LOCUS       NM_172008               4986 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus calnexin (Canx), mRNA.
ACCESSION   NM_172008
VERSION     NM_172008.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4986)
  AUTHORS   Li,J., Akil,O., Rouse,S.L., McLaughlin,C.W., Matthews,I.R.,
            Lustig,L.R., Chan,D.K. and Sherr,E.H.
  TITLE     Deletion of Tmtc4 activates the unfolded protein response and
            causes postnatal hearing loss
  JOURNAL   J Clin Invest 128 (11), 5150-5162 (2018)
   PUBMED   30188326
REFERENCE   2  (bases 1 to 4986)
  AUTHORS   Zhao,N., Mi,L., Zhang,X., Xu,M., Yu,H., Liu,Z., Liu,X., Guan,G.,
            Gao,W. and Wang,J.
  TITLE     Enhanced MiR-711 transcription by PPARgamma induces endoplasmic
            reticulum stress-mediated apoptosis targeting calnexin in rat
            cardiomyocytes after myocardial infarction
  JOURNAL   J Mol Cell Cardiol 118, 36-45 (2018)
   PUBMED   29522763
  REMARK    GeneRIF: The mechanism underlying these effects may involve the
            direct binding of PPARgamma to the pre-miR-711 promoter for the
            upregulation of miR-711, which may induce ER stress-mediated
            cardiomyocyte apoptosis via calnexin.
REFERENCE   3  (bases 1 to 4986)
  AUTHORS   Proft,J., Rzhepetskyy,Y., Lazniewska,J., Zhang,F.X., Cain,S.M.,
            Snutch,T.P., Zamponi,G.W. and Weiss,N.
  TITLE     The Cacna1h mutation in the GAERS model of absence epilepsy
            enhances T-type Ca2+ currents by altering calnexin-dependent
            trafficking of Cav3.2 channels
  JOURNAL   Sci Rep 7 (1), 11513 (2017)
   PUBMED   28912545
  REMARK    GeneRIF: The authors demonstrate that the Genetic Absence Epilepsy
            Rat from Strasbourg (GAERS) missense mutation located in the Cav3.2
            III-IV linker alters the Cav3.2/calnexin interaction, resulting in
            an increased surface expression of the channel and a concomitant
            elevation in calcium influx.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4986)
  AUTHORS   Hirano,M., Imagawa,A. and Totani,K.
  TITLE     Stratified analysis of lectin-like chaperones in the folding
            disease-related metabolic syndrome rat model
  JOURNAL   Biochem Biophys Res Commun 478 (1), 247-253 (2016)
   PUBMED   27425249
  REMARK    GeneRIF: Therefore, these results indicate that obesity
            down-regulates CNX and CRT expressions and their activities and
            diabetes up-regulates the expressions and activities of CNX and
            CRT. Our findings clearly suggest that metabolic syndrome affects
            the lectin-like chaperones in the CNX/CRT cycle at both the
            activity and expression levels.
REFERENCE   5  (bases 1 to 4986)
  AUTHORS   Urresti,J., Ruiz-Meana,M., Coccia,E., Arevalo,J.C., Castellano,J.,
            Fernandez-Sanz,C., Galenkamp,K.M., Planells-Ferrer,L.,
            Moubarak,R.S., Llecha-Cano,N., Reix,S., Garcia-Dorado,D.,
            Barneda-Zahonero,B. and Comella,J.X.
  TITLE     Lifeguard Inhibits Fas Ligand-mediated Endoplasmic
            Reticulum-Calcium Release Mandatory for Apoptosis in Type II
            Apoptotic Cells
  JOURNAL   J Biol Chem 291 (3), 1221-1234 (2016)
   PUBMED   26582200
REFERENCE   6  (bases 1 to 4986)
  AUTHORS   Hay,J.C., Chao,D.S., Kuo,C.S. and Scheller,R.H.
  TITLE     Protein interactions regulating vesicle transport between the
            endoplasmic reticulum and Golgi apparatus in mammalian cells
  JOURNAL   Cell 89 (1), 149-158 (1997)
   PUBMED   9094723
REFERENCE   7  (bases 1 to 4986)
  AUTHORS   Gruenheid,S., Pinner,E., Desjardins,M. and Gros,P.
  TITLE     Natural resistance to infection with intracellular pathogens: the
            Nramp1 protein is recruited to the membrane of the phagosome
  JOURNAL   J Exp Med 185 (4), 717-730 (1997)
   PUBMED   9034150
REFERENCE   8  (bases 1 to 4986)
  AUTHORS   Tjoelker,L.W., Seyfried,C.E., Eddy,R.L. Jr., Byers,M.G.,
            Shows,T.B., Calderon,J., Schreiber,R.B. and Gray,P.W.
