LOCUS       NM_001047102            9372 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus cell adhesion molecule 2 (Cadm2), mRNA.
ACCESSION   NM_001047102 XM_001064526 XM_340958
VERSION     NM_001047102.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 9372)
  AUTHORS   Lamiquiz-Moneo,I., Mateo-Gallego,R., Bea,A.M., Dehesa-Garcia,B.,
            Perez-Calahorra,S., Marco-Benedi,V., Baila-Rueda,L., Laclaustra,M.,
            Civeira,F. and Cenarro,A.
  TITLE     Genetic predictors of weight loss in overweight and obese subjects
  JOURNAL   Sci Rep 9 (1), 10770 (2019)
   PUBMED   31341224
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9372)
  AUTHORS   Liu,N., Yang,C., Bai,W., Wang,Z., Wang,X., Johnson,M., Wang,W.,
            Zhang,P., Yang,H., Liu,H., Cheng,Y. and Tu,Y.
  TITLE     CADM2 inhibits human glioma proliferation, migration and invasion
  JOURNAL   Oncol Rep 41 (4), 2273-2280 (2019)
   PUBMED   30816549
REFERENCE   3  (bases 1 to 9372)
  AUTHORS   Huang,Y.X., Nie,X.G., Li,G.D., Fan,D.S., Song,L.L. and Zhang,X.L.
  TITLE     Downregulation of microRNA-182 inhibits cell viability, invasion
            and angiogenesis in retinoblastoma through inhibition of the
            PI3K/AKT pathway and CADM2 upregulation
  JOURNAL   Int J Oncol 53 (6), 2615-2626 (2018)
   PUBMED   30320366
REFERENCE   4  (bases 1 to 9372)
  AUTHORS   Liu,Y., Li,Y., Ren,Z., Si,W., Li,Y., Wei,G., Zhao,W., Zhou,J.,
            Tian,Y. and Chen,D.
  TITLE     MicroRNA-125a-3p is involved in early behavioral disorders in
            stroke-afflicted rats through the regulation of Cadm2
  JOURNAL   Int J Mol Med 40 (6), 1851-1859 (2017)
   PUBMED   29039453
  REMARK    GeneRIF: Overexpression of miR125a reduced the level of Cadm2
            expression in PC12 cell injury induced by free-serum. In contrast,
            inhibition of miR125a using miR125a inhibitors significantly
            resulted in higher levels of Cadm2 expression. In conclusion,
            miR125a is involved in the behavioral disorder of animal models of
            MCAO by regulation of Cadm2.
REFERENCE   5  (bases 1 to 9372)
  AUTHORS   Miranda-Lora,A.L., Cruz,M., Aguirre-Hernandez,J., Molina-Diaz,M.,
            Gutierrez,J., Flores-Huerta,S. and Klunder-Klunder,M.
  TITLE     Exploring single nucleotide polymorphisms previously related to
            obesity and metabolic traits in pediatric-onset type 2 diabetes
  JOURNAL   Acta Diabetol 54 (7), 653-662 (2017)
   PUBMED   28401323
REFERENCE   6  (bases 1 to 9372)
  AUTHORS   Casey,J.P., Magalhaes,T., Conroy,J.M., Regan,R., Shah,N., Anney,R.,
            Shields,D.C., Abrahams,B.S., Almeida,J., Bacchelli,E., Bailey,A.J.,
            Baird,G., Battaglia,A., Berney,T., Bolshakova,N., Bolton,P.F.,
            Bourgeron,T., Brennan,S., Cali,P., Correia,C., Corsello,C.,
            Coutanche,M., Dawson,G., de Jonge,M., Delorme,R., Duketis,E.,
            Duque,F., Estes,A., Farrar,P., Fernandez,B.A., Folstein,S.E.,
            Foley,S., Fombonne,E., Freitag,C.M., Gilbert,J., Gillberg,C.,
