LOCUS       NM_133605               1728 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus calcium/calmodulin-dependent protein kinase II
            gamma (Camk2g), mRNA.
ACCESSION   NM_133605
VERSION     NM_133605.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1728)
  AUTHORS   Yang,X., Sha,X., Cao,Y., Wang,W. and Shi,J.
  TITLE     Cx43 overexpression reduce the incidence of obstructive sleep apnea
            associated atrial fibrillation via the CaMKgamma/HIF-1 axis
  JOURNAL   Biochem Biophys Res Commun 659, 62-71 (2023)
   PUBMED   37037067
  REMARK    GeneRIF: Cx43 overexpression reduce the incidence of obstructive
            sleep apnea associated atrial fibrillation via the CaMKgamma/HIF-1
            axis.
REFERENCE   2  (bases 1 to 1728)
  AUTHORS   He,X., Wang,Y., Zhou,G., Yang,J., Li,J., Li,T., Hu,H. and Ma,H.
  TITLE     A Critical Role for gammaCaMKII in Decoding NMDA Signaling to
            Regulate AMPA Receptors in Putative Inhibitory Interneurons
  JOURNAL   Neurosci Bull 38 (8), 916-926 (2022)
   PUBMED   35290589
REFERENCE   3  (bases 1 to 1728)
  AUTHORS   Huang,R. and Bi,G.
  TITLE     MicroRNA-219a-5p-mediated inhibition of CaMKIIgamma facilitates
            vestibular compensation in acute vertigo by promoting protein
            kinase C expression
  JOURNAL   Ann N Y Acad Sci 1475 (1), 78-88 (2020)
   PUBMED   32645222
  REMARK    GeneRIF: MicroRNA-219a-5p-mediated inhibition of CaMKIIgamma
            facilitates vestibular compensation in acute vertigo by promoting
            protein kinase C expression.
REFERENCE   4  (bases 1 to 1728)
  AUTHORS   Zhao,L., Xiong,L., Hao,Y.H., Li,W.C., Dong,J., Zhang,J., Yao,B.W.,
            Xu,X.P., Wang,L.F., Zhou,H.M. and Peng,R.Y.
  TITLE     Inhibition of MicroRNA 219 Expression Protects Synaptic Plasticity
            via Activating NMDAR1, CaMKIIgamma, and p-CREB after Microwave
            Radiation
  JOURNAL   Biomed Environ Sci 33 (5), 359-364 (2020)
   PUBMED   32553080
  REMARK    GeneRIF: Inhibition of MicroRNA 219 Expression Protects Synaptic
            Plasticity via Activating NMDAR1, CaMKIIgamma, and p-CREB after
            Microwave Radiation.
REFERENCE   5  (bases 1 to 1728)
  AUTHORS   Liu,Y., Sun,L.Y., Singer,D.V., Ginnan,R., Zhao,W.,
            Jourd'heuil,F.L., Jourd'heuil,D., Long,X. and Singer,H.A.
  TITLE     Thymine DNA glycosylase is a key regulator of CaMKIIgamma
            expression and vascular smooth muscle phenotype
  JOURNAL   Am J Physiol Heart Circ Physiol 317 (5), H969-H980 (2019)
   PUBMED   31518169
  REMARK    GeneRIF: Thymine DNA glycosylase plays a key role in regulating
            CaMKIIgamma expression in vascular smooth muscle cells through
            promoter cytosine methylation/demethylation.
REFERENCE   6  (bases 1 to 1728)
  AUTHORS   Hook,S.S. and Means,A.R.
  TITLE     Ca(2+)/CaM-dependent kinases: from activation to function
  JOURNAL   Annu Rev Pharmacol Toxicol 41, 471-505 (2001)
   PUBMED   11264466
  REMARK    Review article
REFERENCE   7  (bases 1 to 1728)
  AUTHORS   Haeseleer,F., Sokal,I., Verlinde,C.L., Erdjument-Bromage,H.,
            Tempst,P., Pronin,A.N., Benovic,J.L., Fariss,R.N. and Palczewski,K.
  TITLE     Five members of a novel Ca(2+)-binding protein (CABP) subfamily
            with similarity to calmodulin
  JOURNAL   J Biol Chem 275 (2), 1247-1260 (2000)
   PUBMED   10625670
REFERENCE   8  (bases 1 to 1728)
  AUTHORS   Singer,H.A., Benscoter,H.A. and Schworer,C.M.
  TITLE     Novel Ca2+/calmodulin-dependent protein kinase II gamma-subunit
            variants expressed in vascular smooth muscle, brain, and
            cardiomyocytes
  JOURNAL   J Biol Chem 272 (14), 9393-9400 (1997)
   PUBMED   9083077
REFERENCE   9  (bases 1 to 1728)
  AUTHORS   Zhou,Z.L. and Ikebe,M.
  TITLE     New isoforms of Ca2+/calmodulin-dependent protein kinase II in
            smooth muscle
  JOURNAL   Biochem J 299 (Pt 2) (Pt 2), 489-495 (1994)
   PUBMED   8172610
REFERENCE   10 (bases 1 to 1728)
  AUTHORS   Tobimatsu,T., Kameshita,I. and Fujisawa,H.
