LOCUS       NM_001109168            1047 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Rattus norvegicus calcium homeostasis modulator 1 (Calhm1), mRNA.
ACCESSION   NM_001109168 XM_001059715 XM_574681
VERSION     NM_001109168.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1047)
  AUTHORS   Puebla,M., Munoz,M.F., Lillo,M.A., Contreras,J.E. and Figueroa,X.F.
  TITLE     Control of astrocytic Ca2+ signaling by nitric oxide-dependent
            S-nitrosylation of Ca2+ homeostasis modulator 1 channels
  JOURNAL   Biol Res 57 (1), 19 (2024)
   PUBMED   38689353
  REMARK    GeneRIF: Control of astrocytic Ca[2+] signaling by nitric
            oxide-dependent S-nitrosylation of Ca[2+] homeostasis modulator 1
            channels.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1047)
  AUTHORS   Bigiani,A.
  TITLE     Calcium Homeostasis Modulator 1-Like Currents in Rat Fungiform
            Taste Cells Expressing Amiloride-Sensitive Sodium Currents
  JOURNAL   Chem Senses 42 (4), 343-359 (2017)
   PUBMED   28334404
  REMARK    GeneRIF: findings indicate that communication between
            salt-detecting cells and nerve endings might involve ATP release by
            CALMH1 channels.
REFERENCE   3  (bases 1 to 1047)
  AUTHORS   Liu,W., Ao,Q., Guo,Q., He,W., Peng,L., Jiang,J. and Hu,X.
  TITLE     miR-9 Mediates CALHM1-Activated ATP-P2X7R Signal in Painful
            Diabetic Neuropathy Rats
  JOURNAL   Mol Neurobiol 54 (2), 922-929 (2017)
   PUBMED   26781424
  REMARK    GeneRIF: CALHM1 was increased in painful diabetic neuropathy
            compared with controls.
REFERENCE   4  (bases 1 to 1047)
  AUTHORS   Taruno,A., Vingtdeux,V., Ohmoto,M., Ma,Z., Dvoryanchikov,G., Li,A.,
            Adrien,L., Zhao,H., Leung,S., Abernethy,M., Koppel,J., Davies,P.,
            Civan,M.M., Chaudhari,N., Matsumoto,I., Hellekant,G., Tordoff,M.G.,
            Marambaud,P. and Foskett,J.K.
  TITLE     CALHM1 ion channel mediates purinergic neurotransmission of sweet,
            bitter and umami tastes
  JOURNAL   Nature 495 (7440), 223-226 (2013)
   PUBMED   23467090
REFERENCE   5  (bases 1 to 1047)
  AUTHORS   Siebert,A.P., Ma,Z., Grevet,J.D., Demuro,A., Parker,I. and
            Foskett,J.K.
  TITLE     Structural and functional similarities of calcium homeostasis
            modulator 1 (CALHM1) ion channel with connexins, pannexins, and
            innexins
  JOURNAL   J Biol Chem 288 (9), 6140-6153 (2013)
   PUBMED   23300080
REFERENCE   6  (bases 1 to 1047)
  AUTHORS   Ma,Z., Siebert,A.P., Cheung,K.H., Lee,R.J., Johnson,B., Cohen,A.S.,
            Vingtdeux,V., Marambaud,P. and Foskett,J.K.
  TITLE     Calcium homeostasis modulator 1 (CALHM1) is the pore-forming
            subunit of an ion channel that mediates extracellular Ca2+
            regulation of neuronal excitability
  JOURNAL   Proc Natl Acad Sci U S A 109 (28), E1963-E1971 (2012)
   PUBMED   22711817
REFERENCE   7  (bases 1 to 1047)
  AUTHORS   Dreses-Werringloer,U., Lambert,J.C., Vingtdeux,V., Zhao,H.,
            Vais,H., Siebert,A., Jain,A., Koppel,J., Rovelet-Lecrux,A.,
            Hannequin,D., Pasquier,F., Galimberti,D., Scarpini,E., Mann,D.,
            Lendon,C., Campion,D., Amouyel,P., Davies,P., Foskett,J.K.,
            Campagne,F. and Marambaud,P.
