LOCUS       NM_012519               2301 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus calcium/calmodulin-dependent protein kinase II
            delta (Camk2d), mRNA.
ACCESSION   NM_012519
VERSION     NM_012519.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2301)
  AUTHORS   Arias-Chavez,D.J., Mailloux-Salinas,P., Altamirano,J., Huang,F.,
            Gomez-Viquez,N.L. and Bravo,G.
  TITLE     Consumption of combined fructose and sucrose diet exacerbates
            oxidative stress, hypertrophy and CaMKIIdelta oxidation in hearts
            from rats with metabolic syndrome
  JOURNAL   Mol Cell Biochem 477 (4), 1309-1320 (2022)
   PUBMED   35138512
  REMARK    GeneRIF: Consumption of combined fructose and sucrose diet
            exacerbates oxidative stress, hypertrophy and CaMKIIdelta oxidation
            in hearts from rats with metabolic syndrome.
REFERENCE   2  (bases 1 to 2301)
  AUTHORS   Carlson,C.R., Aronsen,J.M., Bergan-Dahl,A., Moutty,M.C., Lunde,M.,
            Lunde,P.K., Jarstadmarken,H., Wanichawan,P., Pereira,L.,
            Kolstad,T.R.S., Dalhus,B., Subramanian,H., Hille,S.,
            Christensen,G., Muller,O.J., Nikolaev,V., Bers,D.M., Sjaastad,I.,
            Shen,X., Louch,W.E., Klussmann,E. and Sejersted,O.M.
  TITLE     AKAP18delta Anchors and Regulates CaMKII Activity at
            Phospholamban-SERCA2 and RYR
  JOURNAL   Circ Res 130 (1), 27-44 (2022)
   PUBMED   34814703
  REMARK    GeneRIF: AKAP18delta Anchors and Regulates CaMKII Activity at
            Phospholamban-SERCA2 and RYR.
REFERENCE   3  (bases 1 to 2301)
  AUTHORS   Tian,T., Yao,D., Zheng,L., Zhou,Z., Duan,Y., Liu,B., Wang,P. and
            Li,Y.
  TITLE     Sphingosine kinase 1 regulates HMGB1 translocation by directly
            interacting with calcium/calmodulin protein kinase II-delta in
            sepsis-associated liver injury
  JOURNAL   Cell Death Dis 11 (12), 1037 (2020)
   PUBMED   33281190
  REMARK    GeneRIF: Sphingosine kinase 1 regulates HMGB1 translocation by
            directly interacting with calcium/calmodulin protein kinase
            II-delta in sepsis-associated liver injury.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2301)
  AUTHORS   Zhang,M., Yang,X., Zimmerman,R.J., Wang,Q., Ross,M.A.,
            Granger,J.M., Luczak,E.D., Bedja,D., Jiang,H. and Feng,N.
  TITLE     CaMKII exacerbates heart failure progression by activating class I
            HDACs
  JOURNAL   J Mol Cell Cardiol 149, 73-81 (2020)
   PUBMED   32971072
  REMARK    GeneRIF: CaMKII exacerbates heart failure progression by activating
            class I HDACs.
REFERENCE   5  (bases 1 to 2301)
  AUTHORS   Chen,C.H., Lin,J.W., Huang,C.Y., Yeh,Y.L., Shen,C.Y.,
            Badrealam,K.F., Ho,T.J., Padma,V.V., Kuo,W.W. and Huang,C.Y.
  TITLE     The combined inhibition of the CaMKIIdelta and calcineurin
            signaling cascade attenuates IGF-IIR-induced cardiac hypertrophy
  JOURNAL   J Cell Physiol 235 (4), 3539-3547 (2020)
   PUBMED   31584202
  REMARK    GeneRIF: The combined inhibition of the CaMKIIdelta and calcineurin
            signaling cascade attenuates IGF-IIR-induced cardiac hypertrophy.
REFERENCE   6  (bases 1 to 2301)
  AUTHORS   Deng,A.Y., Dene,H. and Rapp,J.P.
