LOCUS       NM_012727               1803 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus calcium/calmodulin-dependent protein kinase IV
            (Camk4), mRNA.
ACCESSION   NM_012727
VERSION     NM_012727.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1803)
  AUTHORS   Zheng,Z., Wang,X., Wang,Y., King,J.A.C., Xie,P. and Wu,S.
  TITLE     CaMK4 is a downstream effector of the alpha1G T-type calcium
            channel to determine the angiogenic potential of pulmonary
            microvascular endothelial cells
  JOURNAL   Am J Physiol Cell Physiol 321 (6), C964-C977 (2021)
   PUBMED   34586897
  REMARK    GeneRIF: CaMK4 is a downstream effector of the alpha1G T-type
            calcium channel to determine the angiogenic potential of pulmonary
            microvascular endothelial cells.
REFERENCE   2  (bases 1 to 1803)
  AUTHORS   Joseph,A. and Turrigiano,G.G.
  TITLE     All for One But Not One for All: Excitatory Synaptic Scaling and
            Intrinsic Excitability Are Coregulated by CaMKIV, Whereas
            Inhibitory Synaptic Scaling Is Under Independent Control
  JOURNAL   J Neurosci 37 (28), 6778-6785 (2017)
   PUBMED   28592691
  REMARK    GeneRIF: We find that synaptic excitation and intrinsic
            excitability are coregulated in individual neurons through CaMKIV
            signaling, which is tightly controlled by neuronal activity. In
            contrast, synaptic inhibition is unaffected by changes in firing or
            CaMKIV signaling in individual neurons.
REFERENCE   3  (bases 1 to 1803)
  AUTHORS   Zhao,X., Shen,L., Xu,L., Wang,Z., Ma,C. and Huang,Y.
  TITLE     Inhibition of CaMKIV relieves streptozotocin-induced diabetic
            neuropathic pain through regulation of HMGB1
  JOURNAL   BMC Anesthesiol 16 (1), 27 (2016)
   PUBMED   27216039
  REMARK    GeneRIF: study demonstrates that CaMKIV can relieve STZ-induced
            diabetic neuropathic pain.pCaMKIV can regulate the expression of
            High-mobility group box 1 based on both cellular and animal models.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1803)
  AUTHORS   Navarro,D., Alvarado,M., Morte,B., Berbel,D., Sesma,J., Pacheco,P.,
            Morreale de Escobar,G., Bernal,J. and Berbel,P.
  TITLE     Late maternal hypothyroidism alters the expression of Camk4 in
            neocortical subplate neurons: a comparison with Nurr1 labeling
  JOURNAL   Cereb Cortex 24 (10), 2694-2706 (2014)
   PUBMED   23680840
  REMARK    GeneRIF: Camk4 expression in the cortical subplate was prolonged in
            developmentally hypothyroid pups, whereas heavy Camk4 expression in
            layer VIb remains at P60. Abnormal expression of Camk4 might cause
            altered cortical connectivity.
REFERENCE   5  (bases 1 to 1803)
  AUTHORS   Harrison,B.J., Flight,R.M., Gomes,C., Venkat,G., Ellis,S.R.,
            Sankar,U., Twiss,J.L., Rouchka,E.C. and Petruska,J.C.
  TITLE     IB4-binding sensory neurons in the adult rat express a novel 3'
            UTR-extended isoform of CaMK4 that is associated with its
            localization to axons
  JOURNAL   J Comp Neurol 522 (2), 308-336 (2014)
   PUBMED   23817991
  REMARK    GeneRIF: We have determined that high levels of CaMKIV protein are
            expressed by IB4-binding sensory neurons of the dorsal root
            ganglion
REFERENCE   6  (bases 1 to 1803)
  AUTHORS   Means,A.R., Cruzalegui,F., LeMagueresse,B., Needleman,D.S.,
            Slaughter,G.R. and Ono,T.
  TITLE     A novel Ca2+/calmodulin-dependent protein kinase and a male germ
            cell-specific calmodulin-binding protein are derived from the same
            gene
  JOURNAL   Mol Cell Biol 11 (8), 3960-3971 (1991)
   PUBMED   1649385
REFERENCE   7  (bases 1 to 1803)
  AUTHORS   Ohmstede,C.A., Bland,M.M., Merrill,B.M. and Sahyoun,N.
