LOCUS       NM_013219               4935 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus calcium dependent secretion activator (Cadps),
            mRNA.
ACCESSION   NM_013219 XM_039093070
VERSION     NM_013219.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4935)
  AUTHORS   Yoo,H., Yang,S.H., Kim,J.Y., Yang,E., Park,H.S., Lee,S.J.,
            Rhyu,I.J., Turecki,G., Lee,H.W. and Kim,H.
  TITLE     Down-regulation of habenular calcium-dependent secretion activator
            2 induces despair-like behavior
  JOURNAL   Sci Rep 11 (1), 3700 (2021)
   PUBMED   33580180
  REMARK    GeneRIF: Down-regulation of habenular calcium-dependent secretion
            activator 2 induces despair-like behavior.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4935)
  AUTHORS   Petrie,M., Esquibel,J., Kabachinski,G., Maciuba,S., Takahashi,H.,
            Edwardson,J.M. and Martin,T.F.
  TITLE     The Vesicle Priming Factor CAPS Functions as a Homodimer via C2
            Domain Interactions to Promote Regulated Vesicle Exocytosis
  JOURNAL   J Biol Chem 291 (40), 21257-21270 (2016)
   PUBMED   27528604
  REMARK    GeneRIF: The unique tandem C2-PH domain of CAPS may serve as a
            PI(4,5)P2-triggered switch for dimerization. CAPS dimerization may
            be coupled to oligomeric SNARE complex assembly for vesicle docking
            and priming.
REFERENCE   3  (bases 1 to 4935)
  AUTHORS   Kabachinski,G., Kielar-Grevstad,D.M., Zhang,X., James,D.J. and
            Martin,T.F.
  TITLE     Resident CAPS on dense-core vesicles docks and primes vesicles for
            fusion
  JOURNAL   Mol Biol Cell 27 (4), 654-668 (2016)
   PUBMED   26700319
  REMARK    GeneRIF: results indicate that dense-core vesicles carry CAPS to
            sites of exocytosis, where CAPS promotes vesicle docking and fusion
            competence, probably by initiating SNARE complex assembly.
REFERENCE   4  (bases 1 to 4935)
  AUTHORS   Farina,M., van de Bospoort,R., He,E., Persoon,C.M., van
            Weering,J.R., Broeke,J.H., Verhage,M. and Toonen,R.F.
  TITLE     CAPS-1 promotes fusion competence of stationary dense-core vesicles
            in presynaptic terminals of mammalian neurons
  JOURNAL   Elife 4, e05438 (2015)
   PUBMED   25719439
  REMARK    Erratum:[Elife. 2015 Nov 18;4:e12968. doi: 10.7554/eLife.12968..
            PMID: 26580491]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4935)
  AUTHORS   Imig,C., Min,S.W., Krinner,S., Arancillo,M., Rosenmund,C.,
            Sudhof,T.C., Rhee,J., Brose,N. and Cooper,B.H.
  TITLE     The morphological and molecular nature of synaptic vesicle priming
            at presynaptic active zones
  JOURNAL   Neuron 84 (2), 416-431 (2014)
   PUBMED   25374362
  REMARK    Erratum:[Neuron. 2014 Nov 19;84(4):882]
REFERENCE   6  (bases 1 to 4935)
  AUTHORS   Berwin,B., Floor,E. and Martin,T.F.
  TITLE     CAPS (mammalian UNC-31) protein localizes to membranes involved in
            dense-core vesicle exocytosis
  JOURNAL   Neuron 21 (1), 137-145 (1998)
   PUBMED   9697858
REFERENCE   7  (bases 1 to 4935)
  AUTHORS   Loyet,K.M., Kowalchyk,J.A., Chaudhary,A., Chen,J., Prestwich,G.D.
            and Martin,T.F.
  TITLE     Specific binding of phosphatidylinositol 4,5-bisphosphate to
            calcium-dependent activator protein for secretion (CAPS), a
            potential phosphoinositide effector protein for regulated
            exocytosis
  JOURNAL   J Biol Chem 273 (14), 8337-8343 (1998)
   PUBMED   9525942
REFERENCE   8  (bases 1 to 4935)
  AUTHORS   Ann,K., Kowalchyk,J.A., Loyet,K.M. and Martin,T.F.
