LOCUS       NM_001399143            8101 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus calcium voltage-gated channel auxiliary subunit
            beta 4 (Cacnb4), transcript variant 1, mRNA.
ACCESSION   NM_001399143 XM_017591999
VERSION     NM_001399143.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8101)
  AUTHORS   Tammineni,E.R., Carrillo,E.D., Soto-Acosta,R., Angel-Ambrocio,A.H.,
            Garcia,M.C., Bautista-Carbajal,P., Del Angel,R.M. and Sanchez,J.A.
  TITLE     The beta4 subunit of Cav1.2 channels is required for an optimal
            interferon response in cardiac muscle cells
  JOURNAL   Sci Signal 11 (560) (2018)
   PUBMED   30538175
  REMARK    GeneRIF: Study demonstrated that the beta4 subunit of Cav1.2
            channels can act as an antiviral agent; overexpression of beta4
            increased the amounts of four key antiviral proteins, namely,
            DDX58, IRF7, IFITM3, and STAT2, and contrasting results were
            obtained by silencing beta4.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8101)
  AUTHORS   Xu,H., Dorn,G.W. 2nd, Shetty,A., Parihar,A., Dave,T.,
            Robinson,S.W., Gottlieb,S.S., Donahue,M.P., Tomaselli,G.F.,
            Kraus,W.E., Mitchell,B.D. and Liggett,S.B.
  TITLE     A Genome-Wide Association Study of Idiopathic Dilated
            Cardiomyopathy in African Americans
  JOURNAL   J Pers Med 8 (1), 11 (2018)
   PUBMED   29495422
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8101)
  AUTHORS   Rima,M., Daghsni,M., De Waard,S., Gaborit,N., Fajloun,Z.,
            Ronjat,M., Mori,Y., Bruses,J.L. and De Waard,M.
  TITLE     The beta4 subunit of the voltage-gated calcium channel (Cacnb4)
            regulates the rate of cell proliferation in Chinese Hamster Ovary
            cells
  JOURNAL   Int J Biochem Cell Biol 89, 57-70 (2017)
   PUBMED   28587927
  REMARK    GeneRIF: beta4 subunit of the voltage-gated calcium channel
            (Cacnb4) regulates the rate of cell proliferation in Chinese
            Hamster Ovary cells
REFERENCE   4  (bases 1 to 8101)
  AUTHORS   Tadmouri,A., Kiyonaka,S., Barbado,M., Rousset,M., Fablet,K.,
            Sawamura,S., Bahembera,E., Pernet-Gallay,K., Arnoult,C., Miki,T.,
            Sadoul,K., Gory-Faure,S., Lambrecht,C., Lesage,F., Akiyama,S.,
            Khochbin,S., Baulande,S., Janssens,V., Andrieux,A., Dolmetsch,R.,
            Ronjat,M., Mori,Y. and De Waard,M.
  TITLE     Cacnb4 directly couples electrical activity to gene expression, a
            process defective in juvenile epilepsy
  JOURNAL   EMBO J 31 (18), 3730-3744 (2012)
   PUBMED   22892567
REFERENCE   5  (bases 1 to 8101)
  AUTHORS   Catterall,W.A.
  TITLE     Voltage-gated calcium channels
  JOURNAL   Cold Spring Harb Perspect Biol 3 (8), a003947 (2011)
   PUBMED   21746798
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8101)
  AUTHORS   Hosford,D.A., Lin,F.H., Kraemer,D.L., Cao,Z., Wang,Y. and
            Wilson,J.T. Jr.
  TITLE     Neural network of structures in which GABAB receptors regulate
            absence seizures in the lethargic (lh/lh) mouse model
  JOURNAL   J Neurosci 15 (11), 7367-7376 (1995)
   PUBMED   7472490
REFERENCE   7  (bases 1 to 8101)
  AUTHORS   Hosford,D.A., Wang,Y., Liu,C.C. and Snead,O.C. 3rd.
  TITLE     Characterization of the antiabsence effects of SCH 50911, a GABA-B
            receptor antagonist, in the lethargic mouse, gamma-hydroxybutyrate,
            and pentylenetetrazole models
  JOURNAL   J Pharmacol Exp Ther 274 (3), 1399-1403 (1995)
   PUBMED   7562514
REFERENCE   8  (bases 1 to 8101)
  AUTHORS   Hosford,D.A., Clark,S., Cao,Z., Wilson,W.A. Jr., Lin,F.H.,
            Morrisett,R.A. and Huin,A.