  TITLE     Relationship of genes encoding Ca2+/calmodulin-dependent protein
            kinase Gr and calspermin: a gene within a gene
  JOURNAL   Proc Natl Acad Sci U S A 88 (13), 5784-5788 (1991)
   PUBMED   1648230
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1991 Oct 15;88(20):9375]
REFERENCE   8  (bases 1 to 1803)
  AUTHORS   Sheng,M., Thompson,M.A. and Greenberg,M.E.
  TITLE     CREB: a Ca(2+)-regulated transcription factor phosphorylated by
            calmodulin-dependent kinases
  JOURNAL   Science 252 (5011), 1427-1430 (1991)
   PUBMED   1646483
REFERENCE   9  (bases 1 to 1803)
  AUTHORS   Ohmstede,C.A., Jensen,K.F. and Sahyoun,N.E.
  TITLE     Ca2+/calmodulin-dependent protein kinase enriched in cerebellar
            granule cells. Identification of a novel neuronal
            calmodulin-dependent protein kinase
  JOURNAL   J Biol Chem 264 (10), 5866-5875 (1989)
   PUBMED   2538431
REFERENCE   10 (bases 1 to 1803)
  AUTHORS   Ono,T., Slaughter,G.R., Cook,R.G. and Means,A.R.
  TITLE     Molecular cloning sequence and distribution of rat calspermin, a
            high affinity calmodulin-binding protein
  JOURNAL   J Biol Chem 264 (4), 2081-2087 (1989)
   PUBMED   2914893
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC128706.1.
            
            On Jun 10, 2007 this sequence version replaced NM_012727.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC128706.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1803
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p12"
     gene            1..1803
                     /gene="Camk4"
                     /gene_synonym="Ccdpk; RATCCDPK"
                     /note="calcium/calmodulin-dependent protein kinase IV"
                     /db_xref="GeneID:25050"
                     /db_xref="RGD:2264"
     exon            1..8
                     /gene="Camk4"
                     /gene_synonym="Ccdpk; RATCCDPK"
                     /inference="alignment:Splign:2.1.0"
     exon            9..100
                     /gene="Camk4"
                     /gene_synonym="Ccdpk; RATCCDPK"
                     /inference="alignment:Splign:2.1.0"
     exon            101..168
                     /gene="Camk4"
                     /gene_synonym="Ccdpk; RATCCDPK"
                     /inference="alignment:Splign:2.1.0"
     exon            169..377
                     /gene="Camk4"
                     /gene_synonym="Ccdpk; RATCCDPK"
                     /inference="alignment:Splign:2.1.0"
     CDS             229..1653
                     /gene="Camk4"
                     /gene_synonym="Ccdpk; RATCCDPK"
                     /EC_number="2.7.11.17"
                     /note="caMK IV; calspermin; CAM kinase-GR;
                     Calmodulin-dependent protein kinase IV"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     IV"
                     /protein_id="NP_036859.2"
                     /db_xref="GeneID:25050"
                     /db_xref="RGD:2264"
                     /translation="MLKVTVPSCPSSPCSSVTSSTENLVPDYWIDGSKRDPLSDFFEV
                     ESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKE
                     IFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRD
                     LKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEV
                     DMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVKKL
                     IVLDPKKRLTTFQALQHPWVTGKAANFVHMDTAQKKLQEFNARRKLKAAVKAVVASSR
                     LGSASSSHTNIQESNKASSEAQPAQDGKDKTDPLENKMQAGDHEAAKAAADETMKLQS
                     EEVEEEEGVKEEEEEEEEEEETSRMVPQEPEDRLETDDQEMKRNSEETLKSVEEEMDP
                     KAEEEAAAVGLGVPPQQDAILPEY"
     exon            378..456
                     /gene="Camk4"
                     /gene_synonym="Ccdpk; RATCCDPK"
