LOCUS       NM_001398578            4020 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus caldesmon 1 (Cald1), transcript variant 1, mRNA.
ACCESSION   NM_001398578 XM_039107133
VERSION     NM_001398578.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4020)
  AUTHORS   Meng,Z., Chen,Y., Wu,W., Yan,B., Meng,Y., Liang,Y., Yao,X. and
            Luo,J.
  TITLE     Exploring the Immune Infiltration Landscape and M2
            Macrophage-Related Biomarkers of Proliferative Diabetic Retinopathy
  JOURNAL   Front Endocrinol (Lausanne) 13, 841813 (2022)
   PUBMED   35692390
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4020)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4020)
  AUTHORS   Bianchi-Smiraglia,A., Kunnev,D., Limoge,M., Lee,A., Beckerle,M.C.
            and Bakin,A.V.
  TITLE     Integrin-beta5 and zyxin mediate formation of ventral stress fibers
            in response to transforming growth factor beta
  JOURNAL   Cell Cycle 12 (21), 3377-3389 (2013)
   PUBMED   24036928
REFERENCE   4  (bases 1 to 4020)
  AUTHORS   Tanokashira,D., Morita,T., Hayashi,K., Mayanagi,T., Fukumoto,K.,
            Kubota,Y., Yamashita,T. and Sobue,K.
  TITLE     Glucocorticoid suppresses dendritic spine development mediated by
            down-regulation of caldesmon expression
  JOURNAL   J Neurosci 32 (42), 14583-14591 (2012)
   PUBMED   23077044
  REMARK    GeneRIF: CaD stabilizes the F-actin dynamics in spines, thereby
            enlarging the spine heads, whereas CaD knockdown decreases the
            spine-head size via destabilization of the F-actin dynamics.
REFERENCE   5  (bases 1 to 4020)
  AUTHORS   Morita,T., Mayanagi,T. and Sobue,K.
  TITLE     Caldesmon regulates axon extension through interaction with myosin
            II
  JOURNAL   J Biol Chem 287 (5), 3349-3356 (2012)
   PUBMED   22158623
  REMARK    GeneRIF: caldesmon is an important regulator of axon development.
REFERENCE   6  (bases 1 to 4020)
  AUTHORS   Represa,A., Trabelsi-Terzidis,H., Plantier,M., Fattoum,A.,
            Jorquera,I., Agassandian,C., Ben-Ari,Y. and der Terrossian,E.
  TITLE     Distribution of caldesmon and of the acidic isoform of calponin in
            cultured cerebellar neurons and in different regions of the rat
            brain: an immunofluorescence and confocal microscopy study
  JOURNAL   Exp Cell Res 221 (2), 333-343 (1995)
   PUBMED   7493632
REFERENCE   7  (bases 1 to 4020)
  AUTHORS   Yamashiro,S., Yamakita,Y., Yoshida,K., Takiguchi,K. and
            Matsumura,F.
  TITLE     Characterization of the COOH terminus of non-muscle caldesmon
            mutants lacking mitosis-specific phosphorylation sites
  JOURNAL   J Biol Chem 270 (8), 4023-4030 (1995)
   PUBMED   7876150
REFERENCE   8  (bases 1 to 4020)
  AUTHORS   Yamashiro,S., Yamakita,Y., Hosoya,H. and Matsumura,F.
  TITLE     Phosphorylation of non-muscle caldesmon by p34cdc2 kinase during
            mitosis
  JOURNAL   Nature 349 (6305), 169-172 (1991)
   PUBMED   1986309
REFERENCE   9  (bases 1 to 4020)
  AUTHORS   Walker,G., Kerrick,W.G. and Bourguignon,L.Y.
  TITLE     The role of caldesmon in the regulation of receptor capping in
            mouse T-lymphoma cell
  JOURNAL   J Biol Chem 264 (1), 496-500 (1989)
   PUBMED   2909534
REFERENCE   10 (bases 1 to 4020)
  AUTHORS   Yamashiro-Matsumura,S. and Matsumura,F.
