LOCUS       NM_001398773            4710 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus calcium voltage-gated channel auxiliary subunit
            beta 2 (Cacnb2), transcript variant 1, mRNA.
ACCESSION   NM_001398773 XM_039095295
VERSION     NM_001398773.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4710)
  AUTHORS   Martins,H.C., Gilardi,C., Sungur,A.O., Winterer,J., Pelzl,M.A.,
            Bicker,S., Gross,F., Kisko,T.M., Malikowska-Racia,N., Braun,M.D.,
            Brosch,K., Nenadic,I., Stein,F., Meinert,S., Schwarting,R.K.W.,
            Dannlowski,U., Kircher,T., Wohr,M. and Schratt,G.
  TITLE     Bipolar-associated miR-499-5p controls neuroplasticity by
            downregulating the Cav1.2 subunit CACNB2
  JOURNAL   EMBO Rep 23 (10), e54420 (2022)
   PUBMED   35969184
  REMARK    GeneRIF: Bipolar-associated miR-499-5p controls neuroplasticity by
            downregulating the Cav1.2 subunit CACNB2.
REFERENCE   2  (bases 1 to 4710)
  AUTHORS   Durairaj Pandian,V., Giovannucci,D.R., Vazquez,G. and Kumarasamy,S.
  TITLE     CACNB2 is associated with aberrant RAS-MAPK signaling in
            hypertensive Dahl Salt-Sensitive rats
  JOURNAL   Biochem Biophys Res Commun 513 (3), 760-765 (2019)
   PUBMED   30992131
  REMARK    GeneRIF: The expression level of CACNB2 was up-regulated in the
            high salt (HS) diet fed Dahl Salt-Sensitive (SS) rat kidneys
            compared to low salt diet (LS) fed group. Similar to our in vitro
            observation the RAS-MAPK mRNA levels were increased in HS fed SS
            rat kidneys, compared to LS fed group.
REFERENCE   3  (bases 1 to 4710)
  AUTHORS   Thomas,J.R., Hagen,J., Soh,D. and Lee,A.
  TITLE     Molecular moieties masking Ca2+-dependent facilitation of
            voltage-gated Cav2.2 Ca2+ channels
  JOURNAL   J Gen Physiol 150 (1), 83-94 (2018)
   PUBMED   29208674
REFERENCE   4  (bases 1 to 4710)
  AUTHORS   Zhang,X., Xie,J., Zhu,S., Chen,Y., Wang,L. and Xu,B.
  TITLE     Next-generation sequencing identifies pathogenic and modifier
            mutations in a consanguineous Chinese family with hypertrophic
            cardiomyopathy
  JOURNAL   Medicine (Baltimore) 96 (24), e7010 (2017)
   PUBMED   28614222
REFERENCE   5  (bases 1 to 4710)
  AUTHORS   Wu,J., Yan,Z., Li,Z., Yan,C., Lu,S., Dong,M. and Yan,N.
  TITLE     Structure of the voltage-gated calcium channel Cav1.1 complex
  JOURNAL   Science 350 (6267), aad2395 (2015)
   PUBMED   26680202
REFERENCE   6  (bases 1 to 4710)
  AUTHORS   Yamada,Y., Nagashima,M., Tsutsuura,M., Kobayashi,T., Seki,S.,
            Makita,N., Horio,Y. and Tohse,N.
  TITLE     Cloning of a functional splice variant of L-type calcium channel
            beta 2 subunit from rat heart
  JOURNAL   J Biol Chem 276 (50), 47163-47170 (2001)
   PUBMED   11604404
REFERENCE   7  (bases 1 to 4710)
  AUTHORS   Burgess,D.L., Biddlecome,G.H., McDonough,S.I., Diaz,M.E.,
            Zilinski,C.A., Bean,B.P., Campbell,K.P. and Noebels,J.L.
