LOCUS       NM_053988               1438 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus calbindin 2 (Calb2), mRNA.
ACCESSION   NM_053988
VERSION     NM_053988.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1438)
  AUTHORS   Vishnyakova,P.A., Moiseev,K.Y., Spirichev,A.A., Emanuilov,A.I.,
            Nozdrachev,A.D. and Masliukov,P.M.
  TITLE     Expression of calbindin and calretinin in the dorsomedial and
            ventromedial hypothalamic nuclei during aging
  JOURNAL   Anat Rec (Hoboken) 304 (5), 1094-1104 (2021)
   PUBMED   33040447
  REMARK    GeneRIF: Expression of calbindin and calretinin in the dorsomedial
            and ventromedial hypothalamic nuclei during aging.
REFERENCE   2  (bases 1 to 1438)
  AUTHORS   Altobelli,G.G., Cimini,D., Esposito,G., Iuvone,T. and Cimini,V.
  TITLE     Analysis of calretinin early expression in the rat hippocampus
            after beta amyloid (1-42) peptide injection
  JOURNAL   Brain Res 1610, 89-97 (2015)
   PUBMED   25813826
  REMARK    GeneRIF: Quantitative analysis of the transient changes in
            calretinin expression by hybridochemistry within neuronal cell
            populations in the hippocampus of a beta amyloid-treated rat model
            of Alzheimer's disease and their correlation with endocannabinoid
            increase
REFERENCE   3  (bases 1 to 1438)
  AUTHORS   Szalak,R., Matysek,M., Mozel,S. and Arciszewski,M.B.
  TITLE     Immunocytochemical detection of calretinin in the claustrum and
            endopiriform nucleus of the chinchilla
  JOURNAL   Pol J Vet Sci 18 (4), 857-863 (2015)
   PUBMED   26812830
REFERENCE   4  (bases 1 to 1438)
  AUTHORS   Shigaeva,M.I., Talanov,E.Iu., Venediktova,N.I., Murzaeva,S.V. and
            Mironova,G.D.
  TITLE     [A role for calreticulin in functioning of mitochondrial
            ATP-dependent potassium channel]
  JOURNAL   Biofizika 59 (5), 887-894 (2014)
   PUBMED   25730969
  REMARK    GeneRIF: A role for calreticulin in functioning of mitochondrial
            ATP-dependent potassium channel
REFERENCE   5  (bases 1 to 1438)
  AUTHORS   Wilhelm,B.G., Mandad,S., Truckenbrodt,S., Krohnert,K., Schafer,C.,
            Rammner,B., Koo,S.J., Classen,G.A., Krauss,M., Haucke,V., Urlaub,H.
            and Rizzoli,S.O.
  TITLE     Composition of isolated synaptic boutons reveals the amounts of
            vesicle trafficking proteins
  JOURNAL   Science 344 (6187), 1023-1028 (2014)
   PUBMED   24876496
REFERENCE   6  (bases 1 to 1438)
  AUTHORS   Palczewska,M., Groves,P., Ambrus,A., Kaleta,A., Kover,K.E.,
            Batta,G. and Kuznicki,J.
  TITLE     Structural and biochemical characterization of neuronal calretinin
            domain I-II (residues 1-100). Comparison to homologous calbindin
            D28k domain I-II (residues 1-93)
  JOURNAL   Eur J Biochem 268 (23), 6229-6237 (2001)
   PUBMED   11733019
REFERENCE   7  (bases 1 to 1438)
  AUTHORS   Winsky,L. and Kuznicki,J.
  TITLE     Distribution of calretinin, calbindin D28k, and parvalbumin in
            subcellular fractions of rat cerebellum: effects of calcium
  JOURNAL   J Neurochem 65 (1), 381-388 (1995)
   PUBMED   7790883
REFERENCE   8  (bases 1 to 1438)
  AUTHORS   Strauss,K.I., Isaacs,K.R., Ha,Q.N. and Jacobowitz,D.M.
  TITLE     Calretinin is expressed in the Leydig cells of rat testis
  JOURNAL   Biochim Biophys Acta 1219 (2), 435-440 (1994)
   PUBMED   7918640
REFERENCE   9  (bases 1 to 1438)
  AUTHORS   Strauss,K.I. and Jacobowitz,D.M.
  TITLE     Nucleotide sequence of rat calretinin cDNA
  JOURNAL   Neurochem Int 22 (6), 541-546 (1993)
   PUBMED   8513281
REFERENCE   10 (bases 1 to 1438)
  AUTHORS   Gabrielides,C., McCormack,A.L., Hunt,D.F. and Christakos,S.
