LOCUS       NP_036960                484 aa            linear   ROD 30-MAR-2024
DEFINITION  voltage-dependent L-type calcium channel subunit beta-3 [Rattus
            norvegicus].
ACCESSION   NP_036960
VERSION     NP_036960.1
DBSOURCE    REFSEQ: accession NM_012828.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 484)
  AUTHORS   Becker,A., Wardas,B., Salah,H., Amini,M., Fecher-Trost,C., Sen,Q.,
            Martus,D., Beck,A., Philipp,S.E., Flockerzi,V. and Belkacemi,A.
  TITLE     Cavbeta3 Regulates Ca2+ Signaling and Insulin Expression in
            Pancreatic beta-Cells in a Cell-Autonomous Manner
  JOURNAL   Diabetes 70 (11), 2532-2544 (2021)
   PUBMED   34426509
  REMARK    GeneRIF: Cavbeta3 Regulates Ca(2+) Signaling and Insulin Expression
            in Pancreatic beta-Cells in a Cell-Autonomous Manner.
REFERENCE   2  (residues 1 to 484)
  AUTHORS   Kim,D.I., Park,Y., Jang,D.J. and Suh,B.C.
  TITLE     Dynamic phospholipid interaction of beta2e subunit regulates the
            gating of voltage-gated Ca2+ channels
  JOURNAL   J Gen Physiol 145 (6), 529-541 (2015)
   PUBMED   25964431
REFERENCE   3  (residues 1 to 484)
  AUTHORS   Bourdin,B., Shakeri,B., Tetreault,M.P., Sauve,R., Lesage,S. and
            Parent,L.
  TITLE     Functional characterization of CaValpha2delta mutations associated
            with sudden cardiac death
  JOURNAL   J Biol Chem 290 (5), 2854-2869 (2015)
   PUBMED   25527503
REFERENCE   4  (residues 1 to 484)
  AUTHORS   Beguin,P., Nagashima,K., Mahalakshmi,R.N., Vigot,R., Matsunaga,A.,
            Miki,T., Ng,M.Y., Ng,Y.J., Lim,C.H., Tay,H.S., Hwang,L.A.,
            Firsov,D., Tang,B.L., Inagaki,N., Mori,Y., Seino,S., Launey,T. and
            Hunziker,W.
  TITLE     BARP suppresses voltage-gated calcium channel activity and
            Ca2+-evoked exocytosis
  JOURNAL   J Cell Biol 205 (2), 233-249 (2014)
   PUBMED   24751537
REFERENCE   5  (residues 1 to 484)
  AUTHORS   Agrawal,M., Kumar,V., Singh,A.K., Kashyap,M.P., Khanna,V.K.,
            Siddiqui,M.A. and Pant,A.B.
  TITLE     trans-Resveratrol protects ischemic PC12 Cells by inhibiting the
            hypoxia associated transcription factors and increasing the levels
            of antioxidant defense enzymes
  JOURNAL   ACS Chem Neurosci 4 (2), 285-294 (2013)
   PUBMED   23421680
REFERENCE   6  (residues 1 to 484)
  AUTHORS   Bell,D.C., Butcher,A.J., Berrow,N.S., Page,K.M., Brust,P.F.,
            Nesterova,A., Stauderman,K.A., Seabrook,G.R., Nurnberg,B. and
            Dolphin,A.C.
  TITLE     Biophysical properties, pharmacology, and modulation of human,
            neuronal L-type (alpha(1D), Ca(V)1.3) voltage-dependent calcium
            currents
  JOURNAL   J Neurophysiol 85 (2), 816-827 (2001)
   PUBMED   11160515
REFERENCE   7  (residues 1 to 484)
  AUTHORS   Wei,S.K., Colecraft,H.M., DeMaria,C.D., Peterson,B.Z., Zhang,R.,
            Kohout,T.A., Rogers,T.B. and Yue,D.T.
