LOCUS       NM_001190399             991 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus calcyon neuron-specific vesicular protein (Caly),
            transcript variant 2, mRNA.
ACCESSION   NM_001190399
VERSION     NM_001190399.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 991)
  AUTHORS   Shi,L., Hines,T., Bergson,C. and Smith,D.
  TITLE     Coupling of microtubule motors with AP-3 generated organelles in
            axons by NEEP21 family member calcyon
  JOURNAL   Mol Biol Cell 29 (17), 2055-2068 (2018)
   PUBMED   29949458
  REMARK    GeneRIF: Caly is a multifunctional scaffolding protein that
            regulates axonal transport of late endosomes and lysosome-related
            organelles by coordinately interacting with motor and vesicle coat
            proteins.
REFERENCE   2  (bases 1 to 991)
  AUTHORS   Shi,L., Muthusamy,N., Smith,D. and Bergson,C.
  TITLE     Dynein binds and stimulates axonal motility of the endosome adaptor
            and NEEP21 family member, calcyon
  JOURNAL   Int J Biochem Cell Biol 90, 93-102 (2017)
   PUBMED   28734834
  REMARK    GeneRIF: endocytic and cargo sorting functions of Caly in neurons
REFERENCE   3  (bases 1 to 991)
  AUTHORS   Ha,C.M., Park,D., Han,J.K., Jang,J.I., Park,J.Y., Hwang,E.M.,
            Seok,H. and Chang,S.
  TITLE     Calcyon forms a novel ternary complex with dopamine D1 receptor
            through PSD-95 protein and plays a role in dopamine receptor
            internalization
  JOURNAL   J Biol Chem 287 (38), 31813-31822 (2012)
   PUBMED   22843680
  REMARK    GeneRIF: Calcyon forms a novel ternary complex with dopamine D1
            receptor through PSD-95 protein and plays a role in dopamine
            receptor internalization
REFERENCE   4  (bases 1 to 991)
  AUTHORS   Loos,M., Pattij,T., Janssen,M.C., Counotte,D.S., Schoffelmeer,A.N.,
            Smit,A.B., Spijker,S. and van Gaalen,M.M.
  TITLE     Dopamine receptor D1/D5 gene expression in the medial prefrontal
            cortex predicts impulsive choice in rats
  JOURNAL   Cereb Cortex 20 (5), 1064-1070 (2010)
   PUBMED   19690230
REFERENCE   5  (bases 1 to 991)
  AUTHORS   Davidson,H.T., Xiao,J., Dai,R. and Bergson,C.
  TITLE     Calcyon is necessary for activity-dependent AMPA receptor
            internalization and LTD in CA1 neurons of hippocampus
  JOURNAL   Eur J Neurosci 29 (1), 42-54 (2009)
   PUBMED   19120439
REFERENCE   6  (bases 1 to 991)
  AUTHORS   Xiao,J., Dai,R., Negyessy,L. and Bergson,C.
  TITLE     Calcyon, a novel partner of clathrin light chain, stimulates
            clathrin-mediated endocytosis
  JOURNAL   J Biol Chem 281 (22), 15182-15193 (2006)
   PUBMED   16595675
REFERENCE   7  (bases 1 to 991)
  AUTHORS   Laurin,N., Misener,V.L., Crosbie,J., Ickowicz,A., Pathare,T.,
            Roberts,W., Malone,M., Tannock,R., Schachar,R., Kennedy,J.L. and
            Barr,C.L.
  TITLE     Association of the calcyon gene (DRD1IP) with attention
            deficit/hyperactivity disorder
  JOURNAL   Mol Psychiatry 10 (12), 1117-1125 (2005)
   PUBMED   16172615
REFERENCE   8  (bases 1 to 991)
  AUTHORS   Ali,M.K. and Bergson,C.
  TITLE     Elevated intracellular calcium triggers recruitment of the receptor
            cross-talk accessory protein calcyon to the plasma membrane
  JOURNAL   J Biol Chem 278 (51), 51654-51663 (2003)
   PUBMED   14534309
REFERENCE   9  (bases 1 to 991)
  AUTHORS   Koh,P.O., Bergson,C., Undie,A.S., Goldman-Rakic,P.S. and Lidow,M.S.
  TITLE     Up-regulation of the D1 dopamine receptor-interacting protein,
            calcyon, in patients with schizophrenia
  JOURNAL   Arch Gen Psychiatry 60 (3), 311-319 (2003)
   PUBMED   12622665
REFERENCE   10 (bases 1 to 991)
  AUTHORS   Zelenin,S., Aperia,A. and Diaz Heijtz,R.
