LOCUS       NM_001100724             586 bp    mRNA    linear   ROD 03-DEC-2024
DEFINITION  Rattus norvegicus cathelicidin antimicrobial peptide (Camp), mRNA.
ACCESSION   NM_001100724 XM_001075585 XM_236642
VERSION     NM_001100724.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 586)
  AUTHORS   Horibe,K., Hosoya,A., Hiraga,T. and Nakamura,H.
  TITLE     Expression and localization of CRAMP in rat tooth germ and during
            reparative dentin formation
  JOURNAL   Clin Oral Investig 22 (7), 2559-2566 (2018)
   PUBMED   29396644
REFERENCE   2  (bases 1 to 586)
  AUTHORS   Sun,J., Xu,M., Ortsater,H., Lundeberg,E., Juntti-Berggren,L.,
            Chen,Y.Q., Haeggstrom,J.Z., Gudmundsson,G.H., Diana,J. and
            Agerberth,B.
  TITLE     Cathelicidins positively regulate pancreatic beta-cell functions
  JOURNAL   FASEB J 30 (2), 884-894 (2016)
   PUBMED   26527065
REFERENCE   3  (bases 1 to 586)
  AUTHORS   Pound,L.D., Patrick,C., Eberhard,C.E., Mottawea,W., Wang,G.S.,
            Abujamel,T., Vandenbeek,R., Stintzi,A. and Scott,F.W.
  TITLE     Cathelicidin Antimicrobial Peptide: A Novel Regulator of Islet
            Function, Islet Regeneration, and Selected Gut Bacteria
  JOURNAL   Diabetes 64 (12), 4135-4147 (2015)
   PUBMED   26370175
REFERENCE   4  (bases 1 to 586)
  AUTHORS   Babolewska,E., Pietrzak,A. and Brzezinska-Blaszczyk,E.
  TITLE     Cathelicidin rCRAMP stimulates rat mast cells to generate cysteinyl
            leukotrienes, synthesize TNF and migrate: involvement of PLC/A2,
            PI3K and MAPK signaling pathways
  JOURNAL   Int Immunol 26 (11), 637-646 (2014)
   PUBMED   24990383
REFERENCE   5  (bases 1 to 586)
  AUTHORS   Kumagai,S., Matsui,K., Kawaguchi,H., Yamashita,T., Mohri,T.,
            Fujio,Y. and Nakayama,H.
  TITLE     Cathelicidin antimicrobial peptide inhibits fibroblast migration
            via P2X7 receptor signaling
  JOURNAL   Biochem Biophys Res Commun 437 (4), 609-614 (2013)
   PUBMED   23867818
REFERENCE   6  (bases 1 to 586)
  AUTHORS   Sorensen,O.E., Gram,L., Johnsen,A.H., Andersson,E., Bangsboll,S.,
            Tjabringa,G.S., Hiemstra,P.S., Malm,J., Egesten,A. and
            Borregaard,N.
  TITLE     Processing of seminal plasma hCAP-18 to ALL-38 by gastricsin: a
            novel mechanism of generating antimicrobial peptides in vagina
  JOURNAL   J Biol Chem 278 (31), 28540-28546 (2003)
   PUBMED   12759353
  REMARK    Erratum:[J Biol Chem. 2006 May 5;281(18):12999]
REFERENCE   7  (bases 1 to 586)
  AUTHORS   Travis,S.M., Anderson,N.N., Forsyth,W.R., Espiritu,C., Conway,B.D.,
            Greenberg,E.P., McCray,P.B. Jr., Lehrer,R.I., Welsh,M.J. and
            Tack,B.F.
  TITLE     Bactericidal activity of mammalian cathelicidin-derived peptides
  JOURNAL   Infect Immun 68 (5), 2748-2755 (2000)
   PUBMED   10768969
REFERENCE   8  (bases 1 to 586)
  AUTHORS   Frohm,M., Agerberth,B., Ahangari,G., Stahle-Backdahl,M., Liden,S.,
            Wigzell,H. and Gudmundsson,G.H.
