LOCUS       NM_080692               3547 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus calcium voltage-gated channel auxiliary subunit
            gamma 4 (Cacng4), mRNA.
ACCESSION   NM_080692
VERSION     NM_080692.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3547)
  AUTHORS   Cao,Y., Li,R., Li,Y., Zhang,T., Wu,N., Zhang,J. and Guo,Z.
  TITLE     Identification of Transcription Factor-Gene Regulatory Network in
            Acute Myocardial Infarction
  JOURNAL   Heart Lung Circ 26 (4), 343-353 (2017)
   PUBMED   27746059
REFERENCE   2  (bases 1 to 3547)
  AUTHORS   Ferdous,Z., Qureshi,M.A., Jayaprakash,P., Parekh,K., John,A.,
            Oz,M., Raza,H., Dobrzynski,H., Adrian,T.E. and Howarth,F.C.
  TITLE     Different Profile of mRNA Expression in Sinoatrial Node from
            Streptozotocin-Induced Diabetic Rat
  JOURNAL   PLoS One 11 (4), e0153934 (2016)
   PUBMED   27096430
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3547)
  AUTHORS   Larsson,M., Agalave,N., Watanabe,M. and Svensson,C.I.
  TITLE     Distribution of transmembrane AMPA receptor regulatory protein
            (TARP) isoforms in the rat spinal cord
  JOURNAL   Neuroscience 248, 180-193 (2013)
   PUBMED   23751177
REFERENCE   4  (bases 1 to 3547)
  AUTHORS   Schwenk,J., Harmel,N., Brechet,A., Zolles,G., Berkefeld,H.,
            Muller,C.S., Bildl,W., Baehrens,D., Huber,B., Kulik,A., Klocker,N.,
            Schulte,U. and Fakler,B.
  TITLE     High-resolution proteomics unravel architecture and molecular
            diversity of native AMPA receptor complexes
  JOURNAL   Neuron 74 (4), 621-633 (2012)
   PUBMED   22632720
REFERENCE   5  (bases 1 to 3547)
  AUTHORS   Ferrario,C.R., Loweth,J.A., Milovanovic,M., Ford,K.A.,
            Galinanes,G.L., Heng,L.J., Tseng,K.Y. and Wolf,M.E.
  TITLE     Alterations in AMPA receptor subunits and TARPs in the rat nucleus
            accumbens related to the formation of Ca(2)-permeable AMPA
            receptors during the incubation of cocaine craving
  JOURNAL   Neuropharmacology 61 (7), 1141-1151 (2011)
   PUBMED   21276808
REFERENCE   6  (bases 1 to 3547)
  AUTHORS   Cho,C.H., St-Gelais,F., Zhang,W., Tomita,S. and Howe,J.R.
  TITLE     Two families of TARP isoforms that have distinct effects on the
            kinetic properties of AMPA receptors and synaptic currents
  JOURNAL   Neuron 55 (6), 890-904 (2007)
   PUBMED   17880893
REFERENCE   7  (bases 1 to 3547)
  AUTHORS   Korber,C., Werner,M., Kott,S., Ma,Z.L. and Hollmann,M.
  TITLE     The transmembrane AMPA receptor regulatory protein gamma 4 is a
            more effective modulator of AMPA receptor function than stargazin
            (gamma 2)
  JOURNAL   J Neurosci 27 (31), 8442-8447 (2007)
   PUBMED   17670991
  REMARK    GeneRIF: Cacng4 (gamma-4) modulates the desensitization properties
            of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)
            receptors significantly more strongly than can Cacng2 (gamma-2).
REFERENCE   8  (bases 1 to 3547)
  AUTHORS   Letts,V.A., Mahaffey,C.L., Beyer,B. and Frankel,W.N.
  TITLE     A targeted mutation in Cacng4 exacerbates spike-wave seizures in
            stargazer (Cacng2) mice
  JOURNAL   Proc Natl Acad Sci U S A 102 (6), 2123-2128 (2005)
   PUBMED   15677329
REFERENCE   9  (bases 1 to 3547)
  AUTHORS   Tomita,S., Chen,L., Kawasaki,Y., Petralia,R.S., Wenthold,R.J.,
            Nicoll,R.A. and Bredt,D.S.
  TITLE     Functional studies and distribution define a family of
            transmembrane AMPA receptor regulatory proteins
  JOURNAL   J Cell Biol 161 (4), 805-816 (2003)
   PUBMED   12771129
REFERENCE   10 (bases 1 to 3547)
  AUTHORS   Chu,P.J., Robertson,H.M. and Best,P.M.
