LOCUS       NM_001105710            7126 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus carbamoyl-phosphate synthetase 2, aspartate
            transcarbamylase, and dihydroorotase (Cad), mRNA.
ACCESSION   NM_001105710 XM_001063872 XM_001063923 XM_001063974 XM_001064023
            XM_343027
VERSION     NM_001105710.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7126)
  AUTHORS   Hey-Mogensen,M., Goncalves,R.L., Orr,A.L. and Brand,M.D.
  TITLE     Production of superoxide/H2O2 by dihydroorotate dehydrogenase in
            rat skeletal muscle mitochondria
  JOURNAL   Free Radic Biol Med 72, 149-155 (2014)
   PUBMED   24746616
  REMARK    GeneRIF: We conclude that dihydroorotate dehydrogenase can generate
            superoxide and/or H2O2 directly at low rates and is also capable of
            indirect production at higher rates from other sites through its
            ability to reduce the ubiquinone pool.
REFERENCE   2  (bases 1 to 7126)
  AUTHORS   Grande-Garcia,A., Lallous,N., Diaz-Tejada,C. and Ramon-Maiques,S.
  TITLE     Structure, functional characterization, and evolution of the
            dihydroorotase domain of human CAD
  JOURNAL   Structure 22 (2), 185-198 (2014)
   PUBMED   24332717
REFERENCE   3  (bases 1 to 7126)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   4  (bases 1 to 7126)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 7126)
  AUTHORS   Schroeder,P.E., Patel,D. and Hasinoff,B.B.
  TITLE     The dihydroorotase inhibitor 5-aminoorotic acid inhibits the
            metabolism in the rat of the cardioprotective drug dexrazoxane and
            its one-ring open metabolites
  JOURNAL   Drug Metab Dispos 36 (9), 1780-1785 (2008)
   PUBMED   18515330
REFERENCE   6  (bases 1 to 7126)
  AUTHORS   Kunjara,S., Sochor,M., Bennett,M., Greenbaum,A.L. and McLean,P.
  TITLE     Pyrimidine nucleotide synthesis in the rat mammary gland: changes
            in the lactation cycle and effects of diabetes
  JOURNAL   Biochem Med Metab Biol 48 (3), 263-274 (1992)
   PUBMED   1476792
REFERENCE   7  (bases 1 to 7126)
  AUTHORS   Cammer,W. and Downing,M.
  TITLE     Localization of the multifunctional protein CAD in astrocytes of
            rodent brain
  JOURNAL   J Histochem Cytochem 39 (5), 695-700 (1991)
   PUBMED   1673139
REFERENCE   8  (bases 1 to 7126)
  AUTHORS   Mori,M. and Tatibana,M.
  TITLE     Multi-enzyme complex of glutamine-dependent carbamoyl-phosphate
            synthetase with aspartate carbamoyltransferase and dihydroorotase
            from rat ascites-hepatoma cells. Purification, molecular properties
            and limited proteolysis
  JOURNAL   Eur J Biochem 86 (2), 381-388 (1978)
   PUBMED   26565
REFERENCE   9  (bases 1 to 7126)
  AUTHORS   Bond,J.S.
  TITLE     Acid inactivation of short-lived rat liver enzymes
  JOURNAL   Biochim Biophys Acta 451 (1), 238-249 (1976)
   PUBMED   12803
REFERENCE   10 (bases 1 to 7126)
  AUTHORS   Mori,M., Ishida,H. and Tatibana,M.
  TITLE     Aggregation states and catalytic properties of the multienzyme
            complex catalyzing the initial steps of pyrimidine biosynthesis in
            rat liver
  JOURNAL   Biochemistry 14 (12), 2622-2630 (1975)
   PUBMED   1148171
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000006.1.
