LOCUS       NM_012717               4927 bp    mRNA    linear   ROD 08-APR-2024
DEFINITION  Rattus norvegicus calcitonin receptor like receptor (Calcrl), mRNA.
ACCESSION   NM_012717 XM_006234438
VERSION     NM_012717.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4927)
  AUTHORS   Yarwood,R.E., Imlach,W.L., Lieu,T., Veldhuis,N.A., Jensen,D.D.,
            Klein Herenbrink,C., Aurelio,L., Cai,Z., Christie,M.J., Poole,D.P.,
            Porter,C.J.H., McLean,P., Hicks,G.A., Geppetti,P., Halls,M.L.,
            Canals,M. and Bunnett,N.W.
  TITLE     Endosomal signaling of the receptor for calcitonin gene-related
            peptide mediates pain transmission
  JOURNAL   Proc Natl Acad Sci U S A 114 (46), 12309-12314 (2017)
   PUBMED   29087309
  REMARK    GeneRIF: Endosomal signaling of the CLR mediates pain transmission.
REFERENCE   2  (bases 1 to 4927)
  AUTHORS   Meng,Q., Shi,D., Feng,J., Su,Y., Long,Y., He,S., Wang,S., Wang,Y.,
            Zhang,X. and Chen,X.
  TITLE     Hypercholesterolemia Up-Regulates the Expression of Intermedin and
            Its Receptor Components in the Aorta of Rats via Inducing the
            Oxidative Stress
  JOURNAL   Ann Clin Lab Sci 46 (1), 5-17 (2016)
   PUBMED   26927337
  REMARK    GeneRIF: Increased expression of IMD and all its receptor
            components (CRLR, RAMP1, RAMP2, and RAMP3) were displayed within
            the aorta of rats with Hypercholesterolemia.
REFERENCE   3  (bases 1 to 4927)
  AUTHORS   Zhao,Q., Wang,W., Wang,R. and Cheng,Y.
  TITLE     TRPV1 and neuropeptide receptor immunoreactivity and expression in
            the rat lung and brainstem after lung ischemia-reperfusion injury
  JOURNAL   J Surg Res 203 (1), 183-192 (2016)
   PUBMED   27338549
  REMARK    GeneRIF: TRPV1 in the lungs and CRLR and NK1R in the brainstem of
            rats can be upregulated by lung ischemia-reperfusion injury in a
            rapid manner.
REFERENCE   4  (bases 1 to 4927)
  AUTHORS   Gao,H., Liebenthal,D.A., Yallampalli,U. and Yallampalli,C.
  TITLE     Adrenomedullin promotes rat trophoblast stem cell differentiation
  JOURNAL   Biol Reprod 91 (3), 65 (2014)
   PUBMED   25061099
  REMARK    GeneRIF: Data suggest that stimulation of
            adrenomedullin/adrenomedullin receptor signaling enhances
            trophoblast stem cell differentiation; this stimulation involves
            CALCRL (calcitonin receptor-like receptor) and RAMP2 (receptor
            activity-modifying protein 2).
REFERENCE   5  (bases 1 to 4927)
  AUTHORS   Mistrova,E., Wiegand,S., Sviglerova,J., Pfeil,U., Kuncova,J.,
            Slavikova,J., Kummer,W. and Chottova Dvorakova,M.
  TITLE     Adrenomedullin and the calcitonin receptor-like receptor system
            mRNA expressions in the rat heart and sensory ganglia in
            experimentally-induced long-term diabetes
  JOURNAL   Gen Physiol Biophys 33 (2), 215-225 (2014)
   PUBMED   24177018
  REMARK    GeneRIF: expression of adrenomedullin and the calcitonin
            receptor-like receptor system in the rat heart and sensory ganglia
            in experimentally-induced long-term diabetes
REFERENCE   6  (bases 1 to 4927)
  AUTHORS   Kuwasako,K., Shimekake,Y., Masuda,M., Nakahara,K., Yoshida,T.,
            Kitaura,M., Kitamura,K., Eto,T. and Sakata,T.
