LOCUS       NM_017326               1134 bp    mRNA    linear   ROD 04-APR-2024
DEFINITION  Rattus norvegicus calmodulin 2 (Calm2), mRNA.
ACCESSION   NM_017326
VERSION     NM_017326.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1134)
  AUTHORS   Zhang,Y., Hou,Y.M., Gao,F., Xiao,J.W., Li,C.C. and Tang,Y.
  TITLE     lncRNA GAS5 regulates myocardial infarction by targeting the
            miR-525-5p/CALM2 axis
  JOURNAL   J Cell Biochem 120 (11), 18678-18688 (2019)
   PUBMED   31429119
  REMARK    GeneRIF: lncRNA GAS5 regulates myocardial infarction by targeting
            the miR-525-5p/CALM2 axis.
REFERENCE   2  (bases 1 to 1134)
  AUTHORS   Kozhevnikova,L.M., Tsorin,I.B., Stolyaruk,V.N., Sukhanova,I.F.,
            Vititnova,M.B., Nikiforova,T.D., Kolik,L.G. and Kryzhanovskii,S.A.
  TITLE     Epac Proteins and Calmodulin as Possible Arrhythmogenesis Trigger
            in Alcoholic Cardiomyopathy
  JOURNAL   Bull Exp Biol Med 165 (5), 613-616 (2018)
   PUBMED   30225708
  REMARK    GeneRIF: Epac1/Epac2 and CaM can play a key role in
            arrhythmogenesis development under conditions of alcoholic
            cardiomyopathy.
REFERENCE   3  (bases 1 to 1134)
  AUTHORS   Boczek,T., Lisek,M., Ferenc,B. and Zylinska,L.
  TITLE     Cross talk among PMCA, calcineurin and NFAT transcription factors
            in control of calmodulin gene expression in differentiating PC12
            cells
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1860 (4), 502-515 (2017)
   PUBMED   28153703
  REMARK    GeneRIF: higher occupancy of Calm2 and Calm3 promoters by NFATc2
            and increased expression of these genes in response to NFATc2
            silencing were demonstrated in PMCA2 and PMCA3-reduced lines.
REFERENCE   4  (bases 1 to 1134)
  AUTHORS   Strulovich,R., Tobelaim,W.S., Attali,B. and Hirsch,J.A.
  TITLE     Structural Insights into the M-Channel Proximal
            C-Terminus/Calmodulin Complex
  JOURNAL   Biochemistry 55 (38), 5353-5365 (2016)
   PUBMED   27564677
REFERENCE   5  (bases 1 to 1134)
  AUTHORS   Gomez-Hurtado,N., Boczek,N.J., Kryshtal,D.O., Johnson,C.N., Sun,J.,
            Nitu,F.R., Cornea,R.L., Chazin,W.J., Calvert,M.L., Tester,D.J.,
            Ackerman,M.J. and Knollmann,B.C.
  TITLE     Novel CPVT-Associated Calmodulin Mutation in CALM3 (CALM3-A103V)
            Activates Arrhythmogenic Ca Waves and Sparks
  JOURNAL   Circ Arrhythm Electrophysiol 9 (8) (2016)
   PUBMED   27516456
REFERENCE   6  (bases 1 to 1134)
  AUTHORS   Ni,B., Rush,S., Gurd,J.W. and Brown,I.R.
  TITLE     Molecular cloning of calmodulin mRNA species which are
            preferentially expressed in neurons in the rat brain
  JOURNAL   Brain Res Mol Brain Res 13 (1-2), 7-17 (1992)
   PUBMED   1315919
REFERENCE   7  (bases 1 to 1134)
  AUTHORS   Nojima,H.
  TITLE     Structural organization of multiple rat calmodulin genes
  JOURNAL   J Mol Biol 208 (2), 269-282 (1989)
   PUBMED   2527998
REFERENCE   8  (bases 1 to 1134)
  AUTHORS   Rasmussen,C.D. and Means,A.R.
  TITLE     Calmodulin is required for cell-cycle progression during G1 and
            mitosis
  JOURNAL   EMBO J 8 (1), 73-82 (1989)
   PUBMED   2469574
REFERENCE   9  (bases 1 to 1134)
  AUTHORS   SenGupta,B., Friedberg,F. and Detera-Wadleigh,S.D.