  TITLE     The role of GABAB receptor activation in absence seizures of
            lethargic (lh/lh) mice
  JOURNAL   Science 257 (5068), 398-401 (1992)
   PUBMED   1321503
REFERENCE   9  (bases 1 to 8101)
  AUTHORS   Herring,J.M., Dung,H.C., Yoo,J.H. and Yu,J.
  TITLE     Chronological studies of peripheral motor nerve conduction in
            'lethargic' mice
  JOURNAL   Electromyogr Clin Neurophysiol 21 (2-3), 121-134 (1981)
   PUBMED   7261997
REFERENCE   10 (bases 1 to 8101)
  AUTHORS   Dung,H.C. and Swigart,R.H.
  TITLE     Histo-pathologic observations of the nervous and lymphoid tissues
            of 'lethargic' mutant mice
  JOURNAL   Tex Rep Biol Med 30 (1), 23-39 (1972)
   PUBMED   5037658
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000115.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001399143.2.
            
            On Jan 4, 2022 this sequence version replaced XM_017591999.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L02315.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132263,
                                           SAMD00132276 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-310               JACYVU010000115.1  30625677-30625986   c
            311-394             JACYVU010000115.1  30625159-30625242   c
            395-514             JACYVU010000115.1  30413119-30413238   c
            515-637             JACYVU010000115.1  30410402-30410524   c
            638-768             JACYVU010000115.1  30405420-30405550   c
            769-845             JACYVU010000115.1  30402961-30403037   c
            846-865             JACYVU010000115.1  30401535-30401554   c
            866-946             JACYVU010000115.1  30401239-30401319   c
            947-1005            JACYVU010000115.1  30400239-30400297   c
            1006-1115           JACYVU010000115.1  30391371-30391480   c
            1116-1267           JACYVU010000115.1  30386892-30387043   c
            1268-1363           JACYVU010000115.1  30385003-30385098   c
            1364-1549           JACYVU010000115.1  30372387-30372572   c
            1550-8101           JACYVU010000115.1  30363595-30370146   c
FEATURES             Location/Qualifiers
     source          1..8101
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q12"
     gene            1..8101
                     /gene="Cacnb4"
                     /gene_synonym="CAB4"
                     /note="calcium voltage-gated channel auxiliary subunit
                     beta 4"
                     /db_xref="GeneID:58942"
                     /db_xref="RGD:68385"
     exon            1..310
                     /gene="Cacnb4"
                     /gene_synonym="CAB4"
                     /inference="alignment:Splign:2.1.0"
     CDS             251..1810
                     /gene="Cacnb4"
                     /gene_synonym="CAB4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     voltage-dependent L-type calcium channel subunit beta-4;
                     calcium channel beta 4 subunit; calcium channel,
                     voltage-dependent, beta 4 subunit; calcium channel
                     voltage-dependent subunit beta 4"
                     /codon_start=1
                     /product="voltage-dependent L-type calcium channel subunit
