LOCUS       NM_022399               1865 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus calreticulin (Calr), mRNA.
ACCESSION   NM_022399
VERSION     NM_022399.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1865)
  AUTHORS   Yoshie,M., Kusama,K., Tanaka,R., Okubo,T., Kojima,J., Takaesu,Y.,
            Isaka,K., Nishi,H. and Tamura,K.
  TITLE     Possible Roles of Calreticulin in Uterine Decidualization and
            Receptivity in Rats and Humans
  JOURNAL   Int J Mol Sci 22 (19), 10505 (2021)
   PUBMED   34638846
  REMARK    GeneRIF: Possible Roles of Calreticulin in Uterine Decidualization
            and Receptivity in Rats and Humans.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1865)
  AUTHORS   Ye,J., Qi,L., Du,Z., Yu,L., Chen,K., Li,R., Feng,R. and Zhai,W.
  TITLE     Calreticulin: a potential diagnostic and therapeutic biomarker in
            gallbladder cancer
  JOURNAL   Aging (Albany NY) 13 (4), 5607-5620 (2021)
   PUBMED   33591948
REFERENCE   3  (bases 1 to 1865)
  AUTHORS   Gurth,C.M., Dankovich,T.M., Rizzoli,S.O. and D'Este,E.
  TITLE     Synaptic activity and strength are reflected by changes in the
            post-synaptic secretory pathway
  JOURNAL   Sci Rep 10 (1), 20576 (2020)
   PUBMED   33239744
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1865)
  AUTHORS   Sheng,W., Wang,G., Tang,J., Shi,X., Cao,R., Sun,J., Lin,Y.H.,
            Jia,C., Chen,C., Zhou,J. and Dong,M.
  TITLE     Calreticulin promotes EMT in pancreatic cancer via mediating Ca2+
            dependent acute and chronic endoplasmic reticulum stress
  JOURNAL   J Exp Clin Cancer Res 39 (1), 209 (2020)
   PUBMED   33028359
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1865)
  AUTHORS   Zhang,X., Wang,D., Li,Z., Jiao,D., Jin,L., Cong,J., Zheng,X. and
            Xu,L.
  TITLE     Low-Dose Gemcitabine Treatment Enhances Immunogenicity and Natural
            Killer Cell-Driven Tumor Immunity in Lung Cancer
  JOURNAL   Front Immunol 11, 331 (2020)
   PUBMED   32161598
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1865)
  AUTHORS   Nakamura,M., Michikawa,Y., Baba,T., Okinaga,S. and Arai,K.
  TITLE     Calreticulin is present in the acrosome of spermatids of rat testis
  JOURNAL   Biochem Biophys Res Commun 186 (2), 668-673 (1992)
   PUBMED   1497655
REFERENCE   7  (bases 1 to 1865)
  AUTHORS   Rojiani,M.V., Finlay,B.B., Gray,V. and Dedhar,S.
  TITLE     In vitro interaction of a polypeptide homologous to human Ro/SS-A
            antigen (calreticulin) with a highly conserved amino acid sequence
            in the cytoplasmic domain of integrin alpha subunits
  JOURNAL   Biochemistry 30 (41), 9859-9866 (1991)
   PUBMED   1911778
REFERENCE   8  (bases 1 to 1865)
  AUTHORS   Treves,S., De Mattei,M., Landfredi,M., Villa,A., Green,N.M.,
            MacLennan,D.H., Meldolesi,J. and Pozzan,T.
  TITLE     Calreticulin is a candidate for a calsequestrin-like function in
            Ca2(+)-storage compartments (calciosomes) of liver and brain
  JOURNAL   Biochem J 271 (2), 473-480 (1990)
   PUBMED   2241926
REFERENCE   9  (bases 1 to 1865)
  AUTHORS   Murthy,K.K., Banville,D., Srikant,C.B., Carrier,F., Holmes,C.,
            Bell,A. and Patel,Y.C.
  TITLE     Structural homology between the rat calreticulin gene product and
            the Onchocerca volvulus antigen Ral-1
  JOURNAL   Nucleic Acids Res 18 (16), 4933 (1990)
   PUBMED   2395661
REFERENCE   10 (bases 1 to 1865)
  AUTHORS   Tuan,R.S. and Cavanaugh,S.T.
  TITLE     Identification and characterization of a calcium-binding protein in
            the mouse chorioallantoic placenta
  JOURNAL   Biochem J 233 (1), 41-49 (1986)
   PUBMED   3513762
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU671467.1, BC062395.1 and AW672583.1.