            Glessner,J.T., Green,J., Guter,S.J., Hakonarson,H., Holt,R.,
            Hughes,G., Hus,V., Igliozzi,R., Kim,C., Klauck,S.M., Kolevzon,A.,
            Lamb,J.A., Leboyer,M., Le Couteur,A., Leventhal,B.L., Lord,C.,
            Lund,S.C., Maestrini,E., Mantoulan,C., Marshall,C.R.,
            McConachie,H., McDougle,C.J., McGrath,J., McMahon,W.M.,
            Merikangas,A., Miller,J., Minopoli,F., Mirza,G.K., Munson,J.,
            Nelson,S.F., Nygren,G., Oliveira,G., Pagnamenta,A.T.,
            Papanikolaou,K., Parr,J.R., Parrini,B., Pickles,A., Pinto,D.,
            Piven,J., Posey,D.J., Poustka,A., Poustka,F., Ragoussis,J.,
            Roge,B., Rutter,M.L., Sequeira,A.F., Soorya,L., Sousa,I., Sykes,N.,
            Stoppioni,V., Tancredi,R., Tauber,M., Thompson,A.P., Thomson,S.,
            Tsiantis,J., Van Engeland,H., Vincent,J.B., Volkmar,F.,
            Vorstman,J.A., Wallace,S., Wang,K., Wassink,T.H., White,K.,
            Wing,K., Wittemeyer,K., Yaspan,B.L., Zwaigenbaum,L., Betancur,C.,
            Buxbaum,J.D., Cantor,R.M., Cook,E.H., Coon,H., Cuccaro,M.L.,
            Geschwind,D.H., Haines,J.L., Hallmayer,J., Monaco,A.P.,
            Nurnberger,J.I. Jr., Pericak-Vance,M.A., Schellenberg,G.D.,
            Scherer,S.W., Sutcliffe,J.S., Szatmari,P., Vieland,V.J.,
            Wijsman,E.M., Green,A., Gill,M., Gallagher,L., Vicente,A. and
            Ennis,S.
  TITLE     A novel approach of homozygous haplotype sharing identifies
            candidate genes in autism spectrum disorder
  JOURNAL   Hum Genet 131 (4), 565-579 (2012)
   PUBMED   21996756
REFERENCE   7  (bases 1 to 9372)
  AUTHORS   Hiruma,A., Ikeda,S., Terui,T., Ozawa,M., Hashimoto,T., Yasumoto,S.,
            Nakayama,J., Kubota,Y., Iijima,M., Sueki,H., Matsumoto,Y., Kato,M.,
            Akasaka,E., Ikoma,N., Mabuchi,T., Tamiya,S., Matsuyama,T.,
            Ozawa,A., Inoko,H. and Oka,A.
  TITLE     A novel splicing variant of CADM2 as a protective transcript of
            psoriasis
  JOURNAL   Biochem Biophys Res Commun 412 (4), 626-632 (2011)
   PUBMED   21864505
REFERENCE   8  (bases 1 to 9372)
  AUTHORS   Fogel,A.I., Akins,M.R., Krupp,A.J., Stagi,M., Stein,V. and
            Biederer,T.
  TITLE     SynCAMs organize synapses through heterophilic adhesion
  JOURNAL   J Neurosci 27 (46), 12516-12530 (2007)
   PUBMED   18003830
REFERENCE   9  (bases 1 to 9372)
  AUTHORS   Pellissier,F., Gerber,A., Bauer,C., Ballivet,M. and Ossipow,V.
  TITLE     The adhesion molecule Necl-3/SynCAM-2 localizes to myelinated
            axons, binds to oligodendrocytes and promotes cell adhesion
  JOURNAL   BMC Neurosci 8, 90 (2007)
   PUBMED   17967169
  REMARK    GeneRIF: We show that Necl-3/SynCAM-2 is a plasma membrane protein
            that accumulates in several tissues, including those of the central
            and peripheral nervous system.
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 9372)
  AUTHORS   Maurel,P., Einheber,S., Galinska,J., Thaker,P., Lam,I., Rubin,M.B.,
            Scherer,S.S., Murakami,Y., Gutmann,D.H. and Salzer,J.L.