  TITLE     Human, mouse, and rat calnexin cDNA cloning: identification of
            potential calcium binding motifs and gene localization to human
            chromosome 5
  JOURNAL   Biochemistry 33 (11), 3229-3236 (1994)
   PUBMED   8136357
REFERENCE   9  (bases 1 to 4986)
  AUTHORS   Gilchrist,J.S. and Pierce,G.N.
  TITLE     Identification and purification of a calcium-binding protein in
            hepatic nuclear membranes
  JOURNAL   J Biol Chem 268 (6), 4291-4299 (1993)
   PUBMED   8440713
REFERENCE   10 (bases 1 to 4986)
  AUTHORS   Villa,A., Sharp,A.H., Racchetti,G., Podini,P., Bole,D.G.,
            Dunn,W.A., Pozzan,T., Snyder,S.H. and Meldolesi,J.
  TITLE     The endoplasmic reticulum of Purkinje neuron body and dendrites:
            molecular identity and specializations for Ca2+ transport
  JOURNAL   Neuroscience 49 (2), 467-477 (1992)
   PUBMED   1331857
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB586187.1, L18889.1, EV776124.1 and JAXUCZ010000010.1.
            
            On Jan 9, 2008 this sequence version replaced NM_172008.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ210638.1, SRR26643287.24083.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676785, SAMN16676786
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-103               CB586187.1         1-103
            104-634             L18889.1           1-531
            635-827             EV776124.1         364-556
            828-1879            L18889.1           725-1776
            1880-4986           JAXUCZ010000010.1  35124941-35128047   c
FEATURES             Location/Qualifiers
     source          1..4986
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..4986
                     /gene="Canx"
                     /note="calnexin"
                     /db_xref="GeneID:29144"
                     /db_xref="RGD:2266"
     exon            1..96
                     /gene="Canx"
                     /inference="alignment:Splign:2.1.0"
     exon            97..277
                     /gene="Canx"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..1879
                     /gene="Canx"
                     /codon_start=1
                     /product="calnexin precursor"
                     /protein_id="NP_742005.1"
                     /db_xref="GeneID:29144"
                     /db_xref="RGD:2266"
                     /translation="MEGKWLLCLLLVLGTAAIQAHDGHDDDMIDIEDDLDDVIEEVED
                     SKSKSDTSTPPSPKVTYKAPVPTGEVYFADSFDRGSLSGWILSKAKKDDTDDEIAKYD
                     GKWEVDEMKETKLPGDKGLVLMSRAKHHAISAKLNKPFLFDTKPLIVQYEVNFQNGIE
                     CGGAYVKLLSKTSELNLDQFHDKTPYTIMFGPDKCGEDYKLHFIFRHKNPKTGVYEEK
                     HAKRPDADLKTYFTDKKTHLYTLILNPDNSFEILVDQSVVNSGNLLNDMTPPVNPSRE
                     IEDPEDRKPEDWDERPKIADPDAVKPDDWDEDAPSKIPDEEATKPEGWLDDEPEYIPD
                     PDAEKPEDWDEDMDGEWEAPQIANPKCESAPGCGVWQRPMIDNPNYKGKWKPPMIDNP
                     NYQGIWKPRKIPNPDFFEDLEPFRMTPFSAIGLELWSMTSDIFFDNFIISGDRRVVDD
                     WANDGWGLKKAADGAAEPGVVGQMLEAAEERPWLWVVYILTVALPVFLVILFCCSGKK
                     QSNAMEYKKTDAPQPDVKDEEGKEEEKNKGDEEEEEEKLEEKQKSDAEEDGGTGSQDE
                     EDSKPKAEEDEILNRSPRNRKPRRE"
     exon            278..351
                     /gene="Canx"
                     /inference="alignment:Splign:2.1.0"
     exon            352..410
                     /gene="Canx"
                     /inference="alignment:Splign:2.1.0"
     exon            411..552
                     /gene="Canx"
                     /inference="alignment:Splign:2.1.0"
     exon            553..634
                     /gene="Canx"
