LOCUS       NM_054004               4381 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cullin-associated and neddylation-dissociated 1
            (Cand1), mRNA.
ACCESSION   NM_054004
VERSION     NM_054004.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4381)
  AUTHORS   Fang,R., Li,H.L., Lv,N.X., Yue,P.L., Jia,Y.X., Liu,Z.C., Zhou,H.G.
            and Song,X.D.
  TITLE     Inhibition of miR-29a-3p Alleviates Apoptosis of Lens Epithelial
            Cells via Upregulation of CAND1
  JOURNAL   Curr Eye Res 49 (4), 391-400 (2024)
   PUBMED   38095165
  REMARK    GeneRIF: Inhibition of miR-29a-3p Alleviates Apoptosis of Lens
            Epithelial Cells via Upregulation of CAND1.
REFERENCE   2  (bases 1 to 4381)
  AUTHORS   Zhou,L., Yu,X., Guo,Y. and Liu,X.
  TITLE     LncRNA RMRP knockdown promotes proliferation and migration of
            Schwann cells by mediating the miR-766-5p/CAND1 axis
  JOURNAL   Neurosci Lett 770, 136440 (2022)
   PUBMED   34974108
  REMARK    GeneRIF: LncRNA RMRP knockdown promotes proliferation and migration
            of Schwann cells by mediating the miR-766-5p/CAND1 axis.
REFERENCE   3  (bases 1 to 4381)
  AUTHORS   Nakashima,K., Takeuchi,S., Iwama,S., Kiyota,A., Yasuda,Y.,
            Iwata,N., Enomoto,A., Arima,H. and Sugimura,Y.
  TITLE     Cullin-associated NEDD8-dissociated protein 1, a novel interactor
            of rabphilin-3A, deubiquitylates rabphilin-3A and regulates
            arginine vasopressin secretion in PC12 cells
  JOURNAL   Endocr J 65 (3), 325-334 (2018)
   PUBMED   29367474
  REMARK    GeneRIF: The findings indicate that CAND1 inhibits the
            ubiquitylation of rabphilin-3A and positively regulates AVP
            secretion.
REFERENCE   4  (bases 1 to 4381)
  AUTHORS   Tron,A.E., Arai,T., Duda,D.M., Kuwabara,H., Olszewski,J.L.,
            Fujiwara,Y., Bahamon,B.N., Signoretti,S., Schulman,B.A. and
            DeCaprio,J.A.
  TITLE     The glomuvenous malformation protein Glomulin binds Rbx1 and
            regulates cullin RING ligase-mediated turnover of Fbw7
  JOURNAL   Mol Cell 46 (1), 67-78 (2012)
   PUBMED   22405651
REFERENCE   5  (bases 1 to 4381)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   6  (bases 1 to 4381)
  AUTHORS   Min,K.W., Hwang,J.W., Lee,J.S., Park,Y., Tamura,T.A. and Yoon,J.B.
  TITLE     TIP120A associates with cullins and modulates ubiquitin ligase
            activity
  JOURNAL   J Biol Chem 278 (18), 15905-15910 (2003)
   PUBMED   12609982
REFERENCE   7  (bases 1 to 4381)
  AUTHORS   Yogosawa,S., Kayukawa,K., Kawata,T., Makino,Y., Inoue,S., Okuda,A.,
            Muramatsu,M. and Tamura,T.
  TITLE     Induced expression, localization, and chromosome mapping of a gene
            for the TBP-interacting protein 120A
  JOURNAL   Biochem Biophys Res Commun 266 (1), 123-128 (1999)
   PUBMED   10581176
REFERENCE   8  (bases 1 to 4381)
  AUTHORS   Makino,Y., Yogosawa,S., Kayukawa,K., Coin,F., Egly,J.M., Wang,Zx.,
            Roeder,R.G., Yamamoto,K., Muramatsu,M. and Tamura,Ta.