            
            On Oct 23, 2007 this sequence version replaced NM_001105710.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.8640.1,
                                           SRR26643429.22973.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-257               JAXUCZ010000006.1  31034780-31035036   c
            258-397             JAXUCZ010000006.1  31034436-31034575   c
            398-527             JAXUCZ010000006.1  31031648-31031777   c
            528-670             JAXUCZ010000006.1  31030987-31031129   c
            671-812             JAXUCZ010000006.1  31030684-31030825   c
            813-984             JAXUCZ010000006.1  31030175-31030346   c
            985-1170            JAXUCZ010000006.1  31029817-31030002   c
            1171-1283           JAXUCZ010000006.1  31029601-31029713   c
            1284-1429           JAXUCZ010000006.1  31029189-31029334   c
            1430-1561           JAXUCZ010000006.1  31028827-31028958   c
            1562-1795           JAXUCZ010000006.1  31028457-31028690   c
            1796-2017           JAXUCZ010000006.1  31028129-31028350   c
            2018-2206           JAXUCZ010000006.1  31027827-31028015   c
            2207-2331           JAXUCZ010000006.1  31027449-31027573   c
            2332-2462           JAXUCZ010000006.1  31027181-31027311   c
            2463-2575           JAXUCZ010000006.1  31023416-31023528   c
            2576-2820           JAXUCZ010000006.1  31022993-31023237   c
            2821-3067           JAXUCZ010000006.1  31022546-31022792   c
            3068-3166           JAXUCZ010000006.1  31021963-31022061   c
            3167-3391           JAXUCZ010000006.1  31021590-31021814   c
            3392-3574           JAXUCZ010000006.1  31021316-31021498   c
            3575-3793           JAXUCZ010000006.1  31020927-31021145   c
            3794-3961           JAXUCZ010000006.1  31020490-31020657   c
            3962-4144           JAXUCZ010000006.1  31019662-31019844   c
            4145-4249           JAXUCZ010000006.1  31019460-31019564   c
            4250-4489           JAXUCZ010000006.1  31018469-31018708   c
            4490-4571           JAXUCZ010000006.1  31018166-31018247   c
            4572-4738           JAXUCZ010000006.1  31017811-31017977   c
            4739-4903           JAXUCZ010000006.1  31017522-31017686   c
            4904-5035           JAXUCZ010000006.1  31017254-31017385   c
            5036-5237           JAXUCZ010000006.1  31016830-31017031   c
            5238-5428           JAXUCZ010000006.1  31016344-31016534   c
            5429-5569           JAXUCZ010000006.1  31016113-31016253   c
            5570-5671           JAXUCZ010000006.1  31015852-31015953   c
            5672-5768           JAXUCZ010000006.1  31015350-31015446   c
            5769-5813           JAXUCZ010000006.1  31014650-31014694   c
            5814-5983           JAXUCZ010000006.1  31014381-31014550   c
            5984-6058           JAXUCZ010000006.1  31014216-31014290   c
            6059-6271           JAXUCZ010000006.1  31013585-31013797   c
