LOCUS       NM_080691               2123 bp    mRNA    linear   ROD 18-FEB-2024
DEFINITION  Rattus norvegicus calcium voltage-gated channel auxiliary subunit
            gamma 3 (Cacng3), mRNA.
ACCESSION   NM_080691
VERSION     NM_080691.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2123)
  AUTHORS   Yamasaki,M., Fukaya,M., Yamazaki,M., Azechi,H., Natsume,R., Abe,M.,
            Sakimura,K. and Watanabe,M.
  TITLE     TARP gamma-2 and gamma-8 Differentially Control AMPAR Density
            Across Schaffer Collateral/Commissural Synapses in the Hippocampal
            CA1 Area
  JOURNAL   J Neurosci 36 (15), 4296-4312 (2016)
   PUBMED   27076426
REFERENCE   2  (bases 1 to 2123)
  AUTHORS   Schwenk,J., Harmel,N., Brechet,A., Zolles,G., Berkefeld,H.,
            Muller,C.S., Bildl,W., Baehrens,D., Huber,B., Kulik,A., Klocker,N.,
            Schulte,U. and Fakler,B.
  TITLE     High-resolution proteomics unravel architecture and molecular
            diversity of native AMPA receptor complexes
  JOURNAL   Neuron 74 (4), 621-633 (2012)
   PUBMED   22632720
REFERENCE   3  (bases 1 to 2123)
  AUTHORS   Spencer,K.L., Olson,L.M., Schnetz-Boutaud,N., Gallins,P., Wang,G.,
            Scott,W.K., Agarwal,A., Jakobsdottir,J., Conley,Y., Weeks,D.E.,
            Gorin,M.B., Pericak-Vance,M.A. and Haines,J.L.
  TITLE     Dissection of chromosome 16p12 linkage peak suggests a possible
            role for CACNG3 variants in age-related macular degeneration
            susceptibility
  JOURNAL   Invest Ophthalmol Vis Sci 52 (3), 1748-1754 (2011)
   PUBMED   21169531
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2123)
  AUTHORS   Schwenk,J., Harmel,N., Zolles,G., Bildl,W., Kulik,A., Heimrich,B.,
            Chisaka,O., Jonas,P., Schulte,U., Fakler,B. and Klocker,N.
  TITLE     Functional proteomics identify cornichon proteins as auxiliary
            subunits of AMPA receptors
  JOURNAL   Science 323 (5919), 1313-1319 (2009)
   PUBMED   19265014
REFERENCE   5  (bases 1 to 2123)
  AUTHORS   Soto,D., Coombs,I.D., Renzi,M., Zonouzi,M., Farrant,M. and
            Cull-Candy,S.G.
  TITLE     Selective regulation of long-form calcium-permeable AMPA receptors
            by an atypical TARP, gamma-5
  JOURNAL   Nat Neurosci 12 (3), 277-285 (2009)
   PUBMED   19234459
  REMARK    Erratum:[Nat Neurosci. 2009 Jun;12(6):808]
REFERENCE   6  (bases 1 to 2123)
  AUTHORS   Tomita,S., Fukata,M., Nicoll,R.A. and Bredt,D.S.
  TITLE     Dynamic interaction of stargazin-like TARPs with cycling AMPA
            receptors at synapses
  JOURNAL   Science 303 (5663), 1508-1511 (2004)
   PUBMED   15001777
REFERENCE   7  (bases 1 to 2123)
  AUTHORS   Tomita,S., Chen,L., Kawasaki,Y., Petralia,R.S., Wenthold,R.J.,
            Nicoll,R.A. and Bredt,D.S.
  TITLE     Functional studies and distribution define a family of
            transmembrane AMPA receptor regulatory proteins
  JOURNAL   J Cell Biol 161 (4), 805-816 (2003)
   PUBMED   12771129
REFERENCE   8  (bases 1 to 2123)
  AUTHORS   Robinson,R., Taske,N., Sander,T., Heils,A., Whitehouse,W.,
            Goutieres,F., Aicardi,J., Lehesjoki,A.E., Siren,A., Laue Friis,M.,
            Kjeldsen,M.J., Panayiotopoulos,C., Kennedy,C., Ferrie,C., Rees,M.
            and Gardiner,R.M.
  TITLE     Linkage analysis between childhood absence epilepsy and genes
            encoding GABAA and GABAB receptors, voltage-dependent calcium
            channels, and the ECA1 region on chromosome 8q
  JOURNAL   Epilepsy Res 48 (3), 169-179 (2002)
   PUBMED   11904235
REFERENCE   9  (bases 1 to 2123)
  AUTHORS   Chu,P.J., Robertson,H.M. and Best,P.M.
  TITLE     Calcium channel gamma subunits provide insights into the evolution
            of this gene family
  JOURNAL   Gene 280 (1-2), 37-48 (2001)
   PUBMED   11738816
REFERENCE   10 (bases 1 to 2123)
  AUTHORS   Burgess,D.L., Davis,C.F., Gefrides,L.A. and Noebels,J.L.
  TITLE     Identification of three novel Ca(2+) channel gamma subunit genes
            reveals molecular diversification by tandem and chromosome
            duplication
  JOURNAL   Genome Res 9 (12), 1204-1213 (1999)
   PUBMED   10613843
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000044.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_080691.3.
