LOCUS       NM_001034015            3433 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus calcitonin receptor (Calcr), transcript variant
            1a, mRNA.
ACCESSION   NM_001034015
VERSION     NM_001034015.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3433)
  AUTHORS   Andreassen,K.V., Feigh,M., Hjuler,S.T., Gydesen,S., Henriksen,J.E.,
            Beck-Nielsen,H., Christiansen,C., Karsdal,M.A. and Henriksen,K.
  TITLE     A novel oral dual amylin and calcitonin receptor agonist (KBP-042)
            exerts antiobesity and antidiabetic effects in rats
  JOURNAL   Am J Physiol Endocrinol Metab 307 (1), E24-E33 (2014)
   PUBMED   24801386
  REMARK    GeneRIF: In conclusion, oral KBP-042 is a novel DACRA, which exerts
            antiobesity and antidiabetic efficacy by dual modulation of insulin
            sensitivity and directly decelerating stress on the pancreatic
            alpha- and beta-cells.
REFERENCE   2  (bases 1 to 3433)
  AUTHORS   Gooi,J.H., Chia,L.Y., Walsh,N.C., Karsdal,M.A., Quinn,J.M.,
            Martin,T.J. and Sims,N.A.
  TITLE     Decline in calcitonin receptor expression in osteocytes with age
  JOURNAL   J Endocrinol 221 (2), 181-191 (2014)
   PUBMED   24516262
  REMARK    GeneRIF: Calcitonin receptor mRNA expression declines with age on
            osteocytes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3433)
  AUTHORS   Tural,S., Kara,N., Alayli,G. and Tomak,L.
  TITLE     Association between osteoporosis and polymorphisms of the bone Gla
            protein, estrogen receptor 1, collagen 1-A1 and calcitonin receptor
            genes in Turkish postmenopausal women
  JOURNAL   Gene 515 (1), 167-172 (2013)
   PUBMED   23137636
REFERENCE   4  (bases 1 to 3433)
  AUTHORS   Matsubara,R., Kukita,T., Ichigi,Y., Takigawa,I., Qu,P.F.,
            Funakubo,N., Miyamoto,H., Nonaka,K. and Kukita,A.
  TITLE     Characterization and identification of subpopulations of
            mononuclear preosteoclasts induced by TNF-alpha in combination with
            TGF-beta in rats
  JOURNAL   PLoS One 7 (10), e47930 (2012)
   PUBMED   23110133
REFERENCE   5  (bases 1 to 3433)
  AUTHORS   Abdelmagid,N., Bereczky-Veress,B., Guerreiro-Cacais,A.O.,
            Bergman,P., Luhr,K.M., Bergstrom,T., Skoldenberg,B., Piehl,F.,
            Olsson,T. and Diez,M.
  TITLE     The calcitonin receptor gene is a candidate for regulation of
            susceptibility to herpes simplex type 1 neuronal infection leading
            to encephalitis in rat
  JOURNAL   PLoS Pathog 8 (6), e1002753 (2012)
   PUBMED   22761571
  REMARK    GeneRIF: variability in Calcr was identified as potentially
            critical for infection and viral spread to the CNS and subsequent
            Herpes simplex encephalitis development.
REFERENCE   6  (bases 1 to 3433)
  AUTHORS   Albrandt,K., Brady,E.M., Moore,C.X., Mull,E., Sierzega,M.E. and
            Beaumont,K.
  TITLE     Molecular cloning and functional expression of a third isoform of
            the human calcitonin receptor and partial characterization of the
            calcitonin receptor gene
  JOURNAL   Endocrinology 136 (12), 5377-5384 (1995)
   PUBMED   7588285
REFERENCE   7  (bases 1 to 3433)
  AUTHORS   Lee,S.K., Goldring,S.R. and Lorenzo,J.A.
  TITLE     Expression of the calcitonin receptor in bone marrow cell cultures
            and in bone: a specific marker of the differentiated osteoclast
            that is regulated by calcitonin
  JOURNAL   Endocrinology 136 (10), 4572-4581 (1995)
   PUBMED   7664679
REFERENCE   8  (bases 1 to 3433)
  AUTHORS   Egerton,M., Needham,M., Evans,S., Millest,A., Cerillo,G.,
            McPheat,J., Popplewell,M., Johnstone,D. and Hollis,M.
  TITLE     Identification of multiple human calcitonin receptor isoforms:
            heterologous expression and pharmacological characterization
  JOURNAL   J Mol Endocrinol 14 (2), 179-189 (1995)
   PUBMED   7619207
REFERENCE   9  (bases 1 to 3433)
  AUTHORS   Pandya,S.
  TITLE     Obituary. Dr. Wilder Penfield, 1891-1976
  JOURNAL   Neurol India 24 (2), V-VI (1976)
   PUBMED   796748
REFERENCE   10 (bases 1 to 3433)
  AUTHORS   Blattner,R.J.
  TITLE     Hemolytic anemia associated with Wilson's disease
  JOURNAL   J Pediatr 71 (2), 284-287 (1967)
   PUBMED   4961748
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB791100.1 and L14617.1.
