LOCUS       NM_022535               3203 bp    mRNA    linear   ROD 06-DEC-2024
DEFINITION  Rattus norvegicus calumenin (Calu), transcript variant 1, mRNA.
ACCESSION   NM_022535
VERSION     NM_022535.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3203)
  AUTHORS   Meng,Z., Chen,Y., Wu,W., Yan,B., Meng,Y., Liang,Y., Yao,X. and
            Luo,J.
  TITLE     Exploring the Immune Infiltration Landscape and M2
            Macrophage-Related Biomarkers of Proliferative Diabetic Retinopathy
  JOURNAL   Front Endocrinol (Lausanne) 13, 841813 (2022)
   PUBMED   35692390
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3203)
  AUTHORS   Wang,Y., Cui,X., Wang,Y., Fu,Y., Guo,X., Long,J., Wei,C. and
            Zhao,M.
  TITLE     Protective effect of miR378* on doxorubicin-induced cardiomyocyte
            injury via calumenin
  JOURNAL   J Cell Physiol 233 (10), 6344-6351 (2018)
   PUBMED   29665007
  REMARK    GeneRIF: the above results indicate that miR378* alleviates ERS and
            inhibits the activation of the ERS-mediated apoptosis signaling
            pathway in cardiomyocytes via regulating calumenin expression,
            thereby reducing cardiomyocyte apoptosis after doxorubicin-induced
            injury
REFERENCE   3  (bases 1 to 3203)
  AUTHORS   Wang,Y., Xuan,L., Cui,X., Wang,Y., Chen,S., Wei,C. and Zhao,M.
  TITLE     Ibutilide treatment protects against ER stress induced apoptosis by
            regulating calumenin expression in tunicamycin treated
            cardiomyocytes
  JOURNAL   PLoS One 12 (4), e0173469 (2017)
   PUBMED   28399139
  REMARK    GeneRIF: Study suggests another cardioprotective effect of the
            antiarrhythmic agent ibutilide whereby pretreatment leads to the
            attenuation of endoplasmic reticulum stress induced apoptosis by
            regulating calumenin expression. This study provides further
            evidence for the role of calumenin in the cardiomyocyte endoplasmic
            reticulum stress response.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3203)
  AUTHORS   Lee,J.H., Kwon,E.J. and Kim,D.H.
  TITLE     Calumenin has a role in the alleviation of ER stress in neonatal
            rat cardiomyocytes
  JOURNAL   Biochem Biophys Res Commun 439 (3), 327-332 (2013)
   PUBMED   24012670
  REMARK    GeneRIF: Calumenin was upregulated by endoplasmic reticulum stress
            in neonatal rat ventricular cardiomyocytes.
REFERENCE   5  (bases 1 to 3203)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 3203)
  AUTHORS   Wajih,N., Sane,D.C., Hutson,S.M. and Wallin,R.
  TITLE     The inhibitory effect of calumenin on the vitamin K-dependent
            gamma-carboxylation system. Characterization of the system in
            normal and warfarin-resistant rats
  JOURNAL   J Biol Chem 279 (24), 25276-25283 (2004)
   PUBMED   15075329
REFERENCE   7  (bases 1 to 3203)
  AUTHORS   Hseu,M.J., Yen,C.H. and Tzeng,M.C.
  TITLE     Crocalbin: a new calcium-binding protein that is also a binding
            protein for crotoxin, a neurotoxic phospholipase A2
  JOURNAL   FEBS Lett 445 (2-3), 440-444 (1999)
   PUBMED   10094503
REFERENCE   8  (bases 1 to 3203)
  AUTHORS   Nakamura,T., Yabe,D., Kanazawa,N., Tashiro,K., Sasayama,S. and
            Honjo,T.
  TITLE     Molecular cloning, characterization, and chromosomal localization
            of FKBP23, a novel FK506-binding protein with Ca2+-binding ability
  JOURNAL   Genomics 54 (1), 89-98 (1998)
   PUBMED   9806833
REFERENCE   9  (bases 1 to 3203)
  AUTHORS   Yabe,D., Nakamura,T., Kanazawa,N., Tashiro,K. and Honjo,T.
  TITLE     Calumenin, a Ca2+-binding protein retained in the endoplasmic
            reticulum with a novel carboxyl-terminal sequence, HDEF
  JOURNAL   J Biol Chem 272 (29), 18232-18239 (1997)
   PUBMED   9218460
REFERENCE   10 (bases 1 to 3203)
  AUTHORS   Ozawa,M. and Muramatsu,T.