  TITLE     Brain calbindin-D28k and an Mr 29,000 calcium binding protein in
            cerebellum are different but related proteins: evidence obtained
            from sequence analysis by tandem mass spectrometry
  JOURNAL   Biochemistry 30 (3), 656-662 (1991)
   PUBMED   1988053
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Nov 26, 2020 this sequence version replaced NM_053988.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X66974.1, BC087603.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840105,
                                           SAMN12840110 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               JAXUCZ010000019.1  55050713-55050858   c
            147-223             JAXUCZ010000019.1  55038957-55039033   c
            224-313             JAXUCZ010000019.1  55036446-55036535   c
            314-394             JAXUCZ010000019.1  55034377-55034457   c
            395-451             JAXUCZ010000019.1  55031335-55031391   c
            452-529             JAXUCZ010000019.1  55030523-55030600   c
            530-585             JAXUCZ010000019.1  55030033-55030088   c
            586-625             JAXUCZ010000019.1  55029657-55029696   c
            626-679             JAXUCZ010000019.1  55029335-55029388   c
            680-751             JAXUCZ010000019.1  55027545-55027616   c
            752-1438            JAXUCZ010000019.1  55023849-55024535   c
FEATURES             Location/Qualifiers
     source          1..1438
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..1438
                     /gene="Calb2"
                     /note="calbindin 2"
                     /db_xref="GeneID:117059"
                     /db_xref="RGD:620981"
     exon            1..146
                     /gene="Calb2"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..868
                     /gene="Calb2"
                     /note="CR"
                     /codon_start=1
                     /product="calretinin"
                     /protein_id="NP_446440.1"
                     /db_xref="GeneID:117059"
                     /db_xref="RGD:620981"
                     /translation="MAGPQQQPPYLHLAELTASQFLEIWKHFDADGNGYIEGKELENF
                     FQELEKARKGSGMMSKSDNFGEKMKEFMQKYDKNSDGKIEMAELAQILPTEENFLLCF
                     RQHVGSSAEFMEAWRKYDTDRSGYIEANELKGFLSDLLKKANRPYDEPKLQEYTQTIL
                     RMFDLNGDGKLGLSEMSRLLPVQENFLLKFQGMKLTSEEFNAIFTFYDKDGSGYIDEN
                     ELDALLKDLYEKNKKEMNIQQLTTYRKSVMSLAEAGKLYRKDLEIVLCSEPPM"
     exon            147..223
                     /gene="Calb2"
                     /inference="alignment:Splign:2.1.0"
     exon            224..313
                     /gene="Calb2"
                     /inference="alignment:Splign:2.1.0"
     exon            314..394
                     /gene="Calb2"
                     /inference="alignment:Splign:2.1.0"
     exon            395..451
                     /gene="Calb2"
                     /inference="alignment:Splign:2.1.0"
     exon            452..529
                     /gene="Calb2"
                     /inference="alignment:Splign:2.1.0"
     exon            530..585
                     /gene="Calb2"
                     /inference="alignment:Splign:2.1.0"
     exon            586..625
                     /gene="Calb2"
                     /inference="alignment:Splign:2.1.0"
     exon            626..679
                     /gene="Calb2"
                     /inference="alignment:Splign:2.1.0"
     exon            680..751
                     /gene="Calb2"
                     /inference="alignment:Splign:2.1.0"
     exon            752..1438
                     /gene="Calb2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggcaccga gtgacagcgc tgagaggctt aagatctccg gagccgctcg ccatggctgg
       61 cccgcagcag cagccccctt acctgcacct ggccgagctg actgcatccc agttcctgga
      121 aatctggaag cactttgatg ctgacggaaa tgggtacatt gaaggtaaag agctagaaaa
      181 cttcttccag gagctggaga aggccaggaa aggttctggc atgatgtcca agagcgacaa
      241 ttttggagag aagatgaagg agttcatgca gaagtatgat aagaactcag atgggaaaat
      301 tgagatggca gagctggcgc agatcctgcc aaccgaagag aatttccttt tgtgcttcag
      361 gcagcacgtg ggctccagcg ctgagtttat ggaggcttgg cggaagtatg acacagacag
      421 aagtggctac atcgaagcaa atgagctcaa gggatttctg tccgacctcc tgaagaaggc
      481 caaccgtccc tatgatgaac ctaagctcca ggagtacacc caaaccatac tacgcatgtt
      541 tgacttaaat ggagacggca aattgggtct ctcagagatg tctagactct tgcctgtaca
      601 agaaaacttc ctgctgaaat ttcagggtat gaagctgacc tcagaagagt tcaatgccat
      661 cttcacattc tatgacaagg atggaagcgg ctacatcgat gagaacgagc tggacgccct
      721 cctgaaggat ctgtatgaga agaacaagaa ggagatgaat atccagcagc tcaccaccta
      781 caggaagagc gtcatgtcct tggccgaggc agggaaactc tacagaaagg acctggagat
      841 tgtgctttgc agtgagcccc ccatgtaaag gggtgaaggg acaggggctg cttctgcacc
      901 tcccctaaac cctgcccccc actgccctga ctctcttgaa actccttccc agacctctcc
      961 acccctgcaa cctgcacaca ccagcctgtg gggcaggaaa ggagagatgg aaagagggtg
     1021 gctggtagca ttcctttgag ctgcaccagc ccaaccctgg cctgacagac agctgtgcct
     1081 gtggtgggtg ggtcacacgg ttggtgggta ggggcacagg tggggcttcc ctagtctctt
     1141 tgctgtgatg catgagctcc ttcgctgtat gatttaggct tccgagtcca acagagtgca
     1201 ctccttcctc ttgctgcacc agcctccttc tccccaggcc ccccactgac ccccgcaatt
     1261 tccaggttct gtccaccggc ttgctaatga tataactgtc ttctcagagc tactgtggag
     1321 ggtcattgcc ctcttcttgt gttcttgact tgtgtgttcc ttttattttg gggtttccct
     1381 gtcttctcgt ttaccaaaga agagtttaca gagaataaag tggaaatgtc ctgccgtg
//
