LOCUS       NM_134468               1421 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus calcium/calmodulin-dependent protein kinase I
            (Camk1), mRNA.
ACCESSION   NM_134468 XM_579643
VERSION     NM_134468.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1421)
  AUTHORS   Fukumoto,Y., Harada,Y., Ohtsuka,S., Kanayama,N., Magari,M.,
            Hatano,N., Sakagami,H. and Tokumitsu,H.
  TITLE     Oligomerization of Ca2+/calmodulin-dependent protein kinase kinase
  JOURNAL   Biochem Biophys Res Commun 587, 160-165 (2022)
   PUBMED   34875535
  REMARK    GeneRIF: Oligomerization of Ca(2+)/calmodulin-dependent protein
            kinase kinase.
REFERENCE   2  (bases 1 to 1421)
  AUTHORS   Ozaki,H., Katoh,T., Nakagawa,R., Ishihara,Y., Sueyoshi,N.,
            Kameshita,I., Taniguchi,T., Hirano,T., Yamazaki,T. and Ishida,A.
  TITLE     Ca(2+)/calmodulin-dependent protein kinase phosphatase
            (CaMKP/PPM1F) interacts with neurofilament L and inhibits its
            filament association
  JOURNAL   Biochem Biophys Res Commun 477 (4), 820-825 (2016)
   PUBMED   27369073
  REMARK    GeneRIF: Furthermore, the effect of CaMKP on self-assembly of NFL
            was examined. Electron microscopy revealed that CaMKP markedly
            prevented NFL from forming large filamentous aggregates, suggesting
            that CaMKP-binding to NFL inhibits its filament association. These
            findings may provide new insights into a novel mechanism for
            regulating network formation of neurofilaments during neuronal
            differentiation.
REFERENCE   3  (bases 1 to 1421)
  AUTHORS   Onouchi,T., Kishino-Kaneko,Y., Kameshita,I., Ishida,A. and
            Sueyoshi,N.
  TITLE     Regulation of Ca(2+)/calmodulin-dependent protein kinase
            phosphatase (CaMKP/PPM1F) by protocadherin-gammaC5 (Pcdh-gammaC5)
  JOURNAL   Arch Biochem Biophys 585, 109-120 (2015)
   PUBMED   26386307
  REMARK    GeneRIF: C-terminal cytoplasmic fragment of PcdhgC5 acts as a
            scaffold for CaMKP and CaMKI to regulate CaMKP activity.
REFERENCE   4  (bases 1 to 1421)
  AUTHORS   Jusuf,A.A., Sakagami,H., Kikkawa,S. and Terashima,T.
  TITLE     Expression of Beta Subunit 2 of Ca(2)+/Calmodulin-Dependent Protein
            Kinase I in the Developing Rat Retina
  JOURNAL   Kobe J Med Sci 61 (4), E115-E123 (2015)
   PUBMED   27323839
  REMARK    GeneRIF: expression of CaMKIbeta2 in the retina was detected from
            the earliest development until adulthood, indicating that
            CaMKIbeta2 may be required in both proliferation and
            differentiation of the retinal precursor cells and subsequent
            formation of the functional layers
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1421)
  AUTHORS   Chang,C.W., Cheong,M.L., Chang,G.D., Tsai,M.S. and Chen,H.
  TITLE     Involvement of Epac1/Rap1/CaMKI/HDAC5 signaling cascade in the
            regulation of placental cell fusion
  JOURNAL   Mol Hum Reprod 19 (11), 745-755 (2013)
   PUBMED   23867755
REFERENCE   6  (bases 1 to 1421)
  AUTHORS   Picciotto,M.R., Zoli,M., Bertuzzi,G. and Nairn,A.C.
  TITLE     Immunochemical localization of calcium/calmodulin-dependent protein
            kinase I
  JOURNAL   Synapse 20 (1), 75-84 (1995)
   PUBMED   7624832
REFERENCE   7  (bases 1 to 1421)
  AUTHORS   Dale,S., Wilson,W.A., Edelman,A.M. and Hardie,D.G.