  TITLE     Visualization of the calcitonin receptor-like receptor and its
            receptor activity-modifying proteins during internalization and
            recycling
  JOURNAL   J Biol Chem 275 (38), 29602-29609 (2000)
   PUBMED   10882736
REFERENCE   7  (bases 1 to 4927)
  AUTHORS   McLatchie,L.M., Fraser,N.J., Main,M.J., Wise,A., Brown,J.,
            Thompson,N., Solari,R., Lee,M.G. and Foord,S.M.
  TITLE     RAMPs regulate the transport and ligand specificity of the
            calcitonin-receptor-like receptor
  JOURNAL   Nature 393 (6683), 333-339 (1998)
   PUBMED   9620797
REFERENCE   8  (bases 1 to 4927)
  AUTHORS   Bidegain,M., Roos,B.A., Hill,E.L., Howard,G.A. and Balkan,W.
  TITLE     Calcitonin gene-related peptide (CGRP) in the developing mouse limb
  JOURNAL   Endocr Res 21 (4), 743-755 (1995)
   PUBMED   8582325
REFERENCE   9  (bases 1 to 4927)
  AUTHORS   Chang,C.P., Pearse,R.V. 2nd, O'Connell,S. and Rosenfeld,M.G.
  TITLE     Identification of a seven transmembrane helix receptor for
            corticotropin-releasing factor and sauvagine in mammalian brain
  JOURNAL   Neuron 11 (6), 1187-1195 (1993)
   PUBMED   8274282
REFERENCE   10 (bases 1 to 4927)
  AUTHORS   Njuki,F., Nicholl,C.G., Howard,A., Mak,J.C., Barnes,P.J.,
            Girgis,S.I. and Legon,S.
  TITLE     A new calcitonin-receptor-like sequence in rat pulmonary blood
            vessels
  JOURNAL   Clin Sci (Lond) 85 (4), 385-388 (1993)
   PUBMED   8222502
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Feb 10, 2021 this sequence version replaced NM_012717.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L27487.1, SRR26643287.8274.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676785, SAMN16676809
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-341               JAXUCZ010000003.1  89932276-89932616   c
            342-409             JAXUCZ010000003.1  89913813-89913880   c
            410-500             JAXUCZ010000003.1  89887260-89887350   c
            501-632             JAXUCZ010000003.1  89886968-89887099   c
            633-719             JAXUCZ010000003.1  89885507-89885593   c
            720-849             JAXUCZ010000003.1  89879445-89879574   c
            850-960             JAXUCZ010000003.1  89877304-89877414   c
            961-1073            JAXUCZ010000003.1  89876925-89877037   c
            1074-1165           JAXUCZ010000003.1  89875329-89875420   c
            1166-1292           JAXUCZ010000003.1  89855042-89855168   c
            1293-1446           JAXUCZ010000003.1  89852151-89852304   c
            1447-1507           JAXUCZ010000003.1  89850555-89850615   c
            1508-1574           JAXUCZ010000003.1  89850408-89850474   c
            1575-1793           JAXUCZ010000003.1  89845071-89845289   c
            1794-1835           JAXUCZ010000003.1  89844307-89844348   c
            1836-4927           JAXUCZ010000003.1  89835071-89838162   c
FEATURES             Location/Qualifiers
     source          1..4927
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q24"
     gene            1..4927
                     /gene="Calcrl"
                     /gene_synonym="CLR; Crlr; RATCRLR; RNCLR"
                     /note="calcitonin receptor like receptor"
                     /db_xref="GeneID:25029"
                     /db_xref="RGD:2255"
     exon            1..341
                     /gene="Calcrl"
