LOCUS       NM_031662               3411 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus calcium/calmodulin-dependent protein kinase
            kinase 1 (Camkk1), mRNA.
ACCESSION   NM_031662
VERSION     NM_031662.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3411)
  AUTHORS   Fukumoto,Y., Harada,Y., Ohtsuka,S., Kanayama,N., Magari,M.,
            Hatano,N., Sakagami,H. and Tokumitsu,H.
  TITLE     Oligomerization of Ca2+/calmodulin-dependent protein kinase kinase
  JOURNAL   Biochem Biophys Res Commun 587, 160-165 (2022)
   PUBMED   34875535
  REMARK    GeneRIF: Oligomerization of Ca(2+)/calmodulin-dependent protein
            kinase kinase.
REFERENCE   2  (bases 1 to 3411)
  AUTHORS   Lu,W., Cai,H., Chen,Y., Liao,X., Zhang,L., Ma,T., Sun,H. and Qi,Y.
  TITLE     Ghrelin inhibited pressure overload-induced cardiac hypertrophy by
            promoting autophagy via CaMKK/AMPK signaling pathway
  JOURNAL   Peptides 136, 170446 (2021)
   PUBMED   33197510
  REMARK    GeneRIF: Ghrelin inhibited pressure overload-induced cardiac
            hypertrophy by promoting autophagy via CaMKK/AMPK signaling
            pathway.
REFERENCE   3  (bases 1 to 3411)
  AUTHORS   Fujiwara,Y., Kawaguchi,Y., Fujimoto,T., Kanayama,N., Magari,M. and
            Tokumitsu,H.
  TITLE     Differential AMP-activated Protein Kinase (AMPK) Recognition
            Mechanism of Ca2+/Calmodulin-dependent Protein Kinase Kinase
            Isoforms
  JOURNAL   J Biol Chem 291 (26), 13802-13808 (2016)
   PUBMED   27151216
  REMARK    GeneRIF: Site-directed mutagenesis analysis revealed that Leu(358)
            in CaMKKbeta/Ile(322) in CaMKKalpha confer, at least in part, a
            distinct recognition of AMPK but not of CaMKIalpha.
REFERENCE   4  (bases 1 to 3411)
  AUTHORS   Fujiwara,Y., Hiraoka,Y., Fujimoto,T., Kanayama,N., Magari,M. and
            Tokumitsu,H.
  TITLE     Analysis of Distinct Roles of CaMKK Isoforms Using
            STO-609-Resistant Mutants in Living Cells
  JOURNAL   Biochemistry 54 (25), 3969-3977 (2015)
   PUBMED   26050738
  REMARK    GeneRIF: CaMKKalpha and CaMKKbeta are capable of phosphorylating
            and activating CaMKIV in living cells.
REFERENCE   5  (bases 1 to 3411)
  AUTHORS   Wang,P., Wang,W.P., Sun-Zhang, Wang,H.X., Yan-Lou and Fan,Y.H.
  TITLE     Impaired spatial learning related with decreased expression of
            calcium/calmodulin-dependent protein kinase IIalpha and
            cAMP-response element binding protein in the
            pentylenetetrazol-kindled rats
  JOURNAL   Brain Res 1238, 108-117 (2008)
   PUBMED   18710651
  REMARK    GeneRIF: CaMKII(alpha) expression levels in hippocampus of chronic
            epileptic rats may be related with their impaired spatial learning
            and memory.
REFERENCE   6  (bases 1 to 3411)
  AUTHORS   Wayman,G.A., Tokumitsu,H. and Soderling,T.R.
  TITLE     Inhibitory cross-talk by cAMP kinase on the calmodulin-dependent
            protein kinase cascade
  JOURNAL   J Biol Chem 272 (26), 16073-16076 (1997)
   PUBMED   9195898
REFERENCE   7  (bases 1 to 3411)
  AUTHORS   Okuno,S., Kitani,T. and Fujisawa,H.
  TITLE     Evidence for the existence of Ca2+/calmodulin-dependent protein
            kinase IV kinase isoforms in rat brain
  JOURNAL   J Biochem 119 (6), 1176-1181 (1996)
   PUBMED   8827455
REFERENCE   8  (bases 1 to 3411)
  AUTHORS   Edelman,A.M., Mitchelhill,K.I., Selbert,M.A., Anderson,K.A.,
            Hook,S.S., Stapleton,D., Goldstein,E.G., Means,A.R. and Kemp,B.E.
  TITLE     Multiple Ca(2+)-calmodulin-dependent protein kinase kinases from
            rat brain. Purification, regulation by Ca(2+)-calmodulin, and
            partial amino acid sequence
  JOURNAL   J Biol Chem 271 (18), 10806-10810 (1996)
   PUBMED   8631893
REFERENCE   9  (bases 1 to 3411)
  AUTHORS   Nakamura,Y., Okuno,S., Kitani,T., Otake,K., Sato,F. and Fujisawa,H.