  TITLE     Nectin-like proteins mediate axon Schwann cell interactions along
            the internode and are essential for myelination
  JOURNAL   J Cell Biol 178 (5), 861-874 (2007)
   PUBMED   17724124
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Oct 22, 2022 this sequence version replaced NM_001047102.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.65853.1, DQ272744.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-698               JAXUCZ010000011.1  18971189-18971886   c
            699-848             JAXUCZ010000011.1  18226675-18226824   c
            849-1001            JAXUCZ010000011.1  18152384-18152536   c
            1002-1139           JAXUCZ010000011.1  18149708-18149845   c
            1140-1310           JAXUCZ010000011.1  18127739-18127909   c
            1311-1401           JAXUCZ010000011.1  18113637-18113727   c
            1402-1580           JAXUCZ010000011.1  18089686-18089864   c
            1581-1706           JAXUCZ010000011.1  18004553-18004678   c
            1707-9372           JAXUCZ010000011.1  17994856-18002521   c
FEATURES             Location/Qualifiers
     source          1..9372
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11p12"
     gene            1..9372
                     /gene="Cadm2"
                     /gene_synonym="Igsf4d; Necl-3; SynCAM 2"
                     /note="cell adhesion molecule 2"
                     /db_xref="GeneID:360687"
                     /db_xref="RGD:1305678"
     exon            1..698
                     /gene="Cadm2"
                     /gene_synonym="Igsf4d; Necl-3; SynCAM 2"
                     /inference="alignment:Splign:2.1.0"
     CDS             638..1825
                     /gene="Cadm2"
                     /gene_synonym="Igsf4d; Necl-3; SynCAM 2"
                     /note="nectin-like protein 3; immunoglobulin superfamily
                     member 4D; immunoglobulin superfamily, member 4; synaptic
                     cell adhesion molecule 2"
                     /codon_start=1
                     /product="cell adhesion molecule 2 precursor"
                     /protein_id="NP_001040567.1"
                     /db_xref="GeneID:360687"
                     /db_xref="RGD:1305678"
                     /translation="MIWKRSAVLRFYSVCGLLLQGSQGQFPLTQNVTVVEGGTAILTC
                     RVDQNDNTSLQWSNPAQQTLYFDDKKALRDNRIELVRASWHELSISVSDVSLSDEGQY
                     TCSLFTMPVKTSKAYLTVLGVPEKPQISGFSSPVMEGDLMQLTCKTSGSKPAADIRWF
                     KNDKEIKDVKYLKEEDANRKTFTVSSTLDFRVDRSDDGVAVICRVDHESLNATPQVAM
                     QVLEIHYTPSVKIIPSTPFPQEGQALTLTCESKGKPLPEPVLWTKDGAELPDPDRMVV
                     SGRELNILFLNKTDNGTYRCEATNTIGQSSAEYVLIVHDPNSLAGQNGPDHALIGGIV
                     AVVVFVTLCSIFLLGRYLARHKGTYLTNEAKGAEDAPDADTAIINAEGSQVNAEEKKE
                     YFI"
     exon            699..848
                     /gene="Cadm2"
                     /gene_synonym="Igsf4d; Necl-3; SynCAM 2"
                     /inference="alignment:Splign:2.1.0"
     exon            849..1001
                     /gene="Cadm2"
                     /gene_synonym="Igsf4d; Necl-3; SynCAM 2"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1139