  TITLE     Similar substrate recognition motifs for mammalian AMP-activated
            protein kinase, higher plant HMG-CoA reductase kinase-A, yeast
            SNF1, and mammalian calmodulin-dependent protein kinase I
  JOURNAL   FEBS Lett 361 (2-3), 191-195 (1995)
   PUBMED   7698321
REFERENCE   8  (bases 1 to 1421)
  AUTHORS   Cho,F.S., Phillips,K.S., Bogucki,B. and Weaver,T.E.
  TITLE     Characterization of a rat cDNA clone encoding
            calcium/calmodulin-dependent protein kinase I
  JOURNAL   Biochim Biophys Acta 1224 (1), 156-160 (1994)
   PUBMED   7948038
REFERENCE   9  (bases 1 to 1421)
  AUTHORS   Picciotto,M.R., Czernik,A.J. and Nairn,A.C.
  TITLE     Calcium/calmodulin-dependent protein kinase I. cDNA cloning and
            identification of autophosphorylation site
  JOURNAL   J Biol Chem 268 (35), 26512-26521 (1993)
   PUBMED   8253780
  REMARK    Erratum:[J Biol Chem 1995 Apr 28;270(17):10358]
REFERENCE   10 (bases 1 to 1421)
  AUTHORS   Sheng,M., Thompson,M.A. and Greenberg,M.E.
  TITLE     CREB: a Ca(2+)-regulated transcription factor phosphorylated by
            calmodulin-dependent kinases
  JOURNAL   Science 252 (5011), 1427-1430 (1991)
   PUBMED   1646483
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Nov 27, 2020 this sequence version replaced NM_134468.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L26288.1, SRR26643287.11829.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676806 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                JAXUCZ010000004.1  148047069-148047145 c
            78-192              JAXUCZ010000004.1  148045071-148045185 c
            193-324             JAXUCZ010000004.1  148043304-148043435 c
            325-399             JAXUCZ010000004.1  148042254-148042328 c
            400-538             JAXUCZ010000004.1  148042039-148042177 c
            539-665             JAXUCZ010000004.1  148040909-148041035 c
            666-741             JAXUCZ010000004.1  148040740-148040815 c
            742-854             JAXUCZ010000004.1  148039763-148039875 c
            855-933             JAXUCZ010000004.1  148039166-148039244 c
            934-1021            JAXUCZ010000004.1  148038989-148039076 c
            1022-1139           JAXUCZ010000004.1  148037230-148037347 c
            1140-1421           JAXUCZ010000004.1  148036843-148037124 c
FEATURES             Location/Qualifiers
     source          1..1421
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..1421
                     /gene="Camk1"
                     /gene_synonym="Camki; Gaip"
                     /note="calcium/calmodulin-dependent protein kinase I"
                     /db_xref="GeneID:171503"
                     /db_xref="RGD:629473"
     exon            1..77
                     /gene="Camk1"
                     /gene_synonym="Camki; Gaip"
                     /inference="alignment:Splign:2.1.0"
     exon            78..192
                     /gene="Camk1"
                     /gene_synonym="Camki; Gaip"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..1234
                     /gene="Camk1"
                     /gene_synonym="Camki; Gaip"
                     /EC_number="2.7.11.17"
                     /note="regulator of G-protein signalling 19; caM-KI;
                     caMKI-alpha; caM kinase I alpha; G alpha interacting
                     protein"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     1"
                     /protein_id="NP_604463.1"
                     /db_xref="GeneID:171503"
                     /db_xref="RGD:629473"
                     /translation="MPGAVEGPRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQK
                     LVAIKCIAKKALEGKEGSMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGE
                     LFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMI
                     SDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPF
                     YDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWI
                     AGDTALDKNIHQSVSEQIKKNFAKSKWKQAFNATAVVRHMRKLQLGTSQEGQGQTASH
                     GELLTPTAGGPAAGCCCRDCCVEPGSELPPAPPPSSRAMD"
     exon            193..324
                     /gene="Camk1"
                     /gene_synonym="Camki; Gaip"
                     /inference="alignment:Splign:2.1.0"
     exon            325..399
                     /gene="Camk1"
                     /gene_synonym="Camki; Gaip"
                     /inference="alignment:Splign:2.1.0"
     exon            400..538
                     /gene="Camk1"
                     /gene_synonym="Camki; Gaip"
                     /inference="alignment:Splign:2.1.0"
     exon            539..665
                     /gene="Camk1"
                     /gene_synonym="Camki; Gaip"
                     /inference="alignment:Splign:2.1.0"
     exon            666..741
                     /gene="Camk1"
                     /gene_synonym="Camki; Gaip"
                     /inference="alignment:Splign:2.1.0"
     exon            742..854
                     /gene="Camk1"
                     /gene_synonym="Camki; Gaip"
                     /inference="alignment:Splign:2.1.0"
     exon            855..933
                     /gene="Camk1"
                     /gene_synonym="Camki; Gaip"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1021
                     /gene="Camk1"
                     /gene_synonym="Camki; Gaip"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1139
                     /gene="Camk1"
                     /gene_synonym="Camki; Gaip"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1421
                     /gene="Camk1"
                     /gene_synonym="Camki; Gaip"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccaggtacgg acgcggcggg agctccgcac cagccaccta ggccctcgct gccagccccg
       61 tggcggggca gccgcaggag ccctggctgt ggctgggggg cagtgggcca tgccaggggc
      121 agtggaaggc cccaggtgga agcaggcaga agacattagg gatatttatg acttcaggga
      181 tgttctgggc acgggtgcct tctcagaagt gatcctggca gaggacaaga ggactcagaa
      241 actggtggcc atcaaatgca ttgccaagaa ggccctggag ggcaaagaag gcagcatgga
      301 gaatgagatc gccgtcttac acaagatcaa gcaccccaac attgtagccc tggatgacat
      361 ctatgagagt gggggccacc tctacctcat catgcagctg gtttcaggtg gagagctgtt
      421 tgaccgaatt gtggagaaag gattctacac agaacgggat gccagccgcc tcatcttcca
      481 ggtgctggat gctgtcaagt acctgcacga cctgggcatt gtgcaccggg atctcaagcc
      541 agagaacctg ctatactaca gtctggatga agactccaaa atcatgatct ctgactttgg
      601 cctctccaag atggaggacc caggcagtgt gctctccaca gcctgtggga ctccaggata
      661 tgtggcccct gaggtcctgg cccagaagcc ctacagcaag gccgtggact gctggtccat
      721 aggagtcatt gcctatatac tgctctgtgg ctacccgccg ttctatgatg aaaatgatgc
      781 caaacttttt gaacagattt tgaaggctga gtatgagttt gactctcctt attgggacga
      841 catctctgac tctgccaaag atttcatacg tcatttgatg gagaaagacc cagagaagag
      901 gttcacctgt gagcaggcct tgcagcaccc ctggattgca ggagacacag ctctggataa
      961 gaatatccac cagtcagtga gtgagcagat caagaagaac tttgccaaga gcaagtggaa
     1021 gcaagctttc aatgctaccg ctgtggttcg gcacatgagg aagctgcagc tgggcaccag
     1081 ccaggaggga cagggacaga cagctagcca cggagagctg ctgacaccca cagctggggg
     1141 gccagcagct ggctgctgct gtcgagactg ctgtgtggag ccaggctcag aactgccccc
     1201 tgcaccaccc ccaagctcta gggccatgga ctgaacatca aggagtcagg gtttcgtccg
     1261 tgaggggttg gaggcagcct gcttcctcct caccccagaa ctggggagtt tctgacccca
     1321 tacttcttcc ctcccctctc actcttcact gcattttcca tacaaatgtt tctattttat
     1381 tgttccttct tgtaataaag ggaagataaa acaaaacagt t
//