  TITLE     Molecular cloning of the cDNA encoding the third polypeptide
            (gamma) of brain calmodulin-dependent protein kinase II
  JOURNAL   J Biol Chem 263 (31), 16082-16086 (1988)
   PUBMED   2846534
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from J04063.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J04063.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132301, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1728
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p16"
     gene            1..1728
                     /gene="Camk2g"
                     /note="calcium/calmodulin-dependent protein kinase II
                     gamma"
                     /db_xref="GeneID:171140"
                     /db_xref="RGD:621802"
     exon            1..100
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..1619
                     /gene="Camk2g"
                     /EC_number="2.7.11.17"
                     /note="calcium/calmodulin-dependent protein kinase type II
                     gamma chain; Ca+2/calmodulin-dependent protein kinase II
                     gamma; caMK-II subunit gamma; caM-kinase II gamma chain;
                     caM kinase II subunit gamma; calcium/calmodulin-dependent
                     protein kinase (CaM kinase) II gamma;
                     calcium/calmodulin-dependent protein kinase type II
                     subunit gamma-like"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     II subunit gamma"
                     /protein_id="NP_598289.1"
                     /db_xref="GeneID:171140"
                     /db_xref="RGD:621802"
                     /translation="MATTATCTRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKI
                     INTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDI
                     VAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGL
                     AIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDED
                     QHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRS
                     TVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSVGRQSSAPASPAASAAGLA
                     GQAAKSLLNKKSDGGVKKRKSSSSVHLMEPQTTVVHNATDGIKGSTESCNTTTEDEDL
                     KVRKQEIIKITEQLIEAINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFEN
                     LLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRD
                     GKWLNVHYHCSGAPAAPLQ"
     exon            101..195
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            196..255
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            256..310
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            311..376
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            377..449
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            450..552
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            553..636
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            637..731
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            732..854
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            855..938
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            939..981
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1044
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1088
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1121
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1166
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1215
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1291
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1386
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1631
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1728
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgactgtgca ccgccgcgtc cgcccgcccg ccagtatggc caccaccgcc acctgcaccc
       61 gcttcaccga cgactaccag cttttcgagg agctcggcaa gggtgccttc tcggtggtcc
      121 ggaggtgcgt gaagaaaacg tcgacgcagg agtatgcagc aaaaatcatc aataccaaga
      181 agttgtctgc ccgagatcat cagaaactag aacgagaggc ccggatatgc cgacttctga
      241 aacatccaaa catcgtgcgt ctccatgaca gtatttctga agaagggttt cactacctcg
      301 tgtttgacct tgttacggga ggggagttgt ttgaagacat cgtggccaga gaatactaca
      361 gcgaagctga tgccagccac tgtatacatc agatcctgga gagcgtcaac cacatccacc
      421 agcatgacat cgtccaccgg gacctgaagc ccgagaactt gctgctggcg agtaaatgca
      481 agggtgctgc ggtcaagcta gctgattttg gcctggccat cgaagtgcag ggagagcagc
      541 aggcttggtt tggttttgct ggcaccccag gttacttgtc ccctgaggtc ttgaggaaag
      601 atccctatgg aaaacctgtg gatatctggg cctgcggggt catcctgtat atcctcctgg
      661 tgggctaccc tcccttctgg gatgaggatc agcacaagct ctatcagcag atcaaagctg
      721 gagcctacga tttcccatca ccagaatggg acacagtcac tcctgaagct aagaacttga
      781 tcaaccagat gttgaccata aaccctgcaa agcgtatcac agctgaccag gctctcaagc
      841 acccatgggt ctgtcaacgg tcaacagtgg catccatgat gcatcgccaa gagacagtgg
      901 agtgcttacg caagttcaac gcccggagaa aactgaaggg tgccatcctc acaaccatgc
      961 ttgtctccag gaacttttca gttggcaggc agagctccgc ccccgcctcg cctgccgcga
     1021 gcgccgccgg cctggccggg caagctgcca agagcctatt gaacaagaag tcagatggcg
     1081 gcgtcaagaa aaggaagtcg agttccagcg tgcacctaat ggagccacaa accaccgtgg
     1141 tacataatgc tacagatggg atcaagggct ccacagagag ctgcaacacc accacagaag
     1201 acgaagatct caaagtgcga aaacaggaga tcattaagat cacagaacag ctgatagaag
     1261 ccatcaacaa tggggacttt gaggcctaca cgaagatttg tgacccaggc ctcacttcct
     1321 ttgagccaga agcccttggt aacctcgtgg aggggatgga tttccataag ttttactttg
     1381 agaatctcct gtccaagaac agcaagccta tccacaccac catcctaaac ccacatgtcc
     1441 atgtcatcgg cgaggacgca gcttgcatcg cctacatccg gctcacccag tacatcgatg
     1501 ggcagggtcg gcctcgcacc agtcagtcag aggagacccg ggtgtggcac cgccgggatg
     1561 gcaagtggct caatgtccac tatcactgct caggagcccc tgctgcaccg ctgcagtgag
     1621 ctcaggcaca ggggcattag gagattccag ctggaggctg aaccttcgaa gtcagtgact
     1681 ctggagggcc tgagtgacag ccgcggtcct gtccatttga ggtttaaa
//
