LOCUS       NM_001412817            4175 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus cell adhesion molecule 3 (Cadm3), transcript
            variant 1, mRNA.
ACCESSION   NM_001412817 XM_006250323
VERSION     NM_001412817.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4175)
  AUTHORS   Chen,T., Wu,X.D., Gao,J., Hao,W., Yin,B., Qiang,B.Q., Yuan,J.G.,
            Gong,Y.H. and Peng,X.Z.
  TITLE     [Role of cell adhesion molecules Necl1 in synaptogenesis in primary
            cultured rat neurons]
  JOURNAL   Zhongguo Yi Xue Ke Xue Yuan Xue Bao 30 (3), 275-279 (2008)
   PUBMED   18686604
  REMARK    GeneRIF: Necl1 plays an important role in neuronal synapse
            formation.
REFERENCE   2  (bases 1 to 4175)
  AUTHORS   Fogel,A.I., Akins,M.R., Krupp,A.J., Stagi,M., Stein,V. and
            Biederer,T.
  TITLE     SynCAMs organize synapses through heterophilic adhesion
  JOURNAL   J Neurosci 27 (46), 12516-12530 (2007)
   PUBMED   18003830
REFERENCE   3  (bases 1 to 4175)
  AUTHORS   Maurel,P., Einheber,S., Galinska,J., Thaker,P., Lam,I., Rubin,M.B.,
            Scherer,S.S., Murakami,Y., Gutmann,D.H. and Salzer,J.L.
  TITLE     Nectin-like proteins mediate axon Schwann cell interactions along
            the internode and are essential for myelination
  JOURNAL   J Cell Biol 178 (5), 861-874 (2007)
   PUBMED   17724124
  REMARK    GeneRIF: These results demonstrate a key role for Necl, 2 and 4 in
            initiating peripheral nervous system myelination and implicate the
            Necl proteins as mediators of axo-glial interactions along the
            internode.
REFERENCE   4  (bases 1 to 4175)
  AUTHORS   Gruber-Olipitz,M., Yang,J.W., Slavc,I. and Lubec,G.
  TITLE     Nectin-like molecule 1 is a high abundance protein in cerebellar
            neurons
  JOURNAL   Amino Acids 30 (4), 409-415 (2006)
   PUBMED   16773244
  REMARK    GeneRIF: Nectin-like molecule 1 (Necl-1) is unique for its
            exclusive expression in the brain where it is localized at the
            contact sites among axon terminals and glia cell processes,
            cooperatively forming synapses.
REFERENCE   5  (bases 1 to 4175)
  AUTHORS   Zhou,Y., Du,G., Hu,X., Yu,S., Liu,Y., Xu,Y., Huang,X., Liu,J.,
            Yin,B., Fan,M., Peng,X., Qiang,B. and Yuan,J.
  TITLE     Nectin-like molecule 1 is a protein 4.1N associated protein and
            recruits protein 4.1N from cytoplasm to the plasma membrane
  JOURNAL   Biochim Biophys Acta 1669 (2), 142-154 (2005)
   PUBMED   15893517
REFERENCE   6  (bases 1 to 4175)
  AUTHORS   Kakunaga,S., Ikeda,W., Itoh,S., Deguchi-Tawarada,M., Ohtsuka,T.,
            Mizoguchi,A. and Takai,Y.
  TITLE     Nectin-like molecule-1/TSLL1/SynCAM3: a neural tissue-specific
            immunoglobulin-like cell-cell adhesion molecule localizing at
            non-junctional contact sites of presynaptic nerve terminals, axons
            and glia cell processes
  JOURNAL   J Cell Sci 118 (Pt 6), 1267-1277 (2005)
   PUBMED   15741237
REFERENCE   7  (bases 1 to 4175)
  AUTHORS   Shingai,T., Ikeda,W., Kakunaga,S., Morimoto,K., Takekuni,K.,
            Itoh,S., Satoh,K., Takeuchi,M., Imai,T., Monden,M. and Takai,Y.