                     /gene="Cadm2"
                     /gene_synonym="Igsf4d; Necl-3; SynCAM 2"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1310
                     /gene="Cadm2"
                     /gene_synonym="Igsf4d; Necl-3; SynCAM 2"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1401
                     /gene="Cadm2"
                     /gene_synonym="Igsf4d; Necl-3; SynCAM 2"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1580
                     /gene="Cadm2"
                     /gene_synonym="Igsf4d; Necl-3; SynCAM 2"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1706
                     /gene="Cadm2"
                     /gene_synonym="Igsf4d; Necl-3; SynCAM 2"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..9372
                     /gene="Cadm2"
                     /gene_synonym="Igsf4d; Necl-3; SynCAM 2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagctgctg ctgccgccgc cgccgccgcc tccgtcgccg ccgccgccgc cgctgccgcc
       61 gccactgctg ctgcagccgg agcatccggg agccgccgcc gctgctgcca ccgctaccaa
      121 gcgctgctac cactactgcc gcctcttctc ccaggactct gacaccggag cgcgagcggc
      181 ggtgctgcca gcttgctgcc cctgtccccc acccctccct tccttgacct acccactcct
      241 tgcagccctc gcctgcacct tccccgacac cccggcatct ctgcatcacc tgcctaagca
      301 gcctccgggc gggctctggg acttgccgcg agctccgaaa ggaacgcgag ctccaaaccg
      361 gtgccgggca gatcggttgt cggggctgca ccagcagcag cagaaggaga agaaactatt
      421 tagcccaccg aaaccccatt ctgcgggtgc tctgccactg ccgcttttgc tgccggcaac
      481 cagcttccgc gcgggttcga acaccgcagc agcggtatcg tgggtccggc gggagccggg
      541 aggacgacac cagcggaacc cttgcactgt gtggttcgcc taaccagcat ctccttgccc
      601 cctcgatcct tcccccagac ccttaaaaga agggaccatg atttggaaac gcagcgcggt
      661 tctccgcttc tacagtgtct gcgggctcct gttacaaggc agccaagggc agtttccact
      721 aactcagaat gtcacggttg ttgaaggcgg aactgcaatt ctgacctgca gagttgatca
      781 aaatgataac acctccctcc agtggtcgaa tccagctcag cagactctgt acttcgatga
      841 caagaaagct ttgagggaca atcggatcga gctggttcgc gcttcttggc atgagttgag
      901 catcagtgtc agtgacgtgt ctctctctga tgaaggacag tacacctgtt ccttatttac
      961 aatgcctgtc aaaacctcca aggcctatct cactgtcctg ggtgttccag agaagcctca
     1021 gattagtgga ttttcatccc cagtcatgga gggagacctg atgcagctga cttgcaagac
     1081 gtcaggcagt aagcctgcgg ctgatataag atggttcaaa aatgacaaag agatcaaaga
     1141 tgtgaagtac ttgaaggaag aggatgctaa ccgcaagacc ttcaccgtca gcagcacact
     1201 ggatttccga gtggaccgta gcgatgatgg agtggcggtc atctgcagag tagaccacga
     1261 gtccctcaat gccacccctc aggtagccat gcaggtgcta gaaatacact atacaccatc
     1321 agtgaagatt ataccatcca ctccttttcc acaagaagga caggctttaa cattgacttg
     1381 tgaatctaaa ggaaaaccac tgccagaacc tgttttgtgg acgaaggatg gggcagaatt
     1441 accagatcct gatcgaatgg ttgtgagtgg tagggaactc aacattctct tcctgaacaa
     1501 aacggacaat ggcacttatc gatgcgaagc cactaacacc attggtcaaa gcagcgcaga
     1561 gtacgtcctc attgtacacg atcccaattc tctggctggt cagaatggcc ctgaccatgc
     1621 tctcataggc ggcatagtgg ctgtggttgt atttgttacc ctgtgctcca tattcctgct
     1681 tggccgatat ctggcaagac ataaaggaac atatctcaca aacgaagcta aaggagccga
     1741 agacgcacca gatgccgaca cagccattat caatgctgaa ggcagccaag tcaatgccga