  TITLE     Calcium channel gamma subunits provide insights into the evolution
            of this gene family
  JOURNAL   Gene 280 (1-2), 37-48 (2001)
   PUBMED   11738816
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Oct 27, 2022 this sequence version replaced NM_080692.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.19636.1,
                                           SRR26360176.1428103.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840111, SAMN12840130
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-461               JAXUCZ010000010.1  93245010-93245470   c
            462-545             JAXUCZ010000010.1  93192892-93192975   c
            546-686             JAXUCZ010000010.1  93187568-93187708   c
            687-3547            JAXUCZ010000010.1  93183410-93186270   c
FEATURES             Location/Qualifiers
     source          1..3547
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..3547
                     /gene="Cacng4"
                     /note="calcium voltage-gated channel auxiliary subunit
                     gamma 4"
                     /db_xref="GeneID:140725"
                     /db_xref="RGD:628804"
     exon            1..461
                     /gene="Cacng4"
                     /inference="alignment:Splign:2.1.0"
     CDS             242..1225
                     /gene="Cacng4"
                     /note="neuronal voltage-gated calcium channel gamma-4
                     subunit; TARP gamma-4; transmembrane AMPAR regulatory
                     protein gamma-4; calcium channel, voltage-dependent, gamma
                     subunit 4"
                     /codon_start=1
                     /product="voltage-dependent calcium channel gamma-4
                     subunit"
                     /protein_id="NP_542423.1"
                     /db_xref="GeneID:140725"
                     /db_xref="RGD:628804"
                     /translation="MVRCDRGLQMLLTTAGAFAAFSLMAIAIGTDYWLYSSAHICNGT
                     NLTMDDGPPPRRARGDLTHSGLWRVCCIEGIYKGHCFRINHFPEDNDYDHDSSEYLLR
                     IVRASSVFPILSTILLLLGGLCIGAGRIYSRKNNIVLSAGILFVAAGLSNIIGIIVYI
                     SSNTGDPSDKRDEDKKNHYNYGWSFYFGALSFIVAETVGVLAVNIYIEKNKELRFKTK
                     REFLKASSSSPYSRMPSYRYRRRRSRSSSRSTEASPSRDASPVGLKITGAIPMGELSM
                     YTLSREPLKVTTAASYSPDQDAGFLQMHDFFQQDLKEGFHVSMLNRRTTPV"
     exon            462..545
                     /gene="Cacng4"
                     /inference="alignment:Splign:2.1.0"
     exon            546..686
                     /gene="Cacng4"
                     /inference="alignment:Splign:2.1.0"
     exon            687..3547
                     /gene="Cacng4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agccgcccgg cggcccgcgt agcccgcgca gccctcactc gccgccgcgc ctcggagttt
       61 gagccccgcg caacccgagc gcaggcacgc ccggggcgcg gggtcggagc gcgcagcgcg
      121 gcgccgcccc ccggccctcg gccccccagc ccctggagcc cccggagccg cgcgccgagg
      181 gaggagggcg ggcgggcgcg gcgggccggg ccggcgggcg gcggactatg aggcgcccac
      241 catggtgcga tgcgaccgcg ggctgcagat gctgctgacc acggctggag ccttcgccgc
      301 cttctcgctc atggccatcg ccatcggcac tgactactgg ctgtactcca gcgcgcacat
      361 ctgcaacggc accaacctga ccatggacga cgggcccccg ccccgccgcg cccgcggcga
      421 cctcacccat tcgggactgt ggcgggtgtg ttgcatcgaa ggcatctaca aggggcactg
      481 cttccggatc aaccacttcc cagaggacaa cgattatgac cacgacagct ccgagtacct
      541 cctccgcatt gtgcgagcct ccagtgtctt ccccatcctc agcaccattc tgctcctgct
      601 tggagggctc tgcatcggcg ctgggaggat ctacagccgc aagaacaaca ttgtcctcag
      661 tgcaggaatc ctctttgtgg ctgcaggcct cagtaatatc atcggcatca tcgtctacat
