LOCUS       NM_021739               3864 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus calcium/calmodulin-dependent protein kinase II
            beta (Camk2b), transcript variant 2, mRNA.
ACCESSION   NM_021739
VERSION     NM_021739.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3864)
  AUTHORS   Yang,C., Zhang,M., Li,S., Yi,F., Huang,H., Xie,H., Liu,H., Huang,R.
            and Zhou,J.
  TITLE     Effects of Camk2b Overexpression and Underexpression on the
            Proteome of Rat Hippocampal Neurons
  JOURNAL   Neuroscience 503, 58-68 (2022)
   PUBMED   36041587
  REMARK    GeneRIF: Effects of Camk2b Overexpression and Underexpression on
            the Proteome of Rat Hippocampal Neurons.
REFERENCE   2  (bases 1 to 3864)
  AUTHORS   Liu,W., Li,L., Kuang,H., Xia,Y., Wang,Z., Liu,S. and Yin,D.
  TITLE     Proteomic Profile of Carbonylated Proteins Screen Regulation of
            Apoptosis via CaMK Signaling in Response to Regular Aerobic
            Exercise
  JOURNAL   Biomed Res Int 2018, 2828143 (2018)
   PUBMED   30662904
  REMARK    GeneRIF: Significantly upregulated the expression levels of
            CaMKIIbeta.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3864)
  AUTHORS   Yamazaki,H., Sasagawa,Y., Yamamoto,H., Bito,H. and Shirao,T.
  TITLE     CaMKIIbeta is localized in dendritic spines as both
            drebrin-dependent and drebrin-independent pools
  JOURNAL   J Neurochem 146 (2), 145-159 (2018)
   PUBMED   29675826
  REMARK    GeneRIF: This study provides the first evidence to show that
            CaMKIIbeta interacts with drebrin in dendritic spines.
REFERENCE   4  (bases 1 to 3864)
  AUTHORS   Kury,S., van Woerden,G.M., Besnard,T., Proietti Onori,M.,
            Latypova,X., Towne,M.C., Cho,M.T., Prescott,T.E., Ploeg,M.A.,
            Sanders,S., Stessman,H.A.F., Pujol,A., Distel,B., Robak,L.A.,
            Bernstein,J.A., Denomme-Pichon,A.S., Lesca,G., Sellars,E.A.,
            Berg,J., Carre,W., Busk,O.L., van Bon,B.W.M., Waugh,J.L.,
            Deardorff,M., Hoganson,G.E., Bosanko,K.B., Johnson,D.S., Dabir,T.,
            Holla,O.L., Sarkar,A., Tveten,K., de Bellescize,J., Braathen,G.J.,
            Terhal,P.A., Grange,D.K., van Haeringen,A., Lam,C., Mirzaa,G.,
            Burton,J., Bhoj,E.J., Douglas,J., Santani,A.B., Nesbitt,A.I.,
            Helbig,K.L., Andrews,M.V., Begtrup,A., Tang,S., van Gassen,K.L.I.,
            Juusola,J., Foss,K., Enns,G.M., Moog,U., Hinderhofer,K.,
            Paramasivam,N., Lincoln,S., Kusako,B.H., Lindenbaum,P.,
            Charpentier,E., Nowak,C.B., Cherot,E., Simonet,T.,
            Ruivenkamp,C.A.L., Hahn,S., Brownstein,C.A., Xia,F., Schmitt,S.,
            Deb,W., Bonneau,D., Nizon,M., Quinquis,D., Chelly,J., Rudolf,G.,
            Sanlaville,D., Parent,P., Gilbert-Dussardier,B., Toutain,A.,
            Sutton,V.R., Thies,J., Peart-Vissers,L.E.L.M., Boisseau,P.,
            Vincent,M., Grabrucker,A.M., Dubourg,C., Tan,W.H., Verbeek,N.E.,
            Granzow,M., Santen,G.W.E., Shendure,J., Isidor,B., Pasquier,L.,
            Redon,R., Yang,Y., State,M.W., Kleefstra,T., Cogne,B.,
            Petrovski,S., Retterer,K., Eichler,E.E., Rosenfeld,J.A.,
            Agrawal,P.B., Bezieau,S., Odent,S., Elgersma,Y. and Mercier,S.
