LOCUS       NM_031969               1449 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus calmodulin 1 (Calm1), mRNA.
ACCESSION   NM_031969 NM_001007614 XM_237641
VERSION     NM_031969.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1449)
  AUTHORS   Sun,B. and Kekenes-Huskey,P.M.
  TITLE     Assessing the Role of Calmodulin's Linker Flexibility in Target
            Binding
  JOURNAL   Int J Mol Sci 22 (9), 4990 (2021)
   PUBMED   34066691
  REMARK    GeneRIF: Assessing the Role of Calmodulin's Linker Flexibility in
            Target Binding.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1449)
  AUTHORS   Wang,S., Li,J., Liu,Y., Zhang,J., Zheng,X., Sun,X., Lei,S.,
            Kang,Z., Chen,X., Lei,M., Hu,H., Zeng,X. and Hao,L.
  TITLE     Distinct roles of calmodulin and Ca2+/calmodulin-dependent protein
            kinase II in isopreterenol-induced cardiac hypertrophy
  JOURNAL   Biochem Biophys Res Commun 526 (4), 960-966 (2020)
   PUBMED   32303334
  REMARK    GeneRIF: Distinct roles of calmodulin and
            Ca(2+)/calmodulin-dependent protein kinase II in
            isopreterenol-induced cardiac hypertrophy.
REFERENCE   3  (bases 1 to 1449)
  AUTHORS   Wang,J., Qi,C., Liu,L., Zhao,L., Cui,W., Tian,Y., Liu,B. and Li,J.
  TITLE     Taurine Protects Primary Neonatal Cardiomyocytes Against Apoptosis
            Induced by Hydrogen Peroxide
  JOURNAL   Int Heart J 59 (1), 190-196 (2018)
   PUBMED   29279520
  REMARK    GeneRIF: Tau could inhibit the H2O2-induced decrease in CamKII and
            CaM expression at both the mRNA and protein levels.
REFERENCE   4  (bases 1 to 1449)
  AUTHORS   Strulovich,R., Tobelaim,W.S., Attali,B. and Hirsch,J.A.
  TITLE     Structural Insights into the M-Channel Proximal
            C-Terminus/Calmodulin Complex
  JOURNAL   Biochemistry 55 (38), 5353-5365 (2016)
   PUBMED   27564677
REFERENCE   5  (bases 1 to 1449)
  AUTHORS   Gomez-Hurtado,N., Boczek,N.J., Kryshtal,D.O., Johnson,C.N., Sun,J.,
            Nitu,F.R., Cornea,R.L., Chazin,W.J., Calvert,M.L., Tester,D.J.,
            Ackerman,M.J. and Knollmann,B.C.
  TITLE     Novel CPVT-Associated Calmodulin Mutation in CALM3 (CALM3-A103V)
            Activates Arrhythmogenic Ca Waves and Sparks
  JOURNAL   Circ Arrhythm Electrophysiol 9 (8) (2016)
   PUBMED   27516456
REFERENCE   6  (bases 1 to 1449)
  AUTHORS   Natsukari,N., Zhang,S.P., Nichols,R.A. and Weiss,B.
  TITLE     Immunocytochemical localization of calmodulin in PC12 cells and its
            possible interaction with histones
  JOURNAL   Neurochem Int 26 (5), 465-476 (1995)
   PUBMED   7492944
REFERENCE   7  (bases 1 to 1449)
  AUTHORS   Ni,B., Rush,S., Gurd,J.W. and Brown,I.R.
  TITLE     Molecular cloning of calmodulin mRNA species which are
            preferentially expressed in neurons in the rat brain
  JOURNAL   Brain Res Mol Brain Res 13 (1-2), 7-17 (1992)
   PUBMED   1315919
REFERENCE   8  (bases 1 to 1449)
  AUTHORS   Nojima,H.
  TITLE     Structural organization of multiple rat calmodulin genes
  JOURNAL   J Mol Biol 208 (2), 269-282 (1989)
   PUBMED   2527998
REFERENCE   9  (bases 1 to 1449)
  AUTHORS   Rasmussen,C.D. and Means,A.R.
  TITLE     Calmodulin is required for cell-cycle progression during G1 and
            mitosis
  JOURNAL   EMBO J 8 (1), 73-82 (1989)
   PUBMED   2469574
REFERENCE   10 (bases 1 to 1449)
  AUTHORS   Nojima,H. and Sokabe,H.
