LOCUS       NM_080693               3547 bp    mRNA    linear   ROD 18-FEB-2024
DEFINITION  Rattus norvegicus calcium voltage-gated channel auxiliary subunit
            gamma 5 (Cacng5), mRNA.
ACCESSION   NM_080693 XM_346411
VERSION     NM_080693.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3547)
  AUTHORS   Schwenk,J., Harmel,N., Zolles,G., Bildl,W., Kulik,A., Heimrich,B.,
            Chisaka,O., Jonas,P., Schulte,U., Fakler,B. and Klocker,N.
  TITLE     Functional proteomics identify cornichon proteins as auxiliary
            subunits of AMPA receptors
  JOURNAL   Science 323 (5919), 1313-1319 (2009)
   PUBMED   19265014
REFERENCE   2  (bases 1 to 3547)
  AUTHORS   Soto,D., Coombs,I.D., Renzi,M., Zonouzi,M., Farrant,M. and
            Cull-Candy,S.G.
  TITLE     Selective regulation of long-form calcium-permeable AMPA receptors
            by an atypical TARP, gamma-5
  JOURNAL   Nat Neurosci 12 (3), 277-285 (2009)
   PUBMED   19234459
  REMARK    GeneRIF: Whereas gamma-5 interacts with all AMPA-type glutamate
            receptor subunits, it predominantly regulates the functions of
            calcium-permeable AMPA receptor subunit combinations lacking
            short-form subunits in Bergmann glia.
            Erratum:[Nat Neurosci. 2009 Jun;12(6):808]
REFERENCE   3  (bases 1 to 3547)
  AUTHORS   Kato,A.S., Siuda,E.R., Nisenbaum,E.S. and Bredt,D.S.
  TITLE     AMPA receptor subunit-specific regulation by a distinct family of
            type II TARPs
  JOURNAL   Neuron 59 (6), 986-996 (2008)
   PUBMED   18817736
REFERENCE   4  (bases 1 to 3547)
  AUTHORS   Chu,P.J., Robertson,H.M. and Best,P.M.
  TITLE     Calcium channel gamma subunits provide insights into the evolution
            of this gene family
  JOURNAL   Gene 280 (1-2), 37-48 (2001)
   PUBMED   11738816
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000220.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_080693.3.
            
            On Oct 27, 2022 this sequence version replaced NM_080693.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF361342.1, FQ075985.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN14984033 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-252               JACYVU010000220.1  49661664-49661915   c
            253-339             JACYVU010000220.1  49660235-49660321   c
            340-480             JACYVU010000220.1  49659232-49659372   c
            481-626             JACYVU010000220.1  49655620-49655765   c
            627-3547            JACYVU010000220.1  49652391-49655311   c
FEATURES             Location/Qualifiers
     source          1..3547
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..3547
                     /gene="Cacng5"
                     /note="calcium voltage-gated channel auxiliary subunit
                     gamma 5"
                     /db_xref="GeneID:140726"
                     /db_xref="RGD:628805"
     exon            1..252
                     /gene="Cacng5"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..884
                     /gene="Cacng5"
                     /note="neuronal voltage-gated calcium channel gamma-5
                     subunit; TARP gamma-5; transmembrane AMPAR regulatory
                     protein gamma-5; calcium channel, voltage-dependent, gamma
                     subunit 5"
                     /codon_start=1
                     /product="voltage-dependent calcium channel gamma-5
                     subunit"
                     /protein_id="NP_542424.1"
                     /db_xref="GeneID:140726"
                     /db_xref="RGD:628805"
                     /translation="MSTCGRKALTLLSSVFAVCGLGLLGIAVSTDYWLYLEEGIILPQ
                     NQSTEVKMSLHSGLWRVCFLAGEERGRCFTIEYVMPMNSQMTSESTVNVLKMIRSATP
                     FPLVSLFFMFIGFILSNIGHIRPHRTILAFVSGIFFILSGLSLVVGLVLYISSINDEM
                     LNRTKDAETYFNYKYGWSFAFAAISFLLTESAGVMSVYLFMKRYTAEDMYRPHPGFYR
                     PRLSNCSDYSGQFLHPDAWIRGRSPSDISSDASLQMNSNYPALLKCPDYDQMSSSPC"
     exon            253..339
                     /gene="Cacng5"
                     /inference="alignment:Splign:2.1.0"
     exon            340..480
                     /gene="Cacng5"
                     /inference="alignment:Splign:2.1.0"
     exon            481..626
                     /gene="Cacng5"
                     /inference="alignment:Splign:2.1.0"
     exon            627..3547
                     /gene="Cacng5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccattctgc cctctgtgag gcagcactcc ttgctgccca gtcaccatcc aggaagatga
