LOCUS       NM_031984               1731 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus calbindin 1 (Calb1), mRNA.
ACCESSION   NM_031984
VERSION     NM_031984.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1731)
  AUTHORS   Varshney,S., Adela,R., Kachhawa,G., Dada,R., Kulshreshtha,V.,
            Kumari,R., Agarwal,R. and Khadgawat,R.
  TITLE     Disrupted placental vitamin D metabolism and calcium signaling in
            gestational diabetes and pre-eclampsia patients
  JOURNAL   Endocrine 80 (1), 191-200 (2023)
   PUBMED   36477942
REFERENCE   2  (bases 1 to 1731)
  AUTHORS   Vishnyakova,P.A., Moiseev,K.Y., Spirichev,A.A., Emanuilov,A.I.,
            Nozdrachev,A.D. and Masliukov,P.M.
  TITLE     Expression of calbindin and calretinin in the dorsomedial and
            ventromedial hypothalamic nuclei during aging
  JOURNAL   Anat Rec (Hoboken) 304 (5), 1094-1104 (2021)
   PUBMED   33040447
  REMARK    GeneRIF: Expression of calbindin and calretinin in the dorsomedial
            and ventromedial hypothalamic nuclei during aging.
REFERENCE   3  (bases 1 to 1731)
  AUTHORS   Silva-Pena,D., Garcia-Marchena,N., Alen,F., Araos,P., Rivera,P.,
            Vargas,A., Garcia-Fernandez,M.I., Martin-Velasco,A.I.,
            Villanua,M.A., Castilla-Ortega,E., Santin,L., Pavon,F.J.,
            Serrano,A., Rubio,G., Rodriguez de Fonseca,F. and Suarez,J.
  TITLE     Alcohol-induced cognitive deficits are associated with decreased
            circulating levels of the neurotrophin BDNF in humans and rats
  JOURNAL   Addict Biol 24 (5), 1019-1033 (2019)
   PUBMED   30277635
REFERENCE   4  (bases 1 to 1731)
  AUTHORS   Noble,J.W., Almalki,R., Roe,S.M., Wagner,A., Duman,R. and
            Atack,J.R.
  TITLE     The X-ray structure of human calbindin-D28K: an improved model
  JOURNAL   Acta Crystallogr D Struct Biol 74 (Pt 10), 1008-1014 (2018)
   PUBMED   30289411
REFERENCE   5  (bases 1 to 1731)
  AUTHORS   Stebbing,M.J., Balasubramanyan,S. and Smith,P.A.
  TITLE     Calbindin-D-28K like immunoreactivity in superficial dorsal horn
            neurons and effects of sciatic chronic constriction injury
  JOURNAL   Neuroscience 324, 330-343 (2016)
   PUBMED   26975894
  REMARK    GeneRIF: Calbindin D-28K does not appear to associate with any
            particular neuronal phenotype in the spinal dorsal horn, which may
            reflect that fact that most morphological types can be excitatory
            or inhibitory Its expression and distribution is unaffected by
            chronic constriction injury and increased excitatory synaptic drive
            to Cal+ neurons is unlikely to play a role in chronic constriction
            injury-induced central sensitization
REFERENCE   6  (bases 1 to 1731)
  AUTHORS   Gabrielides,C., McCormack,A.L., Hunt,D.F. and Christakos,S.
  TITLE     Brain calbindin-D28k and an Mr 29,000 calcium binding protein in
            cerebellum are different but related proteins: evidence obtained
            from sequence analysis by tandem mass spectrometry
  JOURNAL   Biochemistry 30 (3), 656-662 (1991)
   PUBMED   1988053
REFERENCE   7  (bases 1 to 1731)
  AUTHORS   Lomri,N., Perret,C., Gouhier,N. and Thomasset,M.
  TITLE     Cloning and analysis of calbindin-D28K cDNA and its expression in
            the central nervous system
  JOURNAL   Gene 80 (1), 87-98 (1989)
   PUBMED   2792772
REFERENCE   8  (bases 1 to 1731)
  AUTHORS   Gross,M.D., Kumar,R. and Hunziker,W.
  TITLE     Expression in Escherichia coli of full-length and mutant rat brain
            calbindin D28. Comparison with the purified native protein
  JOURNAL   J Biol Chem 263 (28), 14426-14432 (1988)
   PUBMED   3049577
REFERENCE   9  (bases 1 to 1731)
  AUTHORS   Hunziker,W. and Schrickel,S.
  TITLE     Rat brain calbindin D28: six domain structure and extensive amino
            acid homology with chicken calbindin D28
  JOURNAL   Mol Endocrinol 2 (5), 465-473 (1988)
   PUBMED   2843757
REFERENCE   10 (bases 1 to 1731)
  AUTHORS   Yamakuni,T., Kuwano,R., Odani,S., Miki,N., Yamaguchi,K. and
            Takahashi,Y.
  TITLE     Molecular cloning of cDNA to mRNA for a cerebellar spot 35 protein
  JOURNAL   J Neurochem 48 (5), 1590-1596 (1987)
   PUBMED   3031218
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK479935.1 and BC081764.1.