  TITLE     Novel Ca2+-binding protein (CAPS) related to UNC-31 required for
            Ca2+-activated exocytosis
  JOURNAL   J Biol Chem 272 (32), 19637-19640 (1997)
   PUBMED   9289490
REFERENCE   9  (bases 1 to 4935)
  AUTHORS   Martin,T.F. and Kowalchyk,J.A.
  TITLE     Docked secretory vesicles undergo Ca2+-activated exocytosis in a
            cell-free system
  JOURNAL   J Biol Chem 272 (22), 14447-14453 (1997)
   PUBMED   9162085
REFERENCE   10 (bases 1 to 4935)
  AUTHORS   Walent,J.H., Porter,B.W. and Martin,T.F.
  TITLE     A novel 145 kd brain cytosolic protein reconstitutes
            Ca(2+)-regulated secretion in permeable neuroendocrine cells
  JOURNAL   Cell 70 (5), 765-775 (1992)
   PUBMED   1516133
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On or before Mar 5, 2021 this sequence version replaced
            XM_039093070.1, NM_013219.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.411765.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-487               JAXUCZ010000015.1  14720726-14721212
            488-601             JAXUCZ010000015.1  14821907-14822020
            602-934             JAXUCZ010000015.1  14829752-14830084
            935-1015            JAXUCZ010000015.1  14919946-14920026
            1016-1249           JAXUCZ010000015.1  14933550-14933783
            1250-1371           JAXUCZ010000015.1  14938648-14938769
            1372-1483           JAXUCZ010000015.1  14993008-14993119
            1484-1623           JAXUCZ010000015.1  14997366-14997505
            1624-1690           JAXUCZ010000015.1  15009062-15009128
            1691-1799           JAXUCZ010000015.1  15017274-15017382
            1800-2012           JAXUCZ010000015.1  15023167-15023379
            2013-2149           JAXUCZ010000015.1  15036093-15036229
            2150-2337           JAXUCZ010000015.1  15039432-15039619
            2338-2439           JAXUCZ010000015.1  15052354-15052455
            2440-2503           JAXUCZ010000015.1  15053701-15053764
            2504-2627           JAXUCZ010000015.1  15054131-15054254
            2628-2734           JAXUCZ010000015.1  15069934-15070040
            2735-2891           JAXUCZ010000015.1  15076284-15076440
            2892-3033           JAXUCZ010000015.1  15077440-15077581
            3034-3189           JAXUCZ010000015.1  15089377-15089532
            3190-3337           JAXUCZ010000015.1  15093360-15093507
            3338-3412           JAXUCZ010000015.1  15101533-15101607
            3413-3496           JAXUCZ010000015.1  15102501-15102584
            3497-3529           JAXUCZ010000015.1  15127143-15127175
            3530-3637           JAXUCZ010000015.1  15133545-15133652
            3638-3742           JAXUCZ010000015.1  15169036-15169140
            3743-4935           JAXUCZ010000015.1  15172019-15173211
FEATURES             Location/Qualifiers
     source          1..4935
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p15"
     gene            1..4935
                     /gene="Cadps"
                     /gene_synonym="Caps; Caps1; Caps2"
                     /note="calcium dependent secretion activator"
                     /db_xref="GeneID:26989"
                     /db_xref="RGD:708573"
     exon            1..487
                     /gene="Cadps"