                     /gene_synonym="CLR; Crlr; RATCRLR; RNCLR"
                     /inference="alignment:Splign:2.1.0"
     exon            342..409
                     /gene="Calcrl"
                     /gene_synonym="CLR; Crlr; RATCRLR; RNCLR"
                     /inference="alignment:Splign:2.1.0"
     exon            410..500
                     /gene="Calcrl"
                     /gene_synonym="CLR; Crlr; RATCRLR; RNCLR"
                     /inference="alignment:Splign:2.1.0"
     exon            501..632
                     /gene="Calcrl"
                     /gene_synonym="CLR; Crlr; RATCRLR; RNCLR"
                     /inference="alignment:Splign:2.1.0"
     exon            633..719
                     /gene="Calcrl"
                     /gene_synonym="CLR; Crlr; RATCRLR; RNCLR"
                     /inference="alignment:Splign:2.1.0"
     CDS             669..2060
                     /gene="Calcrl"
                     /gene_synonym="CLR; Crlr; RATCRLR; RNCLR"
                     /note="calcitonin gene-related peptide type 1 receptor;
                     CGRP type 1 receptor; calcitonin receptor-like"
                     /codon_start=1
                     /product="calcitonin gene-related peptide type 1 receptor
                     precursor"
                     /protein_id="NP_036849.2"
                     /db_xref="GeneID:25029"
                     /db_xref="RGD:2255"
                     /translation="MDKKCTLCFLFLLLLNMALIAAESEEGANQTDLGVTRNKIMTAQ
                     YECYQKIMQDPIQQGEGLYCNRTWDGWLCWNDVAAGTESMQYCPDYFQDFDPSEKVTK
                     ICDQDGNWFRHPDSNRTWTNYTLCNNSTHEKVKTALNLFYLTIIGHGLSIASLIISLI
                     IFFYFKSLSCQRITLHKNLFFSFVCNSIVTIIHLTAVANNQALVATNPVSCKVSQFIH
                     LYLMGCNYFWMLCEGIYLHTLIVVAVFAEKQHLMWYYFLGWGFPLLPACIHAIARSLY
                     YNDNCWISSDTHLLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAV
                     RATLILVPLLGIEFVLFPWRPEGKVAEEVYDYVMHILMHYQGLLVSTIFCFFNGEVQA
                     ILRRNWNQYKIQFGNGFSHSDALRSASYTVSTISDVQGYSHDCPTEHLNGKSIQDIEN
                     VALKPEKMYDLVM"
     exon            720..849
                     /gene="Calcrl"
                     /gene_synonym="CLR; Crlr; RATCRLR; RNCLR"
                     /inference="alignment:Splign:2.1.0"
     exon            850..960
                     /gene="Calcrl"
                     /gene_synonym="CLR; Crlr; RATCRLR; RNCLR"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1073
                     /gene="Calcrl"
                     /gene_synonym="CLR; Crlr; RATCRLR; RNCLR"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1165
                     /gene="Calcrl"
                     /gene_synonym="CLR; Crlr; RATCRLR; RNCLR"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1292
                     /gene="Calcrl"
                     /gene_synonym="CLR; Crlr; RATCRLR; RNCLR"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1446
                     /gene="Calcrl"
                     /gene_synonym="CLR; Crlr; RATCRLR; RNCLR"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1507
                     /gene="Calcrl"
                     /gene_synonym="CLR; Crlr; RATCRLR; RNCLR"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1574
                     /gene="Calcrl"
                     /gene_synonym="CLR; Crlr; RATCRLR; RNCLR"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1793
