LOCUS       NM_001047107            2148 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus cell adhesion molecule 4 (Cadm4), mRNA.
ACCESSION   NM_001047107 XM_001059474 XM_001076576
VERSION     NM_001047107.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2148)
  AUTHORS   Heffernan,C., Jain,M.R., Liu,T., Kim,H., Barretto,K., Li,H. and
            Maurel,P.
  TITLE     Nectin-like 4 Complexes with Choline Transporter-like Protein-1 and
            Regulates Schwann Cell Choline Homeostasis and Lipid Biogenesis in
            Vitro
  JOURNAL   J Biol Chem 292 (11), 4484-4498 (2017)
   PUBMED   28119456
  REMARK    GeneRIF: Intracellular choline levels are significantly elevated in
            NECL4-deficient Schwann cells.
REFERENCE   2  (bases 1 to 2148)
  AUTHORS   Yamana,S., Tokiyama,A., Mizutani,K., Hirata,K., Takai,Y. and
            Rikitake,Y.
  TITLE     The Cell Adhesion Molecule Necl-4/CADM4 Serves as a Novel Regulator
            for Contact Inhibition of Cell Movement and Proliferation
  JOURNAL   PLoS One 10 (4), e0124259 (2015)
   PUBMED   25893857
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2148)
  AUTHORS   Sugiyama,H., Mizutani,K., Kurita,S., Okimoto,N., Shimono,Y. and
            Takai,Y.
  TITLE     Interaction of Necl-4/CADM4 with ErbB3 and integrin alpha6 beta4
            and inhibition of ErbB2/ErbB3 signaling and hemidesmosome
            disassembly
  JOURNAL   Genes Cells 18 (6), 519-528 (2013)
   PUBMED   23611113
REFERENCE   4  (bases 1 to 2148)
  AUTHORS   Fogel,A.I., Akins,M.R., Krupp,A.J., Stagi,M., Stein,V. and
            Biederer,T.
  TITLE     SynCAMs organize synapses through heterophilic adhesion
  JOURNAL   J Neurosci 27 (46), 12516-12530 (2007)
   PUBMED   18003830
REFERENCE   5  (bases 1 to 2148)
  AUTHORS   Maurel,P., Einheber,S., Galinska,J., Thaker,P., Lam,I., Rubin,M.B.,
            Scherer,S.S., Murakami,Y., Gutmann,D.H. and Salzer,J.L.
  TITLE     Nectin-like proteins mediate axon Schwann cell interactions along
            the internode and are essential for myelination
  JOURNAL   J Cell Biol 178 (5), 861-874 (2007)
   PUBMED   17724124
  REMARK    GeneRIF: These results demonstrate a key role for Necl, 2 and 4 in
            initiating peripheral nervous system myelination and implicate the
            Necl proteins as mediators of axo-glial interactions along the
            internode.
REFERENCE   6  (bases 1 to 2148)
  AUTHORS   Spiegel,I., Adamsky,K., Eshed,Y., Milo,R., Sabanay,H.,
            Sarig-Nadir,O., Horresh,I., Scherer,S.S., Rasband,M.N. and Peles,E.
  TITLE     A central role for Necl4 (SynCAM4) in Schwann cell-axon interaction
            and myelination
  JOURNAL   Nat Neurosci 10 (7), 861-869 (2007)
   PUBMED   17558405
  REMARK    GeneRIF: Necl4 protein is important for mediating axon-glia contact
            during myelination in peripheral nerves
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Oct 14, 2022 this sequence version replaced NM_001047107.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ272745.1, SRR22399484.1333283.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               JAXUCZ010000001.1  89203089-89203221
            134-280             JAXUCZ010000001.1  89219795-89219941
            281-433             JAXUCZ010000001.1  89220175-89220327
            434-568             JAXUCZ010000001.1  89220580-89220714
            569-733             JAXUCZ010000001.1  89221136-89221300
            734-824             JAXUCZ010000001.1  89221392-89221482
            825-997             JAXUCZ010000001.1  89222490-89222662
            998-1126            JAXUCZ010000001.1  89223462-89223590
            1127-2148           JAXUCZ010000001.1  89224324-89225345
FEATURES             Location/Qualifiers
     source          1..2148
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2148
                     /gene="Cadm4"
                     /gene_synonym="Igsf4c; Necl-4; Upar"
                     /note="cell adhesion molecule 4"
                     /db_xref="GeneID:365216"
                     /db_xref="RGD:1304722"
     exon            1..133
                     /gene="Cadm4"
                     /gene_synonym="Igsf4c; Necl-4; Upar"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1236
                     /gene="Cadm4"
                     /gene_synonym="Igsf4c; Necl-4; Upar"
                     /note="nectin-like protein 4; immunoglobulin superfamily,
                     member 4C; urokinase plasminogen activator receptor"
                     /codon_start=1
                     /product="cell adhesion molecule 4 precursor"
                     /protein_id="NP_001040572.1"
                     /db_xref="GeneID:365216"
