LOCUS       NM_001077201            9088 bp    mRNA    linear   ROD 18-FEB-2024
DEFINITION  Rattus norvegicus calneuron 1 (Caln1), mRNA.
ACCESSION   NM_001077201 XM_001071918 XM_039089629 XM_344102
VERSION     NM_001077201.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 9088)
  AUTHORS   Hradsky,J., Bernstein,H.G., Marunde,M., Mikhaylova,M. and
            Kreutz,M.R.
  TITLE     Alternative splicing, expression and cellular localization of
            Calneuron-1 in the rat and human brain
  JOURNAL   J Histochem Cytochem 63 (10), 793-804 (2015)
   PUBMED   26116628
  REMARK    GeneRIF: The protein is most abundant in Purkinje cells of the
            cerebellum and principal neurons of the cortex and limbic brain
            whereas no expression in glial cells is apparent.
REFERENCE   2  (bases 1 to 9088)
  AUTHORS   Hisamitsu,T., Nakamura,T.Y. and Wakabayashi,S.
  TITLE     Na(+)/H(+) exchanger 1 directly binds to calcineurin A and
            activates downstream NFAT signaling, leading to cardiomyocyte
            hypertrophy
  JOURNAL   Mol Cell Biol 32 (16), 3265-3280 (2012)
   PUBMED   22688515
  REMARK    GeneRIF: NHE1 directly binds to calcineurin A and activates
            downstream NFAT signaling, leading to cardiomyocyte hypertrophy
REFERENCE   3  (bases 1 to 9088)
  AUTHORS   Shih,P.Y., Lin,C.L., Cheng,P.W., Liao,J.H. and Pan,C.Y.
  TITLE     Calneuron I inhibits Ca(2+) channel activity in bovine chromaffin
            cells
  JOURNAL   Biochem Biophys Res Commun 388 (3), 549-553 (2009)
   PUBMED   19682431
  REMARK    GeneRIF: These results suggest that CalnI attenuates Ca(2+) channel
            activity and that its subcellular localization is important for
            this effect.
REFERENCE   4  (bases 1 to 9088)
  AUTHORS   Mikhaylova,M., Reddy,P.P., Munsch,T., Landgraf,P., Suman,S.K.,
            Smalla,K.H., Gundelfinger,E.D., Sharma,Y. and Kreutz,M.R.
  TITLE     Calneurons provide a calcium threshold for trans-Golgi network to
            plasma membrane trafficking
  JOURNAL   Proc Natl Acad Sci U S A 106 (22), 9093-9098 (2009)
   PUBMED   19458041
  REMARK    GeneRIF: calneuron-1 and calneuron-2 physically associate with
            PI-4Kbeta, inhibit the enzyme profoundly at resting and low calcium
            levels, and negatively interfere with Golgi-to-plasma membrane
            trafficking.
REFERENCE   5  (bases 1 to 9088)
  AUTHORS   McCue,H.V., Burgoyne,R.D. and Haynes,L.P.
  TITLE     Membrane targeting of the EF-hand containing calcium-sensing
            proteins CaBP7 and CaBP8
  JOURNAL   Biochem Biophys Res Commun 380 (4), 825-831 (2009)
   PUBMED   19338761
REFERENCE   6  (bases 1 to 9088)
  AUTHORS   Mikhaylova,M., Sharma,Y., Reissner,C., Nagel,F., Aravind,P.,
            Rajini,B., Smalla,K.H., Gundelfinger,E.D. and Kreutz,M.R.
  TITLE     Neuronal Ca2+ signaling via caldendrin and calneurons
  JOURNAL   Biochim Biophys Acta 1763 (11), 1229-1237 (2006)
   PUBMED   17055077
  REMARK    GeneRIF: Calneurons have a different EF-hand organization than
            other calcium sensor proteins, are prominently expressed in neurons
            and will presumably bind Ca2+ with higher affinity than caldendrin.
            Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000227.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001077201.3.