  TITLE     The expression of the gene coding for the antibacterial peptide
            LL-37 is induced in human keratinocytes during inflammatory
            disorders
  JOURNAL   J Biol Chem 272 (24), 15258-15263 (1997)
   PUBMED   9182550
REFERENCE   9  (bases 1 to 586)
  AUTHORS   Gallo,R.L., Kim,K.J., Bernfield,M., Kozak,C.A., Zanetti,M.,
            Merluzzi,L. and Gennaro,R.
  TITLE     Identification of CRAMP, a cathelin-related antimicrobial peptide
            expressed in the embryonic and adult mouse
  JOURNAL   J Biol Chem 272 (20), 13088-13093 (1997)
   PUBMED   9148921
REFERENCE   10 (bases 1 to 586)
  AUTHORS   Agerberth,B., Gunne,H., Odeberg,J., Kogner,P., Boman,H.G. and
            Gudmundsson,G.H.
  TITLE     FALL-39, a putative human peptide antibiotic, is cysteine-free and
            expressed in bone marrow and testis
  JOURNAL   Proc Natl Acad Sci U S A 92 (1), 195-199 (1995)
   PUBMED   7529412
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On or before Oct 14, 2007 this sequence version replaced
            XM_236642.3, XM_001075585.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF484553.1, CA509601.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680432, SAMN06680452
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-203               JAXUCZ010000008.1  118721796-118721998 c
            204-311             JAXUCZ010000008.1  118721184-118721291 c
            312-383             JAXUCZ010000008.1  118720970-118721041 c
            384-586             JAXUCZ010000008.1  118720184-118720386 c
FEATURES             Location/Qualifiers
     source          1..586
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..586
                     /gene="Camp"
                     /gene_synonym="CRAMP"
                     /note="cathelicidin antimicrobial peptide"
                     /db_xref="GeneID:316010"
                     /db_xref="RGD:1559878"
     exon            1..203
                     /gene="Camp"
                     /gene_synonym="CRAMP"
                     /inference="alignment:Splign:2.1.0"
     CDS             6..533
                     /gene="Camp"
                     /gene_synonym="CRAMP"
                     /note="cathelin-related antimicrobial peptide"
                     /codon_start=1
                     /product="cathelicidin antimicrobial peptide precursor"
                     /protein_id="NP_001094194.1"
                     /db_xref="GeneID:316010"
                     /db_xref="RGD:1559878"
                     /translation="MQPHRDVPSLWRSLSLLLLLGLGLPLAVSQTLSYREAVLRAVDD
                     FNQQSLDTNLYRLLDLDSEPQGDEDPDTPKYVRFRVKETVCSKASQQLPEQCAFKEQG
                     VVKQCMGTVTLNQAAESFDISCDAPGIQPFRFKKISRLAGLLRKGGEKFGEKLRKIGQ
                     KIKDFFQKLAPEIEQ"
     exon            204..311
                     /gene="Camp"
                     /gene_synonym="CRAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            312..383
                     /gene="Camp"
                     /gene_synonym="CRAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            384..586
                     /gene="Camp"
                     /gene_synonym="CRAMP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaccatgca accccatagg gacgtccctt ccctgtggcg ctcactgtca ctgctattgc
       61 tcctgggcct tgggttgcct ctagccgttt cccagaccct cagctacagg gaggctgtac
      121 tccgtgctgt ggatgacttc aaccagcagt ctttggacac caatctctac cgtctcctgg
      181 acctggattc tgagccccaa ggggatgagg acccagatac tcccaagtat gtgaggttcc
      241 gagtgaagga gactgtctgt agcaaggcat cacagcagtt acctgagcaa tgtgccttca
      301 aggaacaggg ggtagtgaag cagtgtatgg ggacagtcac cctgaaccag gctgcagagt
      361 cttttgacat cagttgtgat gcgcctggta tacagccttt ccggttcaag aaaatttccc
      421 ggctggctgg actcctccga aaaggtggag agaagtttgg tgaaaagctt aggaaaatcg
      481 gccagaaaat taaggatttt ttccagaaac ttgcacctga aatagagcag taggcctgcc
      541 ttggcctgtt tttggattcc caaaataata aacttggtaa aagaaa
//
