LOCUS       NM_001081447            2595 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus cactin, spliceosome C complex subunit (Cactin),
            mRNA.
ACCESSION   NM_001081447 XR_009036
VERSION     NM_001081447.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2595)
  AUTHORS   Suzuki,M., Watanabe,M., Nakamaru,Y., Takagi,D., Takahashi,H.,
            Fukuda,S. and Hatakeyama,S.
  TITLE     TRIM39 negatively regulates the NFkappaB-mediated signaling pathway
            through stabilization of Cactin
  JOURNAL   Cell Mol Life Sci 73 (5), 1085-1101 (2016)
   PUBMED   26363554
REFERENCE   2  (bases 1 to 2595)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 2595)
  AUTHORS   Atzei,P., Gargan,S., Curran,N. and Moynagh,P.N.
  TITLE     Cactin targets the MHC class III protein IkappaB-like (IkappaBL)
            and inhibits NF-kappaB and interferon-regulatory factor signaling
            pathways
  JOURNAL   J Biol Chem 285 (47), 36804-36817 (2010)
   PUBMED   20829348
REFERENCE   4  (bases 1 to 2595)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   5  (bases 1 to 2595)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY934505.1.
            
            On Feb 8, 2007 this sequence version replaced XR_009036.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY934505.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2595
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..2595
                     /gene="Cactin"
                     /gene_synonym="RGD1563634"
                     /note="cactin, spliceosome C complex subunit"
                     /db_xref="GeneID:500790"
                     /db_xref="RGD:1563634"
     exon            1..223
                     /gene="Cactin"
                     /gene_synonym="RGD1563634"
                     /inference="alignment:Splign:2.1.0"
     CDS             6..2297
                     /gene="Cactin"
                     /gene_synonym="RGD1563634"
                     /codon_start=1
                     /product="splicing factor Cactin"
                     /protein_id="NP_001074916.1"
                     /db_xref="GeneID:500790"
                     /db_xref="RGD:1563634"
                     /translation="MRGAGRQMGSHSRSRSRSAGRRSRKQRSRSRSCSRSRSRSRSRS
                     RSRSHGGSGRRRREHERRRERKRRSRGRRSDSEGNRVQKSRRRSRSLRPPRWHSQDRS
                     SHSDSGEEQAQGSRARKGHRHSWSPGSSASSSDSPRRSRSPGVAALAASQQQSLQERL
                     RLREERKQQEELLKAFETPEEKRARRLAKKEAKERKKREKMGWGEEYMGYTNTDNPFG
                     DNNLLGTFIWNKALEKKGIGHLEEKELKERNKRIQEENRLELQKVKQLRLEREREKAM
                     REQELELLQREKEAEHFKTWEEQEDSFHLRQAKLRSKIRIRDGRAKPIDLLAKYISAE
                     DDDLAVEMHEPYTFLNGLTVADMEDLLEDIQVYMELEQGKNVDFWRDMTTITEDEIAK
                     LRKLEASGKGPGERREGVNASVSSDVQSVFKGKTYNQLQVIFQGIEGKIRAGGPNLDM
                     GYWESLLQQLRAHMARARLRERHQDVLRQKLFKLKQEQGVESEPLFPILKSEPTATHS
                     PEPEERPPSPGTSVDPVEPEETTAAGEAEGEADGEAVLMEEDLIQQSLADYDAGRYSP
                     RLLTAHELPLDAHVLEPHEDLQRLQLSRQQLQATGDASESAEDIFFRRAREGMGQDEA
                     QFSVEMPLGGRAYLWADKYRPRKPRFFNRVHTGFEWNKYNQTHYDFDNPPPKIVQGYK
                     FNIFYPDLIRKRATPEYFLEACADNRDFAILRFHAGPPYEDIAFKIVSREWEYSHRHG
                     FRCQFANGIFQLWFHFKRYRYRR"
     exon            224..791
                     /gene="Cactin"
                     /gene_synonym="RGD1563634"
                     /inference="alignment:Splign:2.1.0"
     exon            792..937
                     /gene="Cactin"
                     /gene_synonym="RGD1563634"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1100
                     /gene="Cactin"
                     /gene_synonym="RGD1563634"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1215
                     /gene="Cactin"
                     /gene_synonym="RGD1563634"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1408
