LOCUS       NM_012828               2521 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus calcium voltage-gated channel auxiliary subunit
            beta 3 (Cacnb3), mRNA.
ACCESSION   NM_012828
VERSION     NM_012828.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2521)
  AUTHORS   Becker,A., Wardas,B., Salah,H., Amini,M., Fecher-Trost,C., Sen,Q.,
            Martus,D., Beck,A., Philipp,S.E., Flockerzi,V. and Belkacemi,A.
  TITLE     Cavbeta3 Regulates Ca2+ Signaling and Insulin Expression in
            Pancreatic beta-Cells in a Cell-Autonomous Manner
  JOURNAL   Diabetes 70 (11), 2532-2544 (2021)
   PUBMED   34426509
  REMARK    GeneRIF: Cavbeta3 Regulates Ca(2+) Signaling and Insulin Expression
            in Pancreatic beta-Cells in a Cell-Autonomous Manner.
REFERENCE   2  (bases 1 to 2521)
  AUTHORS   Kim,D.I., Park,Y., Jang,D.J. and Suh,B.C.
  TITLE     Dynamic phospholipid interaction of beta2e subunit regulates the
            gating of voltage-gated Ca2+ channels
  JOURNAL   J Gen Physiol 145 (6), 529-541 (2015)
   PUBMED   25964431
REFERENCE   3  (bases 1 to 2521)
  AUTHORS   Bourdin,B., Shakeri,B., Tetreault,M.P., Sauve,R., Lesage,S. and
            Parent,L.
  TITLE     Functional characterization of CaValpha2delta mutations associated
            with sudden cardiac death
  JOURNAL   J Biol Chem 290 (5), 2854-2869 (2015)
   PUBMED   25527503
REFERENCE   4  (bases 1 to 2521)
  AUTHORS   Beguin,P., Nagashima,K., Mahalakshmi,R.N., Vigot,R., Matsunaga,A.,
            Miki,T., Ng,M.Y., Ng,Y.J., Lim,C.H., Tay,H.S., Hwang,L.A.,
            Firsov,D., Tang,B.L., Inagaki,N., Mori,Y., Seino,S., Launey,T. and
            Hunziker,W.
  TITLE     BARP suppresses voltage-gated calcium channel activity and
            Ca2+-evoked exocytosis
  JOURNAL   J Cell Biol 205 (2), 233-249 (2014)
   PUBMED   24751537
REFERENCE   5  (bases 1 to 2521)
  AUTHORS   Agrawal,M., Kumar,V., Singh,A.K., Kashyap,M.P., Khanna,V.K.,
            Siddiqui,M.A. and Pant,A.B.
  TITLE     trans-Resveratrol protects ischemic PC12 Cells by inhibiting the
            hypoxia associated transcription factors and increasing the levels
            of antioxidant defense enzymes
  JOURNAL   ACS Chem Neurosci 4 (2), 285-294 (2013)
   PUBMED   23421680
REFERENCE   6  (bases 1 to 2521)
  AUTHORS   Bell,D.C., Butcher,A.J., Berrow,N.S., Page,K.M., Brust,P.F.,
            Nesterova,A., Stauderman,K.A., Seabrook,G.R., Nurnberg,B. and
            Dolphin,A.C.
  TITLE     Biophysical properties, pharmacology, and modulation of human,
            neuronal L-type (alpha(1D), Ca(V)1.3) voltage-dependent calcium
            currents
  JOURNAL   J Neurophysiol 85 (2), 816-827 (2001)
   PUBMED   11160515
REFERENCE   7  (bases 1 to 2521)
  AUTHORS   Wei,S.K., Colecraft,H.M., DeMaria,C.D., Peterson,B.Z., Zhang,R.,
            Kohout,T.A., Rogers,T.B. and Yue,D.T.
  TITLE     Ca(2+) channel modulation by recombinant auxiliary beta subunits
            expressed in young adult heart cells
  JOURNAL   Circ Res 86 (2), 175-184 (2000)
   PUBMED   10666413
REFERENCE   8  (bases 1 to 2521)
  AUTHORS   Burgess,D.L., Biddlecome,G.H., McDonough,S.I., Diaz,M.E.,
            Zilinski,C.A., Bean,B.P., Campbell,K.P. and Noebels,J.L.
  TITLE     beta subunit reshuffling modifies N- and P/Q-type Ca2+ channel
            subunit compositions in lethargic mouse brain
  JOURNAL   Mol Cell Neurosci 13 (4), 293-311 (1999)
   PUBMED   10328888
REFERENCE   9  (bases 1 to 2521)
  AUTHORS   Castellano,A., Wei,X., Birnbaumer,L. and Perez-Reyes,E.
