LOCUS       NM_021678                347 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus calcium/calmodulin-dependent protein kinase II
            inhibitor 2 (Camk2n2), mRNA.
ACCESSION   NM_021678
VERSION     NM_021678.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 347)
  AUTHORS   Jain,S.S., Paglialunga,S., Vigna,C., Ludzki,A., Herbst,E.A.,
            Lally,J.S., Schrauwen,P., Hoeks,J., Tupling,A.R., Bonen,A. and
            Holloway,G.P.
  TITLE     High-fat diet-induced mitochondrial biogenesis is regulated by
            mitochondrial-derived reactive oxygen species activation of CaMKII
  JOURNAL   Diabetes 63 (6), 1907-1913 (2014)
   PUBMED   24520120
  REMARK    GeneRIF: High-fat diet-induced mitochondrial biogenesis is
            regulated by mitochondrial-derived reactive oxygen species
            activation of CaMKII
REFERENCE   2  (bases 1 to 347)
  AUTHORS   Joiner,M.L., Koval,O.M., Li,J., He,B.J., Allamargot,C., Gao,Z.,
            Luczak,E.D., Hall,D.D., Fink,B.D., Chen,B., Yang,J., Moore,S.A.,
            Scholz,T.D., Strack,S., Mohler,P.J., Sivitz,W.I., Song,L.S. and
            Anderson,M.E.
  TITLE     CaMKII determines mitochondrial stress responses in heart
  JOURNAL   Nature 491 (7423), 269-273 (2012)
   PUBMED   23051746
REFERENCE   3  (bases 1 to 347)
  AUTHORS   Lucchesi,W., Mizuno,K. and Giese,K.P.
  TITLE     Novel insights into CaMKII function and regulation during memory
            formation
  JOURNAL   Brain Res Bull 85 (1-2), 2-8 (2011)
   PUBMED   21070840
  REMARK    Review article
REFERENCE   4  (bases 1 to 347)
  AUTHORS   Skelding,K.A., Rostas,J.A. and Verrills,N.M.
  TITLE     Controlling the cell cycle: the role of
            calcium/calmodulin-stimulated protein kinases I and II
  JOURNAL   Cell Cycle 10 (4), 631-639 (2011)
   PUBMED   21301225
  REMARK    Review article
REFERENCE   5  (bases 1 to 347)
  AUTHORS   Chang,B.H., Mukherji,S. and Soderling,T.R.
  TITLE     Characterization of a calmodulin kinase II inhibitor protein in
            brain
  JOURNAL   Proc Natl Acad Sci U S A 95 (18), 10890-10895 (1998)
   PUBMED   9724800
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF041854.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF041854.1, BP482874.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..347
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..347
                     /gene="Camk2n2"
                     /note="calcium/calmodulin-dependent protein kinase II
                     inhibitor 2"
                     /db_xref="GeneID:59314"
                     /db_xref="RGD:708411"
     exon            1..254
                     /gene="Camk2n2"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..325
                     /gene="Camk2n2"
                     /note="caM-KIIN; caM-KIINbeta; CaM-KII inhibitory protein"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase II
                     inhibitor 2"
                     /protein_id="NP_067710.1"
                     /db_xref="GeneID:59314"
                     /db_xref="RGD:708411"
                     /translation="MSEILPYGEDKMGRFGADPEGSDLSFSCRLQDTNSFFAGNQAKR
                     PPKLGQIGRAKRVVIEDDRIDDVLKGMGEKPPSGV"
     exon            255..347
                     /gene="Camk2n2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggctcccct gctgagctag ggccggtccg gcagctagcc tctgcccgtg ccccgccgca
       61 gtccctagcc cgcccggtgc ccgccatgtc cgagatccta ccctacggcg aggacaagat
      121 gggccgcttc ggcgcagacc ccgagggttc cgacctctct ttcagctgcc gcctgcagga
      181 caccaactcc ttcttcgctg gcaaccaggc caagcggccc cccaagctgg gccagatcgg
      241 ccgagccaag agagtggtga tcgaggatga ccggatagac gacgtgctga aggggatggg
      301 ggagaagcct ccgtccggag tgtagacgcg ccggctctgg cgggggg
//