                     beta-4 isoform 1"
                     /protein_id="NP_001386072.1"
                     /db_xref="GeneID:58942"
                     /db_xref="RGD:68385"
                     /translation="MSSSYAKNGAADGPHSPSSQVARGTTTRRSRLKRSDGSTTSTSF
                     ILRQGSADSYTSRPSDSDVSLEEDREAIRQEREQQAAIQLERAKSKPVAFAVKTNVSY
                     CGALDEDVPVPSTAISFDAKDFLHIKEKYNNDWWIGRLVKEGCEIGFIPSPLRLENIR
                     IQQEQKRGRFHGGKSSGNSSSSLGEMVSGTFRATPTTTAKQKQKVTEHIPPYDVVPSM
                     RPVVLVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKR
                     AIIERSNTRSSLAEVQSEIERIFELARSLQLVVLDADTINHPAQLIKTSLAPIIVHVK
                     VSSPKVLQRLIKSRGKSQSKHLNVQLVAADKLAQCPPEMFDVILDENQLEDACEHLGE
                     YLEAYWRATHTSSSTPMTPLLGRNVGSTALSPYPTAISGLQSQRMRHSNHSTENSPIE
                     RRSLMTSDENYHNERARKSRNRLSSSSQHSRDHYPLVEEDYPDSYQDTYKPHRNRGSP
                     GGCSHDSRHRL"
     exon            311..394
                     /gene="Cacnb4"
                     /gene_synonym="CAB4"
                     /inference="alignment:Splign:2.1.0"
     exon            395..514
                     /gene="Cacnb4"
                     /gene_synonym="CAB4"
                     /inference="alignment:Splign:2.1.0"
     exon            515..637
                     /gene="Cacnb4"
                     /gene_synonym="CAB4"
                     /inference="alignment:Splign:2.1.0"
     exon            638..768
                     /gene="Cacnb4"
                     /gene_synonym="CAB4"
                     /inference="alignment:Splign:2.1.0"
     exon            769..845
                     /gene="Cacnb4"
                     /gene_synonym="CAB4"
                     /inference="alignment:Splign:2.1.0"
     exon            846..865
                     /gene="Cacnb4"
                     /gene_synonym="CAB4"
                     /inference="alignment:Splign:2.1.0"
     exon            866..946
                     /gene="Cacnb4"
                     /gene_synonym="CAB4"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1005
                     /gene="Cacnb4"
                     /gene_synonym="CAB4"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1115
                     /gene="Cacnb4"
                     /gene_synonym="CAB4"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1267
                     /gene="Cacnb4"
                     /gene_synonym="CAB4"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1363
                     /gene="Cacnb4"
                     /gene_synonym="CAB4"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1549
                     /gene="Cacnb4"
                     /gene_synonym="CAB4"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..8101
                     /gene="Cacnb4"
                     /gene_synonym="CAB4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acttctcccc aaggctcggg gaggcgagaa ccgagaagcc ccctcgcctg gacttccctg
       61 agggcgcgcg aggggggagg ggagcgcttc ggccccttta aggtgcggcg ctcggcgaag
      121 tgcgggcagg cggcccgcga gccggcgcgg ggccaggagc cgggtaggga agtcctgcct
      181 ccccctccgc ccgcaccggc ccgcgccctc cgcccaccgc gccgcgaggg ccatgcggcg
      241 cctctgaacc atgtcgtcct cctacgccaa gaacggggcg gcggacgggc cgcactcccc