  TITLE     Mapping of a quantitative trait locus for blood pressure on rat
            chromosome 2
  JOURNAL   J Clin Invest 94 (1), 431-436 (1994)
   PUBMED   8040284
REFERENCE   7  (bases 1 to 2301)
  AUTHORS   Edman,C.F. and Schulman,H.
  TITLE     Identification and characterization of delta B-CaM kinase and delta
            C-CaM kinase from rat heart, two new multifunctional
            Ca2+/calmodulin-dependent protein kinase isoforms
  JOURNAL   Biochim Biophys Acta 1221 (1), 89-101 (1994)
   PUBMED   8130281
REFERENCE   8  (bases 1 to 2301)
  AUTHORS   Mayer,P., Mohlig,M., Schatz,H. and Pfeiffer,A.
  TITLE     New isoforms of multifunctional calcium/calmodulin-dependent
            protein kinase II
  JOURNAL   FEBS Lett 333 (3), 315-318 (1993)
   PUBMED   8224201
REFERENCE   9  (bases 1 to 2301)
  AUTHORS   Schworer,C.M., Rothblum,L.I., Thekkumkara,T.J. and Singer,H.A.
  TITLE     Identification of novel isoforms of the delta subunit of
            Ca2+/calmodulin-dependent protein kinase II. Differential
            expression in rat brain and aorta
  JOURNAL   J Biol Chem 268 (19), 14443-14449 (1993)
   PUBMED   8390994
REFERENCE   10 (bases 1 to 2301)
  AUTHORS   Tobimatsu,T. and Fujisawa,H.
  TITLE     Tissue-specific expression of four types of rat
            calmodulin-dependent protein kinase II mRNAs
  JOURNAL   J Biol Chem 264 (30), 17907-17912 (1989)
   PUBMED   2553697
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from J05072.1.
            
            On Apr 11, 2007 this sequence version replaced NM_012519.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: J05072.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMD00132261, SAMD00132263 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2301              J05072.1           1-2301
FEATURES             Location/Qualifiers
     source          1..2301
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     gene            1..2301
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="calcium/calmodulin-dependent protein kinase II
                     delta"
                     /db_xref="GeneID:24246"
                     /db_xref="RGD:2263"
     exon            1..287
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     CDS             223..1824
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /EC_number="2.7.11.17"
                     /note="calcium/calmodulin-dependent protein kinase type II
                     delta chain; caMK-II subunit delta; caM-kinase II delta
                     chain; caM kinase II subunit delta;
                     Ca++/calmodulin-dependent protein kinase II, delta
                     subunit; calcium/calmodulin-dependent protein kinase (CaM
                     kinase) II delta; Ca++/calmodulin-dependent protein kinase
                     2 delta subunit"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     II subunit delta"
                     /protein_id="NP_036651.1"
                     /db_xref="GeneID:24246"
                     /db_xref="RGD:2263"
                     /translation="MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKI
                     INTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDI
                     VAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGL
                     AIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDED
                     QHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRS
                     TVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKINNKAN
                     VVTSPKENIPTPALEPQTTVIHNPDGNKESTESSNTTIEDEDVKARKQEIIKVTEQLI
                     EAINNGDFEAYTKICDPGLTAFEPEALGNLVEGMDFHRFYFENALPKINKPIHTIILN
                     PHVHLVGDDAACIAYIRLTQYMDGNGMPKTMQSEETRVWHRRDGKWQNIHFHRSGSPT
                     VPIKPPCIPNGKENFSGGTSLWQNI"
     exon            288..382
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            383..442
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            443..497
