LOCUS       NM_001012201            1777 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus cell adhesion molecule 1 (Cadm1), mRNA.
ACCESSION   NM_001012201 XM_343385
VERSION     NM_001012201.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1777)
  AUTHORS   Sun,S., Liu,W. and Li,Y.
  TITLE     CADM1 enhances intestinal barrier function in a rat model of mild
            inflammatory bowel disease by inhibiting the STAT3 signaling
            pathway
  JOURNAL   J Bioenerg Biomembr 52 (5), 343-354 (2020)
   PUBMED   32929607
  REMARK    GeneRIF: CADM1 enhances intestinal barrier function in a rat model
            of mild inflammatory bowel disease by inhibiting the STAT3
            signaling pathway.
REFERENCE   2  (bases 1 to 1777)
  AUTHORS   Cao,W., Shi,P. and Ge,J.J.
  TITLE     miR-21 enhances cardiac fibrotic remodeling and fibroblast
            proliferation via CADM1/STAT3 pathway
  JOURNAL   BMC Cardiovasc Disord 17 (1), 88 (2017)
   PUBMED   28335740
  REMARK    GeneRIF: miR-21 overexpression promotes cardiac fibrosis via STAT3
            signaling pathway by decrease CADM1 expression, indicating miR-21
            as an important signaling molecule for cardiac fibrotic remodeling
            and atrial fibrillation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1777)
  AUTHORS   Rademacher,N., Schmerl,B., Lardong,J.A., Wahl,M.C. and
            Shoichet,S.A.
  TITLE     MPP2 is a postsynaptic MAGUK scaffold protein that links SynCAM1
            cell adhesion molecules to core components of the postsynaptic
            density
  JOURNAL   Sci Rep 6, 35283 (2016)
   PUBMED   27756895
  REMARK    GeneRIF: proteins. Our results highlight a previously unexplored
            role for MPP2 at postsynaptic sites as a scaffold that links
            SynCAM1 cell adhesion molecules to core proteins of the
            postsynaptic density.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1777)
  AUTHORS   Zhang,C., Caldwell,T.A., Mirbolooki,M.R., Duong,D., Park,E.J.,
            Chi,N.W. and Chessler,S.D.
  TITLE     Extracellular CADM1 interactions influence insulin secretion by rat
            and human islet beta-cells and promote clustering of syntaxin-1
  JOURNAL   Am J Physiol Endocrinol Metab 310 (11), E874-E885 (2016)
   PUBMED   27072493
  REMARK    GeneRIF: Our results suggest that, as in the CNS, CADM1
            interactions drive exocytic site assembly and promote actin network
            formation. These results support the broader hypothesis that the
            effects of cell-cell contact on beta-cell maturation and function
            are mediated by the same extracellular protein interactions that
            drive the formation of the presynaptic exocytic machinery. These
            interactions may be therapeutic targets for re...
REFERENCE   5  (bases 1 to 1777)
  AUTHORS   Perez de Arce,K., Schrod,N., Metzbower,S.W.R., Allgeyer,E.,
            Kong,G.K., Tang,A.H., Krupp,A.J., Stein,V., Liu,X., Bewersdorf,J.,
            Blanpied,T.A., Lucic,V. and Biederer,T.
  TITLE     Topographic Mapping of the Synaptic Cleft into Adhesive Nanodomains
  JOURNAL   Neuron 88 (6), 1165-1172 (2015)
   PUBMED   26687224
REFERENCE   6  (bases 1 to 1777)
  AUTHORS   Li,J., Zhang,Z., Bidder,M., Funk,M.C., Nguyen,L., Goodfellow,P.J.
            and Rader,J.S.
  TITLE     IGSF4 promoter methylation and expression silencing in human
            cervical cancer
  JOURNAL   Gynecol Oncol 96 (1), 150-158 (2005)
   PUBMED   15589594
REFERENCE   7  (bases 1 to 1777)
  AUTHORS   Meyer,G., Varoqueaux,F., Neeb,A., Oschlies,M. and Brose,N.