  TITLE     TATA-Binding protein-interacting protein 120, TIP120, stimulates
            three classes of eukaryotic transcription via a unique mechanism
  JOURNAL   Mol Cell Biol 19 (12), 7951-7960 (1999)
   PUBMED   10567521
REFERENCE   9  (bases 1 to 4381)
  AUTHORS   Aoki,T., Okada,N., Ishida,M., Yogosawa,S., Makino,Y. and
            Tamura,T.A.
  TITLE     TIP120B: a novel TIP120-family protein that is expressed
            specifically in muscle tissues
  JOURNAL   Biochem Biophys Res Commun 261 (3), 911-916 (1999)
   PUBMED   10441524
REFERENCE   10 (bases 1 to 4381)
  AUTHORS   Yogosawa,S., Makino,Y., Yoshida,T., Kishimoto,T., Muramatsu,M. and
            Tamura,T.
  TITLE     Molecular cloning of a novel 120-kDa TBP-interacting protein
  JOURNAL   Biochem Biophys Res Commun 229 (2), 612-617 (1996)
   PUBMED   8954946
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D87671.1.
            
            On Aug 30, 2012 this sequence version replaced NM_054004.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D87671.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840108 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4381              D87671.1           3-4383
FEATURES             Location/Qualifiers
     source          1..4381
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..4381
                     /gene="Cand1"
                     /gene_synonym="Tip120; Tip120A"
                     /note="cullin-associated and neddylation-dissociated 1"
                     /db_xref="GeneID:117152"
                     /db_xref="RGD:620479"
     exon            1..420
                     /gene="Cand1"
                     /gene_synonym="Tip120; Tip120A"
                     /inference="alignment:Splign:2.1.0"
     CDS             353..4045
                     /gene="Cand1"
                     /gene_synonym="Tip120; Tip120A"
                     /function="activation of basal transcription"
                     /note="p120 CAND1; TBP-interacting protein TIP120A;
                     TBP-interacting protein of 120 kDa A; cullin-associated
                     and neddylation-dissociated protein 1; cullin associated
                     and neddylation disassociated 1; TBP-interacting protein
                     120A"
                     /codon_start=1
                     /product="cullin-associated NEDD8-dissociated protein 1"
                     /protein_id="NP_446456.1"
                     /db_xref="GeneID:117152"
                     /db_xref="RGD:620479"
                     /translation="MASASYHISNLLEKMTSSDKDFRFMATNDLMTELQKDSIKLDDD
                     SERKVVKMILKLLEDKNGEVQNLAVKCLGPLVSKVKEYQVETIVDTLCTNMLSDKEQL
                     RDISSIGLKTVIGELPPASSGSALAANVCKKITGRLTSAIAKQEDVSVQLEALDIMAD
                     MLSRQGGLLVNFHPSILTCLLPQLTSPRLAVRKRTIIALGHLVMSCGNIVFVDLIEHL
                     LSELSKNDSMSTTRTYIQCIAAISRQAGHRIGEYLEKIIPLVVKFCNVDDDELREYCI
                     QAFESFVRRCPKEVYPHVSTIINICLKYLTYDPNYNYDDEDEDENAMDADGGDDDDQG