  CONSRTM   Undiagnosed Diseases Network; GEM HUGO; Deciphering Developmental
            Disorders Study
  TITLE     De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause
            Intellectual Disability
  JOURNAL   Am J Hum Genet 101 (5), 768-788 (2017)
   PUBMED   29100089
REFERENCE   5  (bases 1 to 3864)
  AUTHORS   Yan,X., Liu,J., Ye,Z., Huang,J., He,F., Xiao,W., Hu,X. and Luo,Z.
  TITLE     CaMKII-Mediated CREB Phosphorylation Is Involved in Ca2+-Induced
            BDNF mRNA Transcription and Neurite Outgrowth Promoted by
            Electrical Stimulation
  JOURNAL   PLoS One 11 (9), e0162784 (2016)
   PUBMED   27611779
  REMARK    GeneRIF: these data establish a potential signaling pathway of
            Ca2+-CaMKII-CREB in neuronal activation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3864)
  AUTHORS   Bayer,K.U., Harbers,K. and Schulman,H.
  TITLE     alphaKAP is an anchoring protein for a novel CaM kinase II isoform
            in skeletal muscle
  JOURNAL   EMBO J 17 (19), 5598-5605 (1998)
   PUBMED   9755160
REFERENCE   7  (bases 1 to 3864)
  AUTHORS   Urquidi,V. and Ashcroft,S.J.
  TITLE     A novel pancreatic beta-cell isoform of
            calcium/calmodulin-dependent protein kinase II (beta 3 isoform)
            contains a proline-rich tandem repeat in the association domain
  JOURNAL   FEBS Lett 358 (1), 23-26 (1995)
   PUBMED   7821422
REFERENCE   8  (bases 1 to 3864)
  AUTHORS   Ochiishi,T., Terashima,T. and Yamauchi,T.
  TITLE     Specific distribution of Ca2+/calmodulin-dependent protein kinase
            II alpha and beta isoforms in some structures of the rat forebrain
  JOURNAL   Brain Res 659 (1-2), 179-193 (1994)
   PUBMED   7820660
REFERENCE   9  (bases 1 to 3864)
  AUTHORS   Malinow,R., Schulman,H. and Tsien,R.W.
  TITLE     Inhibition of postsynaptic PKC or CaMKII blocks induction but not
            expression of LTP
  JOURNAL   Science 245 (4920), 862-866 (1989)
   PUBMED   2549638
REFERENCE   10 (bases 1 to 3864)
  AUTHORS   Bennett,M.K. and Kennedy,M.B.
  TITLE     Deduced primary structure of the beta subunit of brain type II
            Ca2+/calmodulin-dependent protein kinase determined by molecular
            cloning
  JOURNAL   Proc Natl Acad Sci U S A 84 (7), 1794-1798 (1987)
   PUBMED   3470758
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB616255.1, M16112.1, CO395982.1 and JAXUCZ010000014.1.
            
            On Jun 12, 2006 this sequence version replaced NM_021739.1.
            
            Transcript Variant: This variant (2) has multiple differences in
            the coding region, compared to variant 1. The resulting protein
            (isoform 2) is shorter when it is compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M16112.1, SRR26360194.2450487.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                CB616255.1         1-20
            21-1646             M16112.1           1-1626
            1647-2289           CO395982.1         20-662
            2290-3864           JAXUCZ010000014.1  85059166-85060740   c
FEATURES             Location/Qualifiers
     source          1..3864
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..3864
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /note="calcium/calmodulin-dependent protein kinase II
                     beta"
                     /db_xref="GeneID:24245"
                     /db_xref="RGD:2262"
     exon            1..147
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..1711
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /EC_number="2.7.11.17"
                     /note="isoform 2 is encoded by transcript variant 2;
                     calcium/calmodulin-dependent protein kinase type II beta
                     chain; calcium/calmodulin-dependent protein kinase type II
                     subunit beta; caMK-II subunit beta; caM-kinase II beta
                     chain; caM kinase II subunit beta;