            
            On or before Nov 3, 2022 this sequence version replaced
            XM_039089629.1, NM_001077201.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: DQ914830.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA5756307,
                                    SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-198               JACYVU010000227.1  7572864-7573061     c
            199-388             JACYVU010000227.1  7523692-7523881     c
            389-513             JACYVU010000227.1  7435560-7435684     c
            514-657             JACYVU010000227.1  7318182-7318325     c
            658-770             JACYVU010000227.1  7263236-7263348     c
            771-927             JACYVU010000227.1  7108187-7108343     c
            928-9088            JACYVU010000227.1  7081483-7089643     c
FEATURES             Location/Qualifiers
     source          1..9088
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..9088
                     /gene="Caln1"
                     /note="calneuron 1"
                     /db_xref="GeneID:363909"
                     /db_xref="RGD:1305843"
     exon            1..198
                     /gene="Caln1"
                     /inference="alignment:Splign:2.1.0"
     exon            199..388
                     /gene="Caln1"
                     /inference="alignment:Splign:2.1.0"
     CDS             270..1055
                     /gene="Caln1"
                     /note="caBP8; calneuron I"
                     /codon_start=1
                     /product="calcium-binding protein 8"
                     /protein_id="NP_001070669.1"
                     /db_xref="GeneID:363909"
                     /db_xref="RGD:1305843"
                     /translation="MRLPEQPGDGKPENETKGDQETPERGEEPRRSPAPDFPTWEKMP
                     FHHVTAGLLYKGNYLNRSLSAGSDSEQLANISVEELDEIREAFRVLDRDGNGFISKQE
                     LGMAMRSLGYMPSEVELAIIMQRLDMDGDGQVDFDEFMTILGPKLVSSEGRDGFLGNT
                     IDSIFWQFDMQRVTLEELKHILYHAFRDHLTMKDIENIIINEEESLNETSGNCQTEFE
                     GVHSQKQNRQTCVRKSLICAFAMAFIISVMLIAANQILRSGME"
     exon            389..513
                     /gene="Caln1"
                     /inference="alignment:Splign:2.1.0"
     exon            514..657
                     /gene="Caln1"
                     /inference="alignment:Splign:2.1.0"
     exon            658..770
                     /gene="Caln1"
                     /inference="alignment:Splign:2.1.0"
     exon            771..927
                     /gene="Caln1"
                     /inference="alignment:Splign:2.1.0"
     exon            928..9088
                     /gene="Caln1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acatgcttcc ctgacccaca gttggaccgg gcattgtagc cagggtccgt cgcacttttc
       61 ggtggtctgc acggactgag ccaactcggt gtggacgatc tcctggctgt ggctgtgtgg