  TITLE     Distribution of Ca2+/calmodulin-dependent protein kinase kinase
            alpha in the rat central nervous system: an immunohistochemical
            study
  JOURNAL   Neurosci Lett 204 (1-2), 61-64 (1996)
   PUBMED   8929978
REFERENCE   10 (bases 1 to 3411)
  AUTHORS   Tokumitsu,H., Enslen,H. and Soderling,T.R.
  TITLE     Characterization of a Ca2+/calmodulin-dependent protein kinase
            cascade. Molecular cloning and expression of
            calcium/calmodulin-dependent protein kinase kinase
  JOURNAL   J Biol Chem 270 (33), 19320-19324 (1995)
   PUBMED   7642608
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB023658.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB023658.1, L42810.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132267, SAMD00132290
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3411
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..3411
                     /gene="Camkk1"
                     /note="calcium/calmodulin-dependent protein kinase kinase
                     1"
                     /db_xref="GeneID:60341"
                     /db_xref="RGD:62023"
     exon            1..74
                     /gene="Camkk1"
                     /inference="alignment:Splign:2.1.0"
     exon            75..466
                     /gene="Camkk1"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..1624
                     /gene="Camkk1"
                     /EC_number="2.7.11.17"
                     /note="caMKK 1; alpha CaMKK; caMKK alpha; caM-KK alpha;
                     caM-kinase IV kinase; caM-kinase kinase alpha;
                     calcium/calmodulin-dependent protein kinase kinase alpha;
                     caM-KK 1; caM-kinase kinase 1;
                     calcium/calmodulin-dependent protein kinase kinase 1,
                     alpha"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase
                     kinase 1"
                     /protein_id="NP_113850.1"
                     /db_xref="GeneID:60341"
                     /db_xref="RGD:62023"
                     /translation="MERSPAVCCQDPRAELVERVAAISVAHLEEAEEGPEPASNGVDP
                     PPRARAASVIPGSASRPTPVRPSLSARKFSLQERPAGSCLEAQVGPYSTGPASHMSPR
                     AWRRPTIESHHVAISDTEDCVQLNQYKLQSEIGKGAYGVVRLAYNEREDRHYAMKVLS
                     KKKLLKQYGFPRRPPPRGSQAPQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVL
                     DDPAEDNLYLVFDLLRKGPVMEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDI
                     KPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDTGQSFSGKAL
                     DVWATGVTLYCFVYGKCPFIDEYILALHRKIKNEAVVFPEEPEVSEELKDLILKMLDK
                     NPETRIGVSDIKLHPWVTKHGEEPLPSEEEHCSVVEVTEEEVKNSVKLIPSWTTVILV
                     KSMLRKRSFGNPFEPQARREERSMSAPGNLLLKEGCGEGGKSPELPGVQEDEAAS"
     exon            467..514
                     /gene="Camkk1"
                     /inference="alignment:Splign:2.1.0"
     exon            515..568
                     /gene="Camkk1"
                     /inference="alignment:Splign:2.1.0"
     exon            569..620
                     /gene="Camkk1"
                     /inference="alignment:Splign:2.1.0"
     exon            621..754
                     /gene="Camkk1"
                     /inference="alignment:Splign:2.1.0"
     exon            755..791
                     /gene="Camkk1"
                     /inference="alignment:Splign:2.1.0"
     exon            792..813
                     /gene="Camkk1"
                     /inference="alignment:Splign:2.1.0"
     exon            814..902
                     /gene="Camkk1"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1102
                     /gene="Camkk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1156
                     /gene="Camkk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1230
                     /gene="Camkk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1318
                     /gene="Camkk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1447
                     /gene="Camkk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1551
                     /gene="Camkk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..3411
                     /gene="Camkk1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3411
                     /gene="Camkk1"