            6272-6397           JAXUCZ010000006.1  31013320-31013445   c
            6398-6553           JAXUCZ010000006.1  31013046-31013201   c
            6554-6655           JAXUCZ010000006.1  31012855-31012956   c
            6656-6750           JAXUCZ010000006.1  31012577-31012671   c
            6751-7004           JAXUCZ010000006.1  31012213-31012466   c
            7005-7126           JAXUCZ010000006.1  31012091-31012212   c
FEATURES             Location/Qualifiers
     source          1..7126
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q14"
     gene            1..7126
                     /gene="Cad"
                     /note="carbamoyl-phosphate synthetase 2, aspartate
                     transcarbamylase, and dihydroorotase"
                     /db_xref="GeneID:24240"
                     /db_xref="RGD:1588606"
     exon            1..257
                     /gene="Cad"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..6853
                     /gene="Cad"
                     /EC_number="2.1.3.2"
                     /note="carbamyl phosphatate synthetase 2"
                     /codon_start=1
                     /product="multifunctional protein CAD"
                     /protein_id="NP_001099180.2"
                     /db_xref="GeneID:24240"
                     /db_xref="RGD:1588606"
                     /translation="MAALVLEDGSVLQGRPFGAAVSTAGEVVFQTGMVGYPEALTDPS
                     YKAQILVLTYPLIGNYGIPSDEEDEFGLSKWFESSEIHVAGLVVGECCPTPSHWSATC
                     TLHEWLQQHGIPGLQGVDTRELTKKLREQGSLLGKLVQKGTEPSALPFVDPNARPLAP
                     EVSIKTPRVFNAGGAPRIFAVDCGLKYNQIRCLCQLGAEVTVVPWNHELDSRKYDGLF
                     LSNGPGDPASYPGVVSTLNRVLSEPNPRPVFGICLGHQLLALAIGAKTYKMRYGNRGH
                     NQPCLLVGTGRCFLTSQNHGFAVDADSLPAGWAPLFTNANDCSNEGIVHDNLPFFSVQ
                     FHPEHRAGPSDMELLFDVFLETVRDTVAGNAEGRTVRERLAQRLCPPELPIPGSGLPP
                     PRKVLILGSGGLSIGQAGEFDYSGSQAIKALKEENIQTLLINPNIATVQTSQGLADKV
                     YFLPITPHYVTQVIRNERPDGILLTFGGQTALNCGVELTKAGVLARYGVRVLGTPVET
                     IELTEDRRAFAARMAEIGEHVAPSEAANSLEQAQAAAERLGYPVLVRAAFALGGLGSG
                     FASTKEELSALVAPAFAHTSQVLIDKSLKGWKEIEYEVVRDAYGNCVTVCNMENLDPL
                     GIHTGESIVVAPSQTLNDREYQLLRRTAIKVTQHLGIVGECNVQYALNPESEQYYIIE
                     VNARLSRSSALASKATGYPLAYVAAKLALGIPLPELRNSVTGGTAAFEPSLDYCVVKI
                     PRWDLSKFLRVSTKIGSCMKSVGEVMGIGRSFEEAFQKALRMVDENCVGFDHTVKPVS
                     DVELETPTDKRIFVVAAALWAGYSVERLYELTRIDCWFLHRMKRIVTHAKLLEQHRGR
                     PLPQDLLHQAKCLGFSDKQIALAVLSTELVVRKLRQELGICPAVKQIDTVAAEWPAQT
                     NYLYLTYWGNTHDLDFRTPHVLVLGSGVYRIGSSVEFDWCAVGCIQQLRKMGYKTIMV
                     NYNPETVSTDYDMCDRLYFDEISFEVVMDIYELENPEGVILSMGGQLPNNMAMALHRQ
                     QCRVLGTSPEAIDSAENRFKFSRLLDTIGISQPQWRELSDLESARQFCQTVGYPCVVR
                     PSYVLSGAAMNVAYTDGDLERFLSSAAAVSKEHPVVISKFIQEAKEIDVDAVACDGIV
                     SAIAISEHVENAGVHSGDATLVTPPQDITPKTLERIKAIVHAVGQELQVTGPFNLQLI