     1801 agagaaaaaa gagtatttca tttaaaattc aggctccaag ttctgagttt tacctaccag
     1861 gctgactgct ggagaaaact ggcaatcatc tctcaaaaat cattccaacc atcttctcct
     1921 actactttta ttaacaccca tactgtactg ctctcagtag ccagtgtata ccagcaatca
     1981 gcagttgaaa gcatcattct ttaattactg taccatccat aatgcaggac atttcttatt
     2041 gcctaaattt tacaccattg ctcttttaac atacagtgct tgaatataca gccttaacaa
     2101 tgttaatcat ctcactggat catgatactg agttgttttt atacattgaa gaaatgtatg
     2161 cagagccccg cccccacatt tattttccat taagccacag actttgtcgt ttgccattgg
     2221 acagttatca caagtcccag gattaggtga tgacctacta tgtttaagcg taatcgaaga
     2281 ttagaggttt acaaacagtg ttttctacct gtctatcttc aaaggtaaca tgttgtagaa
     2341 acatacgccc tagaaaacac aagctgaaaa ccaccgtagt atactttctg gaatgtttga
     2401 gtttatactg gtaacactgt atcaagttgc tactttaaaa tttagtgttt gatacaggcg
     2461 ccatgtgtat tgattatact catgacatga caccttatac tattatatag atcctaccat
     2521 taggttattg tagcttcatt taccaataaa ttattacaaa catttaactg ctttgggaat
     2581 cataaagatt tcattcattt ctctatttga ttctataatt tatttgttcc atatggattc
     2641 acctgcctaa acaaaactga agtagggcac aattttgaga cattttagta tctgtatata
     2701 gtgcatataa taaatccaat taaacattat ttgatacata tttaactttt ttggctgtag
     2761 gttattcagt cataagtacg cattttctaa cgttcattat atccctttag atattacata
     2821 aactgatatt ataagtagat aacatgtatt agtatttttg tctgtatgtc ctagcactgt
     2881 caacaacaaa tttttgtagt tcttgttaat tttatttgtt atacaatgga agcacaatgt
     2941 tacaaggaaa ggtaatttta agctaaacaa ccagtgcgca gcctcaggtt ttaaatcaca
     3001 accacagttg aataataacc taaaaaccaa ctcttagttt gatttaatta aaaaaaaact
     3061 ttacacattt tcatttggca ggtttcagag ctgcttacct acattgattt gccaaaaagg
     3121 aagtgtttat gatatttttt ctgcataaat gagctaattc tttgtattaa attcctgtct
     3181 atgcattcta tgaggtacaa acttatgaaa cagagagtga tagagaaccc aggccatgct
     3241 cctaactcca aggtgaaagt ctctttctct ggattatttt aaatttttgg tacattgaac
     3301 tattataaaa ttctgtaatc ttaaatatat cacaaagcca atacaaaatc ttctttcttt
     3361 ggatgaaata taacattggt agaatatttt ttattacatt tattggaagt taatgaacaa
     3421 agatccagtt agatgaaaaa aattattttc ccacttataa gcattgcacc tttaagaaga
     3481 aaacaaaaat tatgatatgg tagctgtact tgtgatgtct aacagcatgg tggagtttta
     3541 aaaatacctt ggaacttatt tgggggcggg gagcaagaat gatttaatac actatcctat
     3601 gttaataaca aatgaaaggc aaagggtgct gtatattaga ttatttatca gaaaagtatc
     3661 aaacatttaa ggacaatgtt agaattttta agtttctttt tttttaattg tatagcattt
     3721 atcttgttga tttcttataa aagaaaaagg acaatgtccg tcaagcagca ctttttcaaa
     3781 atatacagag cataaataat atgatgtggt tgagtgttaa cataataaat catatacagt
     3841 atgacatttt aaggaaataa gtctgcattg atgtgattgc atgcttgttt ttacagttca
     3901 ctccatacca tctgtgaaaa aatgcaataa tctgttaata tagtacggta gttggagaga
     3961 atcaggtagg tgcctctaga cacattgaaa ctagaatagg tctataaact gctcatatct
     4021 ttccatgcat aatctttagg aagactccac acagcaaaat tcatcccgtt agtacagaat
     4081 ggaaaggtcc ttactgctaa gtgcgttgta taacggcatc atcaattgct atttaaagcc
     4141 taattcagga cacatttaca aaattgctac tcttcatcga tgctgtattt atatcctcct
     4201 tcatctatat tctacttggc tccaactgct aaaattgttg cctaaataac acaaacatta
     4261 tttataacgc tgtaaaatta gaaaccccaa atcgtttgta tttcaagact tttgactctt