  TITLE     Molecular analysis of human and rat calmodulin complementary DNA
            clones. Evidence for additional active genes in these species
  JOURNAL   J Biol Chem 262 (34), 16663-16670 (1987)
   PUBMED   2445749
REFERENCE   10 (bases 1 to 1134)
  AUTHORS   Dedman,J.R., Jackson,R.L., Schreiber,W.E. and Means,A.R.
  TITLE     Sequence homology of the Ca2+-dependent regulator of cyclic
            nucleotide phosphodiesterase from rat testis with other
            Ca2+-binding proteins
  JOURNAL   J Biol Chem 253 (2), 343-346 (1978)
   PUBMED   201628
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FQ213520.1.
            
            On Sep 22, 2014 this sequence version replaced NM_017326.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ212789.1, FQ213520.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1134              FQ213520.1         1-1134
FEATURES             Location/Qualifiers
     source          1..1134
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q12"
     gene            1..1134
                     /gene="Calm2"
                     /gene_synonym="Cam; Cam2; Camb; CaMII"
                     /note="calmodulin 2"
                     /db_xref="GeneID:50663"
                     /db_xref="RGD:2258"
     exon            1..75
                     /gene="Calm2"
                     /gene_synonym="Cam; Cam2; Camb; CaMII"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..522
                     /gene="Calm2"
                     /gene_synonym="Cam; Cam2; Camb; CaMII"
                     /EC_number="2.7.11.19"
                     /note="calmodulin 2 (phosphorylase kinase, delta)"
                     /codon_start=1
                     /product="calmodulin-2"
                     /protein_id="NP_059022.1"
                     /db_xref="GeneID:50663"
                     /db_xref="RGD:2258"
                     /translation="MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNP
                     TEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYIS
                     AAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK"
     exon            76..106
                     /gene="Calm2"
                     /gene_synonym="Cam; Cam2; Camb; CaMII"
                     /inference="alignment:Splign:2.1.0"
     exon            107..357
                     /gene="Calm2"
                     /gene_synonym="Cam; Cam2; Camb; CaMII"
                     /inference="alignment:Splign:2.1.0"
     exon            358..493
                     /gene="Calm2"
                     /gene_synonym="Cam; Cam2; Camb; CaMII"
                     /inference="alignment:Splign:2.1.0"
     exon            494..1116
                     /gene="Calm2"
                     /gene_synonym="Cam; Cam2; Camb; CaMII"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aattagtccg agtggagcga gcgagtcgag tggttgtctg ttctggtctc ggaaaccggt
       61 agcccttgca gcatggctga ccaactgact gaagagcaga tcgcagaatt caaagaagct
      121 ttctccctat ttgacaagga cggggatggg acaataacaa ccaaggagct ggggacggtg
      181 atgcggtctc tggggcagaa ccccacagaa gcagagctgc aggacatgat caatgaagta
      241 gatgccgacg gtaatggcac aatcgacttc cctgaattcc tgacaatgat ggcaagaaaa
      301 atgaaagaca cagacagtga agaagaaatt agagaagcgt tccgtgtgtt tgataaggat
      361 ggcaatggct acatcagtgc agcagagctt cgccacgtga tgacaaacct tggagagaag
      421 ttaacagatg aagaggttga tgaaatgatc agggaagcag acatcgatgg ggatggtcag
      481 gtaaactacg aagagtttgt acaaatgatg acagcgaagt gaagaccctg tacagaaggt
      541 gttaaatttc ttgtacagaa ctgttaattt gccttttctc tgtttgtaac ttatctgtaa
      601 aaggttcccc cactgtcaga acatgcatgt atagtaatta ggactccatt cctccatgtt
      661 tcttccctat cttctgtcat tgtccttcaa ccttatttta gaaaactgat caagtaccat
      721 gttgcatgtg gcttcctctg gatatatcta agcccttctg cacatctaca cttagatgga
      781 gttggtcaaa gggaacatct gggttatgcc ttttttacag tagctttagg aaccgtcggc
      841 atgttgctgt tgaagtgtgg agttgtgagc gtggactgtg gacagtcgac agcgtgtact
      901 aagagttgca ctactgcaaa cgggtgttct gtccggtact cactcgtaca ctattttttt
      961 gtactgctgg tattgtacca gaaacatttt cttttattgt tacttgcttt ttaaactttg
     1021 tttagccact taaggaagat ctgcttatgg cacaatttgc ctcaaatcca ttccaagttg
     1081 tatatttgtt ttccaataaa aaaaaatgac aatttaaaaa aaaaaaaaaa aaaa
//