      121 ctagtccacc tttgcagttc cagtagtcag actggagtct ctttggaagc agctctaagg
      181 aatacaccag gatctcagag tctcaatgtc ttcgctgacg ctcctttgat gtacccccaa
      241 atctctgacc acatcaccct ggacccccga tgcggctgcc tgagcaacct ggagatggaa
      301 agcctgagaa tgagacaaag ggggaccaag aaacccccga aaggggagag gagccacgga
      361 gaagcccagc ccctgacttc cccacctggg aaaagatgcc gttccaccat gtaactgctg
      421 gcttgttgta caaggggaat tacctcaacc gatctctgtc tgcaggcagc gacagtgagc
      481 agttggctaa tatctctgtg gaagaactcg atgaaatccg agaagccttc cgtgttctgg
      541 acagagatgg gaacggcttc atctctaagc aggagctggg catggcgatg cgttctttgg
      601 ggtacatgcc aagcgaagtg gaactggcta tcatcatgca gcgcctggac atggacggag
      661 atgggcaggt agattttgat gaattcatga cgattcttgg acccaagctg gtatcatccg
      721 aaggtcgaga tggttttctt ggaaatacga tagacagtat cttctggcag ttcgacatgc
      781 agagagtcac tctggaagag ctgaagcata tcctgtacca tgccttccgg gatcacttaa
      841 caatgaagga cattgagaac attattatca acgaggagga gagtttgaac gagacctcgg
      901 ggaactgcca gacagagttt gaaggagtcc attcgcagaa acagaaccgg cagacctgcg
      961 tccgcaagag cctcatatgc gcctttgcca tggcctttat cataagcgtc atgctgatcg
     1021 cagccaacca gatcctgcgg agcggcatgg agtagcagtc tcccaccagc cacaccgcgt
     1081 tgccagctca ccgcgcatgt gcatgccccg cgggcagact ctgttccttc acacaggaga
     1141 tctggacctt tggatggatg caagcgttgg taccgttcaa taaaaactcg agtttgcagt
     1201 gcaaccgggc tcacggatca actccatctc cttggcaggg acacaaaagg gctgtcttca
     1261 atgctttcat ggttttgttt cccaatgcaa taaatagcca ggagctctca gttattgctt
     1321 caaccgccag taacaactct gaagcaaggg ggaaaaaata ctgctttctt ttcgtcttgg
     1381 aattccagta gccatccaga tatcatggtg gcatctgagg gcgagaaaga aagacagacg
     1441 tgagtaacag tcacctccat ccatgaccca attctttcaa cccagggatg cattgagact
     1501 ccctgctgaa gttgacttct gggttgctac agaaaagggg actttccatc tcaccctggc
     1561 ttcctgcctc cacccagtgg agacccctcc caccaaggca cggaggggga aagccattaa
     1621 gcagggcgca actcctttgc agtccccgct gctgttctta atcgcctttt ctacaggact
     1681 cttgtcggta gagctggggc actctcggtt ggtttccacg gctcttggct ttctgtttct
     1741 gaagtccatc ccgcaccagc atcttggaat ctgcagagag cctggctccc agctttcttg
     1801 cctgtgccgc cattagagaa aaaaaagaaa aagaaaaaat attccataac ctgtgtgtct
     1861 ctataaccca gacacgtaga cagacagggg acttttctgt gtaatgctgt ttttcccaaa
     1921 ttgcttactt tggacatgaa cttgttctct atctcacacc tgtctgtgct tctttagaga
     1981 aaaggatgca gtaactaggg tagaggaagg aatgagtctg gcagtgagga ggcctagacc
     2041 ccaggcatct gaagtaacag agccgctccg agtcgccata tttgataata tctgtaactt
     2101 tagattggtg tacatctaac cttcccctca tcgtggactt tattagtgag cctttcccca
     2161 gctaaggaaa ggacacctag aacttgaagc aaaaagatgg aaggatcaga ttgctgtgtt
     2221 ttgcttaata actcatgaaa ttcaggttgt gctgatgact cattaaaaaa aaaaaaaaag
     2281 acagatgcta atgcgcgtgg ctgatagggc agagacttga tcgctgttct gatcccagaa