     4321 ttaacccttc tgaggaatac acaaacccat tggagtttgt aaaatgaaaa tcactggcag
     4381 ataaaaatta gtaggctcta atcgaattgt tttcagttaa atgtagctaa tttggattga
     4441 gtgacgtttc ctgacatgga aaaaaaagtg atgaagttat actttcctgt attgaaaggt
     4501 tatctggttt tcactgaagg aaacaagtta gaagaactgt gggtattccc cattccagca
     4561 aataaaaaat aaatgaagta agatttctaa attggactca tgtcaactga gaagcctgaa
     4621 atgtgcgcaa ttgtatgcac atgagcctct ctgtctctgc taagggaggt cagtaggtag
     4681 gacacgcagt gactggaatg tgtgcactgc tcagagactg tgagcaccca ttcgttacaa
     4741 aaggacgttc ctctctgcca gacgtgttta cagtgcacac tgattgtcct ccagcagtca
     4801 gatctaacca acattcttct tgtcttcttt tcctttttga atgtcctggg aagaatggtt
     4861 accaagacta taagaaaaaa ggaaatgtta taagtaatga caaaataccc cattggaaaa
     4921 ttggtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgcgtgcg
     4981 tgtactgaag agaagaaaga tgaaaacaaa cacagagaaa gagattccaa cttgttttct
     5041 ttgaccagaa attgcaagaa gcaatttaag gaacctgata ttgggattta atgtagaaac
     5101 cggatgatct cattaaagat gttcagtcct tcatagaaac tttccaatca taataacaag
     5161 tagagaaagg aagaacaact ttcctgacaa tggcaaagaa gctaacacct cattggtttt
     5221 gctcgggttt ttgtttgttg ttttcttgta aaaaaaaata taaatattca agtaaaaaga
     5281 caggctcacc tgtaactatg tactcatgac tgaacagcag tgagatgcca tatcggtaca
     5341 cgtacagcag ctgtttgaca gcatggctct tccgtgtaac atagcagtta tcgtgtgatt
     5401 tagtgccact tactgcaaag tgttaccaat gggcacatcg aaaatgcttt cacttcctca
     5461 ccctttcgat gtaattataa tttaaaagat aaaaatagag aatttcacac ctttttccaa
     5521 tggtggggga aaaaagactt tttgtatcag tctgtagctt tcccataata ttttggtccc
     5581 aaaaaacttt tgaaaatgcc caattttatt tcctttaatg gacggtaatc tgtaatgagt
     5641 acagacaatg aaatgattac tcagtggtca caactgacat aattgaaaaa cctaaaggaa
     5701 atgactgaca agtaatgctt tttggtaagc ggcaccaagt acacactaaa aactatgcaa
     5761 aatataggta actacactgt atgtacatgt aagtatcttg tactagctgt gtatggatgt
     5821 tggaaaccca tgtaattata atatgcattt tgaattctgg gaaagaggaa atcttagtgt
     5881 agataatata atttgttttg aaatatacat tggcaatatt gaaatatact cagtgcaata
     5941 tctctaattc tattgctgga tatttaatgc aaagggtttt taatatactc ttaaaggaca
     6001 cccaagagtt tgctaattca cctcacatgt gtgaaagtac taactacagc aagttttatt
     6061 tttttttctt acttaattat tgaagtgaca aaggacactt acttggttta gtgttcaaca
     6121 ttactgcaga ggatgaaaag acatggattt taatctttga ttcataacta atcgaatttg
     6181 accttcttaa actttctttg aaatgtatgt tctttaatag attaatatac tttgattatg
     6241 agtaaaatgt attcaaagaa cgtaaggtac atttagtact taaagtcact tatgttttaa
     6301 tgagatcttc ctctgtatat ttccttttgt ctccctatca caacccaaac atgccctttg
     6361 cacttcgata tacccttcca aaggcagtgg attgagcata gcaagataat catgagactt
     6421 gaaggggatg gtatatgtga atgggttcta aaagcatcag catttttgtg tactgagatt
     6481 actactgaat gcaatagtat tggatatagc tggtaattct ctgccatgca tacttacaat
     6541 aattcttcta cctctctcac ttttaacatg ggctatgata cttcgatata aatagcggaa
     6601 gtaaatattt acaggatatc ccaggaagca ccattttacg accttcataa caatgcactc
     6661 cccactccct gggaaatctc aaaagccaac ttcttgtagt gtattctatg gtgtgtggac
     6721 atgcgtttct ttagcttctc tatccttagc tgcacatagg taacctatga aactttggtg
     6781 gggacagtcc tttccatgcc tcgttaatgt tttgctgtta tgtaattgta actttttaga