                     /gene="Calcrl"
                     /gene_synonym="CLR; Crlr; RATCRLR; RNCLR"
                     /inference="alignment:Splign:2.1.0"
     exon            1794..1835
                     /gene="Calcrl"
                     /gene_synonym="CLR; Crlr; RATCRLR; RNCLR"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..4927
                     /gene="Calcrl"
                     /gene_synonym="CLR; Crlr; RATCRLR; RNCLR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgctcttt tcctggggta agctatttga gaaagaaagt aacctaacac taagtgcagg
       61 cggggcgggg tgatgtaaca ggaagctgtg atgtttccct tctgctgctg atcgcttaca
      121 atctgacaac actccccatc tacccagaac aagccctctc ttcgcagcgg tgcacttctg
      181 ctttaggacc ggcgggctct gttgcctgga cctcacgctg cctgcagcaa agctttttga
      241 ctcttccaca cctcttctcc gggaactctt ttctactatc tcagaaaatc aaattccctc
      301 ctgagactat tcacacagaa tttccttagg agccgtgcgg gggccctatg atgatacacc
      361 aacatcttgt gctaccaact gtcaaaactt tggatggtct aacactcagg tcatgaccct
      421 tgtaattaag aaattctcga agacaatatt gagcatgatt caggagaaaa tgtgatttga
      481 gtctggagac aattgtgcat gtatattttt cttaagatct taaaaagaaa gagaaaacaa
      541 atccagggtt gtcggtcact gattgataga agagaaaaca atattcagac gattgcttat
      601 gattgacaag agcagctgcg gccgctaccc agcttgaaca tatcgcacac ttcagttgga
      661 ctctaatgat ggataaaaag tgtacactat gttttctgtt tctcttgctt cttaatatgg
      721 ctctcatcgc agcagagtcg gaagaaggcg cgaaccaaac agacttggga gtcactagga
      781 acaagatcat gacggctcag tatgaatgtt accaaaagat catgcaggat cccattcaac
      841 aaggagaagg cctttactgc aacagaacct gggacggatg gctatgctgg aatgacgttg
      901 cagcaggaac cgagtcaatg cagtactgcc ctgattactt tcaagatttt gatccttcag
      961 agaaggttac aaagatctgt gaccaagatg gaaactggtt cagacatcca gatagtaaca
     1021 ggacatggac aaactacacc ttgtgtaaca acagcacgca tgagaaagtg aagacagcac
     1081 tgaatttgtt ctacctaact ataattggac atggattatc tattgcctct ctgatcatct
     1141 cactcatcat atttttttat ttcaagagcc taagttgcca acggattaca ttgcataaaa
     1201 acctgttctt ttcatttgtt tgtaattcga ttgtgacaat cattcacctc acggcagtgg
     1261 ccaataacca ggccttagtg gccacaaatc ctgtgagctg caaggtgtcc cagttcattc
     1321 atctttacct gatgggctgt aactactttt ggatgctctg tgaaggcatt tacctgcaca
     1381 cactcattgt ggtggctgtg tttgcagaga agcagcactt gatgtggtat tattttcttg
     1441 gctgggggtt tcctctgctt cctgcctgca tccatgccat cgccagaagc ttgtattaca
     1501 atgacaactg ctggatcagc tcagacactc atctcctcta catcatccat ggtcccattt
     1561 gtgctgcttt actggtaaat ctctttttcc tattaaatat tgtacgtgtt ctcatcacca
     1621 agttgaaagt tacacaccaa gcagaatcca atctctacat gaaagctgta agagccactc
     1681 tcatcttggt accactactt ggcattgaat ttgtgctttt tccatggcgg cctgaaggaa
     1741 aggttgctga ggaggtgtat gactatgtca tgcacattct catgcactat cagggtcttt
     1801 tggtgtctac aattttctgc ttctttaacg gagaggttca agcaattctg agaagaaatt
     1861 ggaaccagta taaaatccaa tttggcaatg gcttttccca ctctgatgct ctccgcagcg
     1921 catcctatac ggtgtcaaca atcagcgatg tgcaggggta cagccacgac tgccccactg
     1981 aacacttaaa tggaaaaagc atccaggata ttgaaaatgt tgccttaaaa ccagaaaaaa
     2041 tgtatgatct agtgatgtga aaatacagaa atctcacttg ttttgtgtca cttgaaccta
     2101 tgattttata gtcggaagat ttaatagcaa atgggtttct tgaataccat gaagaaagcc
     2161 ctcaaatgaa atgagaattg tgtggataaa tgtttaacaa ccctctctct atgggggaga
     2221 aaagcctcaa tttttattgt tggccagtaa atactcctac catagctgat ttcaagttac