                     /gene="Cactin"
                     /gene_synonym="RGD1563634"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1528
                     /gene="Cactin"
                     /gene_synonym="RGD1563634"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1806
                     /gene="Cactin"
                     /gene_synonym="RGD1563634"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..2595
                     /gene="Cactin"
                     /gene_synonym="RGD1563634"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgcatgcg cggcgcgggc cgccaaatgg gttcgcactc tcgctcgcgc tcacgatctg
       61 cgggtcgtag gagtcggaag cagcggagta ggagtagaag ctgcagcagg agccggagcc
      121 gaagccggag ccggagccgg agccggagcc atggggggag cggccgaagg cgacgggaac
      181 atgagcggcg gcgcgaacgc aaacggcgca gtcgagggcg caggtcagat tcggaaggaa
      241 accgtgtgca gaagtctagg aggcgaagcc ggagccttcg gccaccccga tggcactcac
      301 aggaccggtc ctcacactct gactcgggtg aggagcaagc acagggctcc cgagcccgga
      361 agggtcacag gcattcgtgg tccccagggt catcagcatc tagctctgac tccccaagac
      421 gctcccggag tcctggagta gctgccctgg ccgcgagtca gcagcagagc cttcaggaac
      481 ggctgcggct tcgtgaggag cgaaagcagc aagaagagct gctcaaggcc ttcgagacac
      541 ccgaggagaa gcgtgcccgg cgactggcca agaaagaagc taaggagcgc aagaagcgtg
      601 agaagatggg ctggggtgag gagtacatgg gctacaccaa caccgacaac ccctttggag
      661 acaacaacct gctgggcact tttatctgga acaaagcctt ggagaaaaaa ggcatcggtc
      721 acctggagga aaaggagctg aaggaacgta acaagaggat ccaggaggag aaccggctag
      781 agctgcaaaa ggtaaaacag ctgcggctgg agcgggaacg ggagaaggcc atgcgggagc
      841 aggaactgga actgttgcaa cgggagaagg aggcagagca ctttaagacc tgggaggagc
      901 aggaggacag cttccacttg cggcaggcca agcttcgttc caagatccga atccgagacg
      961 ggcgggccaa gcccattgac ttgctggcca agtacatcag tgcagaggac gatgacctgg
     1021 cagtggagat gcatgaacct tacaccttcc tcaacggcct cacggtggca gacatggagg
     1081 acctgctaga ggacatccag gtgtacatgg agctggagca gggcaagaac gtggacttct
     1141 ggcgagacat gacaaccatc acagaggatg agattgccaa gctccgcaag ctggaggcct
     1201 cgggcaaggg cccaggtgag cgccgtgagg gggtcaacgc ctcggtcagc tctgacgtgc
     1261 agtccgtctt caagggaaag acgtacaacc agctgcaggt catcttccag ggcatcgaag
     1321 gcaagatccg tgccggcggc cccaacctcg acatgggcta ctgggagagc ctgctgcagc
     1381 agttgcgcgc gcacatggcc agggccaggc tccgtgagcg ccaccaagat gtccttagac
     1441 agaagctgtt caaactgaag caggagcagg gtgtggagag tgagccgctg tttcccatcc
     1501 tcaagtcaga gcccacagcc actcacagcc ctgaacctga ggaacggcct cccagccctg
     1561 ggacttcagt ggaccccgtg gaacccgagg agaccacagc agcaggcgag gcagagggag
     1621 aggcagatgg cgaggcagtg ctgatggagg aggacctgat ccagcagagc ctggcagact
     1681 atgacgctgg ccgctacagc ccacgactgc tcaccgcgca cgagttgcct ttggacgcgc
     1741 atgtgctgga gccgcatgag gacctgcagc gcctgcagct gtctcgccag cagcttcagg
     1801 ctacaggtga cgcgagcgag agtgctgagg acatcttctt ccggcgtgcg agggagggca
     1861 tggggcagga tgaggcacag ttcagcgtgg agatgccact gggtggccgc gcctacctgt
     1921 gggccgacaa gtatcggccg cggaagccgc gattctttaa ccgtgtgcac acaggctttg
     1981 aatggaacaa atataaccag acacattatg actttgacaa ccctccaccc aagatcgtgc
     2041 agggctacaa atttaacatc ttctacccgg acctcatccg caaacgtgcc acaccagagt
     2101 acttcctgga ggcctgcgct gacaaccggg actttgccat cctgcgtttc cacgcaggcc
     2161 cgccctacga ggacatcgcc ttcaagatcg tcagtcgaga atgggagtac tcgcaccgcc
     2221 atggcttccg ctgccagttt gccaatggaa tcttccagct ctggttccac ttcaagcgct
     2281 accgctaccg ccggtgacgc ctgtgggcag gctgcccgcc cctgccatgc tggcccctgg
     2341 acagctcctg gatgggaagg ttgagaggac caggaggtct tcttcagaag ccttggggat
     2401 ccgtggacca cctctgggct tcagtcacca gcactgtgct ggccgcagcc cctctggcag
     2461 gtcccttcct gtcttgaaag gattttagaa agactgcttg aggtggcaga aaccctttgt
     2521 tcctgttccc gtggacttat tcaaccgcgg agccctacat ggttttgata cgtttaatag
     2581 aaagcttatt ctaaa
//
