LOCUS       NM_181362               4309 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus cullin-associated and neddylation-dissociated 2
            (putative) (Cand2), mRNA.
ACCESSION   NM_181362
VERSION     NM_181362.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4309)
  AUTHORS   Koskimaki,J., Zhang,D., Li,Y., Saadat,L., Moore,T., Lightle,R.,
            Polster,S.P., Carrion-Penagos,J., Lyne,S.B., Zeineddine,H.A.,
            Shi,C., Shenkar,R., Romanos,S., Avner,K., Srinath,A., Shen,L.,
            Detter,M.R., Snellings,D., Cao,Y., Lopez-Ramirez,M.A., Fonseca,G.,
            Tang,A.T., Faber,P., Andrade,J., Ginsberg,M., Kahn,M.L.,
            Marchuk,D.A., Girard,R. and Awad,I.A.
  TITLE     Transcriptome clarifies mechanisms of lesion genesis versus
            progression in models of Ccm3 cerebral cavernous malformations
  JOURNAL   Acta Neuropathol Commun 7 (1), 132 (2019)
   PUBMED   31426861
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4309)
  AUTHORS   Wang,P., Qin,W., Wang,P., Huang,Y., Liu,Y., Zhang,R., Li,S.,
            Yang,Q., Wang,X., Chen,F., Liu,J., Yang,B., Cheng,X., Liao,Y.,
            Wu,Y., Ke,T., Tu,X., Ren,X., Yang,Y., Xia,Y., Luo,X., Liu,M.,
            Li,H., Liu,J., Xiao,Y., Chen,Q., Xu,C. and Wang,Q.K.
  TITLE     Genomic Variants in NEURL, GJA1 and CUX2 Significantly Increase
            Genetic Susceptibility to Atrial Fibrillation
  JOURNAL   Sci Rep 8 (1), 3297 (2018)
   PUBMED   29459676
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4309)
  AUTHORS   Wei,T., Song,J., Xu,M., Lv,L., Liu,C., Shen,J. and Huang,Y.
  TITLE     NEURL rs6584555 and CAND2 rs4642101 contribute to postoperative
            atrial fibrillation: a prospective study among Chinese population
  JOURNAL   Oncotarget 7 (27), 42617-42624 (2016)
   PUBMED   27203392
REFERENCE   4  (bases 1 to 4309)
  AUTHORS   You,J., Wang,M., Aoki,T., Tamura,T.A. and Pickart,C.M.
  TITLE     Proteolytic targeting of transcriptional regulator TIP120B by a
            HECT domain E3 ligase
  JOURNAL   J Biol Chem 278 (26), 23369-23375 (2003)
   PUBMED   12692129
REFERENCE   5  (bases 1 to 4309)
  AUTHORS   Aoki,T., Okada,N., Ishida,M., Yogosawa,S., Makino,Y. and
            Tamura,T.A.
  TITLE     TIP120B: a novel TIP120-family protein that is expressed
            specifically in muscle tissues
  JOURNAL   Biochem Biophys Res Commun 261 (3), 911-916 (1999)
   PUBMED   10441524
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Nov 27, 2020 this sequence version replaced NM_181362.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB029324.1, SRR26643299.20702.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               JAXUCZ010000004.1  150507660-150507782
            124-267             JAXUCZ010000004.1  150513232-150513375
            268-422             JAXUCZ010000004.1  150513928-150514082
            423-546             JAXUCZ010000004.1  150515184-150515307
            547-812             JAXUCZ010000004.1  150517570-150517835
            813-918             JAXUCZ010000004.1  150518691-150518796
            919-1058            JAXUCZ010000004.1  150518899-150519038
            1059-1351           JAXUCZ010000004.1  150521077-150521369
            1352-1493           JAXUCZ010000004.1  150522585-150522726
            1494-2996           JAXUCZ010000004.1  150523058-150524560
            2997-3092           JAXUCZ010000004.1  150526885-150526980
            3093-3262           JAXUCZ010000004.1  150529353-150529522
            3263-3427           JAXUCZ010000004.1  150531510-150531674
