LOCUS       NP_036650                149 aa            linear   ROD 03-APR-2024
DEFINITION  calmodulin-3 [Rattus norvegicus].
ACCESSION   NP_036650
VERSION     NP_036650.1
DBSOURCE    REFSEQ: accession NM_012518.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 149)
  AUTHORS   Sharangdhar,T., Sugimoto,Y., Heraud-Farlow,J., Fernandez-Moya,S.M.,
            Ehses,J., Ruiz de Los Mozos,I., Ule,J. and Kiebler,M.A.
  TITLE     A retained intron in the 3'-UTR of Calm3 mRNA mediates its
            Staufen2- and activity-dependent localization to neuronal dendrites
  JOURNAL   EMBO Rep 18 (10), 1762-1774 (2017)
   PUBMED   28765142
  REMARK    GeneRIF: results identify the retained intron as a critical element
            in recruiting Stau2, which then allows for the localization of
            Calm3L mRNA to distal dendrites
REFERENCE   2  (residues 1 to 149)
  AUTHORS   Boczek,T., Lisek,M., Ferenc,B. and Zylinska,L.
  TITLE     Cross talk among PMCA, calcineurin and NFAT transcription factors
            in control of calmodulin gene expression in differentiating PC12
            cells
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1860 (4), 502-515 (2017)
   PUBMED   28153703
  REMARK    GeneRIF: higher occupancy of Calm2 and Calm3 promoters by NFATc2
            and increased expression of these genes in response to NFATc2
            silencing were demonstrated in PMCA2 and PMCA3-reduced lines.
REFERENCE   3  (residues 1 to 149)
  AUTHORS   Strulovich,R., Tobelaim,W.S., Attali,B. and Hirsch,J.A.
  TITLE     Structural Insights into the M-Channel Proximal
            C-Terminus/Calmodulin Complex
  JOURNAL   Biochemistry 55 (38), 5353-5365 (2016)
   PUBMED   27564677
REFERENCE   4  (residues 1 to 149)
  AUTHORS   Gomez-Hurtado,N., Boczek,N.J., Kryshtal,D.O., Johnson,C.N., Sun,J.,
            Nitu,F.R., Cornea,R.L., Chazin,W.J., Calvert,M.L., Tester,D.J.,
            Ackerman,M.J. and Knollmann,B.C.
  TITLE     Novel CPVT-Associated Calmodulin Mutation in CALM3 (CALM3-A103V)
            Activates Arrhythmogenic Ca Waves and Sparks
  JOURNAL   Circ Arrhythm Electrophysiol 9 (8) (2016)
   PUBMED   27516456
REFERENCE   5  (residues 1 to 149)
  AUTHORS   Yu,C.C., Ko,J.S., Ai,T., Tsai,W.C., Chen,Z., Rubart,M., Vatta,M.,
            Everett,T.H. 4th, George,A.L. Jr. and Chen,P.S.
  TITLE     Arrhythmogenic calmodulin mutations impede activation of
            small-conductance calcium-activated potassium current
  JOURNAL   Heart Rhythm 13 (8), 1716-1723 (2016)
   PUBMED   27165696
REFERENCE   6  (residues 1 to 149)
  AUTHORS   Gautel,M., Castiglione Morelli,M.A., Pfuhl,M., Motta,A. and
            Pastore,A.
  TITLE     A calmodulin-binding sequence in the C-terminus of human cardiac
            titin kinase
  JOURNAL   Eur J Biochem 230 (2), 752-759 (1995)
   PUBMED   7607248
REFERENCE   7  (residues 1 to 149)
  AUTHORS   Natsukari,N., Zhang,S.P., Nichols,R.A. and Weiss,B.
  TITLE     Immunocytochemical localization of calmodulin in PC12 cells and its
            possible interaction with histones
  JOURNAL   Neurochem Int 26 (5), 465-476 (1995)
   PUBMED   7492944
REFERENCE   8  (residues 1 to 149)
  AUTHORS   Nojima,H.
  TITLE     Structural organization of multiple rat calmodulin genes
  JOURNAL   J Mol Biol 208 (2), 269-282 (1989)
   PUBMED   2527998
REFERENCE   9  (residues 1 to 149)
  AUTHORS   Rasmussen,C.D. and Means,A.R.
  TITLE     Calmodulin is required for cell-cycle progression during G1 and
            mitosis
  JOURNAL   EMBO J 8 (1), 73-82 (1989)
   PUBMED   2469574
REFERENCE   10 (residues 1 to 149)
  AUTHORS   Sherbany,A.A., Parent,A.S. and Brosius,J.
  TITLE     Rat calmodulin cDNA
  JOURNAL   DNA 6 (3), 267-272 (1987)
   PUBMED   2885164
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M16659.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M16659.1, X13817.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..149
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     Protein         1..149
                     /product="calmodulin-3"
                     /EC_number="2.7.11.19"
                     /note="caM; Calmodulin III"
                     /calculated_mol_wt=16706
     Region          1..149
                     /region_name="PTZ00184"
                     /note="calmodulin; Provisional"
                     /db_xref="CDD:185504"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000269|PubMed:201628, ECO:0000269|Ref.9;
                     propagated from UniProtKB/Swiss-Prot (P0DP31.1)"
     Site            22
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P0DP25; propagated from
                     UniProtKB/Swiss-Prot (P0DP31.1)"
     Site            45
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by CaMK4.
                     /evidence=ECO:0000269|PubMed:12392717; propagated from
                     UniProtKB/Swiss-Prot (P0DP31.1)"
     Region          77..149
                     /region_name="Necessary and sufficient for interaction
                     with PCP4. /evidence=ECO:0000250|UniProtKB:P0DP25"
                     /note="propagated from UniProtKB/Swiss-Prot (P0DP31.1)"
     Site            82
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P0DP25; propagated from
                     UniProtKB/Swiss-Prot (P0DP31.1)"
     Site            95
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P0DP25; propagated from
                     UniProtKB/Swiss-Prot (P0DP31.1)"
     Site            100
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P0DP31.1)"
     Site            102
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P0DP31.1)"
     Site            111
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P0DP25; propagated from
                     UniProtKB/Swiss-Prot (P0DP31.1)"
     Site            116
                     /site_type="methylation"
                     /note="N6,N6,N6-trimethyllysine, alternate.
                     /evidence=ECO:0000269|PubMed:201628; N6-methyllysine,
                     alternate. /evidence=ECO:0000250|UniProtKB:P0DP25;
                     propagated from UniProtKB/Swiss-Prot (P0DP31.1)"
     Site            139
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P0DP25; propagated from
                     UniProtKB/Swiss-Prot (P0DP31.1)"
     CDS             1..149
                     /gene="Calm3"
                     /gene_synonym="Cam3; Camc; CaMIII; RNCAMIII"
                     /coded_by="NM_012518.3:11..460"
                     /db_xref="GeneID:24244"
                     /db_xref="RGD:2259"
ORIGIN      
        1 madqlteeqi aefkeafslf dkdgdgtitt kelgtvmrsl gqnpteaelq dminevdadg
       61 ngtidfpefl tmmarkmkdt dseeeireaf rvfdkdgngy isaaelrhvm tnlgekltde
      121 evdemiread idgdgqvnye efvqmmtak
//