                     /gene_synonym="Caps; Caps1; Caps2"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..3922
                     /gene="Cadps"
                     /gene_synonym="Caps; Caps1; Caps2"
                     /function="required for Ca2+-activated secretion in
                     permeable neuroendocrine cells"
                     /note="rCAPS; calcium-dependent secretion activator
                     1-like; CAPS-1; calcium-dependent activator protein for
                     secretion 1; Ca2+-dependent activator protein;
                     Ca<2+-dependent activator protein for secretion;
                     Ca++-dependent secretion activator; Ca2+ dependent
                     secretion activator"
                     /codon_start=1
                     /product="calcium-dependent secretion activator 1"
                     /protein_id="NP_037351.2"
                     /db_xref="GeneID:26989"
                     /db_xref="RGD:708573"
                     /translation="MLDPSSSEEESDEILEEESGKEVLGSAASGARLSPSRTSEGSAG
                     SAGMGGSGAGAGVGAGGGGGSGASSGGGAGGLQPSSRAGGGRPSSPSPSVVSEKEKEE
                     LERLQKEEEERKKRLQLYVFVMRCIAYPFNAKQPTDMARRQQKISKQQLQTVKDRFQA
                     FLNGETQIVADEAFMNAVQSYYEVFLKSDRVARMVQSGGCSANDSREVFKKHIEKRVR
                     SLPEIDGLSKETVLSSWMAKFDAIYRGEEDPRKQQARMTASAASELILSKEQLYEMFQ
                     NILGIKKFEHQLLYNACQLDNPDEQAAQIRRELDGRLQMADQIARERKFPKFVSKEME
                     NMYIEELKSSVNLLMANLESMPVSKGGEFKLQKLKRSHNASIIDMGEESENQLSKSDV
                     LLSFSLEVVIMEVQGLKSLAPNRIVYCTMEVEGGEKLQTDQAEASKPTWGTQGDFSTT
                     HALPAVKVKLFTESTGVLALEDKELGRVILHPTPNSPKQSEWHKMTVSKNCPDQDLKI
                     KLAVRMDKPQNMKHSGYLWTIGKNVWKRWKKRFFVLVQVSQYTFAMCSYREKKAEPQE
                     LLQLDGYTVDYTDPQPGLEGGRAFFNAVKEGDTVIFASDDEQDRILWVQAMYRATGQS
                     HKPVPPTQVQKLNAKGGNVPQLDAPISQFYADRAQKHGMDEFISSNPCNFDHASLFEM
                     VQRLTLDHRLNDSYSCLGWFSPGQVFVLDEYCARNGVRGCHRHLCYLRDLLERAENGA
                     MIDPTLLHYSFAFCASHVHGNRPDGIGTVTVEEKERFEEIKERLRVLLENQITHFRYC
                     FPFGRPEGALKATLSLLERVLMKDIVTPVPQEEVKTVIRKCLEQAALVNYSRLSEYAK
                     IEENVGRLITPAKKLEDTIRLAELVIEVLQQNEEHHAEAFAWWSDLMVEHAETFLSLF
                     AVDMDAALEVQPPDTWDSFPLFQLLNDFLRTDYNLCNGKFHKHLQDLFAPLVVRYVDL
                     MESSIAQSIHRGFERESWEPVNNGSGTSEDLFWKLDALQTFIRDLHWPEEEFGKHLEQ
                     RLKLMASDMIESCVKRTRIAFEVKLQKTSRSTDFRVPQSICTMFNVMVDAKAQSTKLC
                     SMEMGQEHQYHSKIDELIEETVKEMITLLVAKFVTILEGVLAKLSRYDEGTLFSSFLS
                     FTVKAASKYVDVPKPGMDVADAYVTFVRHSQDVLRDKVNEEMYIERLFDQWYNSSMNV
                     ICTWLTDRMDLQLHIYQLKTLIRMVKKTYRDFRLQGVLDSTLNSKTYETIRNRLTVEE
                     ATASVSEGGGLQGISMKDSDEEDEEDD"
     exon            488..601
                     /gene="Cadps"
                     /gene_synonym="Caps; Caps1; Caps2"
                     /inference="alignment:Splign:2.1.0"
     exon            602..934
                     /gene="Cadps"
                     /gene_synonym="Caps; Caps1; Caps2"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1015
                     /gene="Cadps"
                     /gene_synonym="Caps; Caps1; Caps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1249