            
            On Mar 14, 2007 this sequence version replaced NM_031984.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081764.1, X04280.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                CK479935.1         2-18
            18-1731             BC081764.1         1-1714
FEATURES             Location/Qualifiers
     source          1..1731
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q13"
     gene            1..1731
                     /gene="Calb1"
                     /gene_synonym="CaBP28K"
                     /note="calbindin 1"
                     /db_xref="GeneID:83839"
                     /db_xref="RGD:69340"
     exon            1..194
                     /gene="Calb1"
                     /gene_synonym="CaBP28K"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..901
                     /gene="Calb1"
                     /gene_synonym="CaBP28K"
                     /note="calbindin 1, 28 kD; cerebellar Ca-binding protein,
                     spot 35 protein; vitamin D-dependent calcium-binding
                     protein, avian-type; D-28K; calbindin D28"
                     /codon_start=1
                     /product="calbindin"
                     /protein_id="NP_114190.1"
                     /db_xref="GeneID:83839"
                     /db_xref="RGD:69340"
                     /translation="MAESHLQSSLITASQFFEIWLHFDADGSGYLEGKELQNLIQELL
                     QARKKAGLELSPEMKTFVDQYGQRDDGKIGIVELAHVLPTEENFLLLFRCQQLKSCEE
                     FMKTWRKYDTDHSGFIETEELKNFLKDLLEKANKTVDDTKLAEYTDLMLKLFDSNNDG
                     KLELTEMARLLPVQENFLLKFQGIKMCGKEFNKAFELYDQDGNGYIDENELDALLKDL
                     CEKNKQELDINNISTYKKNIMALSDGGKLYRTDLALILSAGDN"
     exon            195..271
                     /gene="Calb1"
                     /gene_synonym="CaBP28K"
                     /inference="alignment:Splign:2.1.0"
     exon            272..346
                     /gene="Calb1"
                     /gene_synonym="CaBP28K"
                     /inference="alignment:Splign:2.1.0"
     exon            347..430
                     /gene="Calb1"
                     /gene_synonym="CaBP28K"
                     /inference="alignment:Splign:2.1.0"
     exon            431..487
                     /gene="Calb1"
                     /gene_synonym="CaBP28K"
                     /inference="alignment:Splign:2.1.0"
     exon            488..565
                     /gene="Calb1"
                     /gene_synonym="CaBP28K"
                     /inference="alignment:Splign:2.1.0"
     exon            566..621
                     /gene="Calb1"
                     /gene_synonym="CaBP28K"
                     /inference="alignment:Splign:2.1.0"
     exon            622..661
                     /gene="Calb1"
                     /gene_synonym="CaBP28K"
                     /inference="alignment:Splign:2.1.0"
     exon            662..715
                     /gene="Calb1"
                     /gene_synonym="CaBP28K"
                     /inference="alignment:Splign:2.1.0"
     exon            716..787
                     /gene="Calb1"
                     /gene_synonym="CaBP28K"
                     /inference="alignment:Splign:2.1.0"
     exon            788..1706
                     /gene="Calb1"
                     /gene_synonym="CaBP28K"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccgaacgga gcagcaccgc ggacagcgcc cggccgcgcc gcgcccagct cagcctgctc
       61 agccctctca tcccgaggtt cgcgctcagc gctctctcaa actagccgct gcaccatggc
      121 agaatcccac ctgcagtcat ctctgatcac agcctcacag ttttttgaga tctggcttca
      181 tttcgacgct gatggaagtg gttacctgga aggaaaggag ctgcagaact tgatccagga
      241 gcttctgcag gcacgaaaga aggctggatt ggagctatca cctgagatga aaacctttgt
      301 ggatcaatat gggcagagag atgatgggaa aataggaatt gtagagttgg cccatgtctt
      361 acccaccgaa gagaatttcc tgctgctctt tcgatgccag caactgaagt cctgcgagga
      421 attcatgaag acttggagaa agtatgacac tgaccacagt ggcttcatag aaacggagga
      481 acttaagaac tttcttaagg acctgctaga gaaagcaaac aagaccgtgg atgatacgaa
      541 acttgctgag tacacagacc tcatgctgaa gctgttcgac tcaaataatg atgggaagct
      601 ggagctgaca gagatggcca ggttactacc agtgcaggaa aatttccttc ttaaattcca
      661 gggaatcaaa atgtgtggga aagagttcaa taaggctttt gagttatatg atcaggatgg
      721 caacggatac atagatgaaa atgagctgga tgccttactg aaagacctgt gtgagaaaaa
      781 caaacaggaa ttggatatta acaatatttc tacatacaag aagaacataa tggccttgtc
      841 ggatggaggg aagctgtacc gaacagatct tgcccttatt ctctctgctg gggacaacta
      901 gagttggtgg ccacaaccac ttgctagtga tacattgtat ctaaaaccat aactgtgcgc
      961 tataaaggag taggctgtat tttcttttat atctgtaaat tctactgcat atagagaatt
     1021 atccaggatg tgtggcacat tcttttctgc ttgtttctat actgtttgta atgtacagtt
     1081 tttgtaagca tataattgaa aagaagaaag tctatgctta ggccagtcag tataatccat
     1141 tttcaaagat gaatctaaca tgattctgct ttcataaata cagatgaaca cttggatttc
     1201 cctaaaactc taccatctca acaattctag tgtcagatgt gtaaatgcac agctgtcagt
     1261 gagtaaaaga ataattcatg acaagccaag tgttttttaa tttaggcaat catagaactg
     1321 tcccacaaag cacttctgtg ctgtttccat ctagtggaag ggatgtgctt ctgcttgtga
     1381 agcaccaaat atcaatagtt aactatggct ttatcataaa acgatctccc tagagattta
     1441 atttactgat cagtggcatg tctactgctt gaatagatac cacactgttg gttcaagctg
     1501 gcttggtggc aagggaaggt agccagatga cacataaatc tgtctgatac tatgcctata
     1561 tttccaagaa gtctattgca gagagtatga ccttagccca ttttctaaat tattttcatg
     1621 tgttccagat gacaattatt ctagtaaact gctgttttgt gtcatattct gtgtgtactc
     1681 tctgattaaa ttcaatgtac tgagtaaaaa aaaaaaaaaa aaaaaaaaaa a
//