                     /inference="alignment:Splign:2.1.0"
     exon            457..519
                     /gene="Camk4"
                     /gene_synonym="Ccdpk; RATCCDPK"
                     /inference="alignment:Splign:2.1.0"
     exon            520..602
                     /gene="Camk4"
                     /gene_synonym="Ccdpk; RATCCDPK"
                     /inference="alignment:Splign:2.1.0"
     exon            603..675
                     /gene="Camk4"
                     /gene_synonym="Ccdpk; RATCCDPK"
                     /inference="alignment:Splign:2.1.0"
     exon            676..766
                     /gene="Camk4"
                     /gene_synonym="Ccdpk; RATCCDPK"
                     /inference="alignment:Splign:2.1.0"
     exon            767..841
                     /gene="Camk4"
                     /gene_synonym="Ccdpk; RATCCDPK"
                     /inference="alignment:Splign:2.1.0"
     exon            842..917
                     /gene="Camk4"
                     /gene_synonym="Ccdpk; RATCCDPK"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1044
                     /gene="Camk4"
                     /gene_synonym="Ccdpk; RATCCDPK"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1197
                     /gene="Camk4"
                     /gene_synonym="Ccdpk; RATCCDPK"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1770
                     /gene="Camk4"
                     /gene_synonym="Ccdpk; RATCCDPK"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgaggagaa agcttcatgg attaaataaa atacatcacc tcccccttgc cttccacaag
       61 acatacatct caagacttcc agtggatgca tgacgctgag gagctccagc agagccagag
      121 gcgacagggc caccagcaga gatgacaaat tgaagacttc aatcaaaggc ggcggccagc
      181 ggttccagct cgggcagcgg cggcatcttc cggagtcccg cggcgaagat gctcaaagtc
      241 acggtgccct cctgtccctc ctcgccctgc tcctcggtca cctccagtac tgagaacctc
      301 gtcccggatt actggatcga cggctctaaa cgggatcctc tgagcgattt cttcgaggtg
      361 gagtcagagc tgggacgggg tgctacatcc attgtgtaca gatgcaaaca gaaggggacc
      421 cagaagccct atgctctcaa agtgttaaag aaaacagtgg acaagaagat cgtgagaact
      481 gaaataggag ttctcctgag actctcacac ccgaacatca taaaactcaa ggaaatattt
      541 gaaaccccca cagaaatcag cctggttctt gagctagtca caggaggaga actgtttgac
      601 aggattgtgg agaaaggcta ttacagtgaa cgcgacgcgg ccgatgctgt gaagcagatc
      661 ctggaggcag ttgcttacct gcacgaaaat ggaatcgtcc atcgcgacct caaaccagag
      721 aatcttcttt atgcaacgcc agcccctgat gcaccactca aaattgctga ttttggactt
      781 tctaaaatcg tggaacatca agtgctcatg aagacggtgt gtggaacccc ggggtactgt
      841 gcacctgaga ttctccgagg ctgtgcctat ggccccgagg tggacatgtg gtctgtagga
      901 ataattacct acatcctact ttgtggattt gaaccattct atgatgagag aggtgatcag
      961 ttcatgttca ggagaattct gaattgtgaa tattacttta tctccccctg gtgggatgaa
     1021 gtttctttaa atgccaagga cttggtcaag aaactcattg ttttggaccc taagaagcgg
     1081 ctgactacat tccaagccct ccaacacccg tgggtcacag gaaaagcagc caactttgtc
     1141 cacatggata ccgctcagaa aaagcttcaa gaattcaatg ctaggcgcaa gcttaaggcg
     1201 gcagtgaagg ctgtggtggc ctcttctcgg ctgggaagtg ccagcagcag tcacaccaac
     1261 atccaagaaa gcaacaaagc cagctcggag gcacagcccg cccaagacgg caaggacaag
     1321 acagatcctc tggaaaacaa aatgcaagcg ggggaccacg aggcagccaa ggctgcagcc
     1381 gatgagacga tgaagctaca gtccgaggag gtggaggaag aggaaggtgt aaaagaagag
     1441 gaggaagagg aagaagagga agaggagacc tccaggatgg tacctcagga gccagaggac
     1501 aggctggaga cagatgacca ggaaatgaag agaaattcag aggagacgtt gaagagtgtg
     1561 gaggaagaaa tggacccgaa agctgaggag gaagccgctg ccgtgggact tggggtccct
     1621 ccacagcagg atgctattct gccagagtac taacccggct tcctttaggg ccccaggcca
     1681 accccagcat tttatgcact ttgtccttca gcaaggtggg gaagcatgat aagcactata
     1741 gtgattctgt tttgaggtgc aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1801 aaa
//