                     /inference="alignment:Splign:2.1.0"
     exon            635..827
                     /gene="Canx"
                     /inference="alignment:Splign:2.1.0"
     exon            828..1017
                     /gene="Canx"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1131
                     /gene="Canx"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1288
                     /gene="Canx"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1504
                     /gene="Canx"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1624
                     /gene="Canx"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1745
                     /gene="Canx"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..1825
                     /gene="Canx"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..4986
                     /gene="Canx"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggccgcct ctgccgctgt ctccactgca gcacggggcc cggtgtgcgg gtgggagaag
       61 gtgagggagc cgccagtggt ccccgggagg ctcgagatag atcatggaag ggaagtggtt
      121 actgtgtttg ctactggtcc ttggaactgc agctattcag gctcatgatg gacatgatga
      181 tgacatgatt gatattgaag atgatcttga tgatgttatc gaagaggtag aagattcaaa
      241 atctaaatca gataccagca ctcctccatc tccaaaggtc acctacaaag ctccagttcc
      301 aacaggggag gtttattttg ctgactcctt tgacagaggg tctctgtcag ggtggatttt
      361 atctaaagcc aaaaaagacg acactgatga tgaaattgcc aaatatgacg gaaagtggga
      421 ggtagatgaa atgaaggaaa caaagcttcc aggtgataaa ggacttgtat tgatgtctcg
      481 ggccaagcat catgccatct ctgctaaact gaacaagccc ttcctgtttg ataccaagcc
      541 tctcattgtt cagtatgagg ttaactttca gaatggaata gaatgcggtg gtgcctacgt
      601 gaagctgcta tccaagacct cagaactcaa cctggatcaa ttccacgaca agactccgta
      661 tactattatg tttggtccag ataaatgtgg agaggactac aaactgcatt tcatctttcg
      721 ccacaaaaac cccaagacag gtgtatatga agaaaaacat gctaagaggc cagatgcaga
      781 tctgaagacc tatttcactg acaagaaaac acatctttac acattaatct tgaatccaga
      841 caatagtttt gaaatattag ttgaccagtc tgttgtgaac agtggaaacc tgctaaatga
      901 catgacccct ccggtaaacc cttcacgtga aattgaggac ccagaagacc ggaagcctga
      961 agattgggat gaaaggccca aaatagcaga tccagatgct gtcaagccag atgactggga
     1021 tgaagatgcc ccttctaaga ttccagatga agaggccaca aagcctgaag gctggttaga
     1081 tgatgaaccc gagtatattc cagaccctga tgcagagaaa ccagaagatt gggatgagga
     1141 tatggacgga gaatgggagg ctcctcagat tgccaaccct aagtgtgagt ccgcccctgg
     1201 gtgtggtgtc tggcagcgac ctatgattga caaccccaat tataagggca aatggaagcc
     1261 tcctatgatt gacaatccta actaccaggg aatctggaaa ccaaggaaaa taccaaatcc
     1321 agatttcttt gaagacctgg aaccttttag gatgactcct ttcagcgcta ttggtttgga
     1381 gctctggtcc atgacatccg acatcttttt tgacaacttt atcattagtg gtgaccgaag
     1441 agtagttgat gactgggcca atgatgggtg gggcctgaag aaagctgctg atggggctgc
     1501 agagccaggt gtagtggggc agatgctgga ggcagctgaa gagcgtccat ggctttgggt
     1561 ggtctacatt ctgactgtag cgttgccagt gttccttgtg atcctcttct gctgttctgg
     1621 aaagaaacag tccaatgcta tggagtacaa gaagacagat gctccccagc cagatgtgaa
     1681 ggacgaagaa gggaaggaag aagagaagaa caagggagat gaagaggaag aagaggagaa
     1741 gcttgaagag aaacagaaga gtgatgctga agaagatggt ggcactggca gtcaagatga
     1801 ggaagatagc aagcctaaag cagaggagga tgaaattttg aacagatcac caagaaacag
     1861 aaagccacga agagagtgaa acaatcttaa gaacttgatc tgtgatttcc tctccctccc
     1921 cttcccctgc aaatatggtc ctaggagagg gcctggtgta ccttaggtgg gagctcagaa
     1981 aacctcaaga tgtcaccatc aacaggttcc agtgaatact agcctgtaat tttaaacatc
     2041 tagcagtaaa ctattgcagt tgtaatgtaa aggaccctgt ttctgtagaa aagaaaacat
     2101 ttaacataat ggttgtgaaa tgtaacatga agcaactaac tagtgttttg ttgtttttaa