     2341 cacttccact ggggcagaga actgaatatc tgggtctgaa tttagtggca ggccaagact
     2401 ctcatttctt caagatttcc tggattcact atgaatttaa gccccactgg tcggatttag
     2461 ctagtcctct atagacgtgc taactccctt tgtgtttttc tcaccctaag tctttatttc
     2521 tgtaacgaaa ttgtcctgtt ctaacttcgg atctcagctg gaagatcccc aattcccctt
     2581 ccccttcccc ttccccttcg ccctccgcct ccgcctccgc ctccccctcc ccctccccct
     2641 ccccctcacc ctcaccctca ccctcaccct caccctcccc acttcctcca gccacacaga
     2701 ggtactggcg gcgttgctgt tgctttctat gttctgctgg gtaggtgttt atggtgcgat
     2761 gcatattcct ctagcctact tcccccgctc tgctccctcc ttactccctt cttagacctg
     2821 gatcacgcaa ggtctccaca tagggtcttc ctccagttca cctctacctg tgctccatgc
     2881 agtagtatgg ggacagctct agcaattttc cctctgtaga gtgtgaatat tcaccaagag
     2941 cacaagtcaa actaggtttg agccatagca tactgaggaa ggagcaggtc ggaggtccca
     3001 agacgcccga ggggcacaga gtcacttcgt aaaactgtct ggagtctaaa acatccgggc
     3061 agcagcctgc cttcctttct tccggtgccc tttgcaaacc tgcccgtttt tgttccttct
     3121 gtaggctgag tcaccacggt ccccttagga ccagactcct gaactagaat aagtagagac
     3181 acagaatatt aatagactgc ccaacatccc accccttcag tttcttcctg gggcaattgc
     3241 cttctctctg ccagctgtgt ataagaaggc aagcatggtt ggtggcaacg tgtttcccta
     3301 taatcagctg acgtttgaac ttccaaactg ccccccctcc ccggaatctg gtgagcggat
     3361 ctagaaagtg cagggcttta aggacccgaa agcagcggat acggtgccac aagtgagatt
     3421 ggcgctcaag gtggaacata agggcttctt cgaatgttgc ttttctccaa gctctgcccc
     3481 atactgaaga atgctgatcc cacaagatgc agggtttaga tttcatcagc aatgagcaga
     3541 gatgtgatga aagcccgttt cctactgatg ggacactgcg tgacaggtct cgcgtgggag
     3601 ggtttttatt aaagaggaag ggggcacaga atgggttctg gatgaaagaa gaagagagtg
     3661 ggggaaggga gaacgtggct tttactggcg ctgcgcaagg ggccctgcaa cgaccggcga
     3721 aagatagtga tggcgtcttg tcgtgaggtc cctcaaaagc tggctgtaaa gatgcctgat
     3781 ggccgcggag tcacttttgg ctgtcgtgga tgtgcctgat tgcgaatatc tacaagggcg
     3841 tgagcacctt ctcccaatat tatggaagga aagacaggaa agaagtcatc agattccctc
     3901 tgacagccca taaattaatt tcccagcacc ctcctcatct gaggcacaca ggaactgaat
     3961 gcatcagtgc aggaagtctg ggctagtggt gacctttaga cttggagggc taaaagtctg
     4021 ctaaggtggc ctaccctctg gctgctttgc ttgtgttaag tctttgatat atttatggtg
     4081 tttgggcttc tttttcaggc agccctattg tcaggcctgt tcacataagt gctaccccaa
     4141 ggttccctgt caccaacatc ctcatgacag taattgggga ggagttggtt ggctgatggt
     4201 tccagaaagt tctgcttcct catgctcaag gaaagccata cacgagcagc tgagacaccc
     4261 tctgaaggag aggcaggagg ccttttctgc cttgcctgtg actggactta ggaaatggtg
     4321 acagaggctg gccagccatg ggatgactca gtaactggct cattcttgct cccagctcag
     4381 gtccacatcc ccagaccttc gtgagtgaca gacaccagga cagcaattta cctgggacag
     4441 aaagacaagc tgattctgaa cccctttgct tccaaacaaa tcgttcccct cgctgtccca
     4501 gatgtcgact ggaactgtta acggaggttc ccagaatgtg tgcaagttcc ttgtgagagc
     4561 tataagaggt tgccatagca accattgcat ctaccctgag tttgtcaagg cacagaggga
