LOCUS       NM_001033955             991 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus calcitonin-related polypeptide alpha (Calca),
            transcript variant 2, mRNA.
ACCESSION   NM_001033955
VERSION     NM_001033955.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 991)
  AUTHORS   Li,C., Ajmal,E., Alok,K., Powell,K., Wadolowski,S., Tambo,W.,
            Turpin,J., Barthelemy,E., Al-Abed,Y. and LeDoux,D.
  TITLE     CGRP as a potential mediator for the sexually dimorphic responses
            to traumatic brain injury
  JOURNAL   Biol Sex Differ 15 (1), 44 (2024)
   PUBMED   38816868
  REMARK    GeneRIF: CGRP as a potential mediator for the sexually dimorphic
            responses to traumatic brain injury.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 991)
  AUTHORS   Kong,Q., Gao,S., Li,P., Sun,H., Zhang,Z., Yu,X., Deng,F. and
            Wang,T.
  TITLE     Calcitonin gene-related peptide-modulated macrophage phenotypic
            alteration regulates angiogenesis in early bone healing
  JOURNAL   Int Immunopharmacol 130, 111766 (2024)
   PUBMED   38452411
  REMARK    GeneRIF: Calcitonin gene-related peptide-modulated macrophage
            phenotypic alteration regulates angiogenesis in early bone healing.
REFERENCE   3  (bases 1 to 991)
  AUTHORS   Katagiri,A., Kishimoto,S., Okamoto,Y., Yamada,M., Niwa,H.,
            Bereiter,D.A. and Kato,T.
  TITLE     Effect of chronic intermittent hypoxia on ocular and intraoral
            mechanical allodynia mediated via the calcitonin gene-related
            peptide in a rat
  JOURNAL   Sleep 47 (3) (2024)
   PUBMED   38166171
  REMARK    GeneRIF: Effect of chronic intermittent hypoxia on ocular and
            intraoral mechanical allodynia mediated via the calcitonin
            gene-related peptide in a rat.
REFERENCE   4  (bases 1 to 991)
  AUTHORS   Chen,J., Bendowski,K.T., Bizanti,A., Zhang,Y., Ma,J., Hoover,D.B.,
            Gozal,D., Shivkumar,K. and Cheng,Z.J.
  TITLE     Distribution and morphology of calcitonin gene-related peptide
            (CGRP) innervation in flat mounts of whole rat atria and ventricles
  JOURNAL   Auton Neurosci 251, 103127 (2024)
   PUBMED   38211380
  REMARK    GeneRIF: Distribution and morphology of calcitonin gene-related
            peptide (CGRP) innervation in flat mounts of whole rat atria and
            ventricles.
REFERENCE   5  (bases 1 to 991)
  AUTHORS   Chen,W., Ma,L., Sun,W., Xiao,W., Guo,H., Xiu,J. and Jiang,X.
  TITLE     CGRP promotes osteogenic differentiation by regulating macrophage
            M2 polarization through HDAC6/AKAP12 signaling pathway
  JOURNAL   Regen Med 19 (7-8), 379-391 (2024)
   PUBMED   39072399
  REMARK    GeneRIF: CGRP promotes osteogenic differentiation by regulating
            macrophage M2 polarization through HDAC6/AKAP12 signaling pathway.
REFERENCE   6  (bases 1 to 991)
  AUTHORS   Lee,K.F., Li,E., Huber,L.J., Landis,S.C., Sharpe,A.H., Chao,M.V.
            and Jaenisch,R.
  TITLE     Targeted mutation of the gene encoding the low affinity NGF
            receptor p75 leads to deficits in the peripheral sensory nervous
            system
  JOURNAL   Cell 69 (5), 737-749 (1992)
   PUBMED   1317267
REFERENCE   7  (bases 1 to 991)
  AUTHORS   Sung,C.P., Arleth,A.J., Aiyar,N., Bhatnagar,P.K., Lysko,P.G. and
            Feuerstein,G.
  TITLE     CGRP stimulates the adhesion of leukocytes to vascular endothelial
            cells
  JOURNAL   Peptides 13 (3), 429-434 (1992)
   PUBMED   1326102
REFERENCE   8  (bases 1 to 991)
  AUTHORS   Amara,S.G., Arriza,J.L., Leff,S.E., Swanson,L.W., Evans,R.M. and
            Rosenfeld,M.G.
  TITLE     Expression in brain of a messenger RNA encoding a novel
            neuropeptide homologous to calcitonin gene-related peptide
  JOURNAL   Science 229 (4718), 1094-1097 (1985)
   PUBMED   2994212
REFERENCE   9  (bases 1 to 991)
  AUTHORS   Edbrooke,M.R., Parker,D., McVey,J.H., Riley,J.H., Sorenson,G.D.,
            Pettengill,O.S. and Craig,R.K.
  TITLE     Expression of the human calcitonin/CGRP gene in lung and thyroid
            carcinoma
  JOURNAL   EMBO J 4 (3), 715-724 (1985)
   PUBMED   2408883
REFERENCE   10 (bases 1 to 991)
  AUTHORS   Raulais,D., Hagaman,J., Ontjes,D.A., Lundblad,R.L. and Kingdon,H.S.