      721 ttccagcaac acgggcgacc ccagtgacaa gcgtgacgaa gacaagaaga accattacaa
      781 ctacggctgg tctttttact ttggagccct gtcgtttatt gtggcggaga ccgtgggcgt
      841 tctggctgta aacatttaca ttgagaaaaa caaagagttg aggtttaaga ccaagcggga
      901 gttcctcaag gcctcttcct cctctcctta ctccaggatg ccgagttaca ggtaccggcg
      961 acggcgctcc aggtccagtt cgaggtccac tgaggcctca ccctctagag atgcctctcc
     1021 tgtgggcctg aagatcacgg gggccattcc catgggtgag ctgtccatgt acacgctgtc
     1081 cagagaaccc ctcaaggtga ccacagctgc cagctacagt ccggatcagg atgctggctt
     1141 cctacagatg catgacttct tccaacagga cctaaaggag ggtttccacg tcagcatgct
     1201 gaaccggcgg acgactcccg tgtgacctac ccgcccctct ccgcacaggc ctctcccaag
     1261 gtggctgttt gtgaaacaca gaacagggtg acccttaaga ttatagacag tgaactggag
     1321 ctgagcgcag tcctccctgg cctccagaag atgccatggg cttgctcaga gtgaaggaag
     1381 ttaggagatt ggagtcaggg ataaggtaga aaccgaaggc ggactctctg ctgccctctg
     1441 tgatcttgga acttctcagg aggcctaaga atttcccaga agctgcatca gcctgcctct
     1501 tgggaaccag gaaaccagtc atgccagatg ccaaacgcat cccccttcac cgggcaccgg
     1561 gccacaggaa ggcttcttct agatactggg acctctggtt tcccatcgtc tgtttcctac
     1621 ccagaagttc ctgtgtcctg gagccccgga gtgagcctaa gctcattcca ttcccttctg
     1681 tgtctccctc agcctctccc tgtctggcac cctagcggat ctggtggttg taaatatcac
     1741 ccatcctgaa gagaaagctc tatggctaac tggtgcttcg gccttgagct gtcctgcggc
     1801 cggcttctct ccacctcagg agaccaggag tccagggcaa attcagaggc tctgctggct
     1861 tttcctacct gcttctggaa gtctctgctg agctcagaat atacaggaca tactgactca
     1921 tcttggtggt ctggaggatt tcgtggatct gagggaaggt ggatatgtgg ccttcggctc
     1981 tgtccctcca cactggcctg aggaaccatt ctgtcgcctg agcagcagag ggccctgctg
     2041 ggtcaggcca tgcccccacc tccaaactgg tgttctgaaa cagatgtgca agcttgagaa
     2101 aggggaacct gagagtgggc agagaccaaa aagaagaaag aaagagcatc catttccacg
     2161 aggttgggag tcacagcatc ccggagaaca tcagccgaag atcaagctgg actcacctct
     2221 ttatcctcag aaagatcaac aacatctccc ccgactcctg ccatgatcat ttattctgcc
     2281 cgctccagga ctcggtgaac atttgactca aggggcctcg ctgggctttc tagctttgcc
     2341 cgaatccaag gatcagttct gtgtcccaca gttcgtccaa ccaactcctc tcttcctctt
     2401 gaggcgaaca aaaatcaaaa ccacatgagc gtgttccgtt tagaaagaac tctccagaaa
     2461 gcgagactca ccctcttttc tataacacac gtgctttcta aggatcaacc gtttcttact
     2521 ttttgagact tcttaatcca attttgaaca gtcatctgtg acgcgccccc cgcccccatc
     2581 ccctgtaact gtctcactta gaaatgacaa gccaattctt acctcagtca cctgctcatg
     2641 gagcccaccc ccctaggcta actcggagtt cagatccagg tccagttgtc ctttcctgcc
     2701 cgccctttat tgcccaccac caccaccacc accaccacca gaagacaacc cgtatcatag
     2761 ccagttgcct atgagctggt gagctgagac gtgagcatgc caagactcct ttgtgcttgc
     2821 tcaaaaccat tccctcctgg ccaggttggc tcgtcagtat gtgtcaaagc atgtgcagca
     2881 gtgaggtgcc aatgtcaaga tgtgtgtggt ctgtccctgc tgcaggccct ctccctgcct
     2941 ccctccccac ccaccctccc ctgtcctcac caccattata acgtccaatg aggctgaagg
     3001 aagccccagc ccccagggag acccaggacc agtctgatgt ctcttctggc aatagagcag
     3061 cctgtggtaa acttccacac aagccaccac catcccaacc ctggtcccca aggtttccac
     3121 gattccacat tagaaagctg tgttccgatg actcctacct cttgtccggt tccaacaggc
     3181 ccattccaag aaagagttag gaagaaaaga gacagagggg tagaacacag ggagaaggcc
     3241 tcagctgtcc caaccctcac ggtctttctc ccactggctg ctggcgtcat tctggggacc
     3301 ctggtctcca gcttttccct tcctgtggga caaagggagt agagctggac cctactgctg
     3361 acaggctcag atctggttcc ctgtctgaag ggacactcgg tctgagacca ccttcctgcc
     3421 cttcctctgt cccaaccccc ccttccctgt gtgtttcacc agttaagccc cagtgaccct
     3481 gtacccatca gtggtttggg attattagtt ccgtcttttt tttaattaaa taaaaacgtt
     3541 tttaaaa
//