  TITLE     beta subunit reshuffling modifies N- and P/Q-type Ca2+ channel
            subunit compositions in lethargic mouse brain
  JOURNAL   Mol Cell Neurosci 13 (4), 293-311 (1999)
   PUBMED   10328888
REFERENCE   8  (bases 1 to 4710)
  AUTHORS   Taviaux,S., Williams,M.E., Harpold,M.M., Nargeot,J. and Lory,P.
  TITLE     Assignment of human genes for beta 2 and beta 4 subunits of
            voltage-dependent Ca2+ channels to chromosomes 10p12 and 2q22-q23
  JOURNAL   Hum Genet 100 (2), 151-154 (1997)
   PUBMED   9254841
REFERENCE   9  (bases 1 to 4710)
  AUTHORS   Perez-Reyes,E., Castellano,A., Kim,H.S., Bertrand,P., Baggstrom,E.,
            Lacerda,A.E., Wei,X.Y. and Birnbaumer,L.
  TITLE     Cloning and expression of a cardiac/brain beta subunit of the
            L-type calcium channel
  JOURNAL   J Biol Chem 267 (3), 1792-1797 (1992)
   PUBMED   1370480
REFERENCE   10 (bases 1 to 4710)
  AUTHORS   Williams,M.E., Feldman,D.H., McCue,A.F., Brenner,R., Velicelebi,G.,
            Ellis,S.B. and Harpold,M.M.
  TITLE     Structure and functional expression of alpha 1, alpha 2, and beta
            subunits of a novel human neuronal calcium channel subtype
  JOURNAL   Neuron 8 (1), 71-84 (1992)
   PUBMED   1309651
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Dec 23, 2021 this sequence version replaced XM_039095295.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF394941.1, SRR26360186.495173.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-221               JAXUCZ010000017.1  82473215-82473435
            222-314             JAXUCZ010000017.1  82483184-82483276
            315-434             JAXUCZ010000017.1  82721421-82721540
            435-557             JAXUCZ010000017.1  82788671-82788793
            558-694             JAXUCZ010000017.1  82790432-82790568
            695-771             JAXUCZ010000017.1  82793549-82793625
            772-905             JAXUCZ010000017.1  82797626-82797759
            906-986             JAXUCZ010000017.1  82801246-82801326
            987-1045            JAXUCZ010000017.1  82801764-82801822
            1046-1155           JAXUCZ010000017.1  82808597-82808706
            1156-1307           JAXUCZ010000017.1  82811592-82811743
            1308-1403           JAXUCZ010000017.1  82812963-82813058
            1404-1592           JAXUCZ010000017.1  82814705-82814893
            1593-4710           JAXUCZ010000017.1  82815447-82818564
FEATURES             Location/Qualifiers
     source          1..4710
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.3"
     gene            1..4710
                     /gene="Cacnb2"
                     /gene_synonym="Cacnlb2"
                     /note="calcium voltage-gated channel auxiliary subunit
                     beta 2"
                     /db_xref="GeneID:116600"
                     /db_xref="RGD:67385"
     exon            1..221
                     /gene="Cacnb2"
                     /gene_synonym="Cacnlb2"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..2081
                     /gene="Cacnb2"
                     /gene_synonym="Cacnlb2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     voltage-dependent L-type calcium channel subunit beta-2;