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            498..563
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            564..636
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            637..739
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            740..823
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            824..918
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1041
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1125
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1168
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1206
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1266
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1308
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1357
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1433
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1528
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1757
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..1846
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..2301
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttcgggagcg ctcgcccggc gggaggagga ggaagaagga tcgcggctcg ggctggtctg
       61 gccacctcgc cccgcgcgcc ccgcccctgc gcgcactccc tcgccggcga gctactttcg
      121 gacaaggaaa gtgagggcgg ccccgggtga cagcgcggcg gtgccagtcc cgggaagccg
      181 cgtctgttcg cgtgtcgccc gtcgcactgt ccagaccccg ccatggcttc gaccaccacc
      241 tgcacccggt tcaccgacga gtatcagctc ttcgaggagc tcggaaaggg ggcattctca
      301 gtggtgagaa gatgcatgaa aatccctact ggacaagagt atgctgccaa aattatcaac
      361 accaaaaagc tttctgctag ggatcatcag aaactggaaa gggaagctag aatctgccgt
      421 ctcttgaagc accccaatat tgtgagactt catgacagca tatccgaaga gggcttccat
      481 tacttggtgt ttgacttagt tactggtggc gaactctttg aagacatagt ggcaagagaa
      541 tattacagtg aggctgatgc cagtcattgt atacaacaga ttctagagag tgtaaatcat
      601 tgtcacctaa atggcatagt tcacagggac ctgaagcctg agaatttgct tttagctagc
      661 aaatccaaag gagcagctgt gaaactggca gacttcggct tagccataga agttcaaggc
      721 gaccagcagg cgtggtttgg ttttgctggc acacctgggt atctttctcc agaagtccta
      781 cgtaaagatc cttatggaaa accagtggac atgtgggcat gtggcgtcat cctctacatc
      841 ttgctggtgg gatacccacc cttctgggat gaagatcagc atagactgta tcagcagatc
      901 aaggctggag cgtacgattt tccatcacca gaatgggaca cagtgacacc tgaagccaaa
      961 gacctcatca acaaaatgct gaccatcaac cctgccaaac gcatcacagc ctctgaggcc
     1021 ctgaaacacc catggatctg tcaacgttct actgttgcct ccatgatgca caggcaggag
     1081 actgtagact gcttgaagaa atttaatgct cgacggaaat tgaagggtgc catcttgaca
     1141 actatgctgg ctacgagaaa tttttcagca gccaagagtt tgttgaagaa accggatggg
     1201 gtaaagataa acaacaaagc caacgtggta accagcccca aagaaaatat tcctaccccg
     1261 gcgctggagc cccaaactac tgtaatccac aaccctgatg gaaacaagga gtcaactgag
     1321 agctcaaata ccaccattga ggatgaagac gtgaaagcac gaaagcaaga gatcatcaaa
     1381 gtcactgagc agctgattga agctatcaac aatggggact tcgaggctta cacgaaaatc
     1441 tgtgatccag gcctcactgc ctttgaaccc gaagcattgg gcaacttagt ggaagggatg
     1501 gactttcaca gattctactt tgaaaatgct ttgcccaaaa tcaataaacc aatccacact
     1561 atcatcctga accctcacgt acacctggta ggggatgatg cagcctgcat agcatacatt
     1621 cggctcacac agtacatgga tggaaatgga atgccaaaga caatgcagtc agaagagact
     1681 cgagtgtggc accgccgtga tgggaagtgg cagaatattc actttcatcg ttcggggtcc
     1741 ccaacagtcc ccatcaagcc accctgtatt ccaaatggga aagaaaactt ctcaggaggc
     1801 acctctttgt ggcaaaacat ctgaaaacca ttcacatttg ggtcttctaa ttgtcaacag
     1861 tgccacgtct tcattctgtc ctcaaggcac ctggcggggt gatcctggga catcctctcc
     1921 tcttcatgca tgtttctgag tgcatgaagt tgtgaaggtt ctacgtgtaa tgcatatgtg
     1981 acacgtcatc ttaccatgtg acacgccatc ttaccatgta ttccttcctg tacattgttt
     2041 acactccagc tactggacgg atgttccatg caaacgtcag ttactgctgg caaactaaag
     2101 agggagctcc gacaagaaaa ctccgcaata ctccaagttc agctgatcca tcaggtttct
     2161 ctgtggatgc caagattcaa aagacttcat aaaattactg ttcaatgaat gacagtgtgt
     2221 aagaggaaag gaaatctttc aagaatgctg ccattaatct atttgggctt ctcattggga
     2281 ttttggggtt gatttttttt t
//