                     /gene="Cadps"
                     /gene_synonym="Caps; Caps1; Caps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1371
                     /gene="Cadps"
                     /gene_synonym="Caps; Caps1; Caps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1483
                     /gene="Cadps"
                     /gene_synonym="Caps; Caps1; Caps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1623
                     /gene="Cadps"
                     /gene_synonym="Caps; Caps1; Caps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1690
                     /gene="Cadps"
                     /gene_synonym="Caps; Caps1; Caps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1799
                     /gene="Cadps"
                     /gene_synonym="Caps; Caps1; Caps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..2012
                     /gene="Cadps"
                     /gene_synonym="Caps; Caps1; Caps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2149
                     /gene="Cadps"
                     /gene_synonym="Caps; Caps1; Caps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2150..2337
                     /gene="Cadps"
                     /gene_synonym="Caps; Caps1; Caps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2338..2439
                     /gene="Cadps"
                     /gene_synonym="Caps; Caps1; Caps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2440..2503
                     /gene="Cadps"
                     /gene_synonym="Caps; Caps1; Caps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2504..2627
                     /gene="Cadps"
                     /gene_synonym="Caps; Caps1; Caps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2628..2734
                     /gene="Cadps"
                     /gene_synonym="Caps; Caps1; Caps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2735..2891
                     /gene="Cadps"
                     /gene_synonym="Caps; Caps1; Caps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2892..3033
                     /gene="Cadps"
                     /gene_synonym="Caps; Caps1; Caps2"
                     /inference="alignment:Splign:2.1.0"
     exon            3034..3189
                     /gene="Cadps"
                     /gene_synonym="Caps; Caps1; Caps2"
                     /inference="alignment:Splign:2.1.0"
     exon            3190..3337
                     /gene="Cadps"
                     /gene_synonym="Caps; Caps1; Caps2"
                     /inference="alignment:Splign:2.1.0"
     exon            3338..3412
                     /gene="Cadps"
                     /gene_synonym="Caps; Caps1; Caps2"
                     /inference="alignment:Splign:2.1.0"
     exon            3413..3496
                     /gene="Cadps"
                     /gene_synonym="Caps; Caps1; Caps2"
                     /inference="alignment:Splign:2.1.0"
     exon            3497..3529
                     /gene="Cadps"
                     /gene_synonym="Caps; Caps1; Caps2"
                     /inference="alignment:Splign:2.1.0"
     exon            3530..3637
                     /gene="Cadps"
                     /gene_synonym="Caps; Caps1; Caps2"
                     /inference="alignment:Splign:2.1.0"
