LOCUS       NP_076490                504 aa            linear   ROD 06-DEC-2024
DEFINITION  caM kinase-like vesicle-associated protein [Rattus norvegicus].
ACCESSION   NP_076490
VERSION     NP_076490.1
DBSOURCE    REFSEQ: accession NM_024000.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 504)
  AUTHORS   Liang,Z., Zhan,Y., Shen,Y., Wong,C.C., Yates,J.R. 3rd, Plattner,F.,
            Lai,K.O. and Ip,N.Y.
  TITLE     The pseudokinase CaMKv is required for the activity-dependent
            maintenance of dendritic spines
  JOURNAL   Nat Commun 7, 13282 (2016)
   PUBMED   27796283
  REMARK    GeneRIF: Camkv has a role in activity-dependent maintenance of
            dendritic spines
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 504)
  AUTHORS   Godbout,M., Erlander,M.G., Hasel,K.W., Danielson,P.E., Wong,K.K.,
            Battenberg,E.L., Foye,P.E., Bloom,F.E. and Sutcliffe,J.G.
  TITLE     1G5: a calmodulin-binding, vesicle-associated, protein kinase-like
            protein enriched in forebrain neurites
  JOURNAL   J Neurosci 14 (1), 1-13 (1994)
   PUBMED   8283228
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from L22557.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L22557.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     Protein         1..504
                     /product="caM kinase-like vesicle-associated protein"
                     /function="unknown"
                     /note="vesicle-associated calmodulin-binding protein"
                     /calculated_mol_wt=53975
     Region          22..286
                     /region_name="STKc_CaMK_like"
                     /note="Catalytic domain of an Uncharacterized group of
                     Serine/Threonine kinases with similarity to
                     Calcium/calmodulin-dependent protein kinases; cd14088"
                     /db_xref="CDD:270990"
     Site            order(30..34,38,51,53,83,99..102,106,108,144..145,147,
                     149..150,152,165..166,169,181..185,187)
                     /site_type="active"
                     /db_xref="CDD:270990"
     Site            order(30..33,38,51,53,83,99..102,106,149..150,152,
                     165..166)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270990"
     Site            order(34,106,108,144..145,147,149,169,181..185,187)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270990"
     Site            165..185
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270990"
     Region          370..>485
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          378..504
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63092.1)"
     Site            384
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q3UHL1; propagated from
                     UniProtKB/Swiss-Prot (Q63092.1)"
     Site            438
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q63092.1)"
     Site            462
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q3UHL1; propagated from
                     UniProtKB/Swiss-Prot (Q63092.1)"
     CDS             1..504
                     /gene="Camkv"
                     /gene_synonym="1G5"
                     /coded_by="NM_024000.1:133..1647"
                     /db_xref="GeneID:79011"
                     /db_xref="RGD:621488"
ORIGIN      
        1 mpfgcvtlgd kknynqpsev tdrydlgqvv kteefceifr akdkttgklh tckkfqkrdg
       61 rkvrkaakne igilkmvkhp nilqlvdvfv trkeyfifle latgrevfdw ildqgyyser
      121 dtsnvvrqvl eavaylhslk ivhrnlklen lvyynrlkns kivisdfhla klenglikep
      181 cgtpeylape vvgrqrygrp vdcwaigvim yillsgnppf yeeveeddye nhdknlfrki
      241 lagdyefdsp ywddisqaak dlvtrlmeve qdqritaeea ishewisgna asdknikdgv
      301 caqieknfar akwkkavrvt tlmkrlrape qsgtaatsda atpgaaggav aaaaggaapa
      361 sgasatvgtg gdagcaaksd dmasadrsat patdgsatpa tdgsvtpatd gsitpatdgs
      421 vtpatdrsat patdgratpa teestvpaaq ssaapaakaa atpepavaqp dstalegatg
      481 qappsskgee atgcaqesqr vets
//