            
            Transcript Variant: This variant (1a, previously called 2), lacks
            an alternate in-frame exon compared to variant 1b. The resulting
            isoform (1a, previously called b), has the same N- and C-termini
            but is shorter compared to isoform 1b.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L13041.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN14984027, SAMN14984033
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                CB791100.1         55-105
            52-3433             L14617.1           1-3382
FEATURES             Location/Qualifiers
     source          1..3433
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q13"
     gene            1..3433
                     /gene="Calcr"
                     /note="calcitonin receptor"
                     /db_xref="GeneID:116506"
                     /db_xref="RGD:621001"
     exon            1..21
                     /gene="Calcr"
                     /inference="alignment:Splign:2.1.0"
     exon            22..166
                     /gene="Calcr"
                     /inference="alignment:Splign:2.1.0"
     exon            167..264
                     /gene="Calcr"
                     /inference="alignment:Splign:2.1.0"
     CDS             242..1732
                     /gene="Calcr"
                     /note="isoform 1a precursor is encoded by transcript
                     variant 1a; CT-R; C1A/C1B"
                     /codon_start=1
                     /product="calcitonin receptor isoform 1a precursor"
                     /protein_id="NP_001029187.1"
                     /db_xref="GeneID:116506"
                     /db_xref="RGD:621001"
                     /translation="MTPRRSRMKRRNLRKPKMRFLLLNRFTLLLLLLVSPTPVLQAPT
                     NLTDSGLDQEPFLYLVGRKKLLDAQYKCYDRIQQLPPYEGEGPYCNRTWDGWMCWDDT
                     PAGVMSYQHCPDYFPDFDPTEKVSKYCDENGEWFRHPDSNRTWSNYTLCNAFTPDKLH
                     NAYVLYYLALVGHSMSIAALIASMGIFLFFKNLSCQRVTLHKNMFLTYILNSIIIIIH
                     LVEVVPNGDLVRRDPISCKILHFFHQYMMACNYFWMLCEGIYLHTLIVMAVFTEDQRL
                     RWYYLLGWGFPIVPTIIHAITRAVYYNDNCWLSTETHLLYIIHGPVMAALVVNFFFLL
                     NIVRVLVTKMRQTHEAEAYMYLKAVKATMVLVPLLGIQFVVFPWRPSNKVLGKIYDYL
                     MHSLIHFQGFFVATIYCFCNHEVQVTLKRQWAQFKIQWSHRWGRRRRPTNRVVSAPRA
                     VAFAEPGGLPIYICHQEPRNPPVSNNEGEEGTEMIPMNVIQQDSSA"
     exon            265..343
                     /gene="Calcr"
                     /inference="alignment:Splign:2.1.0"
     exon            344..497
                     /gene="Calcr"
                     /inference="alignment:Splign:2.1.0"
     exon            498..608
                     /gene="Calcr"
                     /inference="alignment:Splign:2.1.0"
     exon            609..721
                     /gene="Calcr"
                     /inference="alignment:Splign:2.1.0"
     exon            722..813
                     /gene="Calcr"
                     /inference="alignment:Splign:2.1.0"
     exon            814..940
                     /gene="Calcr"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1094
                     /gene="Calcr"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1155
                     /gene="Calcr"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1222
                     /gene="Calcr"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1441
                     /gene="Calcr"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1483
                     /gene="Calcr"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..3420
                     /gene="Calcr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcagaggca ggctctgcaa ggagagccag tggcccaagc ccctggacgg actgcagctt
       61 gcagacaact cctggttgga gaggtgcttc tgcacctcac tctgaggttg gcaccccctg
      121 cccagtgaag tctgagttcc tgagacatcc agctagagaa ttcctgcgtc cacctaaggt
      181 aagtgccatt ccacacaaga ggaaaccgag ggagcacggc ttctgaacag cggatctgaa