                     SDDEYSDDDDMSWKVRRAAAKCLDAVVSTRHEMLPEFYKTVSPALISRFKEREENVKA
                     DVFHAYLSLLKQTRPVQSWLCDPDAMEQGETPLTMLQSQVPNIVKALHKQMKEKSVKT
                     RQCCFNMLTELVNVLPGALTQHIPVLVPGIIFSLNDKSSSSNLKIDALSCLYVILCNH
                     SPQVFHPHVQALVPPVVACVGDPFYKITSEALLVTQQLVKVIRPLDQPSSFDATPYIK
                     DLFTCTIKRLKAADIDQEVKERAISCMGQIICNLGDNLGPDLSNTLQIFLERLKNEIT
                     RLTTVKALTLIAGSPLKIDLRPVLGEGVPILASFLRKNQRALKLGTLSALDILIKNYS
                     DSLTAAMIDAVLDELPPLISESDMHVSQMAISFLTTLAKVYPSSLSKISGSILNELIG
                     LVRSPLLQGGALSAMLDFFQALVVTGTNNLGYMDLLRMLTGPVYSQSTALTHKQSYYS
                     IAKCVAALTRACPKEGPAVVGQFIQDVKNSRSTDSIRLLALLSLGEVGHHIDLSGQLE
                     LKSVILEAFSSPSEEVKSAASYALGSISVGNLPEYLPFVLQEITSQPKRQYLLLHSLK
                     EIISSASVVGLKPYVENIWALLLKHCECAEEGTRNVVAECLGKLTLIDPETLLPRLKG
                     YLISGSSYARSSVVTAVKFTISDHPQPIDPLLKNCIGDFLKTLEDPDLNVRRVALVTF
                     NSAAHNKPSLIRDLLDSVLPHLYNETKVRKELIREVEMGPFKHTVDDGLDIRKAAFEC
                     MYTLLDSCLDRLDIFEFLNHVEDGLKDHYDIKMLTFLMLVRLSTLCPSAVLQRLDRLV
                     EPLRATCTTKVKANSVKQEFEKQDELKRSAMRAVAALLTIPEAEKSPLMSEFQSQISS
                     NPELAAIFESIQKDSSSTNLESMDTS"
     exon            421..564
                     /gene="Cand1"
                     /gene_synonym="Tip120; Tip120A"
                     /inference="alignment:Splign:2.1.0"
     exon            565..719
                     /gene="Cand1"
                     /gene_synonym="Tip120; Tip120A"
                     /inference="alignment:Splign:2.1.0"
     exon            720..843
                     /gene="Cand1"
                     /gene_synonym="Tip120; Tip120A"
                     /inference="alignment:Splign:2.1.0"
     exon            844..1100
                     /gene="Cand1"
                     /gene_synonym="Tip120; Tip120A"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1206
                     /gene="Cand1"
                     /gene_synonym="Tip120; Tip120A"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1352
                     /gene="Cand1"
                     /gene_synonym="Tip120; Tip120A"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1645
                     /gene="Cand1"
                     /gene_synonym="Tip120; Tip120A"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1787
                     /gene="Cand1"
                     /gene_synonym="Tip120; Tip120A"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..3281
                     /gene="Cand1"
                     /gene_synonym="Tip120; Tip120A"
                     /inference="alignment:Splign:2.1.0"
     exon            3282..3377
                     /gene="Cand1"
                     /gene_synonym="Tip120; Tip120A"
                     /inference="alignment:Splign:2.1.0"
     exon            3378..3547
                     /gene="Cand1"
                     /gene_synonym="Tip120; Tip120A"
                     /inference="alignment:Splign:2.1.0"
     exon            3548..3712