  TITLE     Reticulocalbin, a novel endoplasmic reticulum resident
            Ca(2+)-binding protein with multiple EF-hand motifs and a
            carboxyl-terminal HDEL sequence
  JOURNAL   J Biol Chem 268 (1), 699-705 (1993)
   PUBMED   8416973
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK476875.1 and BC101908.1.
            
            On Oct 12, 2007 this sequence version replaced NM_022535.1.
            
            Transcript Variant: This variant (1) encodes isoform a. Both
            isoforms are of the same length but differ in their internal aa
            sequence.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR8487231.18105.1,
                                           SRR8487227.144846.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-723               CK476875.1         22-744
            724-3203            BC101908.1         724-3203
FEATURES             Location/Qualifiers
     source          1..3203
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..3203
                     /gene="Calu"
                     /gene_synonym="Cbp50; Rcn"
                     /note="calumenin"
                     /db_xref="GeneID:64366"
                     /db_xref="RGD:620383"
     exon            1..34
                     /gene="Calu"
                     /gene_synonym="Cbp50; Rcn"
                     /inference="alignment:Splign:2.1.0"
     exon            35..265
                     /gene="Calu"
                     /gene_synonym="Cbp50; Rcn"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..992
                     /gene="Calu"
                     /gene_synonym="Cbp50; Rcn"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; CBP-50; crocalbin; reticulocalbin"
                     /codon_start=1
                     /product="calumenin isoform a precursor"
                     /protein_id="NP_071980.2"
                     /db_xref="GeneID:64366"
                     /db_xref="RGD:620383"
                     /translation="MDLRQFLMCLSLCTAFALSKPTEKKDRVHHEPQLSDKVHNDAQN
                     FDYDHDAFLGAEEAKSFDQLTPEESKERLGKIVNKIDGDKDGFVTVDELKGWIKFAQK
                     RWIHEDVERQWKGHDLNEDGLVSWEEYKNATYSYVLDDPDPDDGFNYKQMMVRDERRF
                     KMADKDGDLIATKEEFTAFLHPEEYDYMKDIVVQETMEDIDKNADGFIDLEEYIGDMY
                     SHDGNADEPEWVKTEREQFVEFRDKNRDGKMDKEETKDWILPSDYDHAEAEARHLVYE
                     SDQDKDGKLTKEEIVDKYDLFVGSQATDFGEALVRHDEF"
     exon            266..459
                     /gene="Calu"
                     /gene_synonym="Cbp50; Rcn"
                     /inference="alignment:Splign:2.1.0"
     exon            460..626
                     /gene="Calu"
                     /gene_synonym="Cbp50; Rcn"
                     /inference="alignment:Splign:2.1.0"
     exon            627..687
                     /gene="Calu"
                     /gene_synonym="Cbp50; Rcn"
                     /inference="alignment:Splign:2.1.0"
     exon            688..887
                     /gene="Calu"
                     /gene_synonym="Cbp50; Rcn"
                     /inference="alignment:Splign:2.1.0"
     exon            888..3167
                     /gene="Calu"
                     /gene_synonym="Cbp50; Rcn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacggaatcc tgcggcgtgg agctccgggg aaaagtcagt caccatggac ctgcgtcagt
       61 ttcttatgtg cctgtccctg tgcacggcct ttgctttgag caagcctaca gaaaagaagg
      121 accgagtaca ccatgaacct cagctcagcg acaaagttca caacgatgct cagaattttg
      181 actatgacca tgatgccttc ttgggagcag aagaggcaaa gagttttgat cagctgacac
      241 cagaagagag caaggaaagg cttggaaaga ttgtaaataa aatagatggc gacaaggatg