      241 aatgactcca cggagatcca gaatgaaaag gcggaacctc cgaaaaccga agatgaggtt
      301 ccttctcctg aacaggttca ccctgctgct cctgctccta gtgagcccta ctccagttct
      361 tcaggctcct accaatctca ctgactccgg ccttgatcag gagccattcc tgtacttggt
      421 tggacgcaag aagcttctgg atgctcagta caagtgctat gaccggattc agcagttgcc
      481 cccttatgag ggagaaggtc catattgcaa ccgaacttgg gatggatgga tgtgctggga
      541 cgacactcca gctggtgtaa tgtcctatca gcactgccct gactactttc cggactttga
      601 cccaacagaa aaggtttcaa aatactgcga tgaaaatgga gagtggttta gacaccctga
      661 cagcaaccga acctggtcca actacactct gtgcaatgcc ttcactcctg acaaactgca
      721 taatgcatac gttctttatt acctagcact tgtgggccac tccatgtcaa ttgctgctct
      781 gattgcttcc atggggatct tcttgttttt caagaacctt agctgccaga gagtgactct
      841 gcacaagaac atgttcctca cttatatcct gaactctatc attatcatca tccacctggt
      901 tgaggttgtg cccaatggag acctggtgcg acgggatcct ataagttgca agattctgca
      961 ctttttccat cagtacatga tggcttgcaa ctacttctgg atgctgtgtg aggggatcta
     1021 tcttcacact ctgatcgtca tggctgtgtt caccgaggat caacgtctgc gctggtacta
     1081 tttacttggc tgggggttcc caatagtgcc aactattatc catgccatta ctcgtgccgt
     1141 ctactacaac gacaactgtt ggctgagtac ggagacccac ttgctttaca tcatccatgg
     1201 acccgtcatg gcggctctgg tggtcaactt cttctttctg ctcaacattg tccgtgtgct
     1261 tgtgaccaag atgaggcaaa cccatgaagc cgaggcctac atgtacctga aggctgtaaa
     1321 ggccaccatg gtccttgtgc ccctgctggg gatccagttt gttgtgtttc cctggaggcc
     1381 ctccaacaaa gtgcttggga agatctatga ttatctcatg cactctctga ttcatttcca
     1441 gggattcttt gtcgcgacta tctactgctt ctgtaaccat gaggtgcaag tgaccctgaa
     1501 gcgtcagtgg gcgcagttca agatccagtg gagccatcgc tggggtaggc gccgccgccc
     1561 caccaaccga gtggttagcg ctcctcgtgc tgtagccttt gcagaaccag gtggcctccc
     1621 catttacatc tgccatcagg aaccaaggaa tcctccagtc agcaacaacg aaggcgaaga
     1681 gggtactgaa atgatcccca tgaatgtcat ccagcaagac tcatccgctt gaatgcttga
     1741 atgtgaagca accccccaac attgtgatcc actgagcctt catttcctgg gagaacgata
     1801 gaccatgcgt ttcaagtgat ccccatcctc ccaggagcta agcatatcat ttgtgaagat
     1861 gtattaagtg aatttgtcca tagtgaattt gaagaacgtt attcttggta ctattgcttt
     1921 gggagtcagg ctaggctctc agtgcaactt gtgaactcca ttattcatct aggactgaga
     1981 tgacagtgtt cataggaatg tagacaaggt atccaaaact gccactaaat tgacctagtt
     2041 cagataaggg tgctccatgt taatcttgag ccatttgtac ctttgagaaa ctaaaatcac
     2101 tctcaatgtt tttaatttta acactggact ttgaattaga ctatttctgt atttggctac
     2161 ggatctggtt tttaatgttt ttatttcagt caattcctat attgcacatt ttttcatcca
     2221 tacaatgtca actgcacaaa taacatgacc tctggaagat gctgtgtctt ttataacatg
     2281 atccacgtca ccaggcagac ccaaatactg taaagaattg atctgaatgt tgagtgtgct
     2341 ttggtcactg acatttataa attgggaggt catcaagaac ctatcactaa atttttcaca
     2401 aaactgaccc ccctcaaatg taattttcca tcaaagagaa cactctttaa agatagtttt
     2461 ccactttcct aaactacagg atttataaag caaatcattc caaggtttat aaagcagatt
     2521 acctcttgcc cttgggtgct atttagcagt gagggataga tttgtttacg actggtaatt
     2581 aaaagactcc attcaagtcc attaactgcc ttccacccag cttcaaagct tgacaagatc
     2641 ccgtgttttc caggaagact cagtgtggct aattacaaat cagtttctag ttgacctctt
     2701 gtttgcttct attagcaaaa caaggaggga aaaaagcaaa ccacaatgta aggacttgga
     2761 gtttaaccac atattagttc atcttaaatt aaagacaagc ttctcaccaa aactcagtac
     2821 catatttcca cgcctctctt tactccccag aatgagatct tccaagatcc acaaataaac
     2881 caataccatt accaatttct gaatctgcaa ctgcaatcaa ttatcattat taatttgtat
     2941 gctgaatgag acgcatcctt gagaccctta aaaatctcat ctcctctttg tcatcttgtg
     3001 tcactgcctt tcagaggtga tttagttgcg taaaaacaaa agtaacttga tttgttctgg
     3061 ttacgtactt ggtgcaccca gagaaaattg tatttcgcta gcagctgtgg cccttggata
     3121 ctgagagtct cctttaccaa aatgggagaa ttgaaaggaa ggattttttt tccaatcaca
     3181 gtgttacgtg gtgatgttcc catgttttgt ttacaaacat tgaaatcagt gtatttcagg
     3241 cagctctggt acaaatgtga tagtgtattg ctgaagtgtt tgagacgtta ttgtgcttct
     3301 gtagtagggg ctgatgaaat caaactgact tatcatagca ttgcatgtaa tacctaaatt
     3361 gtgtgaaaca cttcttctgt gtacttgtat aaattaatac aagcatgttg aaaaggcaaa
     3421 aaaaaaaaaa aaa
//