                     AKDDQLKVIECNVRVSRSFPFVSKTLGVDLVALATRIIMGEKVESVGLMTGSGVVGVK
                     VPQFSFSRLAGADVVLGVEMTSTGEVAGFGESRCEAYLKAMLSTGFKIPKKNILLTIG
                     SYKNKSELLPTVRLLESLGYSLYASLGTADFYTEHGVKVTAVDWHFEEAVDGECPPQR
                     SILDQLAENHFELVINLSMRGAGGRRLSSFVTKGYRTRRLAADFSVPLIIDIKCTKLF
                     VEALGQIGPAPPLKVHVDCMTSQKLVRLPGLIDVHVHLREPGGTHKEDFASGTAAALA
                     GGVTMVCAMPNTRPPIIDAPALALAQKLAEAGARCDFTLFLGASSENAGTLGAVAGSA
                     AGLKLYLNETFSELRLDSVAQWMEHFETWPSHLPIVAHAERQSVAAVLMVAQLTRRSV
                     HICHVARKEEILLIKTAKAQGLPVTCEVAPHHLFLNREDLERLGPGKGEVRPELGSRE
                     DMEALWENMAVIDCFASDHAPHTLEEKCGPKPPPGFPGLETMLPLLLTAVSEGRLSLD
                     DLLQRLHHNPRRIFHLPLQEDTYVEVDLEHEWTVPSHMPFSKAHWTPFEGQKVKGTVR
                     RVVLRGEVAYIDGQVLVPPGYGQDVRKWPQGAVPQPPPPTPTTTEITTTPERPRRVIP
                     GLPDGRFHLPPRIHRASDPGLPAEEPKEKPPRKVAESELIGTPDGPCYPVPPVPRQAS
                     PQNLGSSGLLHPQMSPLLHSLVGQHILSVKQFTKDQMSHLFNVAHTLRMMVQKERSLD
                     ILKGKVMASMFYEVSTRTSSSFAAAMARLGGAVLSFSEATSSVQKGESLADSVQTMSC
                     YADVVVLRHPQPGAVELAAKHCRRPVINAGDGVGEHPTQALLDIFTIREELGTVNGMT
                     ITMVGDLKHGRTVHSLACLLTQYRVSLRYVAPPSLRMPSSVWDFVASRGTKQEEFESI
                     EEALPDTDVLYMTRIQKERFGSSQEYEACFGQFILTPHIMTRAKKKMVVMHPMPRVNE
                     ISVEVDSDPRAAYFRQAENGMYIRMALLATVLGRF"
     exon            258..397
                     /gene="Cad"
                     /inference="alignment:Splign:2.1.0"
     exon            398..527
                     /gene="Cad"
                     /inference="alignment:Splign:2.1.0"
     exon            528..670
                     /gene="Cad"
                     /inference="alignment:Splign:2.1.0"
     exon            671..812
                     /gene="Cad"
                     /inference="alignment:Splign:2.1.0"
     exon            813..984
                     /gene="Cad"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1170
                     /gene="Cad"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1283
                     /gene="Cad"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1429
                     /gene="Cad"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1561
                     /gene="Cad"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1795
                     /gene="Cad"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..2017
                     /gene="Cad"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2206
                     /gene="Cad"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2331
                     /gene="Cad"
                     /inference="alignment:Splign:2.1.0"
     exon            2332..2462
                     /gene="Cad"
                     /inference="alignment:Splign:2.1.0"
     exon            2463..2575
                     /gene="Cad"
                     /inference="alignment:Splign:2.1.0"
     exon            2576..2820
                     /gene="Cad"
                     /inference="alignment:Splign:2.1.0"
