LOCUS       NM_144754               2701 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus calcium activated nucleotidase 1 (Cant1), mRNA.
ACCESSION   NM_144754
VERSION     NM_144754.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2701)
  AUTHORS   Nizon,M., Huber,C., De Leonardis,F., Merrina,R., Forlino,A.,
            Fradin,M., Tuysuz,B., Abu-Libdeh,B.Y., Alanay,Y., Albrecht,B.,
            Al-Gazali,L., Basaran,S.Y., Clayton-Smith,J., Desir,J., Gill,H.,
            Greally,M.T., Koparir,E., van Maarle,M.C., MacKay,S., Mortier,G.,
            Morton,J., Sillence,D., Vilain,C., Young,I., Zerres,K., Le
            Merrer,M., Munnich,A., Le Goff,C., Rossi,A. and Cormier-Daire,V.
  TITLE     Further delineation of CANT1 phenotypic spectrum and demonstration
            of its role in proteoglycan synthesis
  JOURNAL   Hum Mutat 33 (8), 1261-1266 (2012)
   PUBMED   22539336
REFERENCE   2  (bases 1 to 2701)
  AUTHORS   Vlaar,A.P., van Son,W.J. and Bakker,W.W.
  TITLE     Histochemical detection of ischemia-like alterations induced in
            kidney tissue in vitro--different sensitivity to oxidant stress of
            glomerular ENTPD1 versus E5NT
  JOURNAL   Nephron Physiol 111 (1), p1-p8 (2009)
   PUBMED   19169047
  REMARK    GeneRIF: soluble apyrase as well as the glomerular ENTPD1 are
            sensitive to oxidant stress, which may explain their downregulation
            in the ischemic condition in vivo. However, soluble 5'-nucleotidase
            and E5NT seem much less sensitive to ROS
REFERENCE   3  (bases 1 to 2701)
  AUTHORS   Yang,M., Horii,K., Herr,A.B. and Kirley,T.L.
  TITLE     Calcium-dependent dimerization of human soluble calcium activated
            nucleotidase: characterization of the dimer interface
  JOURNAL   J Biol Chem 281 (38), 28307-28317 (2006)
   PUBMED   16835225
REFERENCE   4  (bases 1 to 2701)
  AUTHORS   Spanevello,R.M., Mazzanti,C.M., Kaizer,R., Zanin,R.,
            Cargnelutti,D., Hannel,L., Correa,M., Mazzanti,A., Festugatto,R.,
            Graca,D., Schetinger,M.R. and Morsch,V.M.
  TITLE     Apyrase and 5'-nucleotidase activities in synaptosomes from the
            cerebral cortex of rats experimentally demyelinated with ethidium
            bromide and treated with interferon-beta
  JOURNAL   Neurochem Res 31 (4), 455-462 (2006)
   PUBMED   16758353
  REMARK    GeneRIF: results show that apyrase and 5'-nucleotidase activities
            are altered in demyelination events
REFERENCE   5  (bases 1 to 2701)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
REFERENCE   6  (bases 1 to 2701)
  AUTHORS   Failer,B.U., Braun,N. and Zimmermann,H.
  TITLE     Cloning, expression, and functional characterization of a
            Ca(2+)-dependent endoplasmic reticulum nucleoside diphosphatase
  JOURNAL   J Biol Chem 277 (40), 36978-36986 (2002)
   PUBMED   12167635
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097279.1.
            
            On Jun 12, 2005 this sequence version replaced NM_144754.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097279.1, SRR8487231.161410.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2701
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.3"
     gene            1..2701
                     /gene="Cant1"
                     /gene_synonym="srapy"
                     /note="calcium activated nucleotidase 1"
                     /db_xref="GeneID:246272"
                     /db_xref="RGD:628743"
     exon            1..53
                     /gene="Cant1"
                     /gene_synonym="srapy"
                     /inference="alignment:Splign:2.1.0"
     exon            54..712
                     /gene="Cant1"
                     /gene_synonym="srapy"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..1287
                     /gene="Cant1"
                     /gene_synonym="srapy"
                     /EC_number="3.6.1.6"
                     /note="SCAN-1; apyrase homolog; ectonucleoside
                     triphosphate diphosphohydrolase 8"
                     /codon_start=1
                     /product="soluble calcium-activated nucleotidase 1"
                     /protein_id="NP_653355.1"
                     /db_xref="GeneID:246272"
                     /db_xref="RGD:628743"