      301 cagctcgcag gtggcccgag gcaccacgac ccggaggagc aggttgaaaa gatccgatgg
      361 cagcaccact tccaccagct tcatcctcag acaggggtca gcagattcct atacaagcag
      421 gccatcggac tccgatgtct ctttggaaga ggaccgggaa gcgattcggc aagagagaga
      481 acagcaagca gctatccagc ttgagagagc gaagtccaaa cctgtagctt ttgcggtgaa
      541 aacgaatgtg agctactgtg gtgccctgga tgaggatgtg cccgttccca gcacagccat
      601 ctcctttgac gccaaggact ttcttcacat taaagagaaa tataacaatg attggtggat
      661 aggaaggctg gtgaaggagg gctgtgagat cggcttcatc ccaagtccac tgcgtttgga
      721 gaacatacgg attcaacagg aacagaaaag aggccgtttt catggcggga aatcgagtgg
      781 aaactcttcc tccagtctgg gagaaatggt gtcaggaaca tttcgagcaa ctcccacaac
      841 aacagcaaaa cagaagcaga aagtgacaga gcacattcct ccgtatgatg ttgtgccatc
      901 aatgcgtcct gtggtgttag tggggccatc actgaaaggt tatgaggtaa cagacatgat
      961 gcagaaagcc ctctttgatt tcctgaagca caggtttgat gggaggatat caataaccag
     1021 agtgacagct gacatttctc ttgctaagag gtctgtcctc aacaatccta gcaagagagc
     1081 aataattgaa cgttcaaaca ccagatccag cctagcggaa gtacagagtg aaattgaaag
     1141 aattttcgag ttggcaagat ctttgcaatt ggttgttctc gatgcagaca ccatcaatca
     1201 cccagcacag ctgataaaga catcgttagc gcccatcatc gtccacgtga aggtctcgtc
     1261 cccaaaggtt ttacagcggc tgattaagtc cagaggaaag tcccagagta aacacttgaa
     1321 tgttcaactg gtggcagctg ataaactggc ccagtgtccc cctgaaatgt ttgatgttat
     1381 attagatgag aatcaacttg aggatgcctg tgaacatctg ggagagtacc tggaggcata
     1441 ttggcgtgcc acccacacaa gcagtagcac ccctatgacc ccattgctgg ggaggaacgt
     1501 gggctccaca gctctctcac cgtatcccac agcaatctct ggactacaga gtcagcggat
     1561 gaggcatagc aaccactcta cagagaattc tccaattgaa agacgaagcc taatgacctc
     1621 tgatgaaaat taccacaatg agagggcccg caagagtagg aaccgcttgt cctccagctc
     1681 ccagcacagc cgagatcact accctctggt ggaagaagat tatcctgact cataccagga
     1741 cacttacaaa ccccatagga accgaggctc acctggggga tgcagccatg actcccgaca
     1801 taggctttga ggctgcccaa acaaacaaac aaacaaacaa acatcatctg ttgacaattt
     1861 gccatagtac tgctaagata aaccagtcat cttaatttgg caagcatggc acagtatctg
     1921 ctgtgcgggt ggtctgctgt cgtttgatgt aaggggcaag aattaaatag aagtacatta
     1981 tgcccttgag tctaggaggg tattagatac ccggtcatat aggtattttt aagtgctaca
     2041 tttacatgat aacagtacct tttgttttct tcatagattt tagacacatc aatttgtaat
     2101 ttagggtact gatcaaggca catataaaat aatttcccgt gtaggaaatt ccaaatgacc
     2161 agttccagtt ggaaccaatt tataaaccaa ttcctgttgg aatttgggtg aattgactgg
     2221 aaagtctacc tgagcatgtt gaaatcaatt gaaaaaatca gagaagaaaa aaatacccaa
     2281 taaggaaatc aaaatactaa tagaaaccaa acccagctat ggtatttgtt tgctggaagc
     2341 taaatttaca cttcaagttg gaatgtagaa acattttaat aatgttgccg gaatggcttt
     2401 tcaaacttac caaatatatt gatagtgcca aaaaaaaatc tcagaaatct taatgcagaa
     2461 attatataat cgcctcagat tttaatattt ttatttttcc tgatatagct gttgtattca
     2521 aagtgttttg ccttctgttc agtcagtact gttagccagt ttgaagttga caaaatccag
     2581 gggatatttg agaagtggta aagagaagcc ctagcatgga cagttccaga gagtggagaa
     2641 tgaggtgttg ttccttctgc agtcagtctg cacacagctg cacacatctg gagacctggt
     2701 gtcaggtagc agagatgtgg cggggcctct ctggctacaa cggtaattgg cttcagatgg
     2761 gaagtcgtcc atcgtacagc acaccgacac gggcttagga gctgtgccag catggctgag
     2821 tgtctttccc tcacttcagc cagtctccat ctttgaatat aatgaatgtt ttggccctgc
     2881 atcacacttc ttttatgttt catgggcata atcaaattag gtactgaaag ttatgttttc