     4621 acacttaaag aacctagacc ctacctgcct gcactacgac tcccagactc catctcctgc
     4681 tgagatggga aattaacctc caataattgt atggcttccc tgcctttttc ctattgtatt
     4741 gaatgtgtct gtcccctccc cccaactcag gagaaaatga gtcagcctcc tcagctctac
     4801 tcttatctca cctcccagaa caagactctc tacatatcag gggcaataaa accaccccaa
     4861 atcacctggc aggcaaaaac cacaaaaagg aagcctgctg tctttaaaag tatctgcttg
     4921 cttgccgagc tcctccatcc agaaagccaa aactatgaac agaggtgagc taggattctc
     4981 attgaattct tgggcaacct cagtgattgt gggaagttct aggtggtgaa tatgcagaga
     5041 ctggagcctc tccctaggcg tcttccatgc ctgctcctat ctcaaagttt atatgagaag
     5101 tggtctagta tttgaaagaa tgggatagaa aaagaaaaca aaagaaagaa aatggggaaa
     5161 agggtgcctg tgttgagagc ctctctccta gcctgcagtc actgactctc agtgtaattg
     5221 gagaatctaa gagcagggag agagacagct ggcttttatt gcaaactcct cctatgggct
     5281 caagtccaga ctcaggtcat aaatcaaaga acattgtgta cattgcttct ttggatctga
     5341 gactggtagt gtccctgggc tcctatgagg gcatcatcag aagatgaaca aggtgactgt
     5401 tggggatgct ttctggatgg ggaatgactt ggctatgcct ggccgcatgt tgtgtgtgga
     5461 actgtttcct cgcgttccct cggtttctct ctttgtagaa agtgctaagt tttgtacctc
     5521 aaagcatact aggtcatgtc tctatactat attcctaaag gtccacagct accctaatct
     5581 accctgttac ctaagatcca cagagagtct ggaaccttgt tgtgaaaagg gtccttattt
     5641 ttatataatg ctatgaagag gatgcaggtg agctccgatg aatcttctag actttggcac
     5701 atactgtttc tatgacccgg aggtccacag aatcccgctc cctgggaagc atccatcctg
     5761 tagggctgag agtccagaac tcacagccac tttccctccc tccacactga ctccttgact
     5821 cccctcctcc acaagaagaa aaaaaaaatc ccatttctgg aatagaagag ctatgcagcc
     5881 attagagttt ttaatttgaa ttatttatag tcagaataga catgaataga atgagaagct
     5941 aggccacctc gtcttgtccc catcccccat gatcatgtaa atgtcacagt tgcttaactt
     6001 catgccatct gcacttggac taactcactc aggggactgt tctcaactat gtgaccttgc
     6061 cacagtaggt ttggaggaag ggggtcaggt gtaccaggtg tactaactaa accttctctt
     6121 aggatcctat gctcgcagaa gcataccgtc atgttaacat aaatcgttta tatttaatac
     6181 tggttctaat ctaaaatacc acaaagaatg attggttccg ttagatgtgg gagaacatgc
     6241 ttttaattcc cggcacttgg caaactgagg caggagcatt gaagtccaac atctgcctgg
     6301 actgtggagc aagttcaagg gcagcctgag tcccatggtg aagtttcagg caagcctgga
     6361 ctacatacag agttctgggc tagcatgagc taacatagtg ggactccttc ctactaaaag
     6421 aaaaaaagaa tcagtttttt tcccccagtt gcacgaaaca gatccctgta cctcaacatt
     6481 acctgcctag ctatcttgga taatttgtca actggggaca ccccacatgc tggacatggg
     6541 gtcacccttt ccttccggca gggtatcttg gcttttgaac cagtgctttc tttataagtt
     6601 gtcagaagtt atccaagcag gagtagtggg gtataactat catcctagga gttcaaggtc
     6661 atcctcttct actagcagca cacacacact cacacataca cacacacaca cactcacaca
     6721 tacacacaca tacacacact cacacataca cacacataca cacactcaca catacacaca
     6781 catacacaca tacacataca cacacatact cgcacacaca tacacacaca tacacacaca