                     /gene="Cand1"
                     /gene_synonym="Tip120; Tip120A"
                     /inference="alignment:Splign:2.1.0"
     exon            3713..3820
                     /gene="Cand1"
                     /gene_synonym="Tip120; Tip120A"
                     /inference="alignment:Splign:2.1.0"
     exon            3821..4381
                     /gene="Cand1"
                     /gene_synonym="Tip120; Tip120A"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggcctcttg ccctaagaag cgagtgcgga gggagtggga gcgagactgc ccgaacgcaa
       61 gtgtctggct tcccggcgag gcccaggcgt ccgtcccgcc gcccatgaac tcgttgcccc
      121 gcgagcagcg ccgtcgttag gccgtccccg tcactctcgc tcgcccccat ccccgggcag
      181 ccattccccc ctacccacgt ctggccgggg actggacgtc gtgtcgaagc gccttcccca
      241 gtccgcgtcg cgctgcgacc ctggaagcgg gcgccgccgc caacgagagg aggagccccg
      301 gccgcggggc ccagcagcca ctgagccagc aggcgggatc gaggccggca acatggcgag
      361 cgcttcgtac cacatctcca acttgctgga aaaaatgaca tccagcgaca aggacttcag
      421 gtttatggct acaaatgatc tgatgacaga actgcagaaa gactccatca agctggatga
      481 tgacagcgaa aggaaagtcg taaagatgat tctgaagttg ctggaggata aaaatggcga
      541 agtgcagaac ttagctgtga aatgtcttgg tcctttagtg agtaaagtga aagagtacca
      601 agttgagacg attgtagaca ccctctgtac aaacatgctt tctgacaagg agcagcttcg
      661 agatatttcc agtattggcc ttaaaacagt aattggagaa ctccctccag cttccagtgg
      721 ctctgcatta gctgctaatg tatgtaaaaa gattactgga cgccttacca gtgcaatagc
      781 aaagcaggaa gatgtttctg ttcagctaga agctttagat attatggctg atatgttgag
      841 caggcaagga ggactgcttg ttaatttcca tccttcaatt ctgacctgtc tacttcccca
      901 gctgactagc cctagacttg cagtcaggaa aagaacaatt attgctcttg gccacctagt
      961 tatgagctgc ggaaacatag tttttgtaga ccttattgaa catctgttgt cagagttgtc
     1021 caaaaatgac tccatgtcaa caacaaggac ctacatacag tgtattgctg ctattagtag
     1081 gcaagctggc catagaatag gtgaatacct tgaaaagata attcctttgg tggtaaaatt
     1141 ttgtaatgta gatgatgatg aattaagaga atactgcatt caagcttttg aatcatttgt
     1201 gagaagatgc cctaaggaag tttatcctca tgtttctacc attataaaca tttgtctaaa
     1261 ataccttacc tatgatccaa attacaacta tgatgatgaa gatgaagatg agaatgctat
     1321 ggatgctgat ggcggagatg acgatgacca agggagtgac gatgaataca gtgatgacga
     1381 tgacatgagt tggaaagtga ggcgtgcggc tgccaagtgc ctggatgccg tagttagcac
     1441 acggcatgag atgctcccgg aattctacaa gaccgtctct cctgcactga tatccagatt
     1501 taaagagcgc gaagagaatg taaaggcaga tgtttttcat gcataccttt ctcttttgaa
     1561 gcaaactcgt ccagtacaaa gttggctgtg cgaccctgat gcaatggagc aaggagaaac
     1621 acccttaaca atgcttcaga gtcaggttcc caacattgtt aaagccctac ataaacagat
     1681 gaaagaaaaa agtgtaaaga cccgacagtg ttgttttaac atgttaactg aactggtaaa
     1741 tgtgttgcct ggggcactaa cccaacacat tcctgtactt gtaccaggaa tcattttctc
     1801 actcaatgat aagtccagct catcgaatct gaagattgat gcattgtcct gtctgtatgt
     1861 gatcctctgt aaccactctc cgcaagtttt ccacccgcat gttcaggctt tggtccctcc
     1921 agtggtggct tgtgttggtg acccatttta caagatcaca tcagaagccc ttcttgtcac