                     /note="18 a nucleotides"
ORIGIN      
        1 aagcgggcag ggcggggcgc gcccagcggg agcgagcccg gcgcccaccg cagagactgt
       61 cgcctggtgc ctaggttccc aacaggaata tccacggact gaagtgatgg agcgcagtcc
      121 agccgtctgc tgccaagacc ctcgagcgga actggtagag cgggtggcag ccatcagtgt
      181 ggcccaccta gaagaggcag aggagggccc agagcctgcc agcaatggtg tggacccccc
      241 accccgggcc agagctgcct ctgtgatccc tggcagtgct tcaagaccca caccagtgcg
      301 tcccagcctc tctgctagaa agttctccct gcaggaaaga ccagcgggaa gctgtctaga
      361 ggctcaggtt gggccttact ctacaggacc tgccagtcac atgtctcctc gggcttggcg
      421 gagacccacc atcgagtccc accatgtggc catctcagac acagaggact gtgtgcaact
      481 gaaccagtac aagctgcaga gtgagattgg caagggtgcc tatggtgtgg tgaggctggc
      541 ctacaatgaa agggaagaca gacactatgc aatgaaagtt ctttccaaaa agaagttact
      601 gaagcagtat ggctttcctc gccgtcctcc cccgagaggg tcccaagctc ctcagggagg
      661 gccagccaaa cagctgctgc ccctggagcg tgtataccag gagattgcca ttttaaagaa
      721 actggaccac gtgaatgtag tcaagttgat cgaggtcctg gatgatcctg ctgaagacaa
      781 tctctatttg gtgtttgacc tcctgagaaa gggaccagtc atggaagtgc cctgcgacaa
      841 gcccttccca gaggagcaag ctcgcctcta cctccgggac atcatcctgg gcctcgagta
      901 cttgcactgc cagaagattg tgcacaggga catcaagccg tccaatctgc tccttgggga
      961 cgatgggcac gtgaagatcg ccgactttgg tgtcagcaac cagtttgagg ggaatgatgc
     1021 tcagctgtcc agtacggcag ggaccccagc attcatggcc ccggaggcca tctctgacac
     1081 cggccagagc ttcagtggga aggccttgga tgtatgggcc actggggtta cactgtattg
     1141 ttttgtctac gggaagtgcc cattcattga tgagtacatc ctggccctgc acagaaagat
     1201 caagaatgag gccgtggtgt tccctgagga gccggaggtc agcgaggaac tcaaagacct
     1261 gatcctgaag atgctagaca agaatcctga aacaagaatt ggggtgtctg atatcaagtt
     1321 acacccttgg gtgaccaagc atggagagga gcccctccct tcagaggagg aacactgcag
     1381 tgtggtagag gtgactgagg aggaggtgaa gaactcagtc aagctcatcc ccagctggac
     1441 cactgtgatc ctggtcaagt ctatgctgag aaagcgttcc tttggaaacc catttgagcc
     1501 ccaagcacgc agggaagaaa gatctatgtc tgcgccagga aacttactgt tgaaagaagg
     1561 atgtggagaa gggggcaaaa gcccagagct tcccggagtc caggaagatg aggctgcatc
     1621 ctgagtccct gcatgtgccc agggccatcg gcagcatgct cattccgctc ctccagaggc
     1681 ccaccgccct catgcaatca tcgcccctgc aggcaggggg ctggggactg cagcccctct
     1741 cctggccccc ctcacccatt gtgctgcatg acctgcgcac aggcatatcc agggacagga
     1801 ttggaatgtg tatcatttgg ggctcggggg tcccggttgg ttctctctgt tctgatctat
     1861 cttgtgggga atattagaaa ccctacctga ctggctggtg aggcccaggg cagaaggcaa
     1921 gagaccaaaa tagcaggtgg agacctggtg ggctgcttct cagagaactc ccatagtgat
     1981 cggtggcctg cccagctgct gcacacgagg agtgattgtg tcacttctgt gtggaaggtg
     2041 ctgagtgctg gagtcctcag atctctagtg tggatgctac aagtaatgag gcgtgcctgg
     2101 gagaagactg atcttggaga atccagattc ctctcattgt cttttacctg agggcttggg
     2161 tgggagcggc tgttatggag agcatcttct ggctttgggt agtccgtggt acactgtacg
     2221 gcagtcacga ggatctgaca ttcatagact gtgttttaca cttggcactc gctggagaaa
     2281 ggaccaaagt gaatccagct tagagcatag acctgagcct ggagcagtgt acttctcctg
     2341 ccaacctccc ttcctctctc acggatctcc agaatgaagg ttacagaaca ccaggagtga
     2401 caaggagggc cacggactct cagcactgtg gccctgcaga tgtggaagta actgggatct
     2461 aggcgctgag ccgacactgg cttactcact acatgctctg atggaggagg ctcagccaga
     2521 tgagggaccg tacaagacgc actcctgtca ggctggtggc ccttctgtca gttgcttcag
     2581 tacaggacat cagacagtca gcccacacag gtcagagctg cacagttggg acacacgtgg
     2641 acactgccct ttcagaacag atgtcagctc tctggattct gtggtcgtct ggctattcta
     2701 atgtttactg ataatgctca tagggattgg tccccaaagg gagatgagca ggactcaggt
     2761 agccctctct gaaagcctcc cataagagat cctggctgcc cacatgggtt tcaagaatgc
     2821 aggagggcta ggctagaaaa gagagaggct gtgcgggagc gctggttccc actcttatct
     2881 ctgtgcccat gggtgtacat tgctccttca tgtgcacatg cgtgtgtgtg cccatctgct
     2941 gtatacagca cacttgcatg tctcatactg gcacatgcat ctgtaatata gtttctatgt
     3001 caacttatgc ctaggagcag aaggtagccc attgtcaaag ggctcccatt tcaacccaac
     3061 tcctctgcac taaggcagcc agtgtaaccc agggcttgaa aacaaataat ctaatcctat
     3121 ctctaagaat acttttatag agtgaatagg aggcaagtta tgccaaccaa taaatagcaa
     3181 agagtcaggg agcttcaccg atgggaccca cacaggaaaa gctcggagtt gggtggctgg
     3241 ctcattgtcc ccagcagagc caggaaggca tgctcactgt cacctgttgt tgagagcttt
     3301 ggttggcttt ggttttgaat gtagcacaag tgaacaaact ccataagagt gtttataaaa
     3361 attaacttct taggaagtga attaaaaaca ataaaagccc tttgttgagt t
//