                     /db_xref="RGD:1304722"
                     /translation="MGRARRFQWPLLLLWAAAAGPGTAQEVQTENVTVAEGGVAEITC
                     RLHQYDGSIVVIQNPARQTLFFNGTRALKDERFQLEEFSPRRVRIRLSDARLEDEGGY
                     FCQLYTEDTHHQIATLTVLVAPENPVVEVREQAVEGGEVELSCLVPRSRPAAVLRWYR
                     DRKELKGVSSGQENGKVWSVASTVRFRVDRKDDGGIVICEAQNQALPSGHSKQTQYVL
                     DVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGNESLPERAEALGETL
                     TLPGLVSADNGTYTCEAANKHGHARALYVLVVYDPGAVVEAQTSVPYAIVGGILALLV
                     FLIICVLVGMVWCSVRQKGSYLTHEASGLDEQGEAREAFLNGSDGHKRKEEFFI"
     exon            134..280
                     /gene="Cadm4"
                     /gene_synonym="Igsf4c; Necl-4; Upar"
                     /inference="alignment:Splign:2.1.0"
     exon            281..433
                     /gene="Cadm4"
                     /gene_synonym="Igsf4c; Necl-4; Upar"
                     /inference="alignment:Splign:2.1.0"
     exon            434..568
                     /gene="Cadm4"
                     /gene_synonym="Igsf4c; Necl-4; Upar"
                     /inference="alignment:Splign:2.1.0"
     exon            569..733
                     /gene="Cadm4"
                     /gene_synonym="Igsf4c; Necl-4; Upar"
                     /inference="alignment:Splign:2.1.0"
     exon            734..824
                     /gene="Cadm4"
                     /gene_synonym="Igsf4c; Necl-4; Upar"
                     /inference="alignment:Splign:2.1.0"
     exon            825..997
                     /gene="Cadm4"
                     /gene_synonym="Igsf4c; Necl-4; Upar"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1126
                     /gene="Cadm4"
                     /gene_synonym="Igsf4c; Necl-4; Upar"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..2148
                     /gene="Cadm4"
                     /gene_synonym="Igsf4c; Necl-4; Upar"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgggaggtg caggtgccgg gccgggagcg agcggcggcg gcggtggcgg cggcggtggc
       61 ggcggcacca tgggccgggc ccggcgcttc cagtggccgc tgctgctact gtgggcggcc
      121 gcggcggggc cagggacggc acaggaagtg cagacagaga atgtgacggt ggccgagggt
      181 ggggtggctg agatcacctg ccgtctgcat cagtatgatg ggtctatagt cgtcattcag
      241 aacccagccc ggcagaccct ctttttcaat ggcacccgag ccctgaagga cgaacgattc
      301 cagctggagg agttctcccc gcgccgagtg cgcatcaggc tctcagacgc ccgcctggag
      361 gacgaggggg gctacttctg ccagctctac acggaggaca cccaccacca gatcgccacg
      421 ctcactgtct tagtggctcc ggagaatcct gtggtggagg tccgagagca agcagtggag
      481 ggcggcgagg tggaactcag ctgcctggtt ccgcggtcgc gccccgcagc ggtcctgcgc
      541 tggtatcgcg atcgcaagga gctgaaagga gtgagcagcg gccaggagaa cggcaaggtg
      601 tggagcgtgg cgagcactgt gcggttccgc gtggaccgca aggacgacgg cggtatcgtc
      661 atctgtgaag cgcagaacca ggcgctgccc tcggggcaca gcaagcagac gcagtacgtg
      721 ctggatgtgc agtattcccc cacagctcgg atccacgcct ctcaagctgt agtcagggag
      781 ggagacactc tggtgctgac atgtgctgtc acagggaacc ccaggccaaa ccagatccgc
      841 tggaaccgtg ggaatgagtc tctgccagag agggcggagg cgttgggcga gacgctcacg
      901 ctgcctggcc tggtatctgc agataacggc acctacacct gcgaggcggc gaacaagcac
      961 ggccacgcca gggcgctcta cgtgcttgtg gtctatgacc ccggagcagt ggtagaggct
     1021 cagacatcgg ttccctacgc catcgtgggc ggcatcctgg cgctactggt gtttctgatc
     1081 atatgcgtgc tagtaggcat ggtgtggtgc tctgtccgac agaagggctc ctatctgacc
     1141 catgaggcca gtggcttgga tgagcaggga gaagccagag aagccttcct caacggcagt
     1201 gatggacaca agcggaaaga agaattcttc atttgacccc actcccccac tgccagctgc
     1261 aaggaaccag caaagacatt gaccagagtc cgggatggtg ggcttccccc ccactagcta
     1321 acacctcagg cgcttgggca gggattgggg gtgttggatg cctggatctc tcccagggcc
     1381 aaaggctagg gtccagagac ttgggatccc ctagggagac agggacttaa cgtcccttct
     1441 agaccctgag tccagggacg ggtaataggg atttgggttg ggggaagaaa acagggggaa
     1501 ggccagaacc cctagactac agaaccaggt cttgtggggg agggggtcag attctgggaa
     1561 gggtgggtgg gcagggaagg gaaacacaga tttctttggg gtcccagacc ccatgccagc
     1621 cattgtaaga gttccacaga gctctgggca cctctttgca aagccatgtt tgcacggtgg
     1681 ggggaggggc aggggagggc gtggaaatgg gaattctgtg tctttgtgtg aaaactctga
     1741 tgggggcagt aagggagaca accccgaccc ttatccagtc ccccttctcc gggttcctgg
     1801 gcggctcccc ttccctccat cttgacctcc atgtccttcc catcccataa ttgtctgttc
     1861 acccgctctt gggggggcct tcccagtctc tcctccaggc cccccgggga gggggaaagg
     1921 agtttggagg ggatgtgtgg tctctatggt tttatatata atatattaaa aaatcaaaaa
     1981 tctgtatgaa aaatatcaga ttgcacccct ctccccccat tactggcttt tgcccccttt
     2041 tcttgtttaa aaaaacaaaa ggaaacacat ttttgtacgg ggcggggagg gggtcgggag
     2101 gggggtttgg caatcccact aaccaccatt aaactgagga gagaacaa
//