      301 ggtttgtcac tgtggatgaa ctcaaaggct ggattaagtt tgcacaaaag cgctggattc
      361 acgaggatgt agagcggcag tggaaggggc acgacctcaa tgaggatggc ctcgtttcct
      421 gggaggagta taaaaatgcc acctacagct acgttttaga tgatccagac cctgatgatg
      481 gatttaatta taaacagatg atggttagag atgagcggag gttcaaaatg gcagacaaag
      541 atggagacct aattgccaca aaggaggagt ttaccgcttt tctgcaccct gaggaatatg
      601 actacatgaa agacatagtc gtgcaggaaa ccatggagga tatagacaag aatgctgatg
      661 gttttattga tctagaagag tatattggtg acatgtacag tcatgatggg aatgctgatg
      721 aaccagagtg ggtgaagaca gagcgggagc agttcgttga gtttcgagat aagaaccggg
      781 atggaaagat ggacaaggaa gagaccaaag actggatcct cccttcagac tatgaccatg
      841 cagaggccga agccaggcat ctcgtctatg agtccgacca agacaaggat ggcaagctca
      901 ccaaggagga gattgtcgac aagtatgatt tatttgtggg cagccaggcc acagatttcg
      961 gggaggcctt agtacgacac gatgagttct aagctgcaaa cagaggagcc tacatttctt
     1021 caaaagtaat ttatttttac aggtctggtt tcacataaaa ttgtttgcgc tactgagact
     1081 gttattacaa actttttaag acgtgaaaag gcatatcgag atagtgaaat cacccgtccc
     1141 cattcctcct ccctctgagg ggctggaagg aacccatgct tctgaggaac aactctgatt
     1201 agtacacttg tgtctgtagg tttacacttt gtataatgta taacatggtg tgtttatttt
     1261 tgtattgttc tctagttggg agtataatat gaaggatgga gatcctcaac ccacacttgt
     1321 aggcatacat tagccattta cactttctca atcccttacc acattttttt tttaataatt
     1381 ctcacttaac taatttttta aagcctaaga tcaataagaa atgttcagga gagaaaaagc
     1441 agaaggaaag catgtacttc gtgatttacg ttcagagaga gaatgcttca tcttgcttgt
     1501 tgagaagtct catttcatga gtagctgttc agttgtcaca ggcccagcca cggagcctgc
     1561 cattgtctgg gcaaggacag agtcctccgc tgtaagacag cgtcacgcag ctccacttca
     1621 ctcttcccct caggactagc tgtttgctaa ttttgtcaag cacagctgtg gtaggaagaa
     1681 ttagggccca gtgtcttgaa aaatcaacca agtagtgtgt atgatgtctt cacagggcta
     1741 tttctagctc tttctagagc tgtttctaac cagaaacagc tggaaaacaa aaagaacaaa
     1801 gtgtatgcag ggcatgcatc tcattcttag tgaaatcact acaaggaccc atccagcccc
     1861 tttctaagtc ttaaccttgg ttttactgca gttaaaattg attcttttcc aatcatgaca
     1921 ttgaaagtgc ctttaacagg aaaaatggtc accgaatgag aattggacta agataaacga
     1981 tttgggcacc ttacgtgaaa gcattgaacc tcctgataca gaggggatcc cctccccgct
     2041 ttttctcttg tgaacaggaa ctaaatagca gtattagtta aagcttggtt gcagtgttct
     2101 tatcttgtgg gctggtttct aaaacctcat gctgctgatt tgaccaggga tcctcatacc
     2161 tcagatgcaa accactcttc taccgggcct ctgtttacca gagcttgagc tttgcctcaa
     2221 ggatagaagg ctgtacagag gggctctttg gtttgaggac cactgctcac ccttcctgtc
     2281 attaacctgt cacaccccat tttatcatct ccctttctct ctgacacaca aaggtggggt
     2341 aggtgggagg gtcgtggatt attcttatta aaaaacaaaa tcatctgttg ccaaccccat
     2401 ttacccatct ttggtctctt actgatgggc ctcttaagaa ttattgtatt ccaagtcttt
     2461 aaccctcagg ttactaaggt aaatatacat ctgcacagtc tttattactt cctgtatctc
     2521 tgagtaatac attcagctgg tgctgggtga tggtcatatc tgaacctaga cctccccgtt
     2581 ggtcttccac aatcctgttg aggtgggctg cttggtgtgg taaaaagccc agtcgtggtg
     2641 taactttacc ttggcgattg catcaagctc ttgatagcag atacactcta aggttttagc
     2701 cccagtagag gtgtaatgaa catccctcac tgccttccag atcctcaact ctccattgtt
     2761 aaggagacca gagataatta atgccaccaa ccctggctta gaaagggtac gtcatacact
     2821 gtgtggcaag agggcattac agagcctaac gctggcgtga aaatcatgta cttagccagc
     2881 aagtgagtct gcgagggtgg cgtagtctgg acagggtgct cagcatcggg aactgtgctc
     2941 tcaggtccat aagctccaca tagtgttggg gtttgggttt gggtttctgg ttgaaatcaa
     3001 gtttgaggca gtgagcagtg gtctcatgtc tatagagtgt gccctgtgaa tgctaagctc
     3061 tcttgaattt gagtatttgt tcttttttta tagagtgtaa accaagtttt atattctgta
     3121 atgcaaacag gtacctgtct gtttctgaat aaaactgttt acattcaaaa aaaaaaaaaa
     3181 aaaaaaaaaa aaaaaaaaaa aaa
//