                     CAB2; calcium channel voltage-dependent subunit beta 2;
                     calcium channel, voltage-dependent, beta 2 subunit;
                     voltage-gated calcium channel beta2i subunit"
                     /codon_start=1
                     /product="voltage-dependent L-type calcium channel subunit
                     beta-2 isoform 1"
                     /protein_id="NP_001385702.1"
                     /db_xref="GeneID:116600"
                     /db_xref="RGD:67385"
                     /translation="MVQSDTSKSPPIAAVAQESQMELLESAAPAGALGAQSYGKGARR
                     KNRFKGSDGSTSSDTTSNSFVRQGSADSYTSRPSDSDVSLEEDREAVRREAERQAQAQ
                     LEKAKTKPVAFAVRTNVRYSAAQEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLV
                     KEGCEIGFIPSPVKLENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPS
                     SAIDIDATGLDAEENDIPANHRSPKPSANSVTSPHSKEKRMPFFKKTEHTPPYDVVPS
                     MRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSK
                     HAIIERSNTRSSLAEVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYV
                     KISSPKVLQRLIKSRGKSQAKHLNVQMVAADKLAQCPPQESFDVILDENQLEDACEHL
                     ADYLEAYWKATHPPSSNLPNPLLSRTLATSTLPLSPTLASNSQGSQGDQRTDRSAPRS
                     ASQAEEEPCLEPVKKSQHRSSSATHQNHRSGTGRGLSRQETFDSETQESRDSAYVEPK
                     EDYSHEHVDRYVPHREHNHREESHSSNGHRHREPRHRTRDMGRDQDHNECSKQRSRHK
                     SKDRYCDKEGEVISKRRSEAGEWNRDVYIRQ"
     exon            222..314
                     /gene="Cacnb2"
                     /gene_synonym="Cacnlb2"
                     /inference="alignment:Splign:2.1.0"
     exon            315..434
                     /gene="Cacnb2"
                     /gene_synonym="Cacnlb2"
                     /inference="alignment:Splign:2.1.0"
     exon            435..557
                     /gene="Cacnb2"
                     /gene_synonym="Cacnlb2"
                     /inference="alignment:Splign:2.1.0"
     exon            558..694
                     /gene="Cacnb2"
                     /gene_synonym="Cacnlb2"
                     /inference="alignment:Splign:2.1.0"
     exon            695..771
                     /gene="Cacnb2"
                     /gene_synonym="Cacnlb2"
                     /inference="alignment:Splign:2.1.0"
     exon            772..905
                     /gene="Cacnb2"
                     /gene_synonym="Cacnlb2"
                     /inference="alignment:Splign:2.1.0"
     exon            906..986
                     /gene="Cacnb2"
                     /gene_synonym="Cacnlb2"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1045
                     /gene="Cacnb2"
                     /gene_synonym="Cacnlb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1155
                     /gene="Cacnb2"
                     /gene_synonym="Cacnlb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1307
                     /gene="Cacnb2"
                     /gene_synonym="Cacnlb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1403
                     /gene="Cacnb2"