            
            On Oct 7, 2022 this sequence version replaced NM_080691.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF361340.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-840               JACYVU010000044.1  4130618-4131457
            841-924             JACYVU010000044.1  4212395-4212478
            925-1065            JACYVU010000044.1  4219241-4219381
            1066-2123           JACYVU010000044.1  4225219-4226276
FEATURES             Location/Qualifiers
     source          1..2123
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q36"
     gene            1..2123
                     /gene="Cacng3"
                     /note="calcium voltage-gated channel auxiliary subunit
                     gamma 3"
                     /db_xref="GeneID:140724"
                     /db_xref="RGD:628803"
     exon            1..840
                     /gene="Cacng3"
                     /inference="alignment:Splign:2.1.0"
     CDS             630..1577
                     /gene="Cacng3"
                     /note="neuronal voltage-gated calcium channel gamma-3
                     subunit; calcium channel, voltage-dependent, gamma subunit
                     3; TARP gamma-3; transmembrane AMPAR regulatory protein
                     gamma-3"
                     /codon_start=1
                     /product="voltage-dependent calcium channel gamma-3
                     subunit"
                     /protein_id="NP_542422.1"
                     /db_xref="GeneID:140724"
                     /db_xref="RGD:628803"
                     /translation="MRMCDRGIQMLITTVGAFAAFSLMTIAVGTDYWLYSRGVCRTKS
                     TSDNETSRKNEEVMTHSGLWRTCCLEGAFRGVCKKIDHFPEDADYEQDTAEYLLRAVR
                     ASSVFPILSVTLLFFGGLCVAASEFHRSRHSVILSAGIFFVSAGLSNIIGIIVYISAN
                     AGDPGQRDSKKSYSYGWSFYFGAFSFIIAEIVGVVAVHIYIEKHQQLRARSHSELLKK
                     STFARLPPYRYRFRRRSSSRSTEPRSRDLSPISKGFHTIPSTDISMFTLSRDPSKLTM
                     GTLLNSDRDHAFLQFHNSTPKEFKESLHNNPANRRTTPV"
     exon            841..924
                     /gene="Cacng3"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1065
                     /gene="Cacng3"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..2123
                     /gene="Cacng3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actcttctca gcgactcgcc tcctagcaga gctatttttt gccatccgcc ctcaccccca
       61 gcacacgcgc tcgcacacac gcacgcacac gcgcgcatac acacacacaa acacacactc
      121 acacacatac acacgcacac acatacacac gtacacacac acacacacac acacacacac
      181 acacacacac acacacacac acacacacac tcacacacca gacctctctg ggtttctttt
      241 gccttgagtc tcccggggct gtgagaaacc aggcgcatct caaaccaagc cggcagctcc
      301 aagctccgaa gccatgccct gcacaaacgc tagtcctcac caagctcctg aggaatgaaa
      361 gcaacccagg aatcctctga ccgcagcagt gatgtggacc aaccccctgg agcccgcacc
      421 ctcccgaggg ccatagagga ctcagggaac tggagagagc tcaagacagg aaatcccagc
      481 tttcccaaag tccccgtgga tgctgacaaa aggagatctg gatttttgga agaggccgtc
      541 ctaggttacc cagctgcaga gtgattctcc cagtctgtca ctgaatctac ccctccaacc
      601 cccagccgtt cagagtacca tgaagaatta tgaggatgtg tgacagaggt atccagatgt
      661 tgatcaccac tgtaggagcc ttcgcagctt tcagtttaat gaccattgcg gtgggcacgg
      721 actactggct atattccaga ggtgtgtgca ggactaaatc tacaagtgac aatgaaacca
      781 gcaggaaaaa tgaagaagta atgacccact ccgggttgtg gaggacctgc tgcttagaag
      841 gagctttccg aggcgtgtgc aagaaaatcg atcacttccc agaagatgca gactatgaac
      901 aggatacagc agaatatctt ctccgggctg tgagggcctc cagtgtcttc cccatcctca
      961 gcgtcactct gctgtttttc gggggactct gtgtggctgc cagcgagttc caccgcagta
     1021 ggcacagtgt tatcctcagc gccggcatct tcttcgtctc tgcagggcta agcaacatca
     1081 tcggcatcat agtttatatc tcagccaatg ctggagaccc tgggcagagg gactctaaaa
     1141 agagctactc ctacggctgg tccttttatt ttggagcctt ctctttcatc atcgcggaaa
     1201 ttgtgggtgt ggtcgccgtg cacatctata ttgagaagca tcagcagctg cgcgccagat
     1261 cccattcaga gctcctgaag aagtctacat ttgcgcgcct accgccctac aggtatagat
     1321 tccgaagacg gtcaagttct cgctccactg aacctagatc ccgagacctg tctcccatca
     1381 gcaaaggctt ccacaccatc ccttccactg acatctccat gttcaccctg tcccgggacc
     1441 cctctaagct taccatgggg acccttctca actctgaccg ggaccatgct tttctacagt
     1501 tccacaactc cacacccaaa gagttcaaag agtcgttgca taacaatccg gccaacagac
     1561 gtaccacgcc tgtctgagct gacctctgac ctctgccccg ccgcccagca cagccttggg
     1621 ggaagtgtac acagatgtct ctaaggttgc atggcatggt cctcgtgatg gtatcacttc
     1681 ttacaaagaa cgaaaccaaa tggactccgc cccctcccac agtggtccct catcccctag
     1741 accttgaccc gtccacctcc tctgactttt ctcgctggtc ccttaatgtt acccctcact
     1801 gtgtatctgt gccaagtgtt ttcttttctt ccttctttgc tggaaggacc acgacattct
     1861 tccctccttg ggaaaggact tgactaaagt cgaaggtgca gtcatagcag tgggggattt
     1921 ccaaatcccc tgtcggttgt atgcatagct gttcccattg tccacccaca caaactctcc
     1981 gtgaaaccca ccacacaggt ggccctgaga gaggcattca cctttaagtg ttagaaaaac
     2041 atgaccagaa atcagatgtc agtgccccga agcagctcat gttataataa gcactcgtgt
     2101 tattaaaggt ttttgccttg taa
//