     exon            2821..3067
                     /gene="Cad"
                     /inference="alignment:Splign:2.1.0"
     exon            3068..3166
                     /gene="Cad"
                     /inference="alignment:Splign:2.1.0"
     exon            3167..3391
                     /gene="Cad"
                     /inference="alignment:Splign:2.1.0"
     exon            3392..3574
                     /gene="Cad"
                     /inference="alignment:Splign:2.1.0"
     exon            3575..3793
                     /gene="Cad"
                     /inference="alignment:Splign:2.1.0"
     exon            3794..3961
                     /gene="Cad"
                     /inference="alignment:Splign:2.1.0"
     exon            3962..4144
                     /gene="Cad"
                     /inference="alignment:Splign:2.1.0"
     exon            4145..4249
                     /gene="Cad"
                     /inference="alignment:Splign:2.1.0"
     exon            4250..4489
                     /gene="Cad"
                     /inference="alignment:Splign:2.1.0"
     exon            4490..4571
                     /gene="Cad"
                     /inference="alignment:Splign:2.1.0"
     exon            4572..4738
                     /gene="Cad"
                     /inference="alignment:Splign:2.1.0"
     exon            4739..4903
                     /gene="Cad"
                     /inference="alignment:Splign:2.1.0"
     exon            4904..5035
                     /gene="Cad"
                     /inference="alignment:Splign:2.1.0"
     exon            5036..5237
                     /gene="Cad"
                     /inference="alignment:Splign:2.1.0"
     exon            5238..5428
                     /gene="Cad"
                     /inference="alignment:Splign:2.1.0"
     exon            5429..5569
                     /gene="Cad"
                     /inference="alignment:Splign:2.1.0"
     exon            5570..5671
                     /gene="Cad"
                     /inference="alignment:Splign:2.1.0"
     exon            5672..5768
                     /gene="Cad"
                     /inference="alignment:Splign:2.1.0"
     exon            5769..5813
                     /gene="Cad"
                     /inference="alignment:Splign:2.1.0"
     exon            5814..5983
                     /gene="Cad"
                     /inference="alignment:Splign:2.1.0"
     exon            5984..6058
                     /gene="Cad"
                     /inference="alignment:Splign:2.1.0"
     exon            6059..6271
                     /gene="Cad"
                     /inference="alignment:Splign:2.1.0"
     exon            6272..6397
                     /gene="Cad"
                     /inference="alignment:Splign:2.1.0"
     exon            6398..6553
                     /gene="Cad"
                     /inference="alignment:Splign:2.1.0"
     exon            6554..6655
                     /gene="Cad"
                     /inference="alignment:Splign:2.1.0"
     exon            6656..6750