  TITLE     A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels,
            and Alzheimer's disease risk
  JOURNAL   Cell 133 (7), 1149-1161 (2008)
   PUBMED   18585350
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473986.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_574681.2, XM_001059715.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1047
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..1047
                     /gene="Calhm1"
                     /gene_synonym="Fam26c; RGD1564891"
                     /note="calcium homeostasis modulator 1"
                     /db_xref="GeneID:499367"
                     /db_xref="RGD:1564891"
     CDS             1..1047
                     /gene="Calhm1"
                     /gene_synonym="Fam26c; RGD1564891"
                     /note="family with sequence similarity 26, member C"
                     /codon_start=1
                     /product="calcium homeostasis modulator protein 1"
                     /protein_id="NP_001102638.1"
                     /db_xref="GeneID:499367"
                     /db_xref="RGD:1564891"
                     /translation="MDKFRMIFQFLQSNQESFMNGICGIMALASAQMYSAFDFNCPCL
                     PGYNVVYSMGILLTPPLVLFLLGLVMNNNISMLAEEWKRPLGRRAKDPAVLRYMFCSM
                     AQRALIAPVVWVAVTLLDGKCFLCAFCTAVPVATLGNGSLVPGLPAPELARLLARVPC
                     PEIYDGNWLLAREVAVRYLRCISQALGWSFVLLTTLLAFVVRSVRPCFTQVAFLKSKY
                     WSHYIDIERKLFDETCTEHAKAFAKVCIQQFFEAMNHDLELGHTHGVLATASARTTAT
                     EAIQSPSDRTEEEREKLRGITDQGSMNRLLTSWHKCKPPLRLGQEAPLMSNGWAGSEP
                     RPPRKEVATYFSKV"
     exon            1..552
                     /gene="Calhm1"
                     /gene_synonym="Fam26c; RGD1564891"
                     /inference="alignment:Splign:2.1.0"
     exon            553..1047
                     /gene="Calhm1"
                     /gene_synonym="Fam26c; RGD1564891"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggacaagt ttcggatgat cttccagttc ttgcagtcca accaagagtc cttcatgaac
       61 ggcatctgcg gcatcatggc gctggccagt gcccagatgt actctgcctt tgacttcaac
      121 tgcccctgct tgcccggcta caatgtggtc tacagcatgg gcatactgct gacgcctccc
      181 ctggtgctct tcctgcttgg cctggtcatg aacaacaaca tatccatgct agctgaagag
      241 tggaaacgcc ccctggggcg ccgggccaag gaccctgccg tgctacgcta catgttctgt
      301 tccatggccc agcgagcgct catcgcccct gtggtctggg tggcagtcac actgctggac
      361 ggcaagtgtt tcctctgtgc tttctgcaca gccgtgccgg tggccacgct aggcaatggg
      421 agcctggtgc cgggcctgcc tgctccagaa cttgctcgcc tgctggctcg tgtaccttgc
      481 cctgaaatct acgatgggaa ctggctgctg gcccgagagg tggccgtgcg ctatttgcgc
      541 tgcatctctc aggcgctggg ctggtccttc gtgctgctga ccacattact ggcatttgta
      601 gtgcgctccg tgcggccctg cttcacgcag gttgcctttc tcaagagcaa gtactggtcc
      661 cactacattg acattgagcg taagctcttc gatgagactt gcacggagca tgccaaagcc
      721 tttgctaagg tatgtatcca gcagttcttc gaagccatga accatgacct ggagctgggt
      781 catacccacg gagtactggc cacagcttcg gccagaacta cagccacaga ggccatccaa
      841 agtccctccg acaggaccga agaagagagg gagaagctgc gaggcatcac tgaccaaggc
      901 agcatgaaca ggctactcac aagctggcac aaatgcaaac cacccttgag gctgggccag
      961 gaggcaccac tgatgagcaa tggctgggct gggagcgagc cccggcctcc acgcaaggaa
     1021 gtggccacct acttcagcaa agtgtga
//