            3428-3535           JAXUCZ010000004.1  150533407-150533514
            3536-4309           JAXUCZ010000004.1  150534982-150535755
FEATURES             Location/Qualifiers
     source          1..4309
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..4309
                     /gene="Cand2"
                     /gene_synonym="Tip120B"
                     /note="cullin-associated and neddylation-dissociated 2
                     (putative)"
                     /db_xref="GeneID:192226"
                     /db_xref="RGD:620480"
     exon            1..123
                     /gene="Cand2"
                     /gene_synonym="Tip120B"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..3763
                     /gene="Cand2"
                     /gene_synonym="Tip120B"
                     /note="p120 CAND2; TBP-interacting protein b;
                     TBP-interacting protein of 120 kDa B; cullin-associated
                     and neddylation-dissociated protein 2; TBP-interacting
                     protein 120B; TBP-interacting protein Tip120B"
                     /codon_start=1
                     /product="cullin-associated NEDD8-dissociated protein 2"
                     /protein_id="NP_852027.2"
                     /db_xref="GeneID:192226"
                     /db_xref="RGD:620480"
                     /translation="MSTGAFYISSLLEKMTSSDKDFRFMATSDLMSELQKDSIQLDED
                     SERKVVRTLLRLLEDRSGEVQNLAVKCLGPLVGKVKEYQVENIVDTLCANMRSDKEQL
                     RDIAGIGLKTVLSELPPAATGSGLAISVCRKITGQLTSAIAQQEDVAVQLEALDILSD
                     MLSRLGAPLGTFHASLLHCLLPQLSSPRLAVRKRTVVALGHLAAACSTDLFVELADHL
                     VDRLPGPRAPASPAAIRTLIQCLGSVGRQAGHRLGAHLDRLMPLVEEFCNLDDDELRE
                     SCLQAFEAFLRKCPKEMDPHVPNVTSLCLQYMKHDPNYNHDSDEEEQMETEDSEFSEQ
                     ESEDEYSDDDDMSWKVRRAAAKCMAALISSRPDLLPDFHCTLAPALIRRFKEREENVK
                     ADIFGAYIMLLRHTRPPKGWLEAVEEPTQTGRNLNMLRAQVPLVMKALQRQLKDRNVR
                     TRQGCFNLFTELAGVLPGCLAEHMTVLVSGIVFSLADYSSSSTIRMDALAFLQGLLGT
                     EPAEAFHPHLPTLLPPVMACVADPFYKVAAEALLVLQELVRTLWPLDRPRLLDPEPYV
                     GEMSTATLARLRATDLDQEVKERAISCVGHLVGHLGDRLGDDLEPTLLLLLDRLRNEI
                     TRLPAVKALTLVAVSPLRLDLQPILAEALPILASFLRKNQRALRLATLAALDALAQSQ
                     GLGLPPPAVRSVLAELPALVSENDMHVAQLAVDFLTTVTQTQPASLVEVSGPVLEELL
                     QLLHSPLLPAGVLAATEGFLQALVGTRPPCVEYSELISLLTAPVYNQVGDGGPGLHKQ
                     VFHSLARCVAALSAACPQEAAGTASRLVCDARSPHSSTGVKVLAFLSLAEVGQVAGPG
                     PQRELKTVLLEALGSPSEDVRAAAAYALGRVGAGNLPDFLPFLLAQIEAQPRRQYLLL
                     HALREALGAAQPDNLKPYVEDVWALLFQRCESPEEGTRCVVAECIGKLVFVNPPFLLP
                     RFRKQLAAGQPYTRSTVITAVKFLISDQPHSIDPLLKSFIAEFMESLQDPDLNVRRAT
                     LTFFNSAVHNKPSLVRDLLDDILPLLYQETKIRRDLIREVEMGPFKHTVDDGLDVRKA
                     AFECMYSLLESCLGQLDICEFLNHVEDGLKDHYDIRMLTFIMLARLAALCPAPVLQRV
                     DRLIEPLRATCTAKVKAGSVKQELEKQDELKRSAMRAVAALMTNPEVRKSPSVADFST
                     QIRSNPELATLFESIQKDTASGPSMDSMELS"
     exon            124..267
                     /gene="Cand2"
                     /gene_synonym="Tip120B"
                     /inference="alignment:Splign:2.1.0"
     exon            268..422
                     /gene="Cand2"
                     /gene_synonym="Tip120B"
                     /inference="alignment:Splign:2.1.0"
     exon            423..546
                     /gene="Cand2"
                     /gene_synonym="Tip120B"
                     /inference="alignment:Splign:2.1.0"