                     /gene="Cad"
                     /inference="alignment:Splign:2.1.0"
     exon            6751..7126
                     /gene="Cad"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcgtgctt cagctcacta cgcttagggc tccagcttgc cgctcccgcc tgctctccag
       61 cgccccgcgc agcgagccac gtggaccaac tccggcgcgc ggtgtttgct tggttccagt
      121 ggggctcgcc gcgcctcccg cgtctcggtg ctcgccctgc ctcagctccg acccgatggc
      181 ggccctggtg ttggaggacg ggtcggtgct gcagggccgg cccttcgggg ccgctgtgtc
      241 gactgctggg gaagtggtgt ttcagaccgg catggtcggc tacccggagg ccctcactga
      301 cccttcctac aaagctcaga tcctagtgct aacgtaccct ctcatcggca actacggtat
      361 tccctcagat gaagaggacg agttcggcct gagcaagtgg tttgaatcct cggagatcca
      421 tgtggcaggt ctggtggttg gggaatgctg tcccacgccc agccactgga gtgccacctg
      481 caccctgcat gagtggctgc aacagcatgg catccccggc ctgcaaggag tggacactcg
      541 ggagctgact aagaagttgc gggaacaagg gtctcttttg gggaagctgg tccagaaagg
      601 gacagagcct tcagccctgc catttgtgga ccccaatgcc aggcccctgg caccagaggt
      661 ctctattaag accccacggg tattcaatgc ggggggtgcc cctcggatct ttgctgtaga
      721 ctgtggcctc aagtacaatc agatccgatg tctctgccag cttggggctg aggttaccgt
      781 ggtaccctgg aaccatgaat tagacagtcg gaaatatgac ggtctcttcc taagtaatgg
      841 acctggtgat cctgcctcct atcctggtgt ggtgtccaca ctgaatcgag tcttatctga
      901 gcctaatccc cgacctgtgt ttggaatctg ccttggacac cagctattgg ctttagccat
      961 tggggccaaa acttacaaga tgagatacgg aaaccgaggc cacaaccagc cctgtttact
     1021 ggtgggtact gggcgctgct ttctgacctc ccagaatcac gggtttgccg tggacgcgga
     1081 ttcgctgcca gcaggctggg ctcctctatt taccaacgcc aatgactgtt ccaacgaagg
     1141 cattgtacac gacaatctgc ccttcttcag cgtccagttt caccccgagc accgggctgg
     1201 cccttcagat atggagctac tcttcgatgt gtttctagaa accgtgagag atactgtagc
     1261 tgggaacgcc gagggccgga cagtaagaga acgtttggct cagcgcctct gtccccctga
     1321 gcttcccatt cctggttctg ggctcccacc accacgaaaa gttctgatcc tgggctcggg
     1381 gggcctctcc attggccagg ctggagaatt tgactactcg ggctctcagg caattaaagc
     1441 cctaaaggag gagaacatcc aaacattact gatcaacccc aacattgcca cagtgcagac
     1501 ttctcagggg ctggcagaca aggtctattt ccttcccata acacctcact acgtaaccca
     1561 ggtgattcgt aatgaacgcc cagatggtat attactgact ttcgggggtc agacagccct
     1621 gaactgcggt gtggagctga ccaaagctgg ggtactagct cggtatgggg tccgggtctt
     1681 gggtacacct gtggagacca ttgaactgac tgaggaccgg cgagcctttg ctgccagaat
     1741 ggctgagatt ggagagcacg ttgcccccag tgaagctgca aattctcttg aacaggctca
     1801 ggcagctgcc gagcggctag gctaccctgt gctggtgcga gcagcctttg ccctgggtgg
     1861 tcttggttct ggctttgctt ccaccaaaga ggaactctca gctcttgtgg ctccagcctt
     1921 tgcccatacc agccaggtgc tgatagacaa gtctctgaag ggctggaagg agattgaata
     1981 tgaggtggtg agagatgcct atggcaactg cgtaacggta tgtaacatgg agaacttaga
     2041 cccactgggc atccatacgg gggagtccat agtggtggct ccaagccaga cactgaatga
     2101 cagagagtac cagcttctgc ggcggacagc tatcaaggtc acccagcacc tggggattgt
     2161 tggggagtgc aatgtgcagt atgccttgaa ccccgagtct gagcagtatt acatcattga
     2221 agtaaatgcc aggctctccc gaagctctgc cctggccagt aaggccacag gctatccact
