae
  JOURNAL   J Biol Chem 268 (18), 13448-13453 (1993)
   PUBMED   8514780
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000162.1.
            
            [WARNING] On Mar 31, 2024 this sequence was replaced by
            NM_022383.4.
            
            On Nov 27, 2020 this sequence version replaced NM_022383.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089801.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-106               JACYVU010000162.1  49717514-49717619   c
            107-231             JACYVU010000162.1  49704074-49704198   c
            232-332             JACYVU010000162.1  49703101-49703201   c
            333-410             JACYVU010000162.1  49701377-49701454   c
            411-554             JACYVU010000162.1  49699597-49699740   c
            555-640             JACYVU010000162.1  49699429-49699514   c
            641-746             JACYVU010000162.1  49697007-49697112   c
            747-924             JACYVU010000162.1  49696403-49696580   c
            925-1109            JACYVU010000162.1  49694299-49694483   c
            1110-1233           JACYVU010000162.1  49694003-49694126   c
            1234-1316           JACYVU010000162.1  49693809-49693891   c
            1317-1460           JACYVU010000162.1  49693331-49693474   c
            1461-2564           JACYVU010000162.1  49691415-49692518   c
FEATURES             Location/Qualifiers
     source          1..2564
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2564
                     /gene="Cap1"
                     /gene_synonym="Mch1"
                     /note="cyclase associated actin cytoskeleton regulatory
                     protein 1"
                     /db_xref="GeneID:64185"
                     /db_xref="RGD:620309"
     exon            1..106
                     /gene="Cap1"
                     /gene_synonym="Mch1"
                     /inference="alignment:Splign:2.1.0"
     exon            107..231
                     /gene="Cap1"
                     /gene_synonym="Mch1"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..1544
                     /gene="Cap1"
                     /gene_synonym="Mch1"
                     /note="CAP 1; cyclase-associated protein homologue; CAP,
                     adenylate cyclase-associated protein 1; adenylate cyclase
                     associated protein 1"
                     /codon_start=1
                     /product="adenylyl cyclase-associated protein 1"
                     /protein_id="NP_071778.2"
                     /db_xref="GeneID:64185"
                     /db_xref="RGD:620309"
                     /translation="MADMQNLVERLERAVGRLEAVSHTSDMHCGYGDSPSKGAVPYVQ
                     AFDSLLANPVAEYLKMSKEIGGDVQKHAEMVHTGLKLERALLVTASQCQQPAGNKLSD
                     LLAPISEQIQEVITFREKNRGSKFFNHLSAVSESIQALGWVALAAKPGPFVKEMNDAA
                     MFYTNRVLKEYRDVDKKHVDWVRAYLSIWTELQAYIKEFHTTGLAWSKTGPVAKELSG
                     LPSGPSVGSGPPPPPPGPPPPPVPTSSGSDDSASRSALFAQINQGESITHALKHVSDD
                     MKTHKNPALKAQSGPVRSGPKPFSAPKPQTSPSPKPATKKEPALLELEGKKWRVENQE
                     NVSNLVIDDTELKQVAYIYKCVNTTLQIKGKINSITVDNCKKLGLVFDDVVGIVEIIN
                     SRDVKVQVMGKVPTISINKTDGCHAYLSKNSLDCEIVSAKSSEMNVLIPTEGGDFNEF
                     PVPEQFKTLWNGQKLVTTVTEIAG"
     exon            232..332
                     /gene="Cap1"
                     /gene_synonym="Mch1"
                     /inference="alignment:Splign:2.1.0"
     exon            333..410
                     /gene="Cap1"
                     /gene_synonym="Mch1"
                     /inference="alignment:Splign:2.1.0"
     exon            411..554
                     /gene="Cap1"
                     /gene_synonym="Mch1"
                     /inference="alignment:Splign:2.1.0"
     exon            555..640
                     /gene="Cap1"
                     /gene_synonym="Mch1"
                     /inference="alignment:Splign:2.1.0"
     exon            641..746
                     /gene="Cap1"
                     /gene_synonym="Mch1"
                     /inference="alignment:Splign:2.1.0"