     2161 aatcttccag gtttgtcttt ttttcctttt tttaaagata caatgataga atttttgcca
     2221 atttaaaatc ttggcttaat ttaatatatt aatttgttca tgcagaaata acaccaacat
     2281 taggaatgct agggagaatg aattgcagtt tttataacaa tttttttaag tttggtatta
     2341 aaacattcat gtgtctgtcc caaaaattgt aatcacgttc aagtgcagtc atttgtggtt
     2401 ataatcttgt tttgtgtgct tccattactt aattcctctt aaggacacag agattagatg
     2461 gaagctcaat ttatatcaaa tttacattgt attgaataga cccaaaaaga actaaaagga
     2521 gactttcact tggtgttggt cagatcataa agtgcagtgt tctgttgttg gaactgctcc
     2581 attcacaaac agctttgcag aggaaaggag ctggcttaat gcagcagttt atactgtact
     2641 tcccatatag gaggtctgac agctcagatc ctctggagca caaggctttt taaggaaggc
     2701 tggtgtgcct gagtagataa ttacatcact tgttccactg tgttgacact gttttcctca
     2761 tgcatctcct cagtccctag ctttctctgc tatgcatttt cttcacagtg cagcttgcag
     2821 tccgttgctg aaaattataa gctctgcata gtgttggctt tactgtgatt acatgtttct
     2881 tttttagcaa gcccacatct ttctagggtc caactacagg atagattaca gactttccat
     2941 tagtgtctat ttcttttact ctgtgtagac tttagaaagt ctaatccaga gatgggccaa
     3001 ttcagaattg actataattg aacacaggct aaaagtattt atgggaggat tgacacatag
     3061 catgagttat ttgacttttg tgtaggatat ttaaaatctt catttgcagt tcatgtaaca
     3121 gttgcgtctt aaaattcaca caataaagca gtcctgttca attttatttt attttatttt
     3181 attgtggctt gtacaatttt ttaagtgaat ttagggcttt ttgttttggt ttttgtttgt
     3241 ttttgttttg tttttcatgt ggaatgcaga tgggtgctag aggaggctct cccacatcac
     3301 tatagtgtaa tattattaca ccacactgaa atgtattcag aaacagatgt ttcaatttca
     3361 ttctttctcc agaggtggtc cagttgtacc aatgatactt ttccttgcac tgaatatata
     3421 taaacactcc acagtgttta tattggggga atactgggaa agaaatatat ttgttaagga
     3481 tgaaggctgt atctgttgtc tttataaaca ctggttcatt tcttttgagg gtggaatgca
     3541 tttttcttcc tgttcagtgc tttatcacca tctgttgttt gtggtcacag tgaccatagc
     3601 tatgtagcgg acgtttccaa atgtatagag tgaaataaac agttactagc aagaaatgaa
     3661 tatctgtcta caggtttctc cttgaagcaa aggtggagat gaaatctgtt ttagctgttt
     3721 aatcattctg cattgacatt gtttgtgcct actttatctt cacccaggct gtacaatgac
     3781 aggtttattt atgtcattgg tggtgttcat tgcctttctg ggtccctctt cctccctcaa
     3841 ggttctattg aagctacagc ctcctaaaat gtctgacaca ttaatgaatg gccagcagtt
     3901 ttcagctctt accaaaagct tacagggctg gtattgtagc tcagtaggta gaactgccaa
     3961 gcatgtgcaa ggttccatgg gtttgattcc tggcactgaa ttaaaataaa taaaggccca
     4021 tatattctga ttttctatgc tggattcttt atggttgtaa aatacccact ccttcagtag
     4081 tactcttctg tcgtccactt ttcagactgc cccattatta aatgacatta cattaaagcc
     4141 ttgtggtaaa tatctgcatt tgactgaact tcatcataat gttggatgtt tttactgttt
     4201 gaaaagcgtt aacttattct ttttactctt acagagtttc atttagtctt gtatttaact
     4261 tcctctgtcc agtaatggtt tagtcattac tattgtgtaa aatggacaac agcccaaaac
     4321 ggggaagttt tttgtatgtt ttcaattgat ggtatttgag ccagtgctct agcactgagc
     4381 tacaccctgt tctcctagat aatattcttt aagacatatg gaaactattt taacattttt
     4441 cactagaaaa tttttctcag gctccatatt tgaggatatt attgaaagtc atgcccagaa
     4501 catgttgtgt tttacattgc ttccggaatt tatatactac agtgtgtata tacttctagg
     4561 taagagtttt gaagaccttg cacttctaac tgggcacaat agacttgtaa ccccagcact
     4621 cagaagttag aagcagagta aggcaggcca gcctcataca gtatgttcca ggcaaaagtc
     4681 tggggtacct gacactaaaa gtttaatggc tgggtgtact tagtagtagt ggcactatat
     4741 gcatgaggcc ctggattcag ccttccagca ctgcacacaa aagttgttta cacttagctt
     4801 gagtgctaat tgtaatgttt gggtaccggt aagaagcagt gctcatttat ctttgcaact
     4861 cccttcacca aagggagttt ttattttgtt tttattttta ctgcatttgt ataaaaacat
     4921 tttgctgtta gctttttttc ttgtgatttt aaaaataaaa ttttcgtgaa ctccagtaag
     4981 aggtaa
//