  TITLE     Ca(2+) channel modulation by recombinant auxiliary beta subunits
            expressed in young adult heart cells
  JOURNAL   Circ Res 86 (2), 175-184 (2000)
   PUBMED   10666413
REFERENCE   8  (residues 1 to 484)
  AUTHORS   Burgess,D.L., Biddlecome,G.H., McDonough,S.I., Diaz,M.E.,
            Zilinski,C.A., Bean,B.P., Campbell,K.P. and Noebels,J.L.
  TITLE     beta subunit reshuffling modifies N- and P/Q-type Ca2+ channel
            subunit compositions in lethargic mouse brain
  JOURNAL   Mol Cell Neurosci 13 (4), 293-311 (1999)
   PUBMED   10328888
REFERENCE   9  (residues 1 to 484)
  AUTHORS   Castellano,A., Wei,X., Birnbaumer,L. and Perez-Reyes,E.
  TITLE     Cloning and expression of a neuronal calcium channel beta subunit
  JOURNAL   J Biol Chem 268 (17), 12359-12366 (1993)
   PUBMED   7685340
REFERENCE   10 (residues 1 to 484)
  AUTHORS   Castellano,A., Wei,X., Birnbaumer,L. and Perez-Reyes,E.
  TITLE     Cloning and expression of a third calcium channel beta subunit
  JOURNAL   J Biol Chem 268 (5), 3450-3455 (1993)
   PUBMED   7679112
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M88751.1, SRR26643298.42138.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     Protein         1..484
                     /product="voltage-dependent L-type calcium channel subunit
                     beta-3"
                     /note="CAB3; calcium channel voltage-dependent subunit
                     beta 3; Calcium channel subunit beta 3; calcium channel,
                     voltage-dependent, beta 3 subunit"
                     /calculated_mol_wt=54433
     Region          1..52
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P54287.1)"
     Region          16..58
                     /region_name="VGCC_beta4Aa_N"
                     /note="Voltage gated calcium channel subunit beta domain
                     4Aa N terminal; pfam12052"
                     /db_xref="CDD:463445"
     Region          58..125
                     /region_name="SH3_CACNB3"
                     /note="Src Homology 3 domain of Voltage-dependent L-type
                     calcium channel subunit beta3; cd12042"
                     /db_xref="CDD:212975"
     Site            order(68,70,73,84,102..103,119,121..122)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212975"
     Region          129..170
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P54287.1)"
     Site            152
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P54287.1)"
     Region          176..356
                     /region_name="Guanylate_kin"
                     /note="Guanylate kinase; pfam00625"
                     /db_xref="CDD:395500"
     Region          195..345
                     /region_name="Mediates interaction with the alpha subunit.
                     /evidence=ECO:0000269|PubMed:15170217"
                     /note="propagated from UniProtKB/Swiss-Prot (P54287.1)"
     Region          388..484
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P54287.1)"
     Site            393
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P54287.1)"
     CDS             1..484
                     /gene="Cacnb3"
                     /gene_synonym="CACH3B"
                     /coded_by="NM_012828.3:90..1544"
                     /db_xref="GeneID:25297"
                     /db_xref="RGD:2248"
ORIGIN      
        1 myddsyvpgf edseagsads ytsrpsldsd vsleedresa rrevesqaqq qlerakhkpv
       61 afavrtnvsy cgvldeecpv qgsgvnfeak dflhikekys ndwwigrlvk eggdiafips
      121 pqrlesirlk qeqkarrsgn psslsdignr rspppslakq kqkqaehvpp ydvvpsmrpv
      181 vlvgpslkgy evtdmmqkal fdflkhrfdg risitrvtad lslakrsvln npgkrtiier
      241 ssarssiaev qseierifel akslqlvvld adtinhpaql aktslapiiv fvkvsspkvl
      301 qrlirsrgks qmkhltvqmm aydklvqcpp esfdvilden qlddacehla eylevywrat
      361 hhpapgpgml gppsaipglq nqqllgerge ehsplerdsl mpsdeasess rqawtgssqr
      421 ssrhleedya dayqdlyqph rqhtsglpsa nghdpqdrll aqdsehdhnd rnwqrnrpwp
      481 kdsy
//
