LOCUS       NM_012920               1510 bp    mRNA    linear   ROD 01-JUL-2024
DEFINITION  Rattus norvegicus calcium/calmodulin-dependent protein kinase II
            alpha (Camk2a), mRNA.
ACCESSION   NM_012920
VERSION     NM_012920.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1510)
  AUTHORS   Dorovic,D., Lazarevic,V., Arandelovic,J., Stevanovic,V.,
            Paslawski,W., Zhang,X., Velimirovic,M., Petronijevic,N., Puskas,L.,
            Savic,M.M. and Svenningsson,P.
  TITLE     Maternal deprivation causes CaMKII downregulation and modulates
            glutamate, norepinephrine and serotonin in limbic brain areas in a
            rat model of single prolonged stress
  JOURNAL   J Affect Disord 349, 286-296 (2024)
   PUBMED   38199412
  REMARK    GeneRIF: Maternal deprivation causes CaMKII downregulation and
            modulates glutamate, norepinephrine and serotonin in limbic brain
            areas in a rat model of single prolonged stress.
REFERENCE   2  (bases 1 to 1510)
  AUTHORS   Obaid,A.A., Almasmoum,H., Almaimani,R.A., El-Boshy,M., Aslam,A.,
            Idris,S., Ghaith,M.M., El-Readi,M.Z., Ahmad,J., Farrash,W.F.,
            Mujalli,A., Eid,S.Y., Elzubier,M.E. and Refaat,B.
  TITLE     Vitamin D and calcium co-therapy mitigates pre-established cadmium
            nephropathy by regulating renal calcium homeostatic molecules and
            improving anti-oxidative and anti-inflammatory activities in rat
  JOURNAL   J Trace Elem Med Biol 79, 127221 (2023)
   PUBMED   37244046
REFERENCE   3  (bases 1 to 1510)
  AUTHORS   Yuan,G., Cao,C., Cao,D., Li,B., Li,X., Li,H., Shen,H., Wang,Z. and
            Chen,G.
  TITLE     Receptor-interacting protein 3-phosphorylated Ca2+
            /calmodulin-dependent protein kinase II and mixed lineage kinase
            domain-like protein mediate intracerebral hemorrhage-induced
            neuronal necroptosis
  JOURNAL   J Neurochem 164 (1), 94-114 (2023)
   PUBMED   36424866
  REMARK    GeneRIF: Receptor-interacting protein 3-phosphorylated Ca[2+]
            /calmodulin-dependent protein kinase II and mixed lineage kinase
            domain-like protein mediate intracerebral hemorrhage-induced
            neuronal necroptosis.
REFERENCE   4  (bases 1 to 1510)
  AUTHORS   Radiske,A., Gonzalez,M.C., Rossato,J.I., Apolinario,G., de
            Oliveira,J.R., Bevilaqua,L.R.M. and Cammarota,M.
  TITLE     Avoidance memory requires CaMKII activity to persist after recall
  JOURNAL   Mol Brain 14 (1), 167 (2021)
   PUBMED   34775982
  REMARK    GeneRIF: Avoidance memory requires CaMKII activity to persist after
            recall.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1510)
  AUTHORS   Yong,X.L.H., Zhang,L., Yang,L., Chen,X., Tan,J.Z.A., Yu,X.,
            Chandra,M., Livingstone,E., Widagdo,J., Vieira,M.M., Roche,K.W.,
            Lynch,J.W., Keramidas,A., Collins,B.M. and Anggono,V.
  TITLE     Regulation of NMDA receptor trafficking and gating by
            activity-dependent CaMKIIalpha phosphorylation of the GluN2A
            subunit
  JOURNAL   Cell Rep 36 (1), 109338 (2021)
   PUBMED   34233182
REFERENCE   6  (bases 1 to 1510)
  AUTHORS   Cho,K.O., Hunt,C.A. and Kennedy,M.B.
  TITLE     The rat brain postsynaptic density fraction contains a homolog of
            the Drosophila discs-large tumor suppressor protein
  JOURNAL   Neuron 9 (5), 929-942 (1992)
   PUBMED   1419001
REFERENCE   7  (bases 1 to 1510)
  AUTHORS   Benfenati,F., Valtorta,F., Rubenstein,J.L., Gorelick,F.S.,
            Greengard,P. and Czernik,A.J.
  TITLE     Synaptic vesicle-associated Ca2+/calmodulin-dependent protein
            kinase II is a binding protein for synapsin I
  JOURNAL   Nature 359 (6394), 417-420 (1992)
   PUBMED   1328883
REFERENCE   8  (bases 1 to 1510)
  AUTHORS   Sunyer,T. and Sahyoun,N.
  TITLE     Sequence analysis and DNA-protein interactions within the 5'
            flanking region of the Ca2+/calmodulin-dependent protein kinase II
            alpha-subunit gene
  JOURNAL   Proc Natl Acad Sci U S A 87 (1), 278-282 (1990)
   PUBMED   2153289
REFERENCE   9  (bases 1 to 1510)
  AUTHORS   Thiel,G., Czernik,A.J., Gorelick,F., Nairn,A.C. and Greengard,P.
  TITLE     Ca2+/calmodulin-dependent protein kinase II: identification of
            threonine-286 as the autophosphorylation site in the alpha subunit
            associated with the generation of Ca2+-independent activity
  JOURNAL   Proc Natl Acad Sci U S A 85 (17), 6337-6341 (1988)
   PUBMED   2842767
REFERENCE   10 (bases 1 to 1510)
  AUTHORS   Bulleit,R.F., Bennett,M.K., Molloy,S.S., Hurley,J.B. and
            Kennedy,M.B.