  TITLE     Characterization of 83-kilodalton nonmuscle caldesmon from cultured
            rat cells: stimulation of actin binding of nonmuscle tropomyosin
            and periodic localization along microfilaments like tropomyosin
  JOURNAL   J Cell Biol 106 (6), 1973-1983 (1988)
   PUBMED   3384851
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Dec 20, 2021 this sequence version replaced XM_039107133.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.17134.1,
                                           SRR26643296.12999.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               JAXUCZ010000004.1  64233256-64233375
            121-232             JAXUCZ010000004.1  64319181-64319292
            233-379             JAXUCZ010000004.1  64377381-64377527
            380-779             JAXUCZ010000004.1  64380642-64381041
            780-925             JAXUCZ010000004.1  64388281-64388426
            926-1190            JAXUCZ010000004.1  64392728-64392992
            1191-1331           JAXUCZ010000004.1  64395152-64395292
            1332-1375           JAXUCZ010000004.1  64400676-64400719
            1376-1454           JAXUCZ010000004.1  64400816-64400894
            1455-1592           JAXUCZ010000004.1  64403190-64403327
            1593-1688           JAXUCZ010000004.1  64404370-64404465
            1689-1769           JAXUCZ010000004.1  64409324-64409404
            1770-4020           JAXUCZ010000004.1  64411835-64414085
FEATURES             Location/Qualifiers
     source          1..4020
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..4020
                     /gene="Cald1"
                     /gene_synonym="l-Cad"
                     /note="caldesmon 1"
                     /db_xref="GeneID:25687"
                     /db_xref="RGD:2256"
     exon            1..120
                     /gene="Cald1"
                     /gene_synonym="l-Cad"
                     /inference="alignment:Splign:2.1.0"
     exon            121..232
                     /gene="Cald1"
                     /gene_synonym="l-Cad"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..1775
                     /gene="Cald1"
                     /gene_synonym="l-Cad"
                     /note="isoform 1 is encoded by transcript variant 1;
                     non-muscle caldesmon; h-caldesmon; CDM; L-caldesmon"
                     /codon_start=1
                     /product="non-muscle caldesmon isoform 1"
                     /protein_id="NP_001385507.1"
                     /db_xref="GeneID:25687"
                     /db_xref="RGD:2256"
                     /translation="MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRR
                     ARQERLRQKQEEESLGQVTDQVEAHVQNSVPDEESKPATANAQVEGDEEAALLERLAR
                     REERRQKRLQEALERQKEFDPTITDGSLSVPSRRMQNNSAENETAEGEEKGESRSGRY
                     EMEETEVVITSYQKNSYQDAEDKKKEEKEEEEEEEKLKGGNLGENQIKDEKIKKDKEP
                     KEEVKNFLDRKKGFTEVKAQNGEFMTHKLKQTENAFSPSRSGGRASGDKEAEGAPQVE
                     AGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQE
                     EADRKAREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSEDKKPFKCFTPKGSSLKIE
                     ERAEFLNKSVQKSGVKSTHQAAVVSKIDSRLEQYTNAIEGTKASKPMKPAASDLPVPA
                     EGVRNIKSMWEKGSVFSSPSASGTPNKETAGLKVGVSSRINEWLTKSPDGNKSPAPKP