                     calcium/calmodulin-dependent protein kinase (CaM kinase)
                     II beta; Ca++/calmodulin-dependent protein kinase II beta
                     subunit"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     II subunit beta isoform 2"
                     /protein_id="NP_068507.2"
                     /db_xref="GeneID:24245"
                     /db_xref="RGD:2262"
                     /translation="MATTVTCTRFTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKI
                     INTKKLSARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDI
                     VAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGL
                     AIEVQGDQQAWFGFAGTPGYLSPEVLRKEAYGKPVDIWACGVILYILLVGYPPFWDED
                     QHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRS
                     TVASMMHRQETVECLKKFNARRKLKGAILTTMLATRNFSVGRQTTAPATMSTAASGTT
                     MGLVEQAKSLLNKKADGVKPQTNSTKNSSAITSPKGSLPPAALEPQTTVIHNPVDGIK
                     ESSDSTNTTIEDEDAKARKQEIIKTTEQLIEAVNNGDFEAYAKICDPGLTSFEPEALG
                     NLVEGMDFHRFYFENLLAKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRP
                     RTSQSEETRVWHRRDGKWQNVHFHCSGAPVAPLQ"
     exon            148..242
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /inference="alignment:Splign:2.1.0"
     exon            243..302
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /inference="alignment:Splign:2.1.0"
     exon            303..357
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /inference="alignment:Splign:2.1.0"
     exon            358..423
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /inference="alignment:Splign:2.1.0"
     exon            424..496
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /inference="alignment:Splign:2.1.0"
     exon            497..599
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /inference="alignment:Splign:2.1.0"
     exon            600..683
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /inference="alignment:Splign:2.1.0"
     exon            684..778
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /inference="alignment:Splign:2.1.0"
     exon            779..901
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /inference="alignment:Splign:2.1.0"
     exon            902..985
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1028
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1103
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1141
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1213
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1258
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1307
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1383
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1478
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1712
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..3864
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccgccgtg cccgcgagcg ggagccggag tcgccgccgc ccgagcgcag ccgagcgcac
       61 gccgagccca atcgccaccg ccatggccac cacggtgacc tgcacccgtt tcacggacga
      121 gtaccagcta tacgaggata ttggcaaggg ggctttctct gtggtccgac gctgtgtcaa
      181 gctctgcacc ggccatgagt atgcagctaa gatcattaac accaagaagc tgtcagctag
      241 agatcaccag aagctggaga gggaggctcg gatctgccgc ctgctgaagc attccaacat
      301 tgtacgcctc catgacagca tctctgaaga gggcttccac tacctggtct tcgacctggt
      361 cactggtggg gagctctttg aagacattgt ggcgagagag tactacagtg aggctgacgc
      421 cagtcactgt atccagcaga tcctggaggc tgttctccat tgtcaccaaa tgggggtcgt
      481 ccacagagac ctcaagcctg aaaacctgct cctggccagc aaatgcaaag gggccgcagt
      541 gaaactggca gacttcggcc tggccatcga ggttcaggga gaccagcagg catggtttgg
      601 atttgcggga acaccaggct acctgtctcc cgaagttctt cggaaggagg cctatggcaa
      661 accagtggat atctgggcat gtggggtgat cctgtatatc ctgctggtgg gatacccacc
      721 tttctgggat gaggaccagc acaagctgta ccagcagatc aaggctgggg cctatgactt