  TITLE     Conserved and variable regions in the subunits of brain type II
            Ca2+/calmodulin-dependent protein kinase
  JOURNAL   Neuron 1 (1), 63-72 (1988)
   PUBMED   2856087
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from J02942.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J02942.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1510
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..1510
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /note="calcium/calmodulin-dependent protein kinase II
                     alpha"
                     /db_xref="GeneID:25400"
                     /db_xref="RGD:2261"
     exon            1..103
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..1478
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /EC_number="2.7.11.17"
                     /note="calcium/calmodulin-dependent protein kinase type II
                     alpha chain; alpha CaM kinase II; caMK-II subunit alpha;
                     caM-kinase II alpha chain; caM kinase II subunit alpha;
                     calcium/calmodulin-dependent protein kinase (CaM kinase)
                     II alpha; Ca2+/calmodulin-dependent protein kinase II
                     alpha; calcium/calmodulin-dependent protein kinase II
                     alpha subunit"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     II subunit alpha"
                     /protein_id="NP_037052.1"
                     /db_xref="GeneID:25400"
                     /db_xref="RGD:2261"
                     /translation="MATITCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKII
                     NTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIV
                     AREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLA
                     IEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQ
                     HRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRST
                     VASCMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSGGKSGGNKKNDGVKESSEST
                     NTTIEDEDTKVRKQEIIKVTEQLIEAISNGDFESYTKMCDPGMTAFEPEALGNLVEGL
                     DFHRFYFENLWSRNSKPVHTTILNPHIHLMGDESACIAYIRITQYLDAGGIPRTAQSE
                     ETRVWHRRDGKWQIVHFHRSGAPSVLPH"
     exon            104..198
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /inference="alignment:Splign:2.1.0"
     exon            199..258
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /inference="alignment:Splign:2.1.0"
     exon            259..313
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /inference="alignment:Splign:2.1.0"
     exon            314..379
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /inference="alignment:Splign:2.1.0"
     exon            380..452
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /inference="alignment:Splign:2.1.0"
     exon            453..555
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /inference="alignment:Splign:2.1.0"
     exon            556..639
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /inference="alignment:Splign:2.1.0"
     exon            640..734
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /inference="alignment:Splign:2.1.0"
     exon            735..857
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /inference="alignment:Splign:2.1.0"
     exon            858..941
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /inference="alignment:Splign:2.1.0"
     exon            942..984
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1025
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1074
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1150
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1245
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1474
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1510
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcccgagc ctaaagcctc gcctgcctgc ccagtgccag gatggctacc atcacctgca
       61 cccgattcac ggaagagtac cagctcttcg aggaactggg aaagggagcc ttctccgtgg
      121 tgcgcaggtg tgtgaaggtg ctggctggcc aggagtatgc tgccaagatt atcaacacca
      181 agaagctctc agccagagat caccagaagt tggaacgcga ggcccgcatc tgccgcttgt
      241 tgaagcaccc caatatcgtc cgactccatg acagcatctc cgaggagggg caccactacc
      301 ttatcttcga tctggtcact ggtggggagc tgttcgaaga cattgtggcc cgggagtatt
      361 acagtgaggc tgatgccagc cactgtatcc agcagatcct ggaggctgtg ctacactgtc
      421 accagatggg ggtggtgcat cgcgacctga agcctgagaa tctgttgctg gcttcgaagc
      481 tcaagggtgc tgcggtgaag ctggcagact ttggcctggc catagaggtt gagggagagc
      541 agcaggcatg gtttgggttc gcagggacac ctggatacct ctccccagaa gtgctgcgga
      601 aggacccata cgggaagcct gtggacctgt gggcctgtgg cgtcatcctg tatatcttgc
      661 tggttgggta tcccccattc tgggatgagg accagcaccg cctgtaccag cagatcaaag
      721 ctggtgccta cgatttccca tcaccagaat gggacaccgt caccccggaa gccaaggatc
      781 tgatcaataa gatgctgacc atcaacccgt ccaaacgcat cacggccgct gaggctctca
      841 agcacccctg gatctcgcac cgctccactg tggcctcctg catgcacaga caggagaccg
      901 tggactgcct gaagaagttc aatgccagga ggaaactgaa gggagccatc ctcaccacta
      961 tgctggccac caggaacttc tccggaggga agagtggagg aaacaagaag aatgatggcg
     1021 tgaaggaatc ctctgagagc accaacacca ccatcgagga tgaagacacc aaagtgcgca
     1081 aacaggaaat tatcaaagtg acagagcagc tgatcgaagc cataagcaat ggagactttg
     1141 aatcctacac gaagatgtgc gaccctggaa tgacagcctt tgaaccggag gccctgggga
     1201 acctggtcga gggcctggac tttcatcgat tctattttga aaacctgtgg tcccggaaca
     1261 gcaagcccgt gcacaccacc atcctgaacc ctcacatcca cctgatgggt gacgagtcag
     1321 cctgcatcgc ctacatccgc atcactcagt acctggatgc gggtggcatc ccccgcacgg
     1381 cccagtcaga ggagacccgt gtctggcacc gcagggatgg aaaatggcag atcgtccact
     1441 tccacagatc tggggcgccc tccgtcctgc cccattgaag gaccaggcca gggtccctgc
     1501 gctcttgctt
//