     exon            3638..3742
                     /gene="Cadps"
                     /gene_synonym="Caps; Caps1; Caps2"
                     /inference="alignment:Splign:2.1.0"
     exon            3743..4935
                     /gene="Cadps"
                     /gene_synonym="Caps; Caps1; Caps2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttttgcaccc caagccgagg actccgggga ccctcctctc ccaggcgcca ccatgctgga
       61 cccttcgtcc agcgaagagg aatcggatga gatcctggaa gaggagagcg gcaaggaggt
      121 gctgggctcg gccgcgtccg gagcgcgcct gtctccaagc cgcaccagcg agggctcggc
      181 gggcagcgcc ggcatggggg gcagtggcgc cggggccggg gtgggcgccg gcggcggtgg
      241 gggtagcggc gcgagcagcg gcggcggggc cggggggctg cagcccagca gccgcgccgg
      301 cggcggccgg ccctccagcc ccagcccgtc ggtggtgagc gagaaggaga aggaagagtt
      361 ggagcggctg cagaaggaag aggaggagag gaagaagagg ctgcagctgt acgtgttcgt
      421 gatgcgctgc attgcctacc ccttcaacgc caagcagccc accgacatgg ctcggcggca
      481 gcagaagatc agcaaacagc agctgcagac tgtcaaggac cgattccagg ctttcctcaa
      541 tggggagacc caaatcgtgg cagatgaagc ctttatgaat gctgtccaga gctactatga
      601 ggtgtttctc aagagtgacc gtgtggcccg catggtacag agtgggggct gctcagccaa
      661 cgactctcgg gaggtcttca agaaacacat cgagaagagg gtacgcagcc tacctgagat
      721 tgatggcctc agcaaggaga ctgtgctaag ctcctggatg gctaagtttg acgccatcta
      781 ccgtggtgag gaggacccca ggaagcagca agcccggatg acagccagtg cagcttctga
      841 gttgattctg agcaaggaac agctctatga gatgttccag aacattcttg ggatcaagaa
      901 atttgaacat caactcctat ataatgcgtg tcagctggac aatccagatg agcaggcagc
      961 ccagatcaga cgagagctgg acggacgtct ccaaatggca gaccaaatag ccagggaacg
     1021 caaatttcct aagttcgtat ccaaagaaat ggaaaatatg tacatcgagg agctgaagtc
     1081 ctccgtcaac ctactcatgg ccaacttgga gagcatgccg gtgtccaagg gtggagagtt
     1141 caagctgcag aaactgaaac gcagtcacaa cgcgtccatc attgacatgg gtgaggagag
     1201 cgagaaccag ctgtccaagt cggatgtcct gctgtccttc tccttggagg ttgtcatcat
     1261 ggaagtccaa ggccttaagt ccttggctcc aaaccgaatc gtgtactgca caatggaggt
     1321 ggagggtgga gagaaacttc agactgatca agcagaggct tctaaaccaa cctggggcac
     1381 tcaaggcgac ttctctacaa cccacgcgct gccagctgtt aaagtaaagc tattcacaga
     1441 gagcactggt gtcctggcct tggaagacaa ggaactcggg cgggttatcc tccatcccac
     1501 cccaaacagc cccaaacaat ccgagtggca caaaatgaca gtctccaaaa actgccccga
     1561 tcaagacctc aaaatcaaac tcgctgtccg aatggataag cctcaaaaca tgaagcactc
     1621 tgggtactta tggaccattg gtaagaatgt gtggaagagg tggaagaaaa ggttctttgt
     1681 gttggtgcag gtcagccagt acacttttgc catgtgcagc tatcgagaaa agaaagcaga
     1741 acctcaggaa ctcctacagc tggatggcta caccgtggat tacaccgacc ctcagccagg
     1801 tttggagggt ggccgagcct tcttcaatgc agtcaaagaa ggagacacgg tgatatttgc
     1861 cagtgacgat gagcaagatc gaatcctgtg ggtccaagct atgtacaggg ccaccgggca
     1921 gtcgcacaaa cctgtgcccc ctacccaggt gcagaagctc aacgccaagg gcggaaacgt
     1981 gcctcagctg gatgccccca tctcccagtt ttacgcagat agagctcaaa agcatggcat
     2041 ggatgaattt atctcgtcca acccctgtaa ctttgaccac gcttccctct ttgagatggt
     2101 acagcggctg actttggatc acagactaaa cgattcctat tcttgcctgg gctggttcag
     2161 tcctggccag gtgtttgtgt tagacgagta ctgcgctcgg aatggagtcc gaggatgtca
     2221 tcggcatctc tgttacctta gagacttgct ggaacgggca gaaaatggcg ccatgatcga
     2281 ccccacgctt cttcattaca gctttgcctt ctgcgcatcc catgtccacg ggaacaggcc
