LOCUS       NM_053351               1120 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus calcium voltage-gated channel auxiliary subunit
            gamma 2 (Cacng2), mRNA.
ACCESSION   NM_053351
VERSION     NM_053351.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1120)
  AUTHORS   Chen,S., Zhao,Y., Wang,Y., Shekhar,M., Tajkhorshid,E. and Gouaux,E.
  TITLE     Activation and Desensitization Mechanism of AMPA Receptor-TARP
            Complex by Cryo-EM
  JOURNAL   Cell 170 (6), 1234-1246 (2017)
   PUBMED   28823560
  REMARK    GeneRIF: Study elucidates structures of the GluA2-TARP gamma2
            complex in the presence of the partial agonist kainate or the full
            agonist quisqualate together with a positive allosteric modulator
            or with quisqualate alone. Structural and computational analysis
            suggests the full agonist and modulator complex harbors an
            ion-permeable channel gate, providing the first view of an
            activated AMPA receptor.
REFERENCE   2  (bases 1 to 1120)
  AUTHORS   Cannady,R., Fisher,K.R., Graham,C., Crayle,J., Besheer,J. and
            Hodge,C.W.
  TITLE     Potentiation of amygdala AMPA receptor activity selectively
            promotes escalated alcohol self-administration in a
            CaMKII-dependent manner
  JOURNAL   Addict Biol 22 (3), 652-664 (2017)
   PUBMED   26742808
  REMARK    GeneRIF: Evidence indicates that
            alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)
            glutamate receptors (AMPARs) are important modulators of alcohol
            self-administration and relapse-like behavior.
REFERENCE   3  (bases 1 to 1120)
  AUTHORS   Rademacher,N., Schmerl,B., Lardong,J.A., Wahl,M.C. and
            Shoichet,S.A.
  TITLE     MPP2 is a postsynaptic MAGUK scaffold protein that links SynCAM1
            cell adhesion molecules to core components of the postsynaptic
            density
  JOURNAL   Sci Rep 6, 35283 (2016)
   PUBMED   27756895
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1120)
  AUTHORS   Zhao,Y., Chen,S., Yoshioka,C., Baconguis,I. and Gouaux,E.
  TITLE     Architecture of fully occupied GluA2 AMPA receptor-TARP complex
            elucidated by cryo-EM
  JOURNAL   Nature 536 (7614), 108-111 (2016)
   PUBMED   27368053
  REMARK    GeneRIF: cryo-EM structure of the homomeric GluA2 AMPA receptor
            saturated with TARP gamma2 subunits, showing how the TARPs are
            arranged with four-fold symmetry around the ion channel domain and
            make extensive interactions with the M1, M2 and M4 transmembrane
            helices
REFERENCE   5  (bases 1 to 1120)
  AUTHORS   Yamasaki,M., Fukaya,M., Yamazaki,M., Azechi,H., Natsume,R., Abe,M.,
            Sakimura,K. and Watanabe,M.
  TITLE     TARP gamma-2 and gamma-8 Differentially Control AMPAR Density
            Across Schaffer Collateral/Commissural Synapses in the Hippocampal
            CA1 Area
  JOURNAL   J Neurosci 36 (15), 4296-4312 (2016)
   PUBMED   27076426
REFERENCE   6  (bases 1 to 1120)
  AUTHORS   Zhang,Y., Mori,M., Burgess,D.L. and Noebels,J.L.
  TITLE     Mutations in high-voltage-activated calcium channel genes stimulate
            low-voltage-activated currents in mouse thalamic relay neurons
  JOURNAL   J Neurosci 22 (15), 6362-6371 (2002)
   PUBMED   12151514
REFERENCE   7  (bases 1 to 1120)
  AUTHORS   Chu,P.J., Robertson,H.M. and Best,P.M.
  TITLE     Calcium channel gamma subunits provide insights into the evolution
            of this gene family
  JOURNAL   Gene 280 (1-2), 37-48 (2001)
   PUBMED   11738816
REFERENCE   8  (bases 1 to 1120)
  AUTHORS   Chen,L., Chetkovich,D.M., Petralia,R.S., Sweeney,N.T., Kawasaki,Y.,
            Wenthold,R.J., Bredt,D.S. and Nicoll,R.A.
  TITLE     Stargazin regulates synaptic targeting of AMPA receptors by two
            distinct mechanisms
  JOURNAL   Nature 408 (6815), 936-943 (2000)
   PUBMED   11140673
REFERENCE   9  (bases 1 to 1120)
  AUTHORS   Aizawa,M., Ito,Y. and Fukuda,H.
  TITLE     Pharmacological profiles of generalized absence seizures in
            lethargic, stargazer and gamma-hydroxybutyrate-treated model mice
  JOURNAL   Neurosci Res 29 (1), 17-25 (1997)
   PUBMED   9293489
REFERENCE   10 (bases 1 to 1120)
  AUTHORS   Di Pasquale,E., Keegan,K.D. and Noebels,J.L.