                     SDLRPGDVSGKRNLWEKQSVDKVTSPTKV"
     exon            233..379
                     /gene="Cald1"
                     /gene_synonym="l-Cad"
                     /inference="alignment:Splign:2.1.0"
     exon            380..779
                     /gene="Cald1"
                     /gene_synonym="l-Cad"
                     /inference="alignment:Splign:2.1.0"
     exon            780..925
                     /gene="Cald1"
                     /gene_synonym="l-Cad"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1190
                     /gene="Cald1"
                     /gene_synonym="l-Cad"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1331
                     /gene="Cald1"
                     /gene_synonym="l-Cad"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1375
                     /gene="Cald1"
                     /gene_synonym="l-Cad"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1454
                     /gene="Cald1"
                     /gene_synonym="l-Cad"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1592
                     /gene="Cald1"
                     /gene_synonym="l-Cad"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1688
                     /gene="Cald1"
                     /gene_synonym="l-Cad"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1769
                     /gene="Cald1"
                     /gene_synonym="l-Cad"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..4020
                     /gene="Cald1"
                     /gene_synonym="l-Cad"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgtgcgtt aggctgcctg cctgcctgcc tgcttgctct cttgctgggt tgcttaaagg
       61 aatccttgct ttcaaacagc gggacgtcct tctcctcggg aagaagctgc agccccagag
      121 atcgagatat tatctgggct ccctaaaccc gaaacctcac tatggatgat tttgaacgtc
      181 gcagagaact caggaggcaa aagagggagg agatgcggct ggaggcggag agaattgcct
      241 atcagaggaa tgatgatgac gaagaagagg ctgccaggga acggcgccgc cgagcccgac
      301 aggaaaggct gcggcagaag caagaggaag aatccttggg acaggtgaca gaccaagtgg
      361 aggcccatgt ccagaacagt gtccccgatg aagagtctaa gccagccact gcaaatgctc
      421 aggtagaagg tgatgaggag gctgctttgc tggagcgcct ggccaggcga gaagagagac
      481 gtcaaaaacg ccttcaggaa gccttagagc gtcagaagga gtttgatcca accataaccg
      541 atggcagtct ctcagtccca agcagaagga tgcaaaataa ctcggctgaa aatgagacag
      601 cagaggggga agaaaaagga gagagtcgct caggacggta tgagatggaa gaaacagaag
      661 tggtcatcac gtcctaccag aagaacagct atcaggatgc tgaagacaaa aagaaagaag
      721 aaaaggagga ggaggaggag gaagagaagc tgaagggagg gaaccttggc gaaaatcaga
      781 tcaaagatga gaagattaaa aaggacaaag agcccaaaga agaagtcaag aacttcttgg
      841 atcgaaagaa aggatttaca gaagtgaagg cgcagaatgg agaattcatg acccacaaac
      901 ttaaacaaac tgagaatgct ttcagcccca gccgttcagg aggccgggcc agcggggaca
      961 aggaagctga aggcgcccca caagtggaag ccggtaagag gctggaagag ctgcgccgac
     1021 gccgtgggga gacagagagc gaagagttcg aaaaactcaa acaaaagcaa caggaggcag
     1081 ccttggagct ggaagagctg aagaaaaaga gggaagagag aaggaaggtt ctggaggaag
     1141 aggagcagag aaggaagcag gaggaggctg atcgaaaagc tagagaggag gaagagaaga
     1201 ggaggttgaa ggaagagatc gaaaggagaa gggcagaagc tgctgagaaa cgccagaaga
     1261 tgccggaaga tggcctatct gaggacaaga agccgttcaa gtgcttcact cctaaaggct
     1321 catctctcaa gatagaggag cgagcagagt ttttgaataa gtctgtgcag aaaagtggtg