  TITLE     The complete amino-acid sequence of rat thyrocalcitonin
  JOURNAL   Eur J Biochem 64 (2), 607-611 (1976)
   PUBMED   1278175
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF978038.1, CB711853.1, BG663259.1, CB746609.1 and AW523601.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR, 3' UTR,
            and 3' coding sequence compared to variant 1. The resulting isoform
            (Cgrp) has a shorter and distinct C-terminus compared to isoform
            Calca.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB577296.1, CB579587.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840106, SAMN12840112
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-98                CF978038.1         6-103
            99-122              CB711853.1         67-90
            123-460             BG663259.1         65-402
            461-785             CB746609.1         123-447
            786-991             AW523601.1         1-206               c
FEATURES             Location/Qualifiers
     source          1..991
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q34"
     gene            1..991
                     /gene="Calca"
                     /gene_synonym="Cal1; CAL6; Calc; calcitonin; CGRP; CGRP1;
                     RATCAL6"
                     /note="calcitonin-related polypeptide alpha"
                     /db_xref="GeneID:24241"
                     /db_xref="RGD:2254"
     exon            1..122
                     /gene="Calca"
                     /gene_synonym="Cal1; CAL6; Calc; calcitonin; CGRP; CGRP1;
                     RATCAL6"
                     /inference="alignment:Splign:2.1.0"
     exon            123..217
                     /gene="Calca"
                     /gene_synonym="Cal1; CAL6; Calc; calcitonin; CGRP; CGRP1;
                     RATCAL6"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..518
                     /gene="Calca"
                     /gene_synonym="Cal1; CAL6; Calc; calcitonin; CGRP; CGRP1;
                     RATCAL6"
                     /note="isoform Cgrp preproprotein is encoded by transcript
                     variant 2; calcitonin gene-related peptide 1; CGRP-I;
                     alpha-type CGRP; calcitonin gene-related peptide I;
                     calcitonin/calcitonin-related polypeptide, alpha;
                     procalcitonin"
                     /codon_start=1
                     /product="calcitonin gene-related peptide 1 isoform Cgrp
                     preproprotein"
                     /protein_id="NP_001029127.1"
                     /db_xref="GeneID:24241"
                     /db_xref="RGD:2254"
                     /translation="MGFLKFSPFLVVSILLLYQACGLQAVPLRSTLESSPGMATLSEE
                     EARLLAALVQNYMQMKVRELEQEEEQEAEGSSVTAQKRSCNTATCVTHRLAGLLSRSG
                     GVVKDNFVPTNVGSEAFGRRRRDLQA"
     exon            218..358
                     /gene="Calca"
                     /gene_synonym="Cal1; CAL6; Calc; calcitonin; CGRP; CGRP1;
                     RATCAL6"
                     /inference="alignment:Splign:2.1.0"
     exon            359..542
                     /gene="Calca"
                     /gene_synonym="Cal1; CAL6; Calc; calcitonin; CGRP; CGRP1;
                     RATCAL6"
                     /inference="alignment:Splign:2.1.0"
     exon            543..976
                     /gene="Calca"
                     /gene_synonym="Cal1; CAL6; Calc; calcitonin; CGRP; CGRP1;
                     RATCAL6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacaggagcc gctgcccaga tcaagagtca ccgcctcgca accaccgcct ggctccatca
       61 ggaccccgca gtctcagctc caagtcatcg ctcaccaggt gagccctgag gttcctgctc
      121 agggaggcat catgggcttt ctgaagttct cccctttcct ggttgtcagc atcttgctcc
      181 tgtaccaggc atgcggcctc caggcagttc ctttgaggtc aaccttggaa agcagcccag
      241 gcatggccac tctcagtgaa gaagaagctc gcctactggc tgcactggtg cagaactata
      301 tgcagatgaa agtcagggag ctggagcagg aggaggaaca ggaggctgag ggctctagtg
      361 tcactgccca gaagagatcc tgcaacactg ccacctgcgt gacccatcgg ctggcaggct
      421 tgctgagcag gtcgggaggt gtggtgaagg acaactttgt gcccaccaat gtgggctctg
      481 aagccttcgg ccgccgccgc agggaccttc aggcttgaac agataatagc cccagaaaga
      541 aggttacaca ataaagataa actctaattc ttttcatgta taattaaagt catgtgtcag
      601 aaaggctgat ggaagacaca tatatttgca tccttcttgg tactgaaacc cttctcccta
      661 tgacaggaaa taaagctaag tgcagaataa gctcaccata gttggctatt gtgcatcgtg
      721 ttgtatgtga ttctatatcc ataacatgac agcatggttc tggcttatct ggtagcaaat
      781 ctagtcccca taaaccaccc tgtcgatgtt gataactctg ctaaacctca agcggatatg
      841 aaaccactgc ctcttggtct tctggggaca catggtaatg ttgtgactca atggaaccat
      901 atgcttaaag aactgttaat gttgtcactt gtgagcttaa tcaaaattaa aaaatatgta
      961 ttttcgatat cctcaaaaaa aaaaaaaaaa a
//