     6841 agtaatttga tggcagcagt ttgcaatcca atctgacatt ccattttatt tttaatgtgt
     6901 aagaatttct tcagatccag tgctgtattt tacgtacaaa tcatgtatac gatttaattt
     6961 ccagagaagt attatctata taaatgaaaa ttaagtattt gaaaactgcc tccttatgaa
     7021 caaataaccc caataattca aaatattgcc tcagaagccc actttttcta cctaggcatg
     7081 atagggactt ttcaataatg taatttaaat atgttaaaat aaaatgccat tttagcatat
     7141 tttccttcag gaaaaaaata gattacataa atttattaaa tactgatggt gaatctgtaa
     7201 aatacgctta aaattaaagt aagatgtctt gtgttacata gttatgttat aaatatcatt
     7261 tgttttagtc ttcaacatcg tttccatata tgtatatgta atatatatga tcatatatat
     7321 tatatatata agaaatgtga ttattttgga gaaaatgggc ccaaatgtga aaaagttgta
     7381 aagaaaacac tataccccct tggaaatatg atgtatattt caaagatgtt cagttaaaag
     7441 agaagtgaca attgcagagg cacaagaaaa atcttccagg actcagcact taagcacttt
     7501 tcccacatcc agggtcaaag cagtagcgat ccctacacgg acttttaagc gcagcatgaa
     7561 atgcagcatt acacgaacac acagtactgt caaacctcaa atgctttctt tctttagatg
     7621 ctttcccttg tacatgatcc tcgtagacat gtttttatat ttgctgatag tgaaagtcac
     7681 gcgcaataaa atgtcacggt tggaagcagt agtcactaat cggttaaaga caagtacaaa
     7741 tgtaaacagt tgttatcttt ctccgctttg cttttctctg tggttcccat gtgttgactg
     7801 aatgtcataa atagaacaaa aagcaatcta gaagcttttc aaagctagga atattgctcc
     7861 ttataaatat gtaacatttt aatcttttta caaacttact tcgctgtact cgctgtacgt
     7921 gttgtcgatt gattcaatga tgcgattggg tagtgaacta tggacttctg agtctggaat
     7981 ggttaatctc ttcttcacat tcagttcaca tcaatatttg tcaaacggtt gtttggcttt
     8041 ttatgtaacc gtaaatattt cttaaagata gctccattct tatcgtaaat atttcagtgc
     8101 aaacaacctt tgcaacaagt ttgccgtgtt aaaaaaaaaa tttaaagact tatctctgaa
     8161 aactgtgtcc agaaatgcag gcgttcccac taatgtagct tcaaaaataa tgtgttctat
     8221 ttacctgaca tgaaatccgt atcttttgga agggtatact tatgacagca ctcaaatgta
     8281 ttctgtgctg taaagaaaat ccaccaaaat gaagcagatc gcacagaaaa caaaacacaa
     8341 ttatcgaatc tactcttatc atgaacattt acacaaaaca aaatgcatat tgtaatatta
     8401 agtacatgac acttgcatgt tgacatgcct atatacttac aaagtattca atgtgtactg
     8461 agtggcgctt caaatatgtc atgtacaaca ctcctaaaca tgcctacagg gttcccacct
     8521 cactccaccc tttcagtaaa gtctcctcag aaaaagatgt ctgataaata tgaaaataat
     8581 aaaatttgaa ttttagttat ctgctggaca ttactgaact ttttcttcat ttactgtatt
     8641 ttaggcttaa actcagacat tggaaataaa ctttcttttc tctagtgaaa aattacaaaa
     8701 ggtgttgtga agcacattct gttatgccaa acacattatt ttgaatacct tttctcaatt
     8761 gcattttata tccatctatt tgaagttttc tcaatgacat acaattttct tgtaaatttc
     8821 tagagggaac ttttttttaa ataaatgaga gctactaaaa atgttatctt tctgatataa
     8881 catttaatca ttactccttg aaatgtatga accttgtaat atgctgacta agggttaaaa
     8941 aagtgtcgct gacgaaaaga attttgcttg agattgccaa cattcaaaat tttgtaaaag
     9001 taatttgaca tccacttatt tgtgtttact aatgttgact aggaacagaa gcaaaaatat
     9061 ctaaaacaag cttcattttt atttctatac tctaaccgat atattccaac tacctaagat
     9121 aatgcaatta accatatata caccccaagc ttataacaat aagaatttga gataagcttt
     9181 taaatttatg gaagattttc tttgtgtctt tggaagttca cttatcatga gatattttgt
     9241 agtctacttt aaataacaga ttttgttata cagggtaagc caaaggctgt acaagaatta
     9301 gtgccattgg gtctgatatt tgtgttggac catgaaatat tccattaaaa tttgtctgta
     9361 aatacaaggc aa
//