  TITLE     Cloning and expression of a neuronal calcium channel beta subunit
  JOURNAL   J Biol Chem 268 (17), 12359-12366 (1993)
   PUBMED   7685340
REFERENCE   10 (bases 1 to 2521)
  AUTHORS   Castellano,A., Wei,X., Birnbaumer,L. and Perez-Reyes,E.
  TITLE     Cloning and expression of a third calcium channel beta subunit
  JOURNAL   J Biol Chem 268 (5), 3450-3455 (1993)
   PUBMED   7679112
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 27, 2020 this sequence version replaced NM_012828.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M88751.1, SRR26643298.42138.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               JAXUCZ010000007.1  131666551-131666684
            135-257             JAXUCZ010000007.1  131670928-131671050
            258-380             JAXUCZ010000007.1  131671288-131671410
            381-496             JAXUCZ010000007.1  131671824-131671939
            497-561             JAXUCZ010000007.1  131672212-131672276
            562-581             JAXUCZ010000007.1  131672465-131672484
            582-662             JAXUCZ010000007.1  131672679-131672759
            663-721             JAXUCZ010000007.1  131672896-131672954
            722-831             JAXUCZ010000007.1  131673124-131673233
            832-983             JAXUCZ010000007.1  131673468-131673619
            984-1079            JAXUCZ010000007.1  131673851-131673946
            1080-1229           JAXUCZ010000007.1  131674047-131674196
            1230-2521           JAXUCZ010000007.1  131674794-131676085
FEATURES             Location/Qualifiers
     source          1..2521
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..2521
                     /gene="Cacnb3"
                     /gene_synonym="CACH3B"
                     /note="calcium voltage-gated channel auxiliary subunit
                     beta 3"
                     /db_xref="GeneID:25297"
                     /db_xref="RGD:2248"
     exon            1..134
                     /gene="Cacnb3"
                     /gene_synonym="CACH3B"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..1544
                     /gene="Cacnb3"
                     /gene_synonym="CACH3B"
                     /note="CAB3; calcium channel voltage-dependent subunit
                     beta 3; Calcium channel subunit beta 3; calcium channel,
                     voltage-dependent, beta 3 subunit"
                     /codon_start=1
                     /product="voltage-dependent L-type calcium channel subunit
                     beta-3"
                     /protein_id="NP_036960.1"
                     /db_xref="GeneID:25297"
                     /db_xref="RGD:2248"
                     /translation="MYDDSYVPGFEDSEAGSADSYTSRPSLDSDVSLEEDRESARREV
                     ESQAQQQLERAKHKPVAFAVRTNVSYCGVLDEECPVQGSGVNFEAKDFLHIKEKYSND
                     WWIGRLVKEGGDIAFIPSPQRLESIRLKQEQKARRSGNPSSLSDIGNRRSPPPSLAKQ
                     KQKQAEHVPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVT
                     ADLSLAKRSVLNNPGKRTIIERSSARSSIAEVQSEIERIFELAKSLQLVVLDADTINH
                     PAQLAKTSLAPIIVFVKVSSPKVLQRLIRSRGKSQMKHLTVQMMAYDKLVQCPPESFD
                     VILDENQLDDACEHLAEYLEVYWRATHHPAPGPGMLGPPSAIPGLQNQQLLGERGEEH
                     SPLERDSLMPSDEASESSRQAWTGSSQRSSRHLEEDYADAYQDLYQPHRQHTSGLPSA
                     NGHDPQDRLLAQDSEHDHNDRNWQRNRPWPKDSY"
     exon            135..257
                     /gene="Cacnb3"
                     /gene_synonym="CACH3B"
                     /inference="alignment:Splign:2.1.0"
     exon            258..380
                     /gene="Cacnb3"
                     /gene_synonym="CACH3B"
                     /inference="alignment:Splign:2.1.0"
     exon            381..496
                     /gene="Cacnb3"
                     /gene_synonym="CACH3B"
                     /inference="alignment:Splign:2.1.0"
     exon            497..561
                     /gene="Cacnb3"
                     /gene_synonym="CACH3B"
                     /inference="alignment:Splign:2.1.0"
     exon            562..581
                     /gene="Cacnb3"
                     /gene_synonym="CACH3B"
                     /inference="alignment:Splign:2.1.0"
     exon            582..662