  TITLE     Implications of nectin-like
            molecule-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 in cell-cell adhesion
            and transmembrane protein localization in epithelial cells
  JOURNAL   J Biol Chem 278 (37), 35421-35427 (2003)
   PUBMED   12826663
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Oct 19, 2022 this sequence version replaced XM_006250323.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.43131.1,
                                           SRR26643298.52517.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMEA5760433 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-236               JAXUCZ010000013.1  88349483-88349718   c
            237-338             JAXUCZ010000013.1  88331529-88331630   c
            339-479             JAXUCZ010000013.1  88328958-88329098   c
            480-632             JAXUCZ010000013.1  88328289-88328441   c
            633-770             JAXUCZ010000013.1  88327468-88327605   c
            771-941             JAXUCZ010000013.1  88326800-88326970   c
            942-1032            JAXUCZ010000013.1  88324328-88324418   c
            1033-1202           JAXUCZ010000013.1  88323715-88323884   c
            1203-1328           JAXUCZ010000013.1  88320717-88320842   c
            1329-4175           JAXUCZ010000013.1  88317124-88319970   c
FEATURES             Location/Qualifiers
     source          1..4175
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q24"
     gene            1..4175
                     /gene="Cadm3"
                     /gene_synonym="Igsf4b; Necl-1"
                     /note="cell adhesion molecule 3"
                     /db_xref="GeneID:360882"
                     /db_xref="RGD:1307035"
     exon            1..236
                     /gene="Cadm3"
                     /gene_synonym="Igsf4b; Necl-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..1447
                     /gene="Cadm3"
                     /gene_synonym="Igsf4b; Necl-1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; nectin-like protein 1; immunoglobulin
                     superfamily, member 4B"
                     /codon_start=1
                     /product="cell adhesion molecule 3 isoform 1 precursor"
                     /protein_id="NP_001399746.1"
                     /db_xref="GeneID:360882"
                     /db_xref="RGD:1307035"
                     /translation="MGAPSALPLLLLLACSWAPGGANLSQDGYWQEQDLELGTPAPLE
                     EALSSTVWSNPDLLASQDSQPWTSDETVVAGGTVVLKCQVKDHEDSSLQWSNPAQQTL
                     YFGEKRALRDNRIQLVSSTPHELSISISNVALADEGEYTCSIFTMPVRTAKSLVTVLG
                     IPQKPIITGYKSSLREKETATLNCQSSGSKPAAQLAWRKGDQELHGDQTRIQEDPNGK
                     TFTVSSSVSFQVTRDDDGANVVCSVNHESLKGADRSTSQRIEVLYTPTAMIRPEPAHP
                     REGQKLLLHCEGRGNPVPQQYVWVKEGSEPPLKMTQESALIFPFLNKSDSGTYGCTAT
                     SNMGSYTAYFTLNVNDPSPVPSSSSTYHAIIGGIVAFIVFLLLILLIFLGHYLIRHKG
                     TYLTHEAKGSDDAPDADTAIINAEGGQSGGDDKKEYFI"
     exon            237..338
                     /gene="Cadm3"
                     /gene_synonym="Igsf4b; Necl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            339..479
                     /gene="Cadm3"