  TITLE     Increased excitability and inward rectification in layer V cortical
            pyramidal neurons in the epileptic mutant mouse Stargazer
  JOURNAL   J Neurophysiol 77 (2), 621-631 (1997)
   PUBMED   9065835
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 26, 2020 this sequence version replaced NM_053351.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF118818.1, AF361339.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMEA5760433 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-241               JAXUCZ010000007.1  111577517-111577757 c
            242-325             JAXUCZ010000007.1  111471949-111472032 c
            326-466             JAXUCZ010000007.1  111456948-111457088 c
            467-1120            JAXUCZ010000007.1  111454973-111455626 c
FEATURES             Location/Qualifiers
     source          1..1120
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1120
                     /gene="Cacng2"
                     /gene_synonym="Ipr328"
                     /note="calcium voltage-gated channel auxiliary subunit
                     gamma 2"
                     /db_xref="GeneID:84347"
                     /db_xref="RGD:71095"
     exon            1..241
                     /gene="Cacng2"
                     /gene_synonym="Ipr328"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..1002
                     /gene="Cacng2"
                     /gene_synonym="Ipr328"
                     /note="TARP gamma-2; transmembrane AMPAR regulatory
                     protein gamma-2; neuronal voltage-gated calcium channel
                     gamma-2 subunit; calcium channel, voltage-dependent, gamma
                     subunit 2; stargazin"
                     /codon_start=1
                     /product="voltage-dependent calcium channel gamma-2
                     subunit"
                     /protein_id="NP_445803.2"
                     /db_xref="GeneID:84347"
                     /db_xref="RGD:71095"
                     /translation="MGLFDRGVQMLLTTVGAFAAFSLMTIAVGTDYWLYSRGVCKTKS
                     VSENETSKKNEEVMTHSGLWRTCCLEGNFKGLCKQIDHFPEDADYEADTAEYFLRAVR
                     ASSIFPILSVILLFMGGLCIAASEFYKTRHNIILSAGIFFVSAGLSNIIGIIVYISAN
                     AGDPSKSDSKKNSYSYGWSFYFGALSFIIAEMVGVLAVHMFIDRHKQLRATARATDYL
                     QASAITRIPSYRYRYQRRSRSSSRSTEPSHSRDASPVGVKGFNTLPSTEISMYTLSRD
                     PLKAATTPTATYNSDRDNSFLQVHNCIQKDSKDSLHANTANRRTTPV"
     exon            242..325
                     /gene="Cacng2"
                     /gene_synonym="Ipr328"
                     /inference="alignment:Splign:2.1.0"
     exon            326..466
                     /gene="Cacng2"
                     /gene_synonym="Ipr328"
                     /inference="alignment:Splign:2.1.0"
     exon            467..1120
                     /gene="Cacng2"
                     /gene_synonym="Ipr328"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcggttggg tgtttatata atgaagaatt atggggctgt ttgatcgagg tgttcaaatg
       61 cttttaacca ccgttggtgc tttcgctgcc ttcagcttga tgaccatcgc tgtgggaacc
      121 gactattggc tgtactccag aggggtttgc aagaccaaaa gtgtcagtga gaatgaaacc
      181 agcaaaaaga acgaggaagt tatgacccat tccggattat ggagaacctg ctgcctcgaa
      241 gggaacttca aaggtctgtg caagcaaatc gaccactttc ccgaagacgc ggactacgag
      301 gctgacaccg cagagtattt cctcagggcc gtgagggcct cgagtatctt cccaatcctg
      361 agtgtgatcc tgctcttcat gggtggtctc tgcatcgctg caagcgagtt ttacaagaca
      421 cgtcacaaca tcatcctgag cgctggcatc ttcttcgtgt ctgcaggtct aagtaatatt
      481 atcgggatca tcgtgtatat atcagccaat gctggagacc cctccaagag tgactccaaa
      541 aagaacagct actcctacgg ctggtccttc tacttcgggg ccctgtcctt catcatcgcc
      601 gagatggtcg gggtgctggc cgtgcacatg tttatcgacc gccacaaaca gctgcgggcc
      661 acggcccgtg ccaccgacta cctccaggcc tccgccatca cccgcatccc cagctaccgc
      721 taccgctacc agcgccgcag ccgctccagc tcgcgctcca ccgagccctc tcactccagg
      781 gacgcctcgc ccgtgggcgt gaagggcttc aacaccctgc cgtccacgga gatctccatg
      841 tacaccctca gtagggaccc cctgaaggct gccaccacgc ccaccgccac ctacaactcg
      901 gacagggata acagctttct ccaggtccac aactgtatcc agaaggacag caaggactct
      961 ctccacgcca acacagccaa ccgccggacc acgcccgtat gaagaccgtg ggacggggaa
     1021 cccccgggag gcttggcccg cgggcggggg agggaccaca gcagccacgg ggagaccttc
     1081 catacgcaaa aacaaaaaac aaaaaaaaaa aacaaaaaaa
//