                     /gene_synonym="Cacnlb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1592
                     /gene="Cacnb2"
                     /gene_synonym="Cacnlb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..4710
                     /gene="Cacnb2"
                     /gene_synonym="Cacnlb2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acatgctcta gcgtcgtccc gcgcactgag aacctccgat cgtggggcga agaggagcag
       61 gggacctggg gcgtggagga gggacccgca accttggagt cgacttttcg ccgatggtcc
      121 aaagcgacac gtccaagtcg cctcccatag cggcggtggc gcaggagagc cagatggagc
      181 tgctggaaag cgcggctccc gcgggggcgc tcggagcaca gtcatatgga aaaggagcca
      241 ggaggaaaaa cagatttaaa ggctcggatg gcagcacgtc ctcagacact acctccaaca
      301 gctttgtccg gcagggttcg gcagactcct acaccagccg cccatcggat tcagatgtgt
      361 ctttggaaga ggaccgggag gcagtccgta gagaagctga gcggcaggcc caggcccagt
      421 tggaaaaagc aaagacaaaa cctgttgcat ttgcagttcg gaccaatgtc aggtacagcg
      481 cagcccagga ggatgacgtc ccggtgcccg gcatggccat ctcattcgag gcaaaagatt
      541 ttctgcatgt taaggaaaaa tttaataatg actggtggat aggacggctg gttaaagaag
      601 gctgtgaaat cggatttatt ccaagcccgg tcaaactaga gaacatgagg ctacagcatg
      661 aacagagagc caagcaaggg aaattctact ccagtaaatc aggaggaaat tcatcatcca
      721 gtttgggtga catagtaccc agttccagaa aatcgacacc tccatcatct gctatagaca
      781 tagatgctac tggcttagat gcagaagaga atgatattcc agcaaaccac cgctccccta
      841 agcccagtgc aaacagtgta acgtcacccc actccaaaga gaaaagaatg cccttcttta
      901 agaagacaga gcacactcct ccttacgatg tggtaccatc catgagacca gtggtgttgg
      961 tgggcccctc cctgaagggg tatgaggtca cagatatgat gcaaaaagca ctgtttgatt
     1021 ttctaaaaca cagatttgaa ggacggatat ccatcacaag agttactgct gacatctccc
     1081 tggccaaacg ctcagtatta aacaacccca gtaagcacgc aataatagaa agatccaaca
     1141 caaggtcgag cttagcggaa gttcagagtg aaattgaaag gatttttgaa cttgcaagaa
     1201 cactgcaatt ggtagtcctt gacgcggata caattaatca cccagctcaa ctcagtaaga
     1261 cctctctggc ccctatcata gtgtatgtaa agatttcttc tcctaaggtt ttacaaaggt
     1321 taataaaatc tcgaggaaag tctcaagcaa agcacctcaa tgtccagatg gtggcagccg
     1381 ataaactggc ccagtgtccc ccgcaggagt catttgatgt gatcttggat gagaaccaac
     1441 ttgaggatgc ttgtgagcat ctcgccgact atctggaggc gtactggaag gccacccacc
     1501 ctcccagcag taacctcccc aaccctctcc ttagccggac tttagccacc tcaactttac
     1561 ctctgagccc cacccttgcc tctaattcac agggttctca aggtgatcag aggactgatc
     1621 gctctgctcc ccggtctgct tcccaagctg aagaagaacc ttgtctggaa ccagtcaaaa
     1681 aatcccaaca ccgttcttcc tcagccacac accaaaacca ccgcagtggg acaggtcgag
     1741 gcctctctag gcaagaaacg tttgactctg aaacccaaga gagccgagac tctgcctacg
     1801 tggagccaaa ggaagattat tcacatgaac atgtggaccg ctatgttcca caccgtgaac
     1861 ataaccacag agaggagagc cacagcagca atggccacag gcacagggag cctcgccacc
     1921 gcactaggga catgggtcga gaccaggacc acaatgagtg cagcaaacaa cgaagccggc
     1981 ataaatctaa ggatcgctac tgtgacaagg aaggggaagt aatatccaaa agaaggagtg
     2041 aggctggcga gtggaacagg gatgtataca tccgccaatg accgtgcgtg tctctgcccc
     2101 caagtcttgt gtaacatcat ccttaagcaa aatctttggg gctccattgc aaccatctgt
     2161 gatctgtctt gtatattttg tattgctgtt gcttgaatag caatagcatg caatcaagta