  TITLE     The complexity of PDZ domain-mediated interactions at glutamatergic
            synapses: a case study on neuroligin
  JOURNAL   Neuropharmacology 47 (5), 724-733 (2004)
   PUBMED   15458844
REFERENCE   8  (bases 1 to 1777)
  AUTHORS   Shingai,T., Ikeda,W., Kakunaga,S., Morimoto,K., Takekuni,K.,
            Itoh,S., Satoh,K., Takeuchi,M., Imai,T., Monden,M. and Takai,Y.
  TITLE     Implications of nectin-like
            molecule-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 in cell-cell adhesion
            and transmembrane protein localization in epithelial cells
  JOURNAL   J Biol Chem 278 (37), 35421-35427 (2003)
   PUBMED   12826663
REFERENCE   9  (bases 1 to 1777)
  AUTHORS   Biederer,T., Sara,Y., Mozhayeva,M., Atasoy,D., Liu,X.,
            Kavalali,E.T. and Sudhof,T.C.
  TITLE     SynCAM, a synaptic adhesion molecule that drives synapse assembly
  JOURNAL   Science 297 (5586), 1525-1531 (2002)
   PUBMED   12202822
  REMARK    GeneRIF: a brain-specific, immunoglobulin domain-containing protein
            that binds to intracellular PDZ-domain proteins and functions as a
            homophilic cell adhesion molecule at the synapse (SynCAM; Synaptic
            cell adhesion molecule)
REFERENCE   10 (bases 1 to 1777)
  AUTHORS   Fukuhara,H., Kuramochi,M., Fukami,T., Kasahara,K., Furuhata,M.,
            Nobukuni,T., Maruyama,T., Isogai,K., Sekiya,T., Shuin,T.,
            Kitamura,T., Reeves,R.H. and Murakami,Y.
  TITLE     Promoter methylation of TSLC1 and tumor suppression by its gene
            product in human prostate cancer
  JOURNAL   Jpn J Cancer Res 93 (6), 605-609 (2002)
   PUBMED   12079507
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            [WARNING] On Mar 13, 2025 this sequence was replaced by
            NM_001012201.3.
            
            On Nov 27, 2020 this sequence version replaced NM_001012201.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078966.1, SRR22399492.1103538.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-296               JAXUCZ010000008.1  56744408-56744703
            297-443             JAXUCZ010000008.1  57010855-57011001
            444-596             JAXUCZ010000008.1  57012558-57012710
            597-734             JAXUCZ010000008.1  57020118-57020255
            735-893             JAXUCZ010000008.1  57022062-57022220
            894-993             JAXUCZ010000008.1  57032895-57032994
            994-1166            JAXUCZ010000008.1  57036502-57036674
            1167-1256           JAXUCZ010000008.1  57041336-57041425
            1257-1289           JAXUCZ010000008.1  57051767-57051799
            1290-1343           JAXUCZ010000008.1  57059041-57059094
            1344-1475           JAXUCZ010000008.1  57070067-57070198
            1476-1777           JAXUCZ010000008.1  57072186-57072487
FEATURES             Location/Qualifiers
     source          1..1777
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q23"
     gene            1..1777
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="cell adhesion molecule 1"
                     /db_xref="GeneID:363058"
                     /db_xref="RGD:1310999"
     exon            1..296
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..1594
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="nectin-like protein 2; spermatogenic immunoglobulin
                     superfamily; immunoglobulin superfamily, member 4A;
                     synaptic cell adhesion molecule; tumor suppressor in lung
                     cancer 1 homolog"
                     /codon_start=1
                     /product="cell adhesion molecule 1 precursor"
                     /protein_id="NP_001012201.1"
                     /db_xref="GeneID:363058"