     exon            547..812
                     /gene="Cand2"
                     /gene_synonym="Tip120B"
                     /inference="alignment:Splign:2.1.0"
     exon            813..918
                     /gene="Cand2"
                     /gene_synonym="Tip120B"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1058
                     /gene="Cand2"
                     /gene_synonym="Tip120B"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1351
                     /gene="Cand2"
                     /gene_synonym="Tip120B"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1493
                     /gene="Cand2"
                     /gene_synonym="Tip120B"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..2996
                     /gene="Cand2"
                     /gene_synonym="Tip120B"
                     /inference="alignment:Splign:2.1.0"
     exon            2997..3092
                     /gene="Cand2"
                     /gene_synonym="Tip120B"
                     /inference="alignment:Splign:2.1.0"
     exon            3093..3262
                     /gene="Cand2"
                     /gene_synonym="Tip120B"
                     /inference="alignment:Splign:2.1.0"
     exon            3263..3427
                     /gene="Cand2"
                     /gene_synonym="Tip120B"
                     /inference="alignment:Splign:2.1.0"
     exon            3428..3535
                     /gene="Cand2"
                     /gene_synonym="Tip120B"
                     /inference="alignment:Splign:2.1.0"
     exon            3536..4309
                     /gene="Cand2"
                     /gene_synonym="Tip120B"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggggaggtc gcgccgccat attcgattcg acccgcaact cgcggcgcag ccagcatgag
       61 taccggtgcc ttctacatct ccagcctgct ggagaagatg acgtccagcg acaaagactt
      121 caggttcatg gctaccagtg acctgatgtc agagttgcag aaagactcca tccagctgga
      181 tgaggacagc gagcgtaagg tggtgaggac gctcctgcgg ctcctggagg acaggagtgg
      241 tgaggtgcag aacctggctg tcaagtgcct gggtcccctg gtgggcaagg tgaaggagta
      301 ccaagtggag aacattgtgg ataccctttg tgccaacatg cggtcagaca aggagcagct
      361 gcgcgacatc gctggcattg gcctgaagac cgtgctttca gagctgcctc cagctgccac
      421 aggctcgggg ctggctatca gtgtgtgccg caagatcacc ggccagctca ccagtgccat
      481 cgcccagcag gaggatgtgg ctgtgcagct ggaagccctg gacatcctct ccgacatgct
      541 gagcaggcta ggtgccccat tgggcacctt ccatgcaagc ctgctacact gcctattgcc
      601 tcagctgagc agcccgcgcc tggctgtgcg caagcgcacc gttgtcgcac tcggtcatct
      661 ggcagccgcc tgcagcacgg acctcttcgt ggagcttgct gatcatctgg tggaccggct
      721 gcctgggcca cgggcacctg ccagccctgc agccattcga accctgatcc agtgcttggg
      781 cagcgtgggc cggcaggcag gccatcgcct gggggcccac ctggaccgcc tgatgccctt
      841 ggtggaggag ttctgcaacc tggatgacga tgagctgaga gagtcctgcc tccaggcctt
      901 cgaggccttc ctaagaaagt gccccaagga gatggaccct catgtaccca atgtgaccag
      961 cctttgcctg cagtacatga agcacgaccc caactacaac catgacagtg acgaagaaga
     1021 gcaaatggag accgaggaca gtgaattcag tgagcaagag agtgaggacg agtacagtga
     1081 cgatgacgac atgagctgga aggtccgccg agctgcggcc aagtgcatgg cagccctgat
     1141 cagctctcgg cccgacctct tacccgactt ccactgcacg ctggcacctg cgcttatccg
     1201 ccgcttcaag gagcgggagg agaacgtcaa ggcagacatc tttggggctt acatcatgtt
     1261 gctgcgacat acacggcccc ctaaagggtg gctggaggct gtggaggagc ccacccagac
     1321 tggcagaaac ctcaatatgc tacgagcgca ggtgccccta gtgatgaagg ccctgcagcg
     1381 acaacttaaa gaccggaatg ttcggacccg ccaggggtgc ttcaacctct ttaccgagct
     1441 ggcaggcgtc ctccctggct gcctggcaga gcacatgact gtcttggtgt caggcattgt