            
            On Jan 24, 2008 this sequence version replaced NM_022399.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D78308.1, FQ210587.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                BU671467.1         1-23
            24-1863             BC062395.1         1-1840
            1864-1865           AW672583.1         365-366
FEATURES             Location/Qualifiers
     source          1..1865
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q11"
     gene            1..1865
                     /gene="Calr"
                     /note="calreticulin"
                     /db_xref="GeneID:64202"
                     /db_xref="RGD:620288"
     exon            1..154
                     /gene="Calr"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1314
                     /gene="Calr"
                     /note="CABP3; CALBP; CRP55; ERp60; HACBP; calregulin;
                     calcium-binding protein 3; endoplasmic reticulum resident
                     protein 60"
                     /codon_start=1
                     /product="calreticulin precursor"
                     /protein_id="NP_071794.1"
                     /db_xref="GeneID:64202"
                     /db_xref="RGD:620288"
                     /translation="MLLSVPLLLGLLGLAAADPAIYFKEQFLDGDAWTNRWVESKHKS
                     DFGKFVLSSGKFYGDQEKDKGLQTSQDARFYALSARFEPFSNKGQTLVVQFTVKHEQN
                     IDCGGGYVKLFPGGLDQKDMHGDSEYNIMFGPDICGPGTKKVHVIFNYKGKNVLINKD
                     IRCKDDEFTHLYTLIVRPDNTYEVKIDNSQVESGSLEDDWDFLPPKKIKDPDAAKPED
                     WDERAKIDDPTDSKPEDWDKPEHIPDPDAKKPEDWDEEMDGEWEPPVIQNPEYKGEWK
                     PRQIDNPDYKGTWIHPEIDNPEYSPDANIYAYDSFAVLGLDLWQVKSGTIFDNFLITN
                     DEAYAEEFGNETWGVTKAAEKQMKDKQDEEQRLKEEEEDKKRKEEEEAEDKEDEDDRD
                     EDEDEEDEKEEDEEDATGQAKDEL"
     exon            155..256
                     /gene="Calr"
                     /inference="alignment:Splign:2.1.0"
     exon            257..460
                     /gene="Calr"
                     /inference="alignment:Splign:2.1.0"
     exon            461..555
                     /gene="Calr"
                     /inference="alignment:Splign:2.1.0"
     exon            556..765
                     /gene="Calr"
                     /inference="alignment:Splign:2.1.0"
     exon            766..879
                     /gene="Calr"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1023
                     /gene="Calr"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1116
                     /gene="Calr"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1865
                     /gene="Calr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcagagccg ctgcttgaag atcgttttaa agggccagtg tgccgccgcc ccctcggccc
       61 gccatgctcc tttcggtgcc gctcctgctt ggcctcctcg gcctggctgc cgcagaccct
      121 gccatctatt tcaaagagca gttcttggac ggagatgcct ggaccaaccg ctgggtcgaa
      181 tccaaacata agtctgattt tggcaaattc gtcctcagtt ctggcaaatt ctacggggac
      241 caggagaagg ataaagggtt gcagacaagc caagatgccc gattttacgc gctgtccgcc
      301 agattcgaac ccttcagcaa caagggccag acactggtgg tacagttcac cgtgaagcat
      361 gagcagaata tcgactgtgg gggcggctac gtgaagctgt ttccgggtgg cttggaccag
      421 aaggacatgc atggagactc agaatataac atcatgtttg gtccggacat ctgcggtcct
      481 ggcaccaaga aggttcatgt catctttaac tacaagggca agaacgtgct gatcaacaag
      541 gatatccggt gtaaggatga tgaattcaca catctataca cgctgattgt gcggccagac
      601 aacacctacg aggtgaaaat tgacaacagc caggtggagt cgggctcctt ggaggatgat
      661 tgggactttc tgccgcccaa gaagattaag gatcctgacg ctgccaagcc agaagactgg
      721 gatgaacgag ccaagattga tgaccccaca gattccaagc ctgaggactg ggacaagcca
      781 gagcacatcc ctgaccctga tgctaagaag cctgaggact gggacgaaga gatggatgga
      841 gagtgggaac caccagtgat tcaaaatcct gaatacaagg gcgaatggaa gccacgtcaa
      901 attgacaacc cagattacaa gggtacctgg atacacccag agattgacaa tcctgaatac
      961 tcccccgatg cgaatatcta tgcctatgat agttttgctg tactgggctt agacctctgg
     1021 caggtcaagt ctggcacaat ttttgacaac ttcctcatca ccaatgatga ggcctatgca
     1081 gaggagtttg gcaatgagac ctggggtgtc accaaggctg cagagaagca gatgaaggac
     1141 aagcaggatg aggagcagag gcttaaggaa gaagaagaag acaagaagcg taaagaggaa
     1201 gaggaggccg aggataaaga ggatgaggat gacagagatg aagatgaaga tgaagaggat
     1261 gagaaggaag aagatgagga ggatgccact ggccaagcca aggatgagct gtagaggcca
     1321 caccacctgc ctccagggct ggactgaggc ctgaacaccc cgccacagag ctggctgctc
     1381 ccaataatgt ctctatgaga ctcaagaact tttcattttt tttccaggca ggttcaggtc
     1441 tggggtggat tctgattttt gttcccctgc ctccccatcc tccccacccc cctttttttt
     1501 ttactggtgt ttgtctttaa ttcttcagcc ctcacctcct ggcctctcat ttttgaatca
     1561 acattttttc tttctgtccc tttctccatc tcttggtcac tatcctccaa ctctaggaac
     1621 aggtatggag gaaaagccct aggcttgaga tttcatctgc tctcctttct gaatctcaga
     1681 ggagggtagg agaagggggt ggtatcttcc ctccccccag cactgaggaa gaatggggct
     1741 cttccccttt ctcccttgcc cccaggactg ggccatttgt ggggcagcca gttctagcac
     1801 agctcacact gagagtgtaa gaactacaaa caaaatttct attaaattaa gttttgtgtc
     1861 ttccc
//