                     /db_xref="RGD:1310999"
                     /translation="MASPVLPSGSQCAAAAAVAAAAAPPGLRLRLLLLLLSAAALIPT
                     GDGQNLFTKDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQL
                     LNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKDTAV
                     EGEEIEVNCTAMASKPATTIRWFKGNKELKGKSEVEEWSDMYTVTSQLMLKVHKEDDG
                     VPVICQVEHPAVTGNLQTQRYLEVQYKPQVQIQMTYPLQGLTREGDAFELTCEATGKP
                     QPVMVTWVRVDDEMPQHAVLSGPNLFINNLNKTDNGTYRCEASNTVGKAHSDYMLYVY
                     DPPTTIPPPTTTTTTTTTTTTTTTILTIITDTTATTEPAVHGLTQLPNSAEELDSEDL
                     SDSRAGEEGAIGAVDHAVIGGVVAVVVFAMLCLLIILGRYFARHKGTYFTHEAKGADD
                     AADADTAIINAEGGQNNSEEKKEYFI"
     exon            297..443
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            444..596
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            597..734
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            735..893
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            894..993
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1166
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1256
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1289
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1343
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1475
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1777
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggtggggga ggggggctag tcctctgaga gctgggttgg gctcgcggtg ccacgattgg
       61 tcgctcccga ctccgccttc accgcatctc attagcatct cattagctgt ccgctcgggc
      121 tcgggaggca gccaccgctg ccagtctgag gcaggtgccc gacatggcga gtcctgtgct
      181 gccgagcgga tcccagtgtg cggcggcagc ggctgtggcg gcggcggcgg cgcctccagg
      241 gctccggctc cggctcctgc tgttgctcct ctcggccgcg gcactgatcc ccacaggtga
      301 tgggcagaat ctgtttacta aggacgtgac ggtgattgaa ggagaagttg caaccatcag
      361 ctgtcaagtc aataagagtg atgactccgt gattcagcta ctgaacccca acaggcagac
      421 catttacttc agggacttca ggcctttgaa ggacagcagg tttcagctgc tgaatttttc
      481 tagcagtgaa ctcaaagtgt cactgacaaa tgtctcaatt tcggatgaag ggaggtactt
      541 ctgccagctc tacacggacc ctccgcagga gagttatacc accatcacag tcctggtccc
      601 tccacgtaac ttgatgatcg atatccagaa agacacggca gttgaagggg aggagattga
      661 agtcaactgc acggccatgg ccagcaagcc ggctacgacc atcaggtggt tcaaagggaa
      721 caaggaactc aaaggcaaat cagaggtgga agagtggtcg gacatgtaca ctgtgaccag
      781 tcagctgatg ctgaaggtgc acaaggagga tgatggagtc ccagtgatct gccaggtgga
      841 gcaccctgcg gtcactggaa acctgcagac ccagcggtat ctagaagtgc agtataaacc
      901 gcaagtgcag atccagatga cttatcctct gcaaggccta acccgggaag gggatgcatt
      961 cgagttaacg tgtgaagcca ccgggaagcc ccagcctgtg atggtaactt gggtgagagt
     1021 cgatgacgaa atgcctcaac atgccgttct gtctgggccg aatctgttca tcaataacct
     1081 aaacaaaaca gacaatggta cttaccgctg tgaggcttcc aacacagtgg ggaaagctca
     1141 ttcggactat atgctgtatg tatacgatcc ccccacaact atccctcctc ccacaacaac
     1201 caccaccacc actaccacca ccaccaccac caccaccatc cttaccatca tcacagacac
     1261 cacggcgacg acagaaccag cagttcacgg ccttactcag ttgcccaatt ccgcagaaga
     1321 actggacagt gaggatctct cagattctcg agcaggtgaa gagggcgcca ttggggcagt
     1381 ggaccacgcg gtgattggcg gcgtcgtagc cgtggtggtg tttgccatgc tatgtttgct
     1441 catcattctg ggccgctatt ttgccagaca taaaggtaca tacttcactc atgaagccaa
     1501 aggagccgat gacgcagcag acgcagacac agctataatc aatgcagaag gaggacagaa
     1561 caactccgaa gaaaagaaag agtacttcat ctagatcagc ctttttgttc caatgaggtg
     1621 tccaacgggc ctgcttagat gataaagaga cagtgatact ggaactttgg agaagctcgt
     1681 gtggtttttt ttttatgagt gggtggaaag atgcgagact gggaaggctt gggatttgca
     1741 atgtaaaaac aaagacaaaa aatgttcttt gaaagta
//