      781 cccatccccc gagtgggaca ccgttacccc tgaagccaaa aacctcatca accagatgtt
      841 gaccatcaac cccgccaagc gcatcacggc ccacgaggcc ctgaagcacc catgggtctg
      901 ccaacgatcc acggtggcct ccatgatgca cagacaggag actgtggaat gtctgaagaa
      961 gttcaatgca aggaggaagc tcaagggagc catcctcacc actatgctgg ccacacggaa
     1021 tttctcagtg ggcagacaga ccaccgctcc ggccacaatg tccaccgcgg cctccggcac
     1081 caccatgggg ctggtggaac aagccaagag tttactcaac aagaaagcag acggagtcaa
     1141 gccccagaca aacagcacca aaaacagctc ggccatcacc agccccaaag gatccctccc
     1201 tcctgccgcc ctggagcctc aaaccaccgt tatccataac ccagtggacg gcattaagga
     1261 atcttccgac agcaccaaca caaccataga ggacgaagat gccaaagccc ggaagcagga
     1321 aatcatcaag accacagagc agctcatcga ggccgtcaac aacggcgact ttgaggccta
     1381 tgcgaaaatc tgtgacccag gcctgacctc atttgagcct gaagctctgg gcaacctggt
     1441 cgaagggatg gatttccaca gattctactt tgagaacctg ctggccaaga acagcaagcc
     1501 gatccacacc actatcctga acccgcacgt gcacgtcatc ggcgaggatg cagcctgcat
     1561 cgcttacatc cgcctcacac agtacatcga cggccagggc agaccccgca ccagccagtc
     1621 cgaagagacc cgtgtgtggc accgccgcga cggcaagtgg cagaatgtcc atttccactg
     1681 ctcgggcgct ccagtggccc cactgcagtg agagctgcgc ctggtttcac cggacagagt
     1741 tggtgtttgg agcccagccg ccctcgggcg cacggcctgc ctgtcgcatg tttgtgtctg
     1801 cctcgtcccc tcccctggtg cctgtgtctg cagaaaaaca agaccagatg tgatttgttt
     1861 ttttaaaaaa aaaaaaaaag taagatgatg acaacgacaa ccacatgcaa acaaacaaac
     1921 aaaaaatatt ggcatcggat gaaatggaaa acaaacaaac aaacctaaag aaaggaaaaa
     1981 gctgtaaaaa tctggcattt gtggggccgc ccccccaccc aagctccaca tgtgtctgtt
     2041 gcgctcctgg ctttggggac cctcagggcg tgaatgtgcc catgccgact gtgttagtct
     2101 gtaggtaccg cactcacccc acaccttggg cgtctgcatc ctcctcccat gcatgggccc
     2161 cacgtgctaa cctggctgtt gtggcgtcag gtgtcttggg aagggctggg ggctgcctcc
     2221 tttcctgcta gttgtgcctg aaagctgctg ctgttcctgc ttcccctacc cgtccctcat
     2281 cccgagaagg actgggaggg tgctcctcta gccaaggacc tacctttgcc ccatggagtg
     2341 tgtaggagaa gctcgtcctc aagatcatca gaaagtaacc tggttctttg gggagtgagg
     2401 tatggaggta tgtatctcgc ctccaagcct ctcgcctggc agggattggt taggaaggca
     2461 ggctggctgc agcacccacc catctagcta cgaagagagg actgggcagg gatggactcc
     2521 ttcctgtttg gggttcttgt cccttccctg ccaccagcag ctgagcgaga gtggcccacc
     2581 cctggcccgg gcagttcctc tctgaagttg gcaacagacc ctcacgaaga cggagttgcc
     2641 gagatactgg acagagctgg gagcagacgc tggctgcatc tagggggttt gtccactgag
     2701 cttgaagtct gggtgctcga gacttggtta aatgttgcag aatgtgataa agaggggcca
     2761 gaagtcgggt tttagactgc tgggcaatgc aggtccatgt gagggtttga tggtaggagt
     2821 gctttcctaa cctgagccta gagaagaaat aagccagagg atgtgcctcc tcagaggcac
     2881 atggaaggcc aaaattggtt aggtagggct gtattgtgtg aggcctttcc aggtaggcca
     2941 gagatacgta gtagagagaa ggcaggctgg gggcagagat atatgggtgt ggggcctgga
     3001 taccagtggg tggagggagg gtccattagg acagtgtgcc acccccaggg cccagtggtg
     3061 ctcctaggtg ccggctgcct ggactcgtgg gtggcccttg gtgacagagg gaatcatcaa
     3121 ggctggacat gttacaaagt caggctaggg agataggtat aaagccgggt tgggtggggg
     3181 tggtcagggg ctttgatcgc agaggtccgt gggcctccac cccaatgctg cccactttaa
     3241 attcacgtca ttttcaacca ggattttctt tatcttttac tacaaatcaa gccaagggag
     3301 gggcacgaag tggggaacgg gacacaggat cctaaactcc aaggggactg tccacctaca
     3361 gacactcagt ggataccacc tttgatccac actgtgccca ggacagctgc cccctaccca
     3421 tggacacagg gtaaacatct gccaggctcc atgagtggcc caaggccatg gaatagaggc
     3481 agggcttgtc acagacagcg tgaggccctg tggcctgcca ccctgacatc ctggggtctc
     3541 ctttcctctc ccacccacct tgttatctcc acaaagctgc ctgtctggga taatttgggg
     3601 attttttttc tgggggacaa ttcttttgca tgaccctcta aagagcagga cacgtctgct
     3661 ctactggcta ggtgttcgca ggtggtggcg tcgactgtgg ccagtgctgg agcgtgtcac
     3721 tgcctgcagt actggtgacc ctcctctctt ctctttttgc tgagttccat tgtcttttct
     3781 ttccgagcct tgtaggtgta caaaacttat tcttattttg ttctgtctcg ggaaactgca
     3841 aataaaaaaa aaaaaaaaaa aaaa
//