     2941 acaaaataat taggaaaact taaaacactg aattaaaatc ttgcagagaa agaaaaaaaa
     3001 accctcatag aatcagaata tatttattca ctaaaagcaa gacagtttca atacacggca
     3061 ttagagagag ttgagagact gctcggttcc attgatagtg aacagccttt agacttctat
     3121 gagtgtattt atggaattga tgacctatgt cctatgttat taaagacagc tttaatccaa
     3181 gaaattagtg aaattgaccc tttgaaacaa atgtctttct gaaagggctt gtttctgaaa
     3241 tgacgcaata catgtgtttt ctaaagaccc aattggagct agacgtaaag tctctttcta
     3301 ctaatgcttt gaagtcaatt tccgaaacaa gtataattaa tagtatgtta atttctccaa
     3361 aaaaaagaca tgggtcctca aaactgtgta ccagttcatt aattttcctg atcaagagtc
     3421 taagtttcat attcttaatc agttatccta tctcggatcc catcaaccca ttgtcttgac
     3481 tgtatgtgca acccattatg aacctgctta tctgataatg aggctgcctg aaattttgtg
     3541 gtaatctcaa acatttgata catttaaaca cgggctcagt caaattgaca agctaacatc
     3601 tgacactggc ttgtgaagct tttttgtcat ccagcgaggc ttacagaatt ttctgttaag
     3661 acatttaaca gagctgtatt cattgggctc tttaataagc atataatctt ccattaccaa
     3721 atactttgtt agaagacaga agagcatttt tccagcgaac aaactatatt tattacatgt
     3781 atagcacata tttgcatgag aaagaaaaac attagccaaa cattttcctg tatgctttac
     3841 tggtttcttg tttgtgcgca ttaaagcatt taattgcaga gagtgcactt gggtgtataa
     3901 atttagaata gattgctgtt gagccttttc tgcagtagca ttagcaattt ggtcatttaa
     3961 ctactttaag atatttatat tttatggcgc gggtagctgt aacagcattt acatatattt
     4021 cctagtcaac aaggctacct tttctttcaa ctttgaaggg tcacttgttt tgcaagcctc
     4081 tccagccctt ttctccctca ccccccgccc cgcccctttg gctctccatg tcctgctgaa
     4141 agatggaggc cccatgtgat ccgtgcacaa aactcatcca tcagttgcca tcaaaagtcc
     4201 atacctagtt tgctttgcag ttctcttaaa aagctagcta tgttggaaag ggtaagatat
     4261 atattcttga tgaatatatt tactgtttca ctttaattct gcataccttt cgtcttcctc
     4321 ctataagttt ctctcctaca aacgaggaag ggattaagat tcctcctctc tttttaaagg
     4381 ctcagagctg ctttgtagaa atgactaaaa tccagatata cactaaataa aacgtttcac
     4441 tttcgccaag cataccaaga acctctaggg aatgcctatc ccacaagtac tttgctttaa
     4501 ttcatttcac tcaaaacggc aaatgatgag aagcaggaga aatatttcta tatcatctga
     4561 ggctgttttc acttctagag tagaccatga tagaagtctg tgagttttca tggtatataa
     4621 taatgcagac acatgcaaca atgtggacat gtggtcctgg aaaaaagagg aaacgctact
     4681 tgtgggtcct tttgcttgtt tccaagacta cgagatgact acagtatcat aacaaacact
     4741 gttaccgtgt ttatgctaac acttaaaaca acacatagtg gtatttacaa atgactgtga
     4801 ttctctcccg cctttatatg gctctactgg gcagaagatt ggaattgtta gcaattagac
     4861 tcacggtctt tcctaaagag tctcaactgt gcgacggtac aaatcattgc atttcatcct
     4921 caagggaagt ctgaaacaaa tcaagacaat tatttgttcc actttaaatg atctgtgatt
     4981 cgctccaatt atgattgctg tttgcaaaaa aaaatgtatt tttagaatgt taacgtcttt
     5041 tcatacctgc atacttgaac ttgtcttttg tgtgggggcc ttaaacttca tagtagagaa
     5101 tgggggcagt gaaaagggaa agggaaagaa ggcaaggaag cttcacaaag gagagcgtgc
     5161 actcttcaac tctttcagtg aacatatccc aaacgttgag acaccgcacg tcagtgaaga
     5221 atgtttctag gcaaccttga tttgcaagct agtatatttt cttatataat tttattttgg
     5281 tatttgctaa aaacaagaaa aagaaagaac acaacaccac catacaaatt gccctctaca
     5341 atgatacgta tactacctct tttctagaga aaacggtccg tgtttggagg ggaaagtcct
     5401 ggtgagagtg tccattctcc cagccgggct gcagggttgg aagtgttcag acaagcctgc
     5461 cctttagagt tcacgctgtt ttcaaatgct cccagcatgc tctcatttct tcgacgtcag