     2281 agcctatgtg gcagccaagc tagcattggg cattcccctg ccagagctca gaaactctgt
     2341 tacgggggga acagcagcct ttgagcccag cctggactac tgcgtggtaa agattcctcg
     2401 ctgggacctc agcaagttcc tgcgtgtcag taccaagatt gggagctgca tgaagagtgt
     2461 tggtgaagtc atgggcatcg ggcgttcctt tgaggaggcc ttccaaaagg ccctgcgcat
     2521 ggtagacgag aactgtgtag gcttcgacca tacagtgaag ccagtcagcg acgtggagct
     2581 ggagacgccg acggataagc ggatctttgt ggtggctgct gctctgtggg ctggctactc
     2641 tgtggagcgc ctctacgagc tcacccgcat cgactgctgg ttcctgcacc ggatgaagcg
     2701 cattgtgacc cacgccaagt tgctggaaca acaccgtgga cggcccttac cccaagacct
     2761 gctgcaccag gccaagtgcc tcggcttctc agacaagcaa attgctcttg cagtcctgag
     2821 cacagagctg gttgttcgga agctgcgtca ggaactgggg atctgcccag cagtgaagca
     2881 gatcgacaca gttgcagctg agtggccagc ccagacaaat tacctgtacc tgacatactg
     2941 gggcaacacc catgacctcg actttcggac acctcacgtc ctggtccttg gctctggcgt
     3001 ctaccggatc ggctccagcg ttgagtttga ttggtgtgct gtgggctgca tccagcagct
     3061 ccggaagatg ggttataaga ccatcatggt gaactacaac ccagagacag tcagcaccga
     3121 ctatgatatg tgtgaccgac tctactttga tgagatctct tttgaggtgg tgatggacat
     3181 ctatgagtta gaaaaccccg aaggtgtgat tctgtccatg ggcgggcagc tgcccaacaa
     3241 catggctatg gctttgcatc ggcagcagtg ccgagtgctg ggcacctccc ccgaagccat
     3301 cgactcagcc gagaaccggt tcaagttctc ccggctccta gataccattg gtatcagcca
     3361 gcctcagtgg cgagagctca gtgacctcga gtccgctcgc cagttctgcc agaccgttgg
     3421 gtacccctgc gtagtgcgtc cctcctatgt gctgagtggt gctgctatga acgtggccta
     3481 cactgatggg gacctggagc gcttcctgag cagtgcagct gctgtctcta aggagcaccc
     3541 tgtggtcatc tccaaattca ttcaggaggc aaaggagatt gatgtagatg ctgtggcctg
     3601 tgacggcatc gtgtcggcta ttgccatctc tgagcacgtg gagaatgcag gtgtgcattc
     3661 aggggatgcc acgctggtga cccccccaca agacatcacc cccaaaactc tggagcggat
     3721 caaagccatt gtgcatgctg tgggccagga gctacaggtc acggggccct tcaatctgca
     3781 gctcattgcc aaggacgacc agctgaaggt cattgaatgt aacgtgcggg tgtcgcgctc
     3841 cttcccgttc gtgtccaaga cacttggtgt cgacctcgta gccttggcca caaggatcat
     3901 catgggggag aaagtagagt ccgtggggct catgactggc tctggagtcg tgggagtaaa
     3961 ggtacctcag ttctccttct cacgcttggc cggtgctgac gtggtcctgg gtgtggagat
     4021 gaccagtact ggagaggtgg ctggcttcgg agagagccgt tgtgaagcct acctcaaagc
     4081 catgctcagc actggcttta agatcccaaa gaagaacatc ctgctgacca ttggcagcta
     4141 caagaataaa agtgagctgc tcccaactgt gcggttgctg gagagcctgg gctacagtct
     4201 gtatgccagc ttgggaactg ccgacttcta caccgagcac ggcgtcaagg taacagctgt
     4261 ggactggcac tttgaagagg ctgtggatgg tgagtgccca ccacaacgga gcatcttgga
     4321 tcagctggcc gagaatcact ttgagctggt gattaacctg tcgatgcgcg gggctggggg
     4381 tcggcgtctt tcctccttcg ttaccaaggg ctaccgcacc cggcgtctgg ccgcggattt
     4441 ctccgtgcct ctcatcattg atatcaagtg caccaaactc ttcgtggagg ccctaggcca
     4501 gatcgggcca gcccctcctt tgaaagtcca cgttgactgc atgacctccc agaagctagt
     4561 gcgcctgcct ggattgattg atgtccacgt gcaccttcgg gaaccaggtg ggactcacaa
     4621 agaggacttt gcctcaggca cagctgccgc cttggctggg ggcgtcacca tggtttgtgc