     2281 caacctgaca tcaccgaatg tggaattgga aagaaaataa gcacaatcaa ctcttgggag
     2341 ctgacatgcg tcgtcaaacc tgcacaacac cgcatgctct cacagatgga cctgtgcaca
     2401 ctcacacccg cactgaccag aactctgctc ctctgtctga gaagatcttg ctcagtctta
     2461 cagacatgaa aggaaagttt ggtttttgtt ataaaactcc tcatcctttg tcatttgatg
     2521 gtagtgaacg gtttgtccag aaacacttta accctcttta taacttctcc tgtagacgag
     2581 acagagtttg ctatctctgt cacctcgtgt tcctttcttt aagaaaagca actgagcaga
     2641 attcccatgg gcttctcagt tgctgctaca tatggttgta tcctgtggca tatccattct
     2701 gaatcactag ggagacgtat tgatagaagc tacaaacact ttgtcagcta cctttttgcc
     2761 ctctaaatct tgctgcagga gtaggaggaa atcagtcttc ctgaatctgt aaatagaaac
     2821 tttggccttt ccatttctac tgtgtagata agtgatcaac cattttatat gaagggaatc
     2881 aatgaaggat ttatttttat cttgggaatc tgagagagag agagagagag agagagagag
     2941 agagagagag agagagagat tgttgtacaa atgaaactgt aagtactctg tcattttatt
     3001 ttattgtttc aaatcaaaac acaacctaag taactgtttt aaagcagatg gataatgcaa
     3061 ctttatatgc gactaggtgt ctgatactgt gtctgggctg atttatttta tagaaaaaat
     3121 ggagtactga attctatatt tggtaaatat tttaaggaca aacagatacc agcatcagaa
     3181 gtttgagaac tcaaaacaaa cccccagaaa tatcaatgat aagatgtgaa atatttattt
     3241 taaaatgcaa agtcatactt ttacaagcac gttatctttg gagtgctgac atattgcctc
     3301 ttccaatcgg atgatgattc actcaaattc agaaattatg aacaactact gtaagaagtg
     3361 ctaatctgct acaattgtgt attttaactc actaaactat agttttactg acttttacta
     3421 aaggaagata tatggctttg aaaaaggccc aggttatttc tcttatgaac cacagaggaa
     3481 ttgtctctat ataatataca ctgtttcagt atttcagtag actactgtgg gtgataatac
     3541 aaccatggga agactcgaac ttaccactga ggatgaaatg tcagatgttt aggtaataat
     3601 taaattaaag tagaagaaag tttcgcttgt aagttaaagt gacattttaa atggatttag
     3661 tttttctaat attgctttgt ctggactttc tgaagaacca gattgacttc agttggtaaa
     3721 agtcagtttg gggacagtca catgaatcca tgttttttga agtgtgtcca tcagcctaca
     3781 gtgcatgaaa ggcatgactc agtcctccct cattgtgtct taaactacaa tagatagtaa
     3841 attcagaagt tgttcgaaac tgtcaaggaa aataattcaa attatcaagc actgatgtat
     3901 tagatgatct ggcagacatt atttgtaatt tatctataca gaccaaggtg tcactaagtt
     3961 actttcagca ttgaaaagga gctcatgctt ttctgaactt tcaactgcct aaaccgtgca
     4021 agccttcctt ttaatacgtt caaactttag ctggctatta ttcaaaggcg tgtcttcgta
     4081 tcttctctga cagtgttcat gtaaattctg cattcttcca aactgtcaag tttgaacagc
     4141 aaatgatagc acagaatgcc gaattaccag aggacatatt caaaagttat tgtaatttta
     4201 aattttatta ttcttttacc gtattgagca gagctgagat ttctctactg ccaatatcta
     4261 ctgtggtgtc aaccatgcca tagaggtctg agattagtca gtattagttt tgtaataata
     4321 tttttgaagc taaatttctc taaagctgaa gtgccaatta aaatatttct actttgcttg
     4381 taggaaaaaa aacctgaaat ttttgaaaga aaacttctct ggtgcctaaa aactaacttg
     4441 ggggaatttt tagcatttaa aagttggatt tgtcattttt agaagtgact tatgtatgtt
     4501 tttgttaata agtcgtccat cctggagttt agtgtttgtt caaatataac aaactatgta
     4561 gagtttacta gtactcacag tgttacactt actgtttaga tattttaatg tgaatctatt
     4621 ttaattttct ttgtgtttta atttgctcat agaaacatct gtaaaacata ttcaagatgt
     4681 tctggtcact taaaagaact catgttgtat cgacttaaaa tctttattta ggttttatga
     4741 gaatattaaa attgtaagtt aacattcact ttcactcatc ttccctggag tacagagtga
     4801 ttgaatttct cacaaaattc ttgcagcaat taaagaaata ctttgcaaaa taaatggcga
     4861 tgtctttatt cctctcttta aagactttaa taaactagta agtgaattta ataaatgaat
     4921 taaaaaa
//