     6841 tacacacaca cacacacaca cacacacaca gagtgacaca gtgggggtag gggtagggag
     6901 aaggagggag ttctctaaat ggaaggaggc agaggctaga attttccaga aagtagattc
     6961 attgggagag actatatcag ggaatgtagt ttcacccaga atgtttgctc catcctggga
     7021 cctgacagag atcaagtttt taaagggctg atagatgctg gtccctgttt gtctggccta
     7081 ctttaagaat ggccaaggga tgcactgtca ggcactgtct atcaacatgc tcccaccaca
     7141 gctctgtgga tgccaatagg agattagtac ctcccctgag tggatgctga ccccctacaa
     7201 gcccagcatg ccttgcctga ggctctgaga cctgtgaaca ggggccagaa agcagaatag
     7261 aaaaaaaacc caagcgtttt tctatttggg aagggcactg tcattttgga agggcaccag
     7321 aaataggact cttgctgctg gaagccaggg aaaatatata cgttcctaat ggaaaggatt
     7381 gagggtcgca tcacacaggg gtgcaagcta gttttgtgac atgagtttgg tgacgtgttt
     7441 tctttttggg gcccactgtt tcccggccaa tgtgtcacct gtcacacagg ttagtgaggc
     7501 tttcgtttat tccctaaaag cttgctgaat caagatgagc tttcatgtcc ttgtcttggc
     7561 cagcctgaaa aagaaggaga tttggtcccc tagatgaagg tcccatggac tctgaatcca
     7621 tgagtcagta ggttgaaaca aaagccagat tccctggaaa ccatgttccc tgaatccatc
     7681 cgaggatgct taattggaaa ccttccaaat acaggatgga cacaccctgc tttgtcaccc
     7741 cccccccccc cactaccaca ttgctttctc cctggacact gaatgtagca gccgttcaag
     7801 cacacgtggt cctggcttgg aatcattcat aattctagag aagatagaaa gccgcatctc
     7861 taatgactgc caggaagtgg atgagaagtc cgggatgtag gaccagcgac ctgcagctgt
     7921 tcttagatag ccagagacta gcgccggaca catgtttgtc gtagctgtgt tcccaccata
     7981 gcaagagaca cgggcagaga gggagcagca acagggtccc caagtctttg tctcttcttc
     8041 ttcatttcac ctcagagcct gtttgagcca ggcatggtgg catgcggtcc cagcacatgg
     8101 gaggcagagg caggaagaac gtgttgagtt agagagcaga ctgggctaca tggtgagtgc
     8161 cgggccagcc ggggctacag tgtaagatct tgtctcctaa acaatacaaa gaaaacaata
     8221 aaattctact tcctgccctc agttcctgct tcctgaagca gcccgaggtc tagtcaatgt
     8281 tcacaggcaa accacatcgt tcttcccgga gaagacgggt ctagagaaag gtctctctca
     8341 gctcctgatt acaagttcac atagatgggg gactcggagt aatccttagg gaactctcca
     8401 ttgactcctc accggcagtt tggtttctct tccacaagtt cagaaagaag ttaattgtcc
     8461 aagacaaagc catggtgatg ctcgtgaaag ccattcagac tccaaaagtc tggtcctgcc
     8521 aggtgtgggc gagctgtggt cctcgggcga gtacaggtca ttaacttatt ctcaaagcac
     8581 agatgtaaat gtctgggatt taaaccctac gcacagggtg actctgaagc acaggtaaag
     8641 actgttctaa tcaggagctt cttgcctctt tcttccagaa tgttccagtc ggatgtcaat
     8701 catgcatctc aatttcccat tgtacctcat ttgtattctt tggggggggg gttcgtttat
     8761 ttttcccccc tcatttagcg ttagttggtg attttctgct attaagtggt gagacagcag
     8821 gttagtgaaa taaagaaaaa tatctttata tcaagtgtaa atattaacct acatgaactt
     8881 ggcatgcaac ttaagtgacc caatgaagcg atattattaa catgttatct tactgtataa
     8941 agggaaaatg gttgccatat atgtacccga tgttttctgt aactaaactt gtctgtaaat
     9001 atataatctt atttaaaaaa agagtctaat ttaccattat ttatgcaata gaaaaaaata
     9061 aaagttcttt tttttttctt ccttttga
//