     4681 tatgcctaat acccggcccc ccatcattga tgccccagct ctggcgcttg cccagaagct
     4741 ggcagaggct ggcgcccgct gtgactttac cctcttcctc ggagcctcat ctgaaaatgc
     4801 agggactctg ggtgctgtgg ctgggtctgc agcaggcctg aagctctacc tcaatgagac
     4861 cttctctgag ctacggctgg acagtgtggc ccagtggatg gagcattttg aaacctggcc
     4921 ttcccacctc cccattgtgg cccacgcaga gcggcagagt gtcgctgcgg tcctcatggt
     4981 ggctcagctg acacggcgtt cagtgcacat atgtcatgtg gctcggaagg aagagatcct
     5041 gctgattaaa actgcaaagg cacaggggct gccagtgacg tgtgaggtcg cacctcacca
     5101 cctgttccta aaccgggaag acttggagcg cctgggacct gggaagggag aggtccgccc
     5161 tgagctgggt tcccgagagg atatggaagc cctgtgggag aatatggcgg tcatcgactg
     5221 ttttgcctca gaccacgctc cccatacctt ggaagagaag tgtgggccta agcctccacc
     5281 aggctttcca ggactagaga ccatgttgcc gctgctactg acagctgtga gtgaaggccg
     5341 cctcagtctg gatgacctgc tacagcgatt gcaccacaac cctcggcgga tcttccacct
     5401 gcctctccag gaggacacct atgtagaggt ggatctggag catgagtgga cggtccccag
     5461 ccacatgccc ttctctaaag cccactggac cccatttgaa ggtcagaagg tgaagggcac
     5521 cgtgcgccgt gtggtcttga gaggggaggt cgcctatatt gatggacagg tgctggtacc
     5581 cccgggctat ggacaagatg tacggaagtg gcctcagggg gctgttcctc agcctcctcc
     5641 tccaactcct actaccactg aaataaccac gacacctgag agaccacgcc gagtcatccc
     5701 aggccttcct gatggccgat tccacctgcc acctcgaatc caccgggcct ctgacccagg
     5761 gctgccagct gaggaaccca aagagaagcc acccaggaag gtagcagaat cagagctgat
     5821 aggaacccct gatggcccct gctaccctgt accaccagta cctagacagg catcaccaca
     5881 gaatctagga tcttctggcc tgctgcaccc ccagatgtca cctttactgc actccctagt
     5941 gggccaacac atcctgtctg tcaagcagtt cactaaggat cagatgtctc atctgttcaa
     6001 cgtggcgcac acactacgga tgatggtgca gaaagaacgg agcctcgaca tcctaaaggg
     6061 gaaggtcatg gcctctatgt tctacgaggt gagcacccgc accagtagct ccttcgcagc
     6121 agccatggcc cggctcgggg gtgccgttct cagcttctct gaagccacgt cctccgtcca
     6181 gaagggcgaa tccctcgccg actcggtgca gaccatgagt tgctatgctg atgttgttgt
     6241 actccgtcac cctcagcctg gagctgtgga gctggcggcc aagcactgtc gaagaccagt
     6301 gatcaatgct ggagatggag ttggggagca ccccactcag gccctgctgg acatcttcac
     6361 cattcgagaa gagcttggga ctgtcaatgg catgacgatc actatggtag gcgacctgaa
     6421 gcatggacgc acagtgcact ccctggcctg cctgctcacc cagtaccgtg tgagcctacg
     6481 ctacgtggca cctcccagcc tgcgcatgcc atccagcgtg tgggactttg tggcctcccg
     6541 aggcaccaag caggaggagt tcgagagcat cgaggaggcg ctgccagaca ctgacgtgct
     6601 ctacatgact cggatccaga aagaacgatt tggctcttcc caggaatatg aagcttgctt
     6661 tggtcagttc atcctcactc ctcacatcat gacccgggcc aagaaaaaga tggtggtgat
     6721 gcacccaatg cctcgtgtca atgagataag cgtggaggtg gactcggacc ccagagcagc
     6781 ctatttccgc caagctgaga acggcatgta catccgcatg gctctgcttg ccaccgtgct
     6841 aggccgtttt taggacccag ccttctctct cgtctcttca ggcccaggca ggcaaccccg
     6901 atgcccccca cgggggcagc acgcttagca gacatcctgg agcatacagg cagcccaagc
     6961 acatatgtac aaactgggac cttgctctag gctccagact agggaacttt ctgactttgg
     7021 ggtacagtct cagatcctgg gagcccctct gcctcatctc cgttcttaca cctcagatct
     7081 gtacagttac ttttgtactg actgtaataa aacagccaag cagttc
//