     2341 tgatggaatc ggaactgtga ctgttgaaga aaaagagcgc tttgaagaaa tcaaagagag
     2401 actccgagtt ctgctggaaa atcaaattac acatttcagg tactgctttc cgtttggtcg
     2461 acctgaaggt gctttgaaag cgactctctc acttttggaa cgggttttga tgaaagatat
     2521 tgtcactcca gtaccccaag aggaggtcaa aactgtcatc cgtaaatgcc tagagcaggc
     2581 tgctctagtc aactactctc gcctatctga gtatgccaaa atcgaagaaa atgtaggccg
     2641 cttaatcact cctgccaaaa agctcgaaga cacaatccgt cttgctgaac tagtcattga
     2701 agtgctgcaa caaaacgaag agcaccacgc cgaggccttt gcgtggtggt cagacttaat
     2761 ggtggagcac gcggagacgt tcctgtcact ctttgcagtg gacatggatg cagcattaga
     2821 ggtgcaaccc ccagacacgt gggacagttt cccactcttc cagctgctga atgactttct
     2881 ccgtacagac tataacttgt gcaatggaaa gtttcacaaa cacctgcagg atctgttcgc
     2941 cccactcgtt gttagatacg tggatctgat ggagtcctca attgcacaat ctatccacag
     3001 gggctttgag cgggagtcat gggaaccagt caataacgga tcgggtacat cagaagattt
     3061 gttctggaaa cttgatgccc ttcagacttt catccgtgac ctacactggc ctgaggaaga
     3121 gtttggaaag cacttagagc agcggctaaa actaatggca agcgacatga ttgagtcctg
     3181 cgtcaagaga accaggattg catttgaagt taagctgcaa aaaaccagtc gatcaacaga
     3241 ttttcgagtc ccacagtcaa tatgcaccat gtttaatgtt atggttgatg ccaaagctca
     3301 atcaacaaaa ctttgcagca tggaaatggg ccaggagcat caataccatt caaaaataga
     3361 cgaactaatt gaagaaaccg ttaaggaaat gatcacactc ttggtggcaa agtttgtaac
     3421 tatattggaa ggcgtactgg caaagttatc cagatacgac gaggggactt tgttttcttc
     3481 gtttctgtca tttacggtga aggcagcatc taagtatgtg gacgtaccta aacccgggat
     3541 ggatgtggcc gacgcctacg tgactttcgt ccgccactct caggatgtcc ttcgtgataa
     3601 ggtcaatgag gagatgtata tagaaaggtt atttgatcaa tggtacaaca gctccatgaa
     3661 cgtcatctgc acctggctga ccgaccggat ggacctccag cttcacattt atcagctgaa
     3721 aacactaatt aggatggtaa agaaaaccta cagagatttc cgattgcaag gggtcctgga
     3781 ttccacctta aacagcaaga cctatgagac cattcgaaat cggctcactg tagaggaagc
     3841 taccgcgtcc gtgagtgagg gagggggctt gcaaggcatc agcatgaagg acagtgacga
     3901 ggaagatgaa gaagacgact agatcattct ctgggtccaa gagtccactg ggatggagtc
     3961 ctgtaatcaa tgcatgtctt tagtctgtta gttaacccca ttagggaatt ttctgtcaac
     4021 caccatgccc atgagatgtt taccaataca gacaccattt tagctgcgtg gtaccaagat
     4081 tagcacatgg tttcctggtt tctgtgtcta tatgtttaca agcaatatgg aataccattc
     4141 ttaaacactg ttcatggaga gaatacatag ttcagctgct aggtgtgtcc cttttgttag
     4201 cagaacaaaa cgatgcttca ccctgtgctc cgtatgtact gataggaagc agacgtggga
     4261 gccagtgtgt ttccaagtct ctgtttcaca tatgtgggta tcaggtactt aaattagtac
     4321 ataaataaat taatttaagc acatagatct gcttggtttt ggtctccgtt ttgttctcat
     4381 cccccgaaac tgaaagcaat gggcgtttgt gtcctggcaa acacagcttt gcatttttcc
     4441 ttgtagtttc cccccaccac caaaaaagtt aattattgat taacttggat taataataaa
     4501 gtggattaat tattttaatt gtcatggcaa gggggccatg tgatcaggac gtagcatcaa
     4561 gcaaggttca gaccaattgt cttctgtgga agtttatcct agtacatgtc acgttttctg
     4621 tttcaataac tgtatatgta aaaaaaaaaa gtatcgaaat gacaacccta gactataaat
     4681 gtatttataa taagatatgg atatctcctc cagtagactg taaccatgat ttccattatt
     4741 ttgttccaca ctgtttttat atctgtcacg tacattgcac tctgatctgt aactgagcga
     4801 ccctggggtc ctctgtagag ctgtttcttt ctgtggaaag tagtggatcc atcttgcttt
     4861 ttgccttata taaaagccta cagttgtaaa agtgtgggga actgtggctt ctcaataaac
     4921 aattattcaa acgtc
//