                     /translation="MPIQPFDQREWNEPMHSLRISVGGLPVLASMTKATDPRFRPRWR
                     VILTSFVGAALLWLLYSHHQTPVSGRPPIHNAHNWRLRQERISQYNDTYPLSPPQRTP
                     GGIRYRIAVIADLDTGSKAQEENTWFSYLKKGYLTLSDSGDRVSVEWDKDRGVLESHL
                     AEKGRGMELSDLIVFNGKLYSVDDRTGVIYQIEGTKAVPWVILSDGDGAVEKGFKAEW
                     LAVKDEHLYVGGLGKEWTTTTGEVVNENPEWVKVVGHRGSVEHENWVSSYNALRAAAG
                     IQPPGYLIHESACWSDTLQRWFFLPRRASHERYSEREDERKGSNLLLSAAQDFRDISV
                     RQVGALVPTHGFSSFKFIPNTDDQIIVALKSEEDNGRIATYVMAFTLDGRFLLPETKI
                     GSVKYEGIEFI"
     exon            713..916
                     /gene="Cant1"
                     /gene_synonym="srapy"
                     /inference="alignment:Splign:2.1.0"
     exon            917..2672
                     /gene="Cant1"
                     /gene_synonym="srapy"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccctacgca ggtaggcggc agcccgcggg ctccggagcc aggctctcag tgggtcctgt
       61 ccagtgtgca gtctgatgcc catccagccc tttgaccagc gggaatggaa tgagcctatg
      121 cactccctcc ggatcagtgt agggggcctt ccagtgctgg catccatgac caaggccacg
      181 gaccctcgct tccgtccccg ctggagggtg attctgacgt cctttgtggg tgctgccctc
      241 ctctggctgc tgtattccca ccatcagacc ccagtatcgg gcaggccccc catccacaac
      301 gcacacaact ggaggctcag gcaggagcgc atctctcaat acaatgacac ctacccccta
      361 tcacccccac agaggactcc aggtgggatt cggtaccgaa ttgcagtcat tgctgacttg
      421 gacacggggt ccaaggccca ggaggagaac acttggttta gttaccttaa gaaaggctac
      481 ctgaccctgt cggacagtgg ggacagggtc agtgtggagt gggataaaga ccgtggagtc
      541 ctggagtccc acctggcaga aaaggggcgg ggcatggagc tctcggacct gatcgtcttc
      601 aacgggaaac tctactctgt ggatgaccgc acgggggtca tctaccagat cgaaggtacc
      661 aaagcagtgc cctgggtgat cctttctgat ggcgatggag ctgtggagaa gggcttcaaa
      721 gcggaatggc tggctgtgaa ggacgagcat ctgtacgtgg gtggcctggg caaggagtgg
      781 acgaccacaa cgggggaggt ggtgaacgag aaccctgagt gggtgaaggt ggtgggccac
      841 aggggcagtg tggaacacga gaactgggtg tccagctaca atgccctgag agctgccgca
      901 gggatccaac cgccaggcta cctcattcat gagtccgcct gctggagcga cacactgcag
      961 cgctggttct tcctgccacg acgggcgagc cacgagcgct acagcgaaag ggaggacgag
     1021 cgaaagggca gcaacctgct gctgagcgca gcccaggact tcagggacat ctctgtgagg
     1081 caagtggggg cgctggtccc cacccatggc ttctcatcct tcaagttcat ccccaacacg
     1141 gatgaccaga tcatcgtggc tctcaagtca gaagaggaca atggcaggat tgccacctat
     1201 gtcatggcct ttacgctgga cggccgcttc ctgcttccag agaccaagat cggcagtgtg
     1261 aagtatgaag gaatagaatt catctagagt aagcttgcac cccagcaggg ctggggccgg
     1321 tgaccgcaat acaccaggac tcagtttcat aaaaaccggg agctcttcca ctcgtttgct
     1381 ttttcctttt ttgaactaag agctgtgtgc ctggctagag ttccagaata gggagctgcg
     1441 cctggccctt acgggtgtgc gtgctgcttg gagactggga gcagggaccg cactggaccc
     1501 caggtgctca cttgcactgc cacctggtgg tagggactgg tcactgctgc aggcaccttc
     1561 cgagcctctg gcctttgaat ccagccatgc ctttccttcc ctggtctctg acctttctat
     1621 gagttctctg tccagtgttt ttgaagcagc caggtgttaa accctagcct aaccatggga
     1681 gtatgagaca gtgtgaggtg ggcctgccag acaggcactc ggaggccccc tcctcctcca
     1741 cgagaccctg gcattccata ctctggaaag tgaatgttta catgacaggg tgaggaccca
     1801 ccccttggga gacgcctgcc cacactctga agccactcta gcacaggatt ccttacgagc
     1861 tgatcataac ttcatttctc ccctcaggag gattttgtgc tgtacagcct tttaaagtct
     1921 gattaccaac ttatttttat taaagcaatt tctcttcctg aagtacagag tcactaaact
     1981 tcaccacacg gtgaaggagt ccccatacct acttgcagga gcaaggggct tgtccctaca
     2041 gccacgatgg cagccccagc ttttacagaa cgggcttcag gatcctgggc ccctgtcttc
     2101 tagcaacttc caaaagttgc catgctctca cccctcagca gtggctgagg gagggactgt
     2161 gtctgactag agatcggccc tcgctggctc ttggtgagtg tttggtaacc ttctctccag
     2221 gggagcctca ctgtcttctg ctttcctgtt cagtccctgt tcaagagagc ctaggcagcc
     2281 gagtcgggct cagaggttgt tctgtaggta acagccacct tagctgtctg caacacagga
     2341 tgcaggtact gtcgtgggct cagggccctg atgagcatcg caaacccctt ccacaggaag
     2401 ctaggagagc cattgccact ggggcctgac tgccctcagt ccgacaggct gtttctgtct
     2461 tgtgctgagg tcttggtgta cttgtgctgg gagctcagcc aaactttggt gtgtgtcagc
     2521 tgtgttagat tgtgtgattc tgaactgaaa gagatgagag gtggagagac ctgggccccc
     2581 ttgctaagaa gccttccaca caccttcctt tccctaatgt gagcagaatg attgtgtctc
     2641 tccgttttgt aaacaataaa gtgtcagggg aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2701 a
//
