LOCUS       NP_001100835             385 aa            linear   ROD 11-OCT-2024
DEFINITION  calcium/calmodulin-dependent protein kinase type 1D isoform 1
            [Rattus norvegicus].
ACCESSION   NP_001100835 XP_001065973 XP_001066029 XP_001066090 XP_001066143
VERSION     NP_001100835.1
DBSOURCE    REFSEQ: accession NM_001107365.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 385)
  AUTHORS   Gaines,P., Lamoureux,J., Marisetty,A., Chi,J. and Berliner,N.
  TITLE     A cascade of Ca(2+)/calmodulin-dependent protein kinases regulates
            the differentiation and functional activation of murine neutrophils
  JOURNAL   Exp Hematol 36 (7), 832-844 (2008)
   PUBMED   18400360
REFERENCE   2  (residues 1 to 385)
  AUTHORS   Kamata,A., Sakagami,H., Tokumitsu,H., Owada,Y., Fukunaga,K. and
            Kondo,H.
  TITLE     Spatiotemporal expression of four isoforms of
            Ca2+/calmodulin-dependent protein kinase I in brain and its
            possible roles in hippocampal dendritic growth
  JOURNAL   Neurosci Res 57 (1), 86-97 (2007)
   PUBMED   17056143
REFERENCE   3  (residues 1 to 385)
  AUTHORS   Sakagami,H., Kamata,A., Nishimura,H., Kasahara,J., Owada,Y.,
            Takeuchi,Y., Watanabe,M., Fukunaga,K. and Kondo,H.
  TITLE     Prominent expression and activity-dependent nuclear translocation
            of Ca2+/calmodulin-dependent protein kinase Idelta in hippocampal
            neurons
  JOURNAL   Eur J Neurosci 22 (11), 2697-2707 (2005)
   PUBMED   16324104
REFERENCE   4  (residues 1 to 385)
  AUTHORS   Verploegen,S., Ulfman,L., van Deutekom,H.W., van Aalst,C.,
            Honing,H., Lammers,J.W., Koenderman,L. and Coffer,P.J.
  TITLE     Characterization of the role of CaMKI-like kinase (CKLiK) in human
            granulocyte function
  JOURNAL   Blood 106 (3), 1076-1083 (2005)
   PUBMED   15840691
REFERENCE   5  (residues 1 to 385)
  AUTHORS   Yamada,T., Suzuki,M., Satoh,H., Kihara-Negishi,F., Nakano,H. and
            Oikawa,T.
  TITLE     Effects of PU.1-induced mouse calcium-calmodulin-dependent kinase
            I-like kinase (CKLiK) on apoptosis of murine erythroleukemia cells
  JOURNAL   Exp Cell Res 294 (1), 39-50 (2004)
   PUBMED   14980499
REFERENCE   6  (residues 1 to 385)
  AUTHORS   Verploegen,S., Lammers,J.W., Koenderman,L. and Coffer,P.J.
  TITLE     Identification and characterization of CKLiK, a novel granulocyte
            Ca(++)/calmodulin-dependent kinase
  JOURNAL   Blood 96 (9), 3215-3223 (2000)
   PUBMED   11050006
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_001066143.1, XP_001066029.1, XP_001066090.1, XP_001065973.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.49098.1,
                                           SRR26643298.69836.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..385
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.3"
     Protein         1..385
                     /product="calcium/calmodulin-dependent protein kinase type
                     1D isoform 1"
                     /EC_number="2.7.11.17"
                     /note="calcium/calmodulin-dependent protein kinase type
                     1D"
                     /calculated_mol_wt=42788
     Region          12..312
                     /region_name="STKc_CaMKI_delta"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type I delta;
                     cd14168"
                     /db_xref="CDD:271070"
     Site            order(29..33,37,50,52,82,98..101,105,107,143..144,146,
                     148..149,151,164..165,168,182..186,188)
                     /site_type="active"
                     /db_xref="CDD:271070"
     Site            order(29..32,37,50,52,82,98..101,105,148..149,151,
                     164..165)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271070"
     Site            order(33,105,107,143..144,146,148,168,182..186,188)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271070"
     Site            164..186
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271070"
     CDS             1..385
                     /gene="Camk1d"
                     /gene_synonym="RGD1560691"
                     /coded_by="NM_001107365.2:251..1408"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:307124"
                     /db_xref="RGD:1560691"
ORIGIN      
        1 marengesss swkkqaedik kifefketlg tgafsevvla eekatgklfa vkcipkkalk
       61 gkessienei avlrkikhen ivalediyes pnhlylvmql vsggelfdri vekgfytekd
      121 astlirqvld avyylhrmgi vhrdlkpenl lyysqdeesk imisdfglsk megkgdvmst
      181 acgtpgyvap evlaqkpysk avdcwsigvi ayillcgypp fydendsklf eqilkaeyef
      241 dspywddisd sakdfirnlm ekdpnkrytc eqaarhpwia gdtalsknih esvsaqirkn
      301 fakskwrqaf natavvrhmr rlqlgsslds snasvssnls lasqkdclap stlcsflsss
      361 sgvagvgaer rprpttvttg htgsk
//