                     /gene_synonym="Igsf4b; Necl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            480..632
                     /gene="Cadm3"
                     /gene_synonym="Igsf4b; Necl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            633..770
                     /gene="Cadm3"
                     /gene_synonym="Igsf4b; Necl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            771..941
                     /gene="Cadm3"
                     /gene_synonym="Igsf4b; Necl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1032
                     /gene="Cadm3"
                     /gene_synonym="Igsf4b; Necl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1202
                     /gene="Cadm3"
                     /gene_synonym="Igsf4b; Necl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1328
                     /gene="Cadm3"
                     /gene_synonym="Igsf4b; Necl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..4175
                     /gene="Cadm3"
                     /gene_synonym="Igsf4b; Necl-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctccctcc cggtacccgc ctcggccccg ggcttggaag ccgctccggg ggcgcccctt
       61 tggacagcga cgccggctac ccagagcccc cggccccagt ccccggagat ccaggctcgc
      121 cagcgcccag ccagggaggt ggccaggaag cgcgatgggg gccccttccg ccctgcccct
      181 gctcctgctc ctcgcctgct cctgggcgcc cggcggggcc aatctttccc aggacggcta
      241 ctggcaggag caggatttgg agctgggaac tccggctcca ctggaggagg ccctcagctc
      301 cacagtctgg agcaaccctg acctgctggc cagtcaagat agccagccct ggacgtctga
      361 tgaaacagtg gtggctggtg gcacagtagt gctcaagtgc caagtgaaag accatgaaga
      421 ctcatctctg cagtggtcta accctgccca gcagactcta tactttgggg agaaaagagc
      481 ccttcgagat aatcggattc agctggttag ctccaccccg catgagctca gcatcagcat
      541 cagcaacgtg gcactggccg acgagggcga gtacacatgc tccatcttca ctatgcctgt
      601 gcggaccgcc aagtccctcg tcactgtgct cggaatccca cagaaaccca taatcactgg
      661 ttataagtca tcgttgcggg aaaaggagac agccactcta aattgtcagt cttctgggag
      721 caaacctgca gcccagctcg cctggagaaa aggtgaccaa gaactccacg gggaccagac
      781 gcgaatccag gaagatccca atgggaaaac cttcactgtg agcagctcgg tgtcattcca
      841 ggttacccgg gatgatgatg gagcaaacgt cgtgtgctct gtgaaccatg aatctctgaa
      901 gggagctgac agatccacct ctcagcgcat tgaagtgtta tacacaccaa cagccatgat
      961 taggccagaa cctgctcatc ctcgtgaagg ccagaagctg ttgttacatt gtgaggggcg
     1021 tggcaatcca gtccctcagc agtacgtgtg ggtaaaagaa ggcagcgagc cacccctcaa
     1081 gatgacccaa gagagtgcac tcatcttccc atttttgaac aaaagtgaca gtggcaccta
     1141 tggctgtaca gccacgagca acatgggcag ctatacagcc tacttcactc tcaatgtcaa
     1201 cgaccctagt ccagtgccct catcctccag tacttaccac gccatcattg gagggatcgt
     1261 ggctttcatc gtcttcctgc tgctcattct gctcattttc cttggacact atttgatccg
     1321 gcacaaagga acgtacctga cacacgaagc gaagggctcc gacgacgccc cagatgcaga
     1381 tacggccatc atcaacgcag aaggcgggca gtcaggcggg gatgacaaga aggaatattt
     1441 catctagggg cacccacaca cctcctgcgc cccccaggag ccccatgggg actgctgggc
     1501 tgtcaccaac ctggacttgt acagagcgac cccagggccg cccctcccgc ttgctcccca
     1561 gtccacccag ccccctgtac agaatgtctg ctttgggtgc ggttttgtac tcggtttgga