       61 gcacctgtgg gaggaaggcc ctgaccctgc tgagcagtgt ctttgctgtc tgtggcctgg
      121 gcctgctggg catcgcggtc agcacggact actggctgta cttggaagaa ggcataatcc
      181 ttccccagaa ccagagcacg gaggtcaaga tgtccctgca ctcgggcctc tggcgggtct
      241 gcttcctcgc aggtgaggag cgaggacgct gtttcaccat agagtatgtg atgcccatga
      301 actcccagat gacgtcagaa tccacagtca atgttctaaa aatgattcgc tcggccaccc
      361 cgttcccact ggtcagccta ttcttcatgt tcatcgggtt catcctgagc aacatcggac
      421 acatccgtcc gcaccggacc atactggctt ttgtctctgg catcttcttt atcctatccg
      481 gcctctctct tgtggtgggc ctggtgctgt acatctccag catcaatgac gagatgctca
      541 acagaaccaa ggatgcagag acctatttca actacaaata tggatggtcg tttgcctttg
      601 ctgccatctc cttcctctta acagagagtg ctggggtgat gtctgtgtat ctgtttatga
      661 agaggtatac tgctgaggac atgtacaggc cccacccagg cttctaccgg ccacggctga
      721 gcaactgttc tgattactct ggccagtttc tacatccaga tgcctggatc cggggccgca
      781 gcccctcgga catctccagt gatgcctccc tacagatgaa cagtaactac ccagctttgc
      841 tcaagtgccc agactatgac cagatgtcat catctccctg ctgagccagc cctagcgtcc
      901 tccccacctg aacttttgga tggctcaaca gcatttccct ctccccctga gccgaggccc
      961 aagctgttcc ctgcttagcc attgttactt gaccacatcc tctccctaca cccagaatag
     1021 ctagctcttc cttcggtggg catcagagac tggagtcaga ggcatgctga ttggctgaga
     1081 gcatggctga agccctgcct ctagagtgcc aatcatagcc acgggctcct gggaagccac
     1141 agcagcccaa gcagtgctgt gccggaagat gcctatgttc tagttgagtt ttgttcctgc
     1201 acttccgggt tagccaaggt cagtctggag ttgccaagtt tctgatacag acaaagccag
     1261 acttggaggc ttgcctccaa gcctggctct ccatccatga gctggactgt gagaccaaaa
     1321 ggtgactctg ctccagtgat ctaactggct cagaaacctc aagccgactg ttccttttat
     1381 gtcatccaca aaacacatct ctctgtgtag cactgcccca ccccacccct cccccaggct
     1441 ctggaccatt cccgattttc atccttccag aacacagctg ccctggtcag ggactaagat
     1501 aagtattcag cagtgccaat gatgtcacaa aggtgttaat ggcggaagat gtcttaatac
     1561 acatgatccc tcgacaagct atttcatggg gtcttttgat gccttaaccc aaagaagtga
     1621 ctgataatga gaactcaaga atttgacggt tttgtgttca gagcgccaag cactgtgtcc
     1681 aaccctgggg gcattgtccc tggctttcag ggaccatatt tctatccaat tctctaagat
     1741 cgaatcgtgt agacaggttt ctgtaccacc atagctgtga gctgcatttg atgacgcgat
     1801 ttgatgacgc agtgcgtttt gagcccaaac aagccagact ccagatgacc cagctgcttt
     1861 gccgaggatg cctgtgaaca tttgggggtt gccaacttaa tccgaatatg gggaagcatc
     1921 tgcttcccag tttcatggca tatgtgggca aatcacatgc ctccacgatg ccagacaatg
     1981 tgacaactgc tttcctgacg gaatcgctga gctgggaaat tgcaagcgct actgagaaga
     2041 ccatgaaacc cccatagttc tccgggtgtc agctcagctg gaccatcctg agagttctga
     2101 gaggcaagtc aaggtagcat tctctatgcg gtgtgttttt gctggacttc ctctcgcctc
     2161 gttcccttta agatgccaaa tgtacccgaa tatacaaagc cacagcgggc gacttgcaag
     2221 ctctggcaaa tggcaccgga aaccacacag ctggtgccta caggaggaca tggactcaat
     2281 cagcatggag gaggccagca gttcaagatc aagttgtcag aggactgatc tctgaggcat
     2341 ctgctcctgg cttacagatg gcagtcttct tgttgtatgc tcatggggta cacctgaggc
     2401 tttttttttt tttgcatatc caaattacct cttaaaagga cacaccaggg gctggggaga
     2461 taactcagca gaattctggt ctagcatgca tgaaactctg gatttgaccc ccaacaccgt
     2521 agagtccagg ggtggcggta cacatctgta atcctaacac ttggaatgca gaggcaggcg
     2581 gagcttcaag gttactctca actacatagc tagtttgagg ctaacctggg ctacacgaga
     2641 ctctgtctca agaaatttaa aatcaggtat gggttagagt tcattccaat aaattcaatg
     2701 atcacgatta ataactatga atataattta agtgctcatg tacaaatata ttcacattct
     2761 gaggtactga agatggcggt ctcggagtac aaaactggga gagggcataa ctccgcccct
     2821 aacgtgcaga ttgctttgta gattgatcca tcagtttcac agacagtgga aggaacattt
     2881 ttgcctctcg gttcagtccc tgactcaatg cttgggcaac cccttcagtt ctgagaagct
     2941 cagctaagat ggcttccatg catcctcccc gcacccacac ccacacctcc agcgatccag
     3001 tccacattgt tattgtgtgc cgatttctgt atcggcctgt gagccgaggg cgactggcag
     3061 gccctggccc tggcttccgg ctccatcctc acctcacaat ggccgtcgtt cgcttttgcc
     3121 gctgtttgct ggagtctgct tgccggagtc tgtttggaga cggctgagag gcattttcaa
     3181 gctggacagg cgtttggatg tgcttggcta caacttttgt caatgttatt aacacctgcg
     3241 atgtactttt ctctctctaa agcacatctc tatcactgtg ccaggtttgc ctgtgtacac
     3301 gtggggaaga atctattccc cccttactgt aagctgactg cagagtgtgg tattgttaga
     3361 gcgtgctatt cccagtttga ggctgagctg tcaagtccaa gggtgttccc accctggaat
     3421 gggtcctgta cacttaccat agtaatggct ctgggtccct ttcttcccca tgaggggatt
     3481 ggagaatgta tcaacacata tgaccatcgt catttctttt ccatctataa actggtttca
     3541 aaaacta
//