     5521 cgaggttttc ttgaaattgg cccacggctt atcatgatgt gagtttaatt taacaagaag
     5581 ccatcctagg ggactaagca aagtgaaagg aactacctct gtgcaaaatg tagcctctag
     5641 ctcaggtcta aggaagagaa atccagagac taggtgttta aaggcagagt tggttgatcc
     5701 tagacctcta ggggtactaa gggcatgcta tggccactta ctgggtaaga gatctgcgtt
     5761 gtctggtacg cccatgtaat tggaacaaac ctcatatcaa catttcaaat aaatgattac
     5821 ataaccctta ttcctttata ttaaccttca tctctcatga cagcgttaca ttttttaatt
     5881 atataaaagt aatccttgga tggctgtatg agtaaaaact acagaagatc atgtaataaa
     5941 atctgcttca ttagttcctc acatctttaa atagtgtcaa cactgtaact gttaattaag
     6001 tcactcactc cagcggggtc tactttggca aacaacagtc ctttgctttt aaatgacggt
     6061 gatggaacca ggcaacttaa gtgctcttga acggacattg agaataactt cttgttgagt
     6121 taagcaatcc agtttatcaa aatagtaaaa ctggcttatg tgggcagaca gctacagcat
     6181 tcagaagtta ctctttacgg tttcaccgtt tgttgaaagg acctttctcc aacgaaatca
     6241 tcctctgata gcaatgtctt tccttgtgga taatttaaga caaaatgctg catgtagtga
     6301 tggtatatta tgggacaatt aggaagtatc tcagcagata atcttaatta agggctgtaa
     6361 ctcctatttg ccataaatac atataaataa gaggaaatag tgctaagact tggggagtct
     6421 taactttcca tgaacctttc tttttggtgg atgtaagata ttcacagaga gatggaagaa
     6481 aatgttacca atgaatttat tgtagtttag ggaattcgct gattcttcct agtttgaaaa
     6541 tcataaagag ttaaaaagag aaccaagaac agtagaagat ctttagcttt tcgagagtct
     6601 tgggttatat tttaagtatt taaatctccc aacaaatggc tcgatctgta tttatgcagg
     6661 ggcctttctt ggcctatttg cacactactt catacacttc actgaaacca ggatgaattc
     6721 catacacaca gagcgcgggg ggaaatcggt gagaattctg ctcgcacggg gtgggggtgt
     6781 cacgggtgcg ggggaaattg atatgaattc cattcacaag ggagtgtcac ggattctggg
     6841 aaatcggtgt gaattccgtt tgcatggggg gtgtcacaca tgcggggtca ttaacgctat
     6901 attgttgcat tctatttttc atatgcctta caatattttc tggaacgtta ttaaaatgaa
     6961 agcattttat tgccaaaata aatctatgtt gttacttctg cattagcagt agaaaaataa
     7021 tgtagcaaaa aatatatatt gtacagtaca aaattataat atatatatat tttgccaata
     7081 aatgaaaata gattgaggtg aaagaagcac atttgttata gcacaaactt acaacagaac
     7141 ccactgttaa atctggcaga cctgttttta gatgtacgta gatttggttt tctttcttat
     7201 cagatttatt tcatctctca tatttgtaat tgtgctgctt gatactttcc agcaatttat
     7261 ttcatagcct tgcaatctgt gagtgtaatt tacttatttt gtccccttac ataaagcata
     7321 tgaacttcat tttgtgttac gactcatact ctattactgt gttttctgtt cccgtttctt
     7381 ctcccttggt aacagatggc acagcaggtg agctcacagg gctcctctag gctttggatg
     7441 tttgaaagtt tatgtttttt ttcccagcct caagttagag atcagcaaaa tgtccccatg
     7501 gaaaaatatg aagtagggat tccattgctt tgtacctgat actatttgaa gcataaataa
     7561 agccattagc tgtattttta ggaggtgggt gggatttaaa atctgatgct attaatagga
     7621 aacgtactaa aaataactat ggcaagatgg tagtaaaaga tcccccctat tctgagggct
     7681 gttgatatcc caggctattc ctatgtctct gctgatgtgg tggggggaaa tgcctttgtc
     7741 agataacttc ctttttcctt tgggtgttta ttttaataat ctgtcccttt cgttttttgt
     7801 tacatagata tgcgtagcgt tctacaaggc atgctggggc aaatacacta tgcaaatgta
     7861 caccgtgctg catgcttggt tctccctctg ctttagcggc ttaaaaaaaa aaagagaaaa
     7921 acaaaaccgt ggtgttattt ttgtgaacaa agacatttaa atttaacgac aaaaaaaaaa
     7981 gtgcagagtg catgcataca gtatcctcat ttctatgggt tgttttatgg aatttaaatg
     8041 tgtacaaaga ctgcattaat tttttctttt atataataaa tgaaaaaaaa aaccactgaa
     8101 a
//