     1381 tcaaatcaac tcatcaagca gctgtggtct ccaagattga cagccggctg gagcaatata
     1441 ccaatgcaat cgagggaacg aaagcttcaa aacctatgaa gcctgcagca tccgatcttc
     1501 ctgtccctgc agaaggtgtc cgcaatatca agagcatgtg ggagaaaggg agtgtgtttt
     1561 catccccctc tgcctcgggg acaccaaata aggaaactgc tggcctgaag gtgggggttt
     1621 ccagccgcat caatgaatgg ctaactaaat cgccggacgg caacaagtca cccgctccca
     1681 agccttctga cttaaggcca ggagatgtat ctggcaagcg gaacctctgg gaaaagcaat
     1741 ccgtggataa ggtcacttct cccactaagg tctgaaacaa tcggagaaag aacccaactg
     1801 caagccatct tgctgggcca gctcagttgg agagggctaa tcgctctgtt tatatttatg
     1861 ttttccaata tcccagtaaa tccatgtata tgctcactat atttaataac cacaagtaga
     1921 ggtgttcatg gtcaaagtgc tgcctttgca gaggagcctg tttctaaaga aacccatgct
     1981 gtgaagtaag cttgctactg tcatatgaac agtgatacca accacatcag aagtcgacaa
     2041 aagaaaatcg agcttaagat tgtccaagga atgtatgcgg tatctaggtg gggggaaatg
     2101 acccataggc tttgttttgt ctcagtacag acatcatgtt tctgcacttt agactaaagc
     2161 atggaagaaa ttatctaagt aggcaatcaa aattctctga aagtgatcca cttcagatct
     2221 gatatagggc agtgatgatt gtcttttttt taaaaaagaa gatgtactgt tgacatattg
     2281 cttttcttct atgctgattc atacctagat tgggtgatta ttttagctga cagtggtact
     2341 gatttttttc ttcaggttag ttgctttgtg gatttctctg gtagcgatag tagactgaac
     2401 cacatttaga taacccaact atgtaatgta tgtgcatacg tgtatacaga cacactaatg
     2461 gtagatgact ctttcatgtg ctgcgctatt ctatttcata gtacgccctt gtaactaacc
     2521 aatatcacag ctttcaaaga ttaaagaaaa tcacaatagt atatcaatat ttcatatttg
     2581 ccagtagaaa catggaagtt aggtatagat atgttttcaa tgcccaatga cttataagaa
     2641 aaaagtattg gaaaaataag agattacaag tgtcaaaact agttgaaact tcttataaga
     2701 catagtattt agtttataat tgagagcagt cttgaattcc agtgtgaatt ttattaagtc
     2761 taccatctgg acaaagccca aaccctgttt atttgtggcc gtgaagttca cctcctccac
     2821 acacaaaaaa agttgaccta catgatacct aaggtgtctc ctttctctac cacttagagc
     2881 caaccatttt gatgactaat gcataagtta gaattcatgt agacgcctaa agaaagacca
     2941 acttcgcctc atgtagaagt aggcaggtaa aagtgagcaa aagcacggca gtccctctag
     3001 gtactcgtgc tctttaatta aaaatgtctg cctttagtag tcagttggta ctgccataag
     3061 ttgataatat cttgaaattt gaaaagtata tgtaaatttc aattgtttta ctcccccctc
     3121 ccaccaaggg cctttgggaa ttcatcattc agatatcaga ttctacttca gcttatgcct
     3181 ttactcttcc caatagataa aagtactcta gtgtcttacc aaatgttctt atagagaaca
     3241 ttctatgcat acagtgtcat tgtacaaact catacctcag ctgacttaac caaattatct
     3301 ttatctccgt tccttccaca gtaggagagc ctttaacatt tccaatccac agatttcttt
     3361 ttaagaggat aagggttggc tcaaggggtg accactgcct tgagaagttt acttttctca
     3421 tgaattagta agagttagtt ggattcccta gcttttagca aacttgggcc aaaggaagga
     3481 aagccactaa gactacacaa gtcatctccc cacgacagag tagacacaag tctatgataa
     3541 gatgaataga atgcacatgg cacacccata gacatgactt ccatcattgg agtaaaatgg
     3601 atcaaagttt gatttaaggc agatgcttga gggatcatgg taatgtgtgt taaccaaggc
     3661 cttcccctgc tatcttacag gctttttgtt tgtcattttc gcttttaaga aagttcagag
     3721 tggtgaaatg atggttttga tcctaacttt tattccaata tttggatgac aatgagtttt
     3781 agggtaaaag tttttctgtt tggatttaat ctttgaagaa gcaaattcct catttacttg
     3841 tttgattaca gctctctgtt atctttaaga gaggaaactg caagctgact agcatgttct
     3901 gtgaatctgc cattgttaaa aacgttataa acacttaata tttttcactg ataattgatc
     3961 gctgcaataa aaatatattg tgaaaatgca tccacaataa atggaattct tccagctgtc
//