     exon            747..924
                     /gene="Cap1"
                     /gene_synonym="Mch1"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1109
                     /gene="Cap1"
                     /gene_synonym="Mch1"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1233
                     /gene="Cap1"
                     /gene_synonym="Mch1"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1316
                     /gene="Cap1"
                     /gene_synonym="Mch1"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1460
                     /gene="Cap1"
                     /gene_synonym="Mch1"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..2564
                     /gene="Cap1"
                     /gene_synonym="Mch1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atttccggtg ggggtgccgc gcccagtgag ggcccggaag tgggtcgcgc taagaccgct
       61 gggcggttct tgccggaagt ggagagcggc tgatcgcagt ccggagcagg tggaacatta
      121 tggctgacat gcaaaatctt gtagaaagat tggagagggc agtgggccgc ctggaggcgg
      181 tgtcacatac ttctgacatg cactgtggat atggagacag tccttcaaaa ggagcagttc
      241 catatgtgca agcatttgac tcgctgcttg ccaatcccgt ggcggagtac ttgaagatga
      301 gtaaggagat tgggggagat gtgcagaaac acgcggagat ggtccacaca ggcctgaagt
      361 tggagcgagc tctcctggtt acagcttctc agtgccagca gccagccggt aataaactct
      421 cggatttgtt ggcccctatc tcggagcaga tccaggaagt tataaccttc cgggagaaga
      481 accgaggcag caagtttttc aatcatctat cagctgtcag tgaaagcatc caggccctgg
      541 gctgggtggc tctggctgcg aaacccggcc cctttgtgaa agagatgaat gatgccgcca
      601 tgttttacac aaaccgagtc ctcaaggagt acagagatgt ggataaaaag catgtggact
      661 gggttagagc ttacttgagt atatggacag aactgcaggc ttacatcaag gagttccata
      721 ccactggcct ggcctggagc aagacggggc ctgtggcaaa agaactgagt ggattgccat
      781 ctggaccttc tgtgggatca ggcccacctc ctcccccacc aggccctcct cctcccccag
      841 ttcctaccag ttctggctct gacgactctg cttcacgctc agcactgttt gcacagatta
      901 atcaggggga aagcatcaca catgccctga aacatgtatc tgatgacatg aagactcaca
      961 agaaccctgc cctgaaagct cagagtggtc cagttcggag tggccccaaa ccattctctg
     1021 cacctaaacc ccaaactagc ccctccccca aaccagccac aaagaaggag ccagctctgc
     1081 tggaactgga aggcaagaaa tggagagtgg aaaaccagga gaatgtttcc aacctggtga
     1141 tcgatgacac tgagctgaag caggtggctt acatctacaa gtgtgtcaac acgacattgc
     1201 aaatcaaggg caaaatcaat tccattacag tagataactg taagaagctt ggcctggtgt
     1261 ttgatgacgt ggtgggcatt gtggagataa tcaatagtag ggatgtcaaa gttcaggtga
     1321 tgggaaaagt gccaaccatt tccattaaca aaacagatgg ctgccacgct tacctgagta
     1381 agaactccct ggactgcgag atagtcagtg ccaaatcttc tgagatgaac gtcctcattc
     1441 ctacagaagg cggtgatttt aacgagttcc cagtccctga gcagttcaag accttgtgga
     1501 acggacagaa gttggtcacc acagtgacag aaatcgctgg ataagtgaat gcatgggtcc
     1561 tgtgccctct cccttcacac catgggatac atctgtatgg agacggttct tttctagatt
     1621 tcctctacct ttctgctctt aaactgcttc tctgctctga gaagcccagc tacctgcctt
     1681 cactgaatat acctcaggct gagacgggcg ggacagcagg tcagtggatt ttcaccggaa
     1741 ggtgcagctt ctccacatca gcgcggctgc accgcagtcc gagcttatgg agcttccggc
     1801 ccagactggg acactgaagc tttcagctct ggggtcattc taccaacaaa cagtccttga
     1861 gggttcaaga caccctggaa tgcatgctgt tctaacagtg agcatggagg tagcgggagc
     1921 cagtgattcc atgaggttct agccaaccta gttttcagcg ttgacaagtg aggccagggt
     1981 tgctcttgac caaaagctaa gcattgccac ccagcattcc aagcagactt gtttcctaga
     2041 agcatccttc attctgcatt ccatcctggg tcggcatcta ccacacacag caggcattcc
     2101 tcttgcagct gcaggacagt agcagttccc aaaaagtctt aaccccctcc cccgccccga
     2161 ttcccatggg ggaacaactt agaaaaaagg ggggaagaaa aacacagcat tccaaggagt
     2221 ctggcggtcc tccttcctgc cagatgactg tcaccgtgtc cactcctcct gcttgtcacg
     2281 ctcagcagct gaggcctcct cgtagggacc tggatagggc taagacctcc actgcagctg
     2341 tttggggctt ggtttacacc agagtcttgc acagcattgg tatcgcaaac ccagaattct
     2401 ctctaggaca cactgaccaa aatatgcaac cttttttttt ttttttttgt gggaaaagag
     2461 gaagagagat tgtcctgtga cttctgccca ttacctgagg cctgtggaaa taaaccttta
     2521 tgtacttaaa gttatacaga aaatagaata aagttaatac caaa
//