     1621 atggggggga ggagggcggg gggagagggg tgggtcgccc tcagcccctt ttgtggcttc
     1681 tctgcgtttg ggttattatt atttttgtaa caatcccaaa tcaaatctgt ctccaaggct
     1741 ggagaggcag gggccatggg ggtaaggtga gcaatgaacc tgcaatgttc agaggaggaa
     1801 gttggaggga ttagaaacga atgaggagcg ggggctggtt tgctggtggg ggcttaacac
     1861 agccctcctt ccatttttac agcagatgtg ttcgccaagg aacctgggaa tggaagtagg
     1921 ggcctagtag tgtctcatct cctaccagcc ctgcactaca gacagggaga caggtgtcat
     1981 actgacacct ctcttccact acatgagaaa gaaacaaaga gagtgttcga gatatgatct
     2041 ggagatagca tgcagccaca cagggatcca gggcttcaac atgttcctcc cagagagagt
     2101 agatatccgg agagggtggc gaaaacagcc ctgatcaccc attgcccccc acatgaatga
     2161 agctaggctc ctttaagaga atctgccctt gggggacaat agagttcagc tttctctccc
     2221 agctccagca gctgtggaga agggagctgt ggacctgtac aacgtctgct gcccccacct
     2281 cagaggggcc cctcactctt acccaagccc ctggactgtt gcacggcaac cgctcctctt
     2341 atggcattgc tcagcaacta ctcctccacc ctgtgtcacc ctgtgccctc tcctgttccc
     2401 tgtgccagcc ctcggtccct cctccctcag cagccaggca gacatgacaa caaaattact
     2461 aaaaggagct tcactgcagt gagctgtttc ctgcccaaac cgagggaata atgtgaactc
     2521 tgtacaggtg tgtgtgtatg tgtatgtgtt tgtgtgtgta agtgtgtgta agtatgcatg
     2581 gatgtgtgta catgtgtgtt tgtgtgaaca agaagaaaag ggattgagaa gaaggaccag
     2641 aggtcttggg tgggtggaca gggcatggga catgagaggc ggattttggg agtggatggt
     2701 ttctagtcag ggtttgtgac agtagggatc tgctccatcc aagtcatttc cagaccactc
     2761 tcaatgcctg tctgagagag aggagtccca ggatgtggtt taccgggctg tgcattttgt
     2821 ccctctctga aacaccatgc atccgccaca tttccctgga cctcccatct ctgagccatg
     2881 gggccggggc cagggccaca gcctctgcta tgcacccttc tccctggcac tgaccctggg
     2941 tttccatctt cagtacccag tgactagagg actgggtacc cacatcagct tttggtttac
     3001 cgtcttcctt cttatggcca agctggttac tgtggagagg agtttggtca ccttctccat
     3061 cctggctggc ctgtccctta gacccaggat gctcttggca tcatgctccc cctcctccgg
     3121 catgtcctcc ctgctctgac aacaggtgtg caaaatgggg cagctgcaat ccagcaggtc
     3181 tgcccactcc ttcagttcag gtaatacctt cgtgaatctt ccagcccctg gttaggaacc
     3241 tgggcacccc aggtagcccc tcgcttaagc cagggcttct cctcttatag cagcaaggga
     3301 gccctgggtc ccagggctgg gctcctatct gggctccttg tctcccagca cccgcttttt
     3361 gggaaaacga cttttcctct tcgagctgaa ccactctgtc catattacac agaagccata
     3421 tttgtaccag gcgggtgggc ggggggagag gggctgtcgt gcagtgtgtg tctgtctggg
     3481 ggtgggggtg ggagaaggga gcagggaggg gatcgtgtat ctttataatc tttctaactc
     3541 tcctgtgcta atctcagagg gaccaccctc aatatatctg gattatccca tgtggtcagg
     3601 ctgcctcttt ttgctactct cactgctggc tgggctgcat gtaaataagg gctgacctca
     3661 tgtccccggc acctggcact caaagggtcc tcgccatgcc actctgtggg gcatctgtat
     3721 gtggaatcaa gggacagagt atctgagtaa tttgcttccc agagaatatt tacatttaaa
     3781 gcatgtcatc tgactgctac cctgttaccc tctgaccagc catgctggcc accaccgtga
     3841 tggaggtgaa gacctgagca aagccctcca ggaaggagag catcaccagt ttttgccaaa
     3901 ctctcttttt agctccctcc cgatgcacct gaaattagac ctgggtactg atccttctac
     3961 acgtcaatct gagagggtta atgggaatcc acctaccgaa catgtatcct gcatttctcc
     4021 tggccagaga aataccattt ctacctccct ccagaaactt tacctattgc caagtcaagg
     4081 aagcattctc acagtctgtg tgtctcacaa cagaatatga atagagatta cccagtgggc
     4141 tagagtctca cattaaagta tgctgtccca tggtc
//