     2221 ttactataca ttcttttgta agtaccacag aaattggcct agtacaagct gcagtcctca
     2281 gtctatatcc tgaactcttc aaaagctgtt tggggtagct gccacctgaa cagagtggct
     2341 tcagaaatgt agttaatgta ttcagtgagc cagatgcagc acagataaca agtggaattc
     2401 ctccatattt ttaataccca gatacctgac ctgtcattct ttcatggacc actgtttctt
     2461 gcttgtacct ctggctgact aaatttgggg acagattcag tcttgcctta cacaaagggg
     2521 attataaagt tagaatctat tttctatgta ctagtactgt gtactgtgta gacagtttgt
     2581 aaatgttatt tctgcaaaca ccttattata attatatata taatatatat atatatcagt
     2641 ttgatcatac aattttaggg tcttaatgcc aagtcagcag atttgcttta tgaatcacag
     2701 ggactagaaa tgcccacatt caggaaattt ctaatattgt ctagactcct ctccctattc
     2761 taagagagag cctgtatata gtgtaaatac gtgtgattgc ttgacttgag gtttgatttc
     2821 tgaatgtaat cccatccttg taagtttttc attttaacca taaattatgg taaatgtaac
     2881 caactccaga ggtttttcta ctccatacag tccacactga ttgtgacaaa cacgttctta
     2941 gcagctagtg tctgtggtag tcactgcact ggagtatcca agcggagccc accatgtgca
     3001 catgcgtgtg tgagtgtgag agtgagtggc tgagacaaag tggaatgcag aagactaatg
     3061 cggaaaccag aggctgatgg acctggcttt gcatttaact gttgtatgtt gctttcgaac
     3121 ccactgagca gccagggaat gtgaggaagc ttgctgccaa aggaactagg gaagcactta
     3181 gtggctgact ccctgctttt gcccctgaag agagaaaaca tgggcgtctt gtactgtgag
     3241 tgttccactg gaaatggaca atctttgtgt gtcagagtat tttgttttag taagaaatgt
     3301 ttacacagct tgtgcaatta tttcgtaggg aaataaattt ttataacttg tcccacttca
     3361 ctttctaaac gtgcctattg ctcctcttgt tcatcctcag ccaccgctct tcttcccctg
     3421 caccaagctg tgcagctgca ctgtcggaat ctagaagtgc ttcttagaac caaagttcct
     3481 gctaaatctt tagaagttat cagggcaaaa atggaatgac ttgaagcaaa aaaagttgaa
     3541 acattttctt ttacgagaca tctctaaggg agaacgtaga agacactttt ttcacacctc
     3601 aatttgcttt cgttaagaag cttaaactgc tcttagccga ggctatccaa tctctgtctc
     3661 tcaagagccc agtgctgatg gagaggtaag actgtatgag ctccacacgc ccctagcatt
     3721 cgaagccttc gcaggaaaat gtctatctgt gattacccaa ccagatcagt atatactaaa
     3781 acaagtaagt tacaataaat atatttttgt tttgtttccg ggttacttca cattcttctg
     3841 aaatattctt aggcattcgt atgaaaagca gtttgacatt tactacttta tactataccc
     3901 aagaaaactc aagcatttaa aacgtgagtt gcatatgtat ttgaccagtg ggttacctgc
     3961 ttagagaatg aaattttcct cagaacagca ctccacgctt acagaaatac agacgatacc
     4021 cagcaatctc tgacccaaac tgagagcgta cgcatcacag acagactttc tacagtgatc
     4081 tactcctttc cggtgtgtgt gtttcatcca gaggaatggc tgagacactc agcctcatga
     4141 tggatggtgt ttctcttacc tgcagttacc aggcttccct ttcagaccag ttctaatgct
     4201 gtccgtccat ttgcttaatg cgagcatgtg cgtgcacatc acagcatccc ccctactctg
     4261 ccgaaagctc tgacataggc acctgtgtgt gaaagctaca tacttgggct cccaaggaac
     4321 atggctgact tcctgactaa tgggatgtaa cactgctctt ttcatgagca aaagtttaat
     4381 cttacctgac tcacttgtag aatcctgatt ttttttttcc tgtagtcaag ctaggaaacg
     4441 ctggaaatgt agttaacagt gttatacttg tgtcagtcac ttgaatttct cctctgcttt
     4501 ctcaactgct catttactta ctgttacaaa aaaaggtgct gctaaaagta ggacgtcttc
     4561 agtcacactg tactgcagac aatgccacac tcaacttgtc tgctctgcat ccctgttaac
     4621 aaacactccc tgtcacgaca ctgaactgtt tgatgaactt ggtttaaagt aattcatgga
     4681 aacaaataaa gagctggctt ctgcactgtt
//