  TITLE     Calcyon in the rat brain: cloning of cDNA and expression of mRNA
  JOURNAL   J Comp Neurol 446 (1), 37-45 (2002)
   PUBMED   11920718
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC060543.1 and AF303658.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Both variants 1 and 2 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ213422.1, BC060543.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-519               BC060543.1         5-523
            520-991             AF303658.1         579-1050
FEATURES             Location/Qualifiers
     source          1..991
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..991
                     /gene="Caly"
                     /gene_synonym="Calcyon; Drd1ip"
                     /note="calcyon neuron-specific vesicular protein"
                     /db_xref="GeneID:192349"
                     /db_xref="RGD:621719"
     exon            1..77
                     /gene="Caly"
                     /gene_synonym="Calcyon; Drd1ip"
                     /inference="alignment:Splign:2.1.0"
     exon            78..237
                     /gene="Caly"
                     /gene_synonym="Calcyon; Drd1ip"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..783
                     /gene="Caly"
                     /gene_synonym="Calcyon; Drd1ip"
                     /note="dopamine receptor D1 interacting protein; calcyon;
                     D1 dopamine receptor-interacting protein"
                     /codon_start=1
                     /product="neuron-specific vesicular protein calcyon"
                     /protein_id="NP_001177328.1"
                     /db_xref="GeneID:192349"
                     /db_xref="RGD:621719"
                     /translation="MVKLGCSFSGKPGKETGDQDGAAMDSVPLISPLDVSQLQPSFPD
                     QVVIKTQTEYQLTSADQPKKFADLEGQRLACSHPEEGRRLPTARMIAFAMALLGCVLI
                     MYKAIWYDQFTCPDGFLLRHKICTPLTLEMYYTEMDPERHRSILAAIGAYPLSRKHGT
                     EMPAIWGNSYRAGKEEHKGTTPAAMTVSTAAAAAAAEGNEPSGKPLDMREKEDPQKAE
                     DVPSQSPK"
     exon            238..351
                     /gene="Caly"
                     /gene_synonym="Calcyon; Drd1ip"
                     /inference="alignment:Splign:2.1.0"
     exon            352..465
                     /gene="Caly"
                     /gene_synonym="Calcyon; Drd1ip"
                     /inference="alignment:Splign:2.1.0"
     exon            466..818
                     /gene="Caly"
                     /gene_synonym="Calcyon; Drd1ip"
                     /inference="alignment:Splign:2.1.0"
     exon            819..972
                     /gene="Caly"
                     /gene_synonym="Calcyon; Drd1ip"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagcgtctg gaactgcatc ctccgcatcc acaccgcatc cctctcctcc cgcgactgcg
       61 tcctgcagca actgcctgct gggacaagga ccacccccca ccatggtgaa actaggctgc
      121 agcttctcag ggaagccagg caaggaaaca ggagaccagg atggggctgc catggacagt
      181 gtgcctctga tcagccccct ggatgtcagc cagcttcagc catcattccc tgaccaggtg
      241 gtcatcaaaa cacagacaga atatcaactt acctctgcgg accagccaaa gaagttcgca
      301 gatttggagg gtcagaggct ggcctgcagc cacccagagg aaggacgcag actgcccact
      361 gcaaggatga ttgcctttgc tatggcactt ctgggctgtg tgctgatcat gtacaaggcc
      421 atttggtatg accagttcac ctgcccagat ggcttcctac ttcggcacaa gatctgcacc
      481 ccactgaccc tggagatgta ctacaccgag atggaccccg aacgccaccg cagcatcctg
      541 gcagccatcg gggcctaccc actgagccgc aagcacggca ctgagatgcc cgccatctgg
      601 ggaaacagct accgggccgg caaggaggag cataagggca ccaccccagc tgcgatgact
      661 gtgtccactg cagctgcagc tgcagcggca gagggcaacg agccgtcagg gaagcctttg
      721 gacatgagag agaaagaaga tccgcagaag gcggaggatg tgccgtccca gtcccccaag
      781 tgactgtctg ccccgccccc gctctgccag tgactaggca tcccccacca gcttctttga
      841 catgcatact gcctgatgca tctccaccca gtgattgtgc tcctgcccca aagcacccca
      901 ctgaagtcac cccaccctgg tggacctctg gctctgttac ttttctttaa gtaaagactc
      961 acatctatct gaaaaaaaaa aaaaaaaaaa a
//