  TITLE     Structure of a gene for rat calmodulin
  JOURNAL   J Mol Biol 193 (3), 439-445 (1987)
   PUBMED   3035194
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Nov 27, 2020 this sequence version replaced NM_031969.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X13933.1, FQ225380.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               JAXUCZ010000006.1  125217316-125217432
            118-148             JAXUCZ010000006.1  125220071-125220101
            149-292             JAXUCZ010000006.1  125221671-125221814
            293-399             JAXUCZ010000006.1  125223700-125223806
            400-535             JAXUCZ010000006.1  125224191-125224326
            536-1449            JAXUCZ010000006.1  125224471-125225384
FEATURES             Location/Qualifiers
     source          1..1449
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..1449
                     /gene="Calm1"
                     /gene_synonym="Calm; Cam1; CaMI"
                     /note="calmodulin 1"
                     /db_xref="GeneID:24242"
                     /db_xref="RGD:2257"
     exon            1..117
                     /gene="Calm1"
                     /gene_synonym="Calm; Cam1; CaMI"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..564
                     /gene="Calm1"
                     /gene_synonym="Calm; Cam1; CaMI"
                     /EC_number="2.7.11.19"
                     /note="caM; Calmodulin 1 (phosphorylase kinase, delta);
                     calmodulin I"
                     /codon_start=1
                     /product="calmodulin-1"
                     /protein_id="NP_114175.1"
                     /db_xref="GeneID:24242"
                     /db_xref="RGD:2257"
                     /translation="MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNP
                     TEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYIS
                     AAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK"
     exon            118..148
                     /gene="Calm1"
                     /gene_synonym="Calm; Cam1; CaMI"
                     /inference="alignment:Splign:2.1.0"
     exon            149..292
                     /gene="Calm1"
                     /gene_synonym="Calm; Cam1; CaMI"
                     /inference="alignment:Splign:2.1.0"
     exon            293..399
                     /gene="Calm1"
                     /gene_synonym="Calm; Cam1; CaMI"
                     /inference="alignment:Splign:2.1.0"
     exon            400..535
                     /gene="Calm1"
                     /gene_synonym="Calm; Cam1; CaMI"
                     /inference="alignment:Splign:2.1.0"
     exon            536..1449
                     /gene="Calm1"
                     /gene_synonym="Calm; Cam1; CaMI"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcacaacgc aggtagcgcg ttagcagcag cagcggaggc atctcggcgg tcacagcccc
       61 tgcgctggtg cagccaccct cgcctgctcc gctcttcctt ccttcgctcg caccatggct
      121 gatcagctga ctgaagaaca gattgctgaa ttcaaggaag ctttctccct atttgataaa
      181 gatggggacg gcaccatcac aacaaaggag ctggggactg tcatgcggtc actgggtcag
      241 aacccaacag aggctgaact gcaggatatg atcaacgagg tggatgccga cgggaatggc
      301 accattgact tcccagagtt cttgactatg atggctagaa aaatgaaaga cacagatagc
      361 gaagaagaaa tccgtgaggc attccgagtc tttgacaagg atggcaatgg ctacatcagt
      421 gcggcagaac tgcgccacgt catgacaaac ctcggggaaa agctaacaga tgaagaagta
      481 gacgaaatga tcagagaagc agatattgat ggagacggac aggtcaacta tgaagaattc
      541 gtacagatga tgactgcaaa atgaagacct actttcaact actttccccc tctagaagaa
      601 tcaaattgaa atcttttact tacctcttac aaaaaaaaaa aaagaaaaaa gaaaaaagtt
      661 catttcttca ttctgtttgt atctagcaaa actgaatgtc aaaagtacct tctgtccaca
      721 cacaaaatct gcatgtattg gttggtggtc ctgcccccta aagatcaagc cccctacatg
      781 agttttacag tataaatact cgtactacct tataaggaag cacttagtgg actccttcaa
      841 gttccatttg ctaatgatta acacactgtc tgggctggcc agtttctcat gcatgcagct
      901 tggtgattga gcacagtcag gcctttgtat taaaactgaa aaatggaaaa aacaaattca
      961 aactctcaga tggcttctag ttcaatctgt tcagataaat gtcagcagcc agtttaccgc
     1021 aaacaaacat ttaaaattgg tttacctcag gatgatgtgc aggaaacggg tgaaggctaa
     1081 actttgagac acagccctag atgtaggaca gtcctcttca agtgccccaa tcccatggtg
     1141 acagtgacac cctggtggcg agcccgagtg tgatggttca ccgctgtgca cattgcattg
     1201 gagtgaagtg aacaaggctg tcaccaaatc acacacgttt taataagaaa tgtttactaa
     1261 gggagcatct ttggactctc tgttttaaaa ccttgtgaac catgactcgg agccagcaga
     1321 gtaggctgtg tctgtggact tgagcacacc atcaacattg ctgttcagga aattataatt
     1381 tacgtccatt ccaagttgta aatgctagtc ttttattttt tttttccaat aaaaagacca
     1441 ttaacttaa
//