     1981 tcagcagctt gtcaaagtaa tccgtcctct ggaccaaccc tcctccttcg atgcaacgcc
     2041 ttacatcaaa gatctcttca cttgtacaat taagcgctta aaagcagctg acattgatca
     2101 ggaagtcaag gagagggcta tttcctgtat gggacagatt atttgcaatc ttggagacaa
     2161 tttgggccct gacttatcaa atacacttca gattttcttg gagagactca agaatgaaat
     2221 cacccggcta acgacagtga aagcactgac cctgattgct gggtcacctt tgaagataga
     2281 tctgaggcct gtgctgggag agggagtccc tatccttgct tcatttctca ggaaaaatca
     2341 gagagctttg aaactgggga ccctctctgc cctagatatt ctcattaaaa actatagtga
     2401 cagtttgacg gccgccatga ttgatgcagt tctggatgag ctccctcctc ttatcagcga
     2461 aagtgatatg cacgtgtccc agatggctat cagcttcctt actaccctgg caaaagtata
     2521 tccctcctcc ctttcaaaga taagcggatc tattctcaat gaactgattg gacttgtaag
     2581 gtcacctctg ctgcagggag gagctcttag tgccatgcta gacttcttcc aagctttggt
     2641 tgtcactgga acaaacaatc taggatacat ggatttgctg cgcatgctaa cgggtccagt
     2701 ttactctcag agcacagctc ttactcataa gcagtcttac tattccattg ccaaatgtgt
     2761 agctgccctt actcgagcat gccctaaaga gggaccggct gtagtaggtc agtttattca
     2821 agatgtcaag aactccaggt ctacagattc cattcgtctc ttagcgctcc tttctctagg
     2881 agaagttgga caccatattg acttaagtgg gcagttggag ctaaaatctg taatattaga
     2941 ggctttctcc tctcctagtg aagaagttaa atcagctgca tcctatgcgt taggcagcat
     3001 cagtgtaggc aacctccctg agtatctgcc atttgtacta caagaaataa ccagtcagcc
     3061 caaaaggcag tacctgctgc tgcattccct gaaggaaatc attagctctg cgtcagtggt
     3121 cggccttaag ccgtatgtcg agaacatctg ggccttgctg ctaaagcact gtgagtgcgc
     3181 ggaggagggc accagaaacg tcgtcgccga gtgtctaggg aagctcactc ttattgatcc
     3241 tgaaactctc ctcccgaggc ttaaagggta tttgatatca gggtcatcct atgccagaag
     3301 ctcagtggtt acagctgtga agttcactat ttctgaccac cctcagccca ttgatccact
     3361 gctcaagaac tgcataggtg attttctaaa aacgttggaa gacccagatt tgaatgtaag
     3421 aagagtggcc ttggtcacat tcaattctgc agcccataac aagccgtcac tgatacggga
     3481 ccttctggat tctgttcttc cacatcttta caatgagaca aaagttagga aggaacttat
     3541 aagagaggta gagatgggcc cgtttaagca cacggttgat gacggcctgg acattagaaa
     3601 ggcagctttt gagtgtatgt acacacttct agacagctgt cttgacagac tggatatctt
     3661 tgaatttcta aatcatgtgg aagatggttt gaaggaccat tatgatatta agatgctaac
     3721 atttttaatg ttggtgagac tatctaccct ttgtccaagt gcagtactac agaggttgga
     3781 ccggcttgtt gagccactac gagctacgtg tacaactaag gtgaaggcga actctgtaaa
     3841 gcaggagttt gaaaagcagg acgagttaaa gcgctcggcc atgagggcag tagctgcact
     3901 gctcaccatt ccagaggcag agaagagccc tctcatgagt gagttccagt cacagatcag
     3961 ctccaacccg gagctggcag ccatctttga aagtatccag aaagattctt cgtccactaa
     4021 cttggaatca atggacacta gttagacgtg tgttccacat gaggaccatt acatttgacc
     4081 gcacagtgca ctgaaccgac aagttgacca tagacacggg agagaagtgt ctagagcttc
     4141 aggatgttcc acttttattt tcattcatgg gaagtttgtt cagctttctt ccattgttgt
     4201 ttttgtagct tttacttcag aaatctgtat ttccataatc cagaggttgt aagaccactg
     4261 atggttttag tggttagggc aacgtttgaa atgggaacta aagtttggat ttatggaatg
     4321 tggaaatagg gtccagtatc tgtttgccct gtaatgtgta ggattaaaat gttaaaactt
     4381 t
//