     1501 cttttcactg gctgactact ccagctcctc caccatacgg atggatgccc tggccttcct
     1561 acagggcctt ctgggtacag agccagctga ggccttccac ccacacttgc cgaccctcct
     1621 accgcctgtg atggcctgtg tggctgaccc tttctacaag gtggcagctg aggccttatt
     1681 ggtgctccag gagctggtgc ggaccctgtg gccactggat aggcctcggc tgctggaccc
     1741 tgagccgtac gtgggagaga tgtccacagc taccctggca cgactccgag ccactgacct
     1801 ggaccaggag gtgaaggaac gggccatctc ttgtgtgggc caccttgtgg gtcaccttgg
     1861 cgaccggctt ggggatgacc tagagcccac acttctgctt ctccttgatc gcctacggaa
     1921 tgagataacc cggttgcctg ctgtcaaggc actgacactg gtggcggtgt ccccattgcg
     1981 acttgatctg cagcccatcc tggccgaggc actgcccatc ctcgcttcat ttctgcgcaa
     2041 gaatcaacgg gccctgcggc tggccacact ggccgccctg gatgctctgg ctcagagtca
     2101 gggcctcggc ctgcccccgc ctgctgttcg gagtgtgcta gctgagctgc ctgctctggt
     2161 cagtgagaat gacatgcatg tggcccagct ggctgttgac ttcctcacca cggtgacgca
     2221 gacccagccg gcctctctgg ttgaagtcag tgggcctgtt ctggaggagc tgctgcagct
     2281 gctgcactca cccttgctgc ctgctggggt gctggcagcc actgaaggct tcctgcaggc
     2341 gctggtgggg acccgccctc catgtgtgga gtactcagag ctcattagcc tgctcactgc
     2401 acctgtttat aaccaggttg gggatggagg acccggcctg cacaagcagg tgttccactc
     2461 attggctcgg tgtgtggctg ccctctcagc tgcctgtccc caggaggcag caggcactgc
     2521 cagccgcctg gtgtgtgatg ccaggtcacc ccactcaagc acaggggtca aagtcttggc
     2581 attcctatca ctggctgagg tgggccaggt ggctgggcca ggcccccaga gggagctgaa
     2641 gacagtgctt ctggaagccc tggggtctcc cagtgaggac gtgagggctg cagctgcata
     2701 tgccctgggc cgtgtgggtg ctggcaacct gcctgacttc ctgcccttcc tgctggcaca
     2761 aatcgaggcc caaccccgac gacagtacct gctgctacat gcactcaggg aggccctggg
     2821 ggctgcccag cctgacaacc tgaagcccta tgttgaggat gtgtgggcac tgctcttcca
     2881 gcgctgtgag agccctgagg aaggcactcg gtgtgtggtg gctgaatgca tcggaaagct
     2941 agtgtttgtg aaccctccct tcctcctgcc ccgattccgg aagcagcttg ctgcaggtca
     3001 gccatacacg cggagcacag tgatcactgc agtcaagttc ctcatctcag accagccaca
     3061 ctccatcgac cctctcctga agagcttcat tgcagagttc atggaaagcc tgcaggaccc
     3121 agacctgaac gtgcgccggg ccacactcac cttcttcaac tcagctgtgc acaacaaacc
     3181 gtcgctggtc cgggacctgt tggatgacat cctacccctc ctctaccagg agaccaagat
     3241 ccgccgggac ctcatccgag aggtagagat ggggcccttc aagcatactg tagatgatgg
     3301 gctggatgtg aggaaggctg ccttcgagtg catgtactcg ctactggaga gctgcctggg
     3361 ccagctggac atctgcgagt ttctgaacca cgtggaggat gggctaaagg accattatga
     3421 catccggatg ctgaccttca tcatgctggc ccggctggcc gctctttgcc ctgcacctgt
     3481 cctgcagagg gtggaccggc tcatcgagcc actcagagcc acctgtactg ccaaggtcaa
     3541 agctggttct gtgaagcagg agctggagaa gcaggatgag ctgaagcgct cagcaatgcg
     3601 ggcagtggct gccctgatga ctaaccctga ggtgcggaag agccccagtg tggctgactt
     3661 ttctacccag atccgatcca acccagaact cgccaccctc tttgagagca tccaaaagga
     3721 cacagcctct ggccccagca tggactctat ggaacttagc tagctgtccc caatacaagc
     3781 ctcccttctc atccctattg gccttggcct ctcctgtcct tcctagtcag cctcagtgcc
     3841 tttgctaggg tcccctgctc acagccccag tgtcaaagct gggcccatta actcaggaca
     3901 ttcatgaggg tgatgtccca ccacctttac actgcacccc tccactcact taaaagccag
     3961 cattgattgc cctgtgcata agaccggaag acaagcaggg ggttgacttc ctacttcact
     4021 tgctctggcc tccaaatgtc aattagcacc ctgggcctgg ccatgggtag ggtatgtaga
     4081 acccatgcaa gctctaggtc ttggcacaag agaaccaatt tatactgaat gcctcactaa
     4141 ttagagtaaa aactgtttac agggaagatg gtatggatca ttggactgtc cactgtttta
     4201 aacatcccta ttctcatggc ccaggcatgt aacagtgttg gtttgtgctc ttcccatgtg
     4261 tgtagttgtt agtactgaaa atttaagtat aaataacagt ccagggttt
//