                     /gene="Cacnb3"
                     /gene_synonym="CACH3B"
                     /inference="alignment:Splign:2.1.0"
     exon            663..721
                     /gene="Cacnb3"
                     /gene_synonym="CACH3B"
                     /inference="alignment:Splign:2.1.0"
     exon            722..831
                     /gene="Cacnb3"
                     /gene_synonym="CACH3B"
                     /inference="alignment:Splign:2.1.0"
     exon            832..983
                     /gene="Cacnb3"
                     /gene_synonym="CACH3B"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1079
                     /gene="Cacnb3"
                     /gene_synonym="CACH3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1229
                     /gene="Cacnb3"
                     /gene_synonym="CACH3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..2521
                     /gene="Cacnb3"
                     /gene_synonym="CACH3B"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctgcgcgg ctcggtggca tctcgggcgc ggcccgccgt cctcgccccc ggcgccgctc
       61 gctcccccca ccccaccccg gactccccca tgtatgacga ctcctacgtg cccgggtttg
      121 aggactcgga ggcgggttca gccgactcct acaccagccg cccctctctg gactcagacg
      181 tttccctgga ggaggaccgg gagagtgccc ggcgagaagt ggagagtcag gctcagcagc
      241 agctggaaag agccaagcac aaacctgtgg catttgctgt gaggaccaat gtcagctact
      301 gtggagttct ggatgaggaa tgcccagtcc agggctctgg agtcaacttc gaggccaaag
      361 attttctgca cattaaagag aagtacagca atgactggtg gatcgggagg ctagtgaaag
      421 aaggtggcga tattgccttc atccccagcc cccaacgcct ggagagcatc cggctcaaac
      481 aggaacagaa ggccaggaga tccgggaacc cttccagcct gagtgacatt ggcaaccgac
      541 gttcccctcc tccatctcta gccaagcaga agcaaaagca ggcggaacat gtccccccgt
      601 atgatgtggt gccctccatg cggcctgtgg tgctggtggg accctctctg aaaggttatg
      661 aggtcacaga catgatgcag aaggctctct tcgacttcct taaacacagg tttgatggca
      721 ggatctccat cacccgcgtc acggctgacc tctcactggc caagcgctct gtgctcaaca
      781 atcctggcaa gaggaccatc atcgagcgct cttctgcccg ctccagcatt gctgaggtgc
      841 agagtgagat tgagcgcata ttcgagctgg ccaaatccct gcagctagtg gtgttggatg
      901 ctgacaccat caaccaccca gcacagctag ccaagacctc actggccccc atcatcgtct
      961 tcgtcaaagt gtcctcgcca aaggtactgc agcgactgat ccgctccagg gggaagtccc
     1021 agatgaagca cctcactgta cagatgatgg catatgataa gctggttcag tgcccacctg
     1081 agtcatttga tgtgattctg gatgagaacc agctggacga cgcctgtgag cacctagctg
     1141 aatacctaga ggtttactgg cgcgctaccc accacccagc accgggcccc gggatgctgg
     1201 gtccgcccag tgccatccct ggacttcaga accagcagct gctgggggag cgaggtgagg
     1261 agcattcacc cctggagcgg gacagtttga tgccctcgga tgaggccagt gagagctccc
     1321 gccaggcctg gaccggatct tcacagcgca gctcccgcca tctggaggag gactatgcag
     1381 atgcctacca ggacctgtac cagcctcacc gtcaacacac ctcggggcta cccagtgcta
     1441 acgggcatga cccccaagac cggctcctag cccaggactc ggagcatgac cacaatgacc
     1501 ggaactggca gcgtaaccgg ccttggccta aggacagcta ctgaccacct cctgccctac
     1561 cctggcaggc acagacacag cggctggggt gtccacctca ggcaggttgg agttagattg
     1621 gcgttaggct gcctctaggt tcagctcaca caaccctctg cccagcccta ggtccagggc
     1681 tgactgtggt cccaaggttc tgggagaagc aaggggcccc ctcacctcct gggcacagtg
     1741 accccgtagg ttctcatcca ggtactagct gtgttctgca tccttggcac cttcccctgc
     1801 ataagaagct gccccggtga gcaatgatct caggccggga tcacttagca ggggtcttcc
     1861 agccagaatg gatacccctc taaacagcag gagggtgtga gtgcaggcaa tgtagcatga
     1921 ggaagagaca tggttcctga gcaggcgtaa accctaagca aaggaactcc gttcacgtca
     1981 ctgccgcaca ttagaaatga agcaatcaga gctcaacatg gcggcacttc tatcccatca
     2041 gctggggtgg gcacttacac ctaagacagg agcagtgcag gtgaggcagg acagacagct
     2101 catggctgta gctctgttag agaacggccc tcctcaccaa accaggaagc ttagcatctg
     2161 gcaagactag ggaactgggg cacagtcaag cccaaagccg gcctggactg cggggaaggg
     2221 ggagcagctt ccagcccccc cacccccctt gctttcctca ttctttgccc ttgcgtctgt
     2281 catttctgtt ccttccctcc atgcctcctg caagataggg gctccctggc tcgtagctgc
     2341 cacttgttaa gttagggtta gatgagagga acagacacaa tgaacagccc cagaggctgt
     2401 cacctggcta cccttgcctt atggctctag cgtttgacct acagagcatg ctccattaag
     2461 aacccgcccc acctcattgt catctccaat aaaacataac gcacagtccc ttgggtgtct
     2521 c
//
